Journal of Medical Biochemistry最新文献

{"title":"Evaluation of plasma Alpha klotho levels in obese cases.","authors":"Ibrahim Solak, Ibrahim Guney, Nevin Sekmenli, Huseyin Kurku, Mehmet Ali Eryilmaz","doi":"10.5937/jomb0-60664","DOIUrl":"10.5937/jomb0-60664","url":null,"abstract":"<p><strong>Background: </strong>Klotho is an anti-ageing gene that extends lifespan when overexpressed and accelerates ageing when disrupted. In our study, we will investigate the correlations between plasma <span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\">α</span>-Klotho (<span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\">α</span>-KL) protein levels with body mass index (BMI), carotid intima media thickness (CIMT), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), high-sensitivity C-reactive protein (hsCRP) and cholesterol values in obese patients.</p><p><strong>Methods: </strong>This study was conducted as a single-centre, cross-sectional study.</p><p><strong>Results: </strong>The study included 90 participants: 35 women (38.9%) and 55 men (61.1%). Of the participants included in the study, 30 were normal weight (33.3%) (Group 1), 30 were overweight (33.3%) (Group 2), and 30 were obese (33.3%) (Group 3). There were statistically significant differences in the <span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\">α</span>-KL protein (p = 0.010), hsCRP (p&lt; 0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) (p = 0.022) between the study groups. There is no significant difference between the study groups for CIMT (p= 0.380), TOS (p= 0.613), TAS (p= 0.056), or OSI (p= 0.943).</p><p><strong>Conclusions: </strong>In this study, the overweight group had a-KL protein levels that were significantly higher than those in the obese group, whereas hsCRP levels were significantly higher in the obese group than in the overweight and normal weight groups. There were no significant differences in CIMT, TAS, TOS, and OSI values between the study groups. There were no significant correlations between <span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\">α</span>-KL protein values and BMI, hsCRP CIMT, TAS, TOS, or OSI in participants in the study.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1307-1315"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of the serum CCR5 and LXA4 levels with airway remodelling in bronchial asthma patients.","authors":"Haiyue Huang, Ruirui Luo, Xuan Yang, Zhigang Wu, Zhongxi Ding","doi":"10.5937/jomb0-61476","DOIUrl":"10.5937/jomb0-61476","url":null,"abstract":"<p><strong>Background: </strong>To analyse the expression levels of serum chemokine receptor 5 (CCR5) and lipoxin A4 (LXA4) in patients with bronchial asthma and their correlations with immune dysfunction and airway remodelling.</p><p><strong>Methods: </strong>According to disease severity, 240 patients with bronchial asthma admitted to our hospital from January 2023 to May 2025 were divided into mild-to-moderate asthma (n = 180) and severe asthma (n = 60) groups. As the control group, 150 more healthy people who were admitted for a physical examination during that time were chosen. Serum CCR5 and LXA4 levels, as well as immune function indicators (CD 3+, CD 4+, CD8 +, and CD 4+/CD 8+), were measured in each group. The airway remodelling indicators [airway lumen area (LA), airway wall area (WA) and total airway area (TA)] of the right upper lobe tip segment were examined via CT. The correlations between serum CCR5 and LXA4 levels and immune dysfunction, as well as airway remodelling, were analysed using a bivariate Spearman correlation test, and a multivariate logistic model was established to identify independent risk factors influencing serum CCR5 and LXA4 levels in patients with bronchial asthma.</p><p><strong>Results: </strong>Compared with the mild-to-moderate group, the severe group had higher serum levels of LXA4 and CCR5. Serum CCR5 was higher in the severe group than in the mild to moderate group, and LXA4 was lower in the severe group than in the mild to moderate group. There were statistically significant differences (P&lt;0.05). Serum CD8+ T cell levels were higher than in the control group, whereas CD3+, CD4+, and CD4+/CD8+ T cell levels were lower in the mild to moderate and severe groups. Furthermore, the severe group had lower levels of CD3+, CD4+, and CD4+/CD8+ T cells than the mild-to-moderate group, whereas the mild-to-moderate group had higher levels of CD8+ T cells. The mild-to-moderate and severe groups had lower levels of LA, WA, and TA in the right superior lobe apex segment than the control group, and patients in the severe group had lower levels of these three parameters than those in the mild-to-moderate group. There was a negative connection between serum CCR5 and LXA4 and CD3+, CD4+, and CD4+/CD8+ (P&lt; 0.05) and a positive correlation with CD8+, LA, WA, and TA. Multivariate logistic regression analysis revealed that disease severity, CD3+, CD4+, CD8+, CD 4+/CD 8+, LA, WA, and TA were independent risk factors for increased serum CCR5 and LXA4 in patients with bronchial asthma (P&lt;0.05).</p><p><strong>Conclusions: </strong>Serum CCR5 and LXA4 are closely related to the severity of bronchial asthma, immune dysfunction and airway remodelling.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1396-1403"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating tumor-associated biomarkers and pulmonary function in lung cancer patients with comorbid COPD: A retrospective prognostic analysis.","authors":"Hongxia Ma, Qian Zhang, Junnan Yue, Jun Su, Xingrui Meng, Fangyuan Ren, Zheng Li","doi":"10.5937/jomb0-65203","DOIUrl":"10.5937/jomb0-65203","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is closely associated with lung cancer development and progression through persistent systemic inflammation and immune-biochemical alterations. Circulating tumor-associated biochemical biomarkers may reflect disease severity and provide valuable prognostic information. This study aimed to explore the potential association between circulating tumor markers and prognosis in lung cancer patients with comorbid COPD, acknowledging the exploratory nature of this retrospective analysis.</p><p><strong>Methods: </strong>Clinicopathological characteristics and circulating biochemical biomarkers, including carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), carbohydrate antigen 199 (CA199), cytokeratin-19 fragment (CYFRA21-1), and vascular endothelial growth factor (VEGF), were analyzed. Multivariate logistic regression was performed to identify independent prognostic biochemical predictors. Receiver operating characteristic (ROC) curve analysis was used to evaluate prognostic performance.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1232-1242"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenascin-C, presepsin (SCD14-ST), and neutrophil-to-lymphocyte ratio as complementary circulating biomarkers for sepsis-associated organ dysfunction and 28-day all-cause mortality: A biomarker-enriched prognostic model.","authors":"Yuxiang Xie, Chengzhi Xie","doi":"10.5937/jomb0-64095","DOIUrl":"https://doi.org/10.5937/jomb0-64095","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is characterized by dysregulated host responses with subsequent organ dysfunction. Conventional biomarkers (e.g., procalcitonin) incompletely reflect tissue injury and immune activation. We evaluated the clinical laboratory value of circulating Tenascin-C (TNC), presepsin (sCD14-ST), and the neutrophil-to-lymphocyte ratio (NLR) as complementary biomarkers of organ dysfunction severity and short-term prognosis in sepsis.</p><p><strong>Methods: </strong>This retrospective observational study enrolled 103 adult ICU patients fulfilling Sepsis-3 criteria (June 2023-June 2025). Peripheral blood was collected within 12 h of ICU admission. Serum TNC was measured by ELISA; sCD14-ST was quantified by chemiluminescent enzyme immunoassay; NLR was calculated from routine blood counts. Associations with organ dysfunction were assessed using Spearman correlation with SOFA scores. Independent associations with 28-day all-cause mortality were examined using multivariable logistic regression. Predictive performance of a clinical baseline model (age, SOFA, PCT) versus a biomarker-enriched model (baseline + TNC, sCD14-ST, NLR) was evaluated by ROC analysis.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 5","pages":"1086-1096"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nutritional intervention on insulin resistance-associated inflammatory biomarkers and gene polymorphisms in gestational diabetes mellitus.","authors":"Jiayu Li, Lili Sun, Linjing Zhang","doi":"10.5937/jomb0-63663","DOIUrl":"https://doi.org/10.5937/jomb0-63663","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance is a central biochemical abnormality in gestational diabetes mellitus (GDM) and is closely linked to chronic low-grade inflammation. Pro-inflammatory cytokines and adipokines, including tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and adiponectin (APN), play key roles in metabolic dysregulation during pregnancy. This study investigated the effects of nutritional intervention on insulin resistance-related inflammatory biomarkers and their gene polymorphisms in pregnant women with GDM.</p><p><strong>Methods: </strong>In this retrospective comparative cohort study, 400 pregnant women diagnosed with GDM at Hainan Women and Children's Medical Center between October 2023 and December 2024 were enrolled and assigned to a conventional treatment group (CT, n = 200) or a nutritional intervention group (NC, n = 200). Both groups received standard glycemic management, while the NC group additionally underwent individualized nutritional intervention. Serum levels of TNF-a, IL-6, and APN were measured by enzyme-linked immunosorbent assay, and polymorphisms of the corresponding genes were analyzed using fluorescence quantitative PCR. Glycemic and lipid parameters were evaluated concurrently. Clinical efficacy and pregnancy outcomes were assessed as secondary endpoints.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 5","pages":"1097-1112"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical biochemical significance of STAT6, ERG, and miR-647 expression in prostate cancer: Associations with tumor aggressiveness and patient prognosis.","authors":"Xin Hong, Lin Zhao, Tian Wang, Xiaobing Yang, Changzhen Hao","doi":"10.5937/jomb0-63731","DOIUrl":"10.5937/jomb0-63731","url":null,"abstract":"<p><strong>Background: </strong>Reliable molecular indicators that can facilitate early detection and prognosis prediction in prostate cancer are still insufficient. Although Transcription 6 (STAT6), ERG, and microRNA-647 (miR-647) have recently been recognized as key participants in tumor-related signaling pathways, their specific biochemical functions in the context of prostate cancer have yet to be clearly defined. This study evaluated the expression profiles of STAT6 mRNA, ERG mRNA, and miR-647 in prostate cancer tissue and explored their associations with clinicopathological features and patient outcomes.</p><p><strong>Methods: </strong>Surgical specimens were obtained from 70 patients, including both prostate cancer tissues and their corresponding adjacent non-tumorous counterparts. Quantitative real-time PCR (qPCR) was used to measure STAT6 mRNA, ERG mRNA, and miR-647 expression. The relationships between biomarker expression and clinical parameters - including age, tumor diameter, lymph node involvement, T stage, and pathological differentiation - were examined. Overall survival (OS) and progression-free survival (PFS) were evaluated using Kaplan-Meier curves with log-rank comparisons, while Spearman correlation analysis was employed to determine the associations among the examined molecular markers.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 5","pages":"1079-1085"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary biomarkers in the early diagnosis of diabetic kidney disease and diabetic retinopathy: A pilot study.","authors":"Brankica Terzić, Zoran Radojičić, Predrag Đurić, Dušan Pualić, Mirko Resan, Mirjana Mijušković","doi":"10.5937/jomb0-61991","DOIUrl":"10.5937/jomb0-61991","url":null,"abstract":"<p><strong>Background: </strong>Diabetic kidney disease (DKD) and diabetic retinopathy (DR) are the most frequent microvascular complications of diabetes mellitus. Although microalbuminuria is a conventional early marker of DKD, its limited sensitivity and the growing recognition of nonalbuminuric DKD highlight the need for more sensitive early detection tools. Urinary biomarkers such as type IV collagen, transferrin, and liver-type fatty acid-binding protein (L-FABP) may capture early glomerular or tubular injury before the onset of overt albuminuria. This pilot study evaluated the diagnostic performance of these biomarkers in adults with type 2 diabetes mellitus (T2DM) and explored their associations with DR.</p><p><strong>Methods: </strong>A cross-sectional per-protocol study included 80 T2DM patients and 10 healthy controls. Diabetic participants were categorised as normoalbuminuric (&lt;30 mg/day) or microalbuminuric (30-300 mg/day). First-morning urine samples were used for final analyses. Urinary type IV collagen, transferrin, and L-FABP were quantified using ELISA and expressed in ng/mL. Group comparisons used t-tests or ANOVA for normally distributed variables, and Mann-Whitney U or Kruskal-Wallis tests for non-normally distributed data. Correlations were assessed using Pearson or Spearman coefficients. Diagnostic performance was analyzed using ROC curves.</p><p><strong>Results: </strong>The cohort (55% male; mean age 59.85± 8.87 years) had similar BMI, smoking status, and eGFR across groups. Biomarker levels differed significantly among microalbuminuric, normoalbuminuric, and control groups (p&lt;0.001): type IV collagen (0.97 vs. 0.55 vs. 0.48), transferrin (45.51 vs. 14.83 vs. 6.57), and L-FABP (480.15 vs. 228.08 vs. 89.91). Type IV collagen demonstrated the best diagnostic ability for early DKD (AUC 90.4%). DR was present in 24 patients (30%), and transferrin levels were significantly higher in those with DR (81.38 vs. 38.12 ng/mL; p=0.03).</p><p><strong>Conclusions: </strong>Urinary type IV collagen, transferrin, and L-FABP show promise for early DKD detection, while transferrin additionally correlates with DR. Larger studies are needed to confirm these findings.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 5","pages":"1035-1043"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-based superoxide dismutase supplementation in the athlete population.","authors":"Petrovičova Olina Dudašova, Brižita Đorđević, Vanja Todorović","doi":"10.5937/jomb0-63037","DOIUrl":"https://doi.org/10.5937/jomb0-63037","url":null,"abstract":"<p><p>Physical exercise significantly influences the redox balance, with its intensity, duration, and type affecting the produc-tion of free radicals, including reactive oxygen and nitrogen species. An excess of free radicals can lead to oxidative stress. Elite athletes, due to rigorous training and often insufficient rest, are particularly susceptible to oxidative stress, which can negatively affect their health and sports performance. Plant-based superoxide dismutase (SOD), combined with gliadin isolated from wheat, is a relatively new dietary supplement known for its antioxidant proper-ties. The aim of this review was to evaluate the effects of SOD/gliadin supplementation among athletes. We exam-ined the impact of this supplementation on redox status, inflammatory markers, indicators of muscle damage, and sports performance. Overall, the analysis of the data indi-cated some beneficial effects on all observed aspects of athletes' health and performance. The effects of supple-mentation appear to depend on the type of sport, the ath-lete's training status, and the design of the supplementa-tion study. However, very few studies have been published on this topic; therefore, further research is needed to clarify the potential benefits of SOD/gliadin supplementation for athletes. Future studies should include a larger number of participants and implement controlled conditions with stan-dardised dosage regimens, enabling more robust, compa-rable, and reliable outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 5","pages":"975-987"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of serum sterol sulfotransferase, ANGPTL8, and SDC1 on liver function in patients with intrahepatic cholestasis during pregnancy.","authors":"Qixin Wang, Ming Wang, Wenqi Wu","doi":"10.5937/jomb0-62650","DOIUrl":"10.5937/jomb0-62650","url":null,"abstract":"<p><strong>Background: </strong>To explore the relationships between serum Sterol Sulfotransferase, Recombinant Angiopoietin Like Protein 8 (ANGPTL8), and Recombinant Syndecan (SDC1) and liver function in patients with intrahepatic cholestasis of pregnancy (ICP), as well as their influence on perinatal outcomes.</p><p><strong>Methods: </strong>The control group comprised 200 healthy pregnant women who underwent physical examinations during the same period, while the study group comprised 210 ICP patients admitted to our hospital between June 2023 and December 2024. The study group's and the control group's serum Sterol Sulfotransferase, ANGPTL8, SDC1, and liver function markers were compared. Pearson correlation analysis was used to assess the relationships between serum levels of Sterol Sulfotransferase, ANGPTL8, and SDC1 and various liver function indicators. The patients in the study group were divided into a poor-outcome group (86 patients) and a good-outcome group (124 patients) based on perinatal outcomes. Serum Sterol Sulfotransferase, ANGPTL8, and SDC1 levels were examined between the groups with negative and positive outcomes. Factors predicting unfavourable perinatal outcomes in patients with ICPs were examined using univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>Despite lower serum Sterol Sulfotransferase levels, the study group had higher levels of ANGPTL8 and SDC1 than the control group. P &lt; 0 .0 5 indicated that the differences were statistically significant. The study group's levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were significantly higher than those of the control group (P&lt;0.05). The Pearson correlation analysis showed that while the levels of ANGPTL8 and SDC1 were positively associated with AST, ALT, and ALP (P&lt; 0.05), the level of serum Sterol Sulfotransferase was negatively associated with these levels. Compared to the group that experienced a positive outcome, the unfavourable outcome group's serum Sterol Sulfotransferase level was lower, whereas SDC1 and ANGPTL8 levels were greater than those in the group with favourable results. Decreased serum Sterol Sulfotransferase levels (S23 mmol/L), increased ANGPTL8 levels (650 pg/mL), and poor perinatal outcomes were associated with elevated SDC1 levels (53 ng/mL) in patients with ICP (P&lt;0.05).</p><p><strong>Conclusions: </strong>Serum Sterol Sulfotransferase, ANGPTL8 and SDC1 are closely related to liver function and perinatal outcomes in patients with ICP. As the level of serum Sterol Sulfotransferase decreases and the levels of ANGPTL8 and SDC1 increase, it can lead to aggravated liver function impairment in patients with ICP, and it leads to adverse perinatal outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 5","pages":"1063-1071"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical monitoring-guided clinical management improves inflammatory and oxidative stress profiles in sudden sensorineural hearing loss.","authors":"Yafang Luo, Jiani Wu, Yeting Xie","doi":"10.5937/jomb0-63128","DOIUrl":"10.5937/jomb0-63128","url":null,"abstract":"<p><strong>Background: </strong>Sudden sensorineural hearing loss (SSNHL) is strongly linked to dysregulated inflammatory and oxidative stress pathways. However, the biochemical impact of applying these biomarkers to guide clinical management remains unclear. This study evaluated whether inflammationand oxidative stress-based biochemical monitoring can optimize treatment responses and improve clinical outcomes in SSNHL.</p><p><strong>Methods: </strong>A total of 102 patients with SSNHL were randomly allocated to either a routine-management group or a biomarker-guided management group. Serial serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), malondialdehyde (MDA), and superoxide dismutase (SOD) were quantified by ELISA before and after intervention. Hearing thresholds and quality-of-life indices were assessed concurrently.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 5","pages":"1156-1162"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}