Journal of Medical Biochemistry最新文献

{"title":"Influence mechanism of serum free immunoglobulin light chain on pulmonary inflammatory response and serum levels of inflammatory factors in patients with chronic obstructive pulmonary disease.","authors":"Ying Fang, Dandan Hu, Qin Li, Mei Chen, Cuiying Yin","doi":"10.5937/jomb0-49201","DOIUrl":"10.5937/jomb0-49201","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of chronic obstructive pulmonary disease (COPD) is not fully understood. This work aimed to demonstrate the role of serum free light chains (sFLC) in the pulmonary inflammatory response of COPD patients and its relationship with serum inflammatory cytokine (IC) levels.</p><p><strong>Methods: </strong>Eighty subjects were enrolled, including 40 COPD patients (COPD group) and 40 healthy controls (control group). All patients were further rolled into four subgroups regarding the Global Initiative for Chronic Obstructive Lung Disease (GOLD) staging criteria. The serum levels of sFLC and ICs were compared between the two groups, and their correlations with lung function indicators were analyzed.</p><p><strong>Results: </strong>The serum sFLC levels of COPD patients were markedly superior to those of healthy controls. The levels of serum sFLC and ICs (tumour necrosis factor-a (TNF-a), interleukin (IL)-6, IL-8) gradually increased with the severity of the disease. The levels of ICs were negatively correlated with lung function indicators (FEV1% predicted, FEV1/FVC).</p><p><strong>Conclusions: </strong>These findings suggest that serum sFLC may play a critical role in the pulmonary inflammatory response of COPD patients and serve as a potential indicator for evaluating COPD severity and predicting disease progression.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"908-914"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of 99Tcm-DTPA orbit SPECT/CT combined with thyroid function test in the treatment of radioactive iodine I-131 in patients with thyroid-associated ophthalmopathy-hyperthyroidism.","authors":"Li Su, Ping Mi, Wenqiang Niu, Ting Zhou, Wang Yang, Cheng Chen, Chenggang Huang","doi":"10.5937/jomb0-48734","DOIUrl":"10.5937/jomb0-48734","url":null,"abstract":"<p><strong>Background: </strong>Thyroid-associated ophthalmopathy (TAO) is an autoimmune response to inflammation of the thyroid and orbital tissue. This research evaluated the efficacy of 99Tcm-DTPA orbital SPECT/CT combined with thyroid function test in radioactive iodine I-131 (RAI) treatment of TAO-hyperthyroidism.</p><p><strong>Methods: </strong>We retrospectively studied clinical activity score (CAS), blood thyrotropine (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thickness of extra-ocular muscle (EOM), and uptake rate (UR) of 99Tcm-DTPA orbital SPECT/CT of 43 patients after 6 months of treatment with 20 mCi RAI. Parameters were compared before and after RAI in patients assessed as effectively treated (normal thyroid function or hypothyroidism), and correlations between blood FSH, FT3, FT4, thickness of EOM, and UR were analyzed after treatment.</p><p><strong>Results: </strong>After RAI, 35 cases (70 eyes, 81.4%) had normal or hypothyroidism, and 8 cases (16 eyes, 18.6%) had hyperthyroidism. Compared with the patients who failed treatment, effectively treated patients had lower CAS, FT3, FT4, and UR and higher blood TSH. In patients with effective treatment, UR of the inferior rectus muscle was positively correlated with FT3 and FT4. Adverse RAI outcomes were associated with smoking and higher iodine-thyroid iodine uptake before treatment.</p><p><strong>Conclusions: </strong>Combined with TSH, FT3, and FT4 levels, the reduction of 99Tcm-DTPA orbital SPECT/CT UR also indicates an improvement in the disease course of patients. The UR of the inferior rectus muscle can be an objective index to evaluate the curative effect of TAO patients.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"897-907"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation of the clinical characteristics of chronic diarrhoea in children and evaluation of the prognostic value of nutritional and immune indicators.","authors":"Jianyun Hao, Xin Ma, Youzhe Gong, Dan Zhu, Huijuan Ning, Xuemei Zhong","doi":"10.5937/jomb0-48174","DOIUrl":"10.5937/jomb0-48174","url":null,"abstract":"<p><strong>Background: </strong>This research aimed to assess the clinical characteristics of chronic diarrhoea in children and explore the prognostic value of nutritional status and immune indicators.</p><p><strong>Methods: </strong>A total of 190 patients with chronic diarrhoea from January 2017 to June 2020 were enrolled to analyze their epidemiology. The patients were divided into a better prognosis group (cured and improved) and a poor prognosis group (uncured). The efficacy of nutritional status and immune indicators in children's chronic diarrhoea prognosis was analyzed.</p><p><strong>Results: </strong>Most patients were 0-3 years old (74.2%), of which 54.3% were less than 1 year old, and 48.95% had a course of 1 to 2 months. The albumin, immunoglobulin G (IgG), IgA and IgM levels, albumin, globulin, and the ratio of albumin to globulin in the better prognosis group were higher than those in the poor prognosis group. The AUC (area under the curve) of the combined detection in evaluating the prognosis of children with chronic diarrhoea was greater than that of the albumin and globulin alone (P<0.05). IgG 10.05 g/L and IgA 7.72 g/L were protective factors affecting the prognosis of children with chronic diarrhoea.</p><p><strong>Conclusions: </strong>Children with chronic diarrhoea are mainly infants and young children with various clinical symptoms and are prone to comorbidities such as malnutrition, anemia, hypoalbuminemia, and impaired immune function. In evaluating the prognosis of children, evaluating nutritional status and immune indicators together is valuable.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"879-889"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury.","authors":"Bingbing Pu, Yu Chen, Qingguo Bi, Jian Shen, Lihui Wang, Ye Han","doi":"10.5937/jomb0-45469","DOIUrl":"10.5937/jomb0-45469","url":null,"abstract":"<p><strong>Background: </strong>Serum neuritin and neuron-specific enolase (NSE) have predictive value for the prognosis of patients with combined traumatic brain injury (TBI) and spinal cord injury (SCI). Studying their predictive effects has positive value for disease control and treatment.</p><p><strong>Methods: </strong>Sixty patients with combined TBI and SCI were recruited and rolled into three groups according to prognosis: Group I (n=42, favourable prognosis), Group II (n=11, poor prognosis), and Group III (n=7, death). Clinical indicators were compared between the groups, and the predictive value of different indicators for prognosis was analyzed.</p><p><strong>Results: </strong>The proportion of patients with combined injuries to other organs and hypotension, as well as levels of platelets (PLT), D-dimer (D-D), antithrombin III (AT-III), S100 protein (S100), NSE, and serum neurofilament levels were significantly higher in Groups II and III compared to Group I. Conversely, the Glasgow Coma Scale (GCS) scores were significantly lower in Group I (P<0.05). Multivariable logistic regression analysis revealed that other organ injuries, GCS score, PLT, D-D, and AT-III significantly influenced the prognosis of TBI combined with SCI patients (P<0.05), while hypotension, NSE, serum neurofilament levels, S100, and accompanying organ injuries were highly correlated with the prognosis of TBI combined with SCI patients (P<0.001). The predictive sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of NSE combined with serum neurofilament in predicting the prognosis of TBI combined with SCI patients were significantly higher than the singular predictive efficacy of NSE or serum neurofilament alone (P<0.05).</p><p><strong>Conclusions: </strong>To evaluate the prognosis of TBI combined with SCI patients, consideration should be given to factors such as other organ injuries, hypotension, consciousness assessment, and levels of various biomarkers. Furthermore, combined testing of serum neurofilament and NSE can more accurately predict the prognosis of TBI combined with SCI patients.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"870-878"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance unraveled: Hormonal correlations in gestational diabetes.","authors":"Siyu Chen, Xuru Bai, Xuerui Yin, Lan Bai","doi":"10.5937/jomb0-49981","DOIUrl":"10.5937/jomb0-49981","url":null,"abstract":"<p><strong>Background: </strong>To investigate the correlation between the variations of cortisol and insulin-like growth factor 1 (IGF1) and sex hormone binding globulin (SHBG) levels with insulin resistance and glucolipid metabolism in gestational glucose diabetics.</p><p><strong>Methods: </strong>The study included 110 pregnant women diagnosed with gestational diabetes mellitus in the GDM group, and 130 healthy pregnant women in the control group. Data collection, examination of relevant indexes, and comparison of differences in indexes between groups were conducted. Pearson correlation analysis was utilized to identify risk variables associated with GDM development, while binary logistic regression was employed to determine risk factors for GDM development.</p><p><strong>Results: </strong>The GDM group showed significantly greater levels of FPG, HbA1c, FINS, TG, FFA, Lp-PLA2, HOMA-IR, Cortisol, and IGF-1 compared to the control group (P<0.05), but considerably lower levels of SHBG, and HOMA-β. HOMA-IR was found to be positively correlated with FPG, HbA1c, FINS, TG, FFA, Lp-PLA2, Cortisol and IGF-1, whereas, negatively correlated with SHBG. FINS and SHBG were found to be independent protective factors for GDM (OR=0.463, 0.801, P<0.05), whereas, HbA1c, TG, FFA, and gestational BMI were found to be independent risk factors for GDM (OR=1.992, 4.234, 1.990, 1.629, P<0.05).</p><p><strong>Conclusions: </strong>SHBG, IGF-1, and Cortisol are all linked to glucose-lipid metabolism indices, and aberrant serum hormone expression is a major contributor to insulin resistance.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"835-842"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estradiol and testosterone associated with risk of breast cancer: A meta-analysis.","authors":"Yanqing Liu, Yujuan Kang, Xiaofei Li, Nina Qu","doi":"10.5937/jomb0-50871","DOIUrl":"10.5937/jomb0-50871","url":null,"abstract":"<p><strong>Background: </strong>This paper aimed to investigate the correlation between estradiol and testosterone in patients with breast cancer.</p><p><strong>Methods: </strong>The research papers on the correlation between estradiol and testosterone on the risk of breast cancer were searched and collected. The time limit is that each database was established until December 2023. After screening, the modified Jadad scale was used to evaluate the quality of the research literature. NoteExpress 3.2 was used for literature management, and Excel 2003 was used for data collection and extraction. Statistical analysis was performed using RevMan 5.4.1 software to determine whether there was heterogeneity in the study according to the size of the Q test (P-value), and then the OR value of combined effects was calculated using fixed or random effects models, and forest maps were drawn. At the same time, papers with the greatest weight were excluded for sensitivity analysis, and the literature bias was evaluated by drawing a funnel plot.</p><p><strong>Results: </strong>A total of 628 pieces of research were retrieved, and 11 case-control trials met the criteria for inclusion. Meta-analysis results showed that the level of E2 in breast cancer patients was higher than that in the non-breast cancer control group, but the difference was not statistically significant (OR=121.56, 95%CI (-3.32-264.44), P=0.06). The level of E2 in premenopausal patients with breast cancer was higher than that in the non-breast cancer control group, but the difference was not statistically significant (OR=8.26, 95%CI (-2.83-19.34), P=0.14). The level of E2 in postmenopausal patients with breast cancer was higher than that in the non-breast cancer control group, and the difference was statistically significant (OR=20.36, 95%CI (7.04-33.68), P=0.003). Preoperative T level was higher in patients with breast cancer than in the non-breast cancer control group, but the difference was not statistically significant (OR=14.77, 95%CI (-14.11-43.65), P=0.32). The T level before and after surgery in breast cancer patients was higher than that in the non-breast cancer control group, and the difference was statistically significant (OR=12.91, 95%CI (4.43-21.39), P=0.003). Sensitivity analysis showed that the combined effect size results were stable and reliable OR (95%CI) was 24.41 (10.21~38.61), P=0.0007. Funnel plot results showed publication bias.</p><p><strong>Conclusions: </strong>There is a positive correlation between the levels of estradiol and testosterone and the occurrence and development of breast cancer after menopause.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"819-827"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of low-volume blood collection tubes for routine hematologic testing.","authors":"Giuseppe Lippi, Loredana Martini, Barbara Cortivo, Chiara Zecchetto, Anna Ferrari","doi":"10.5937/jomb0-51438","DOIUrl":"10.5937/jomb0-51438","url":null,"abstract":"<p><strong>Background: </strong>Low-volume blood tubes offer several advantages in facilitating blood collection, reducing iatrogenic anemia and spurious hemolysis, but their clinical reliability must be validated. We planned this investigation for establishing the reliability of routine hematologic testing in low-volume tubes before their implementation into clinical practice.</p><p><strong>Methods: </strong>Blood was drawn from 44 ostensibly healthy laboratory professionals into three blood tubes, as follows: 3.0 mL of blood into a 3.0 mL K2EDTA standard reference blood tube, 0.5 mL of blood into a second 3.0 mL K2EDTA standard blood tube, and 0.5 mL of blood into a 0.25-0.5 mL K2EDTA low-volume blood tube. Hematologic testing was performed on Sysmex XN-10 hematology analyzer.</p><p><strong>Results: </strong>Statistically significant differences were observed in total white blood cell count, neutrophil count, lymphocyte count, red blood cell count, platelet count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean platelet volume in both 0.5 mL-filled 3.0 mL standard blood tubes and 0.5 mL-filled low-volume blood tubes. Although none of these variations was found to be clinically significant in the 0.5 mL-filled low-volume blood tube compared to the desirable specifications, hematocrit, MCV and MCHC displayed a clinically significant bias in the 0.5 mL filled 3.0 mL K2EDTA standard blood tube.</p><p><strong>Conclusions: </strong>These results suggests that K2EDTA low-volume blood tubes could safely replace standard blood tubes for preventing the receipt of insufficient samples, but also for facilitating blood collection in patients with difficult veins and reducing the risk of iatrogenic anemia and spurious hemolysis.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"955-959"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Function evaluation of the autoanalyser internal quality control of the Kehua Polaris c2000 automatic biochemical analyser.","authors":"Yiyi Wang, Lei Shi, Jue Zhang, Chen Chen","doi":"10.5937/jomb0-47151","DOIUrl":"10.5937/jomb0-47151","url":null,"abstract":"<p><strong>Background: </strong>The present study aims to (1) evaluate the autoanalyser quality control (QC) module of the Kehua Polaris c2000 automatic modularised biochemical analyser and (2) verify the impact of the analyser's automatic implementation of internal QC (IQC) testing at a set time point on the results of IQC and turnaround time (TAT).</p><p><strong>Methods: </strong>For 5 consecutive days, three different methods were used to conduct IQC. Method 1: Internal QC was carried out at 8:00 every day. Method 2: The QC products were placed in the instrument calibration QC plate in the afternoon, and the instrument was set to measure the products at 7:00 the next day automatically. Method 3: The QC products were placed in the instrument calibration QC plate, and the instrument was set up for automatic measurement at 7:30 every day. All three methods were compared and evaluated. The effect of IQC on the TAT was monitored using method 2.</p><p><strong>Results: </strong>There were no statistical differences in the IQC results between methods 2 and 1. However, there were statistical differences in some items between methods 3 and 1; thus, the IQC results of method 2 can be adopted. Implementing method 2 for IQC can help achieve a significant TAT-saving of 35.23 min during the automatic retest process after the IQC indicates an out-of-control situation. This time reduction is highly valuable for improving efficiency and streamlining the testing workflow.</p><p><strong>Conclusions: </strong>Using the autoanalyser QC module of the Kehua Polaris c2000 automatic modular biochemical analysis system to perform IQC has no impact on the IQC test results and can save TAT, as well as automatically correct most out-of-control occurrences.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"853-859"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors.","authors":"Yan Jin, Minghui Li, Wei Ding, Huiwen Wu","doi":"10.5937/jomb0-48471","DOIUrl":"10.5937/jomb0-48471","url":null,"abstract":"<p><strong>Background: </strong>Aim was to demonstrate the influencing factors of infant bone mineral density (BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers.</p><p><strong>Methods: </strong>200 children aged 0 č 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the results of ultrasound BMD examination. The sunshine duration of infants with different BMD and 25(OH)D, calcium and phosphorus levels of nursing mothers were analyzed, and univariate and multivariate analyses of BMD were implemented.</p><p><strong>Results: </strong>The results revealed that the sunshine duration and serum 25-(OH)D level of nursing mothers in abnormal group were inferior to those in normal group (P<0.05). Additionally, a notable positive correlation existed between sunshine duration, serum 25-(OH)D level of nursing mothers and BMD (r = 0.911 and 0.503, P<0.05). According to Logistic regression analysis, outdoor activity time 0 č 1 h/d, premature infants, and breastfeeding alone were independent risk factors (RFs) for abnormal BMD in infants, and vitamin D(VD) and calcium supplementation were independent protective factors (P<0.05).</p><p><strong>Conclusions: </strong>VD and calcium intake, adequate sunshine duration, mixed feeding, and increasing serum 25-(OH)D can reduce the occurrence of abnormal BMD in infants.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"960-966"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between insulin resistance and blood lipids in children.","authors":"Li Jiang, Lulian Xu, Yang Lu, Xu Xu","doi":"10.5937/jomb0-48461","DOIUrl":"10.5937/jomb0-48461","url":null,"abstract":"<p><strong>Background: </strong>This work focused on the correlation between insulin resistance (IR) and blood lipids (BL) in children with simple obesity, as well as the intervention effects of high-intensity interval training (HIIT) in weight loss in children.</p><p><strong>Methods: </strong>80 children aged 6 to 17 years with simple obesity were selected from our hospital and randomly grouped into two groups. Children in the control (Ctrl) group underwent traditional moderate-intensity continuous training (MICT), while those in the other group received HIIT (HIIT group). After four weeks, body composition-related indicators, BL levels, and IR were measured.</p><p><strong>Results: </strong>After exercise, children in both groups possessed obvious reductions in body mass index (BMI), body fat percentage (BFP), triglyceride (TG), and homeostasis model assessment of IR (HOMA-IR), demonstrating remarkable differences in contrast to those after intervention (P<0.05). The HIIT group also exhibited considerable differences in waist circumference (WC), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (P<0.05). After exercise, the HIIT group demonstrated more observable BMI, WC, TG, and HOMA-IR reductions, showing great differences with the Ctrl group (P<0.05). HOMA-IR exhibited positive correlations with TC, TG, and HDL-C but a negative one with LDL-C (P<0.05).</p><p><strong>Conclusions: </strong>HIIT improved the body composition and BL levels in children with simple obesity, downregulated HOMA-IR, and positively impacted their health status. Furthermore, IR was associated with BL-relevant indicators in children with simple obesity.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"43 6","pages":"860-869"},"PeriodicalIF":2.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}