外周血炎症因子在非泌乳性乳腺炎严重程度与血糖异常之间的中介作用。

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-03-21 DOI:10.5937/jomb0-52268

Dianchun Qi, Yiqi Lin, Jiaxin Zhang, Yiping Wang

{"title":"外周血炎症因子在非泌乳性乳腺炎严重程度与血糖异常之间的中介作用。","authors":"Dianchun Qi, Yiqi Lin, Jiaxin Zhang, Yiping Wang","doi":"10.5937/jomb0-52268","DOIUrl":null,"url":null,"abstract":"Background: The association between severity of non-lactating mastitis and glycemic abnormalities was analyzed to investigate the mediating role of peripheral inflammatory factor levels in the association.Methods: A total of 337 cases were included in this study, including 195 cases in the control group and 142 cases in the case group. Multifactorial logistic regression was used to analyze the associations between the severity of NLM and glycemic abnormality and peripheral inflammatory factors , and a mediation model was used to explore the mediating roles of the levels of hs-CRP, WBC, and IL-6 in the associations between the two.Results: The inflammatory factors IL-6, WBC, and hs-CRP had mediating effects, with effect values of 0.009 (0.003-0.038), 0.006(0.001-0.047), and 0.007(0.001-0.051), and mediating effect percentages of 2.38%, 2.12%, and 2.24%, respectively.Conclusions: NLM severity and glycemic abnormalities were positively correlated with peripheral inflammatory factors , and peripheral inflammatory factors played a partial mediating role in the association.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"256-263"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085170/pdf/","citationCount":"0","resultStr":"{\"title\":\"Mediation effect of peripheral blood inflammatory factors in the association between severity of nonlactating mastitis and glycemic abnormalities.\",\"authors\":\"Dianchun Qi, Yiqi Lin, Jiaxin Zhang, Yiping Wang\",\"doi\":\"10.5937/jomb0-52268\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The association between severity of non-lactating mastitis and glycemic abnormalities was analyzed to investigate the mediating role of peripheral inflammatory factor levels in the association.Methods: A total of 337 cases were included in this study, including 195 cases in the control group and 142 cases in the case group. Multifactorial logistic regression was used to analyze the associations between the severity of NLM and glycemic abnormality and peripheral inflammatory factors , and a mediation model was used to explore the mediating roles of the levels of hs-CRP, WBC, and IL-6 in the associations between the two.Results: The inflammatory factors IL-6, WBC, and hs-CRP had mediating effects, with effect values of 0.009 (0.003-0.038), 0.006(0.001-0.047), and 0.007(0.001-0.051), and mediating effect percentages of 2.38%, 2.12%, and 2.24%, respectively.Conclusions: NLM severity and glycemic abnormalities were positively correlated with peripheral inflammatory factors , and peripheral inflammatory factors played a partial mediating role in the association.\",\"PeriodicalId\":16175,\"journal\":{\"name\":\"Journal of Medical Biochemistry\",\"volume\":\"44 2\",\"pages\":\"256-263\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085170/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Biochemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5937/jomb0-52268\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Biochemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5937/jomb0-52268","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：分析非泌乳性乳腺炎严重程度与血糖异常之间的关系，探讨外周炎症因子水平在这一关系中的中介作用。方法：共纳入337例患者，其中对照组195例，病例组142例。采用多因素logistic回归分析NLM严重程度与血糖异常及外周炎症因子的相关性，并采用中介模型探讨hs-CRP、WBC、IL-6水平在两者相关性中的中介作用。结果：炎症因子IL-6、WBC、hs-CRP具有调节作用，其调节作用值分别为0.009（0.003-0.038）、0.006（0.001-0.047）、0.007(0.001-0.051)，调节作用百分比分别为2.38%、2.12%、2.24%。结论：NLM严重程度、血糖异常与外周炎症因子呈正相关，外周炎症因子在其中起部分中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mediation effect of peripheral blood inflammatory factors in the association between severity of nonlactating mastitis and glycemic abnormalities.

Background: The association between severity of non-lactating mastitis and glycemic abnormalities was analyzed to investigate the mediating role of peripheral inflammatory factor levels in the association.

Methods: A total of 337 cases were included in this study, including 195 cases in the control group and 142 cases in the case group. Multifactorial logistic regression was used to analyze the associations between the severity of NLM and glycemic abnormality and peripheral inflammatory factors , and a mediation model was used to explore the mediating roles of the levels of hs-CRP, WBC, and IL-6 in the associations between the two.

Results: The inflammatory factors IL-6, WBC, and hs-CRP had mediating effects, with effect values of 0.009 (0.003-0.038), 0.006(0.001-0.047), and 0.007(0.001-0.051), and mediating effect percentages of 2.38%, 2.12%, and 2.24%, respectively.

Conclusions: NLM severity and glycemic abnormalities were positively correlated with peripheral inflammatory factors , and peripheral inflammatory factors played a partial mediating role in the association.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.