Journal of Infection and Chemotherapy最新文献_第9页

The immun function of dendritic cells in SFTS patients. SFTS患者树突状细胞的免疫功能

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-08-05 DOI: 10.1016/j.jiac.2024.08.002

Jingwen Liu, Zhengbin Chai, Quanping Ma, Dan Li, Guangying Yuan

{"title":"The immun function of dendritic cells in SFTS patients.","authors":"Jingwen Liu, Zhengbin Chai, Quanping Ma, Dan Li, Guangying Yuan","doi":"10.1016/j.jiac.2024.08.002","DOIUrl":"10.1016/j.jiac.2024.08.002","url":null,"abstract":"Objectives: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel bunyavirus in which host immune system suppression is thought to be crucial in disease development. Dendritic cells (DCs) are professional antigen-presenting cells (APCs) critical for initiation and orchestration of the immune response. And it have been suggested that functionally impaired DCs may mediate the suppression of host-specific T-cell immune responses and thus facilitate viral persistence and disease progression.This study was designed to improve the in vitro culture method for DCs and investigate the different immunologic functions of DCs between SFTS patients and healthy people.Methods: All confirmed SFTS patients (N = 10) were recruited from the Jinan Infectious Diseases Hospital in 2019; routine laboratory parameters were collected. The frequencies, phenotypes were analyzed by flow cytometry. And the levels of 8 cytokines in the cell culture supernatant were detected by flow cytometry.Results: On day 8 of the incubation period, cells were harvested and analyzed by flow cytometry. There were significant differences in the rates of CD1a-, CD83-positive cells between SFTS patients and healthy people (all P < 0.05). The detection of 8 cytokines in the culture supernatant showed that the expressions of IFN-α and IFN-γ in the culture supernatant of DC cells in SFTS patients were lower than those in normal people (P < 0.05, P < 0.01).Conclusions: The present results indicate that DCs may be functionally impaired in SFTS. A decreased level of circulating mDCs was closely correlated with SFTS progression.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 mRNA vaccine-related myocarditis and pericarditis: An analysis of the Japanese Adverse Drug Event Report database. 与 SARS-CoV-2 mRNA 疫苗相关的心肌炎和心包炎：日本药物不良事件报告数据库分析。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-08-03 DOI: 10.1016/j.jiac.2024.07.025

Keisuke Takada, Kazuaki Taguchi, Masaru Samura, Yuki Igarashi, Yuko Okamoto, Yuki Enoki, Koji Tanikawa, Kazuaki Matsumoto

{"title":"SARS-CoV-2 mRNA vaccine-related myocarditis and pericarditis: An analysis of the Japanese Adverse Drug Event Report database.","authors":"Keisuke Takada, Kazuaki Taguchi, Masaru Samura, Yuki Igarashi, Yuko Okamoto, Yuki Enoki, Koji Tanikawa, Kazuaki Matsumoto","doi":"10.1016/j.jiac.2024.07.025","DOIUrl":"10.1016/j.jiac.2024.07.025","url":null,"abstract":"Background: The association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines and myocarditis/pericarditis in the Japanese population has not been systematically investigated. This study was aimed at clarifying the association between SARS-CoV-2 mRNA vaccines (BNT162b2 and mRNA-1273) and myocarditis/pericarditis as well as influencing factors by using the Japanese Adverse Drug Event Report database.Methods: Reporting odds ratios (RORs) and 95 % confidence intervals (95 % CIs) for the association between the vaccines and myocarditis/pericarditis were calculated using data from the database (April 2004-December 2023). Age, sex, onset time, and outcomes in symptomatic patients were evaluated.Results: The total number of reports was 880,999 (myocarditis: 1846; pericarditis: 761). The adverse events associated with the vaccines included myocarditis (919 cases) and pericarditis (321 cases), with the ROR [95 % CIs] being significant for both (myocarditis: 30.51 [27.82-33.45], pericarditis: 21.99 [19.03-25.40]). Furthermore, the ROR [95 % CIs] of BNT162b2 and mRNA-1273 were 15.64 [14.15-17.28] and 54.23 [48.13-61.10], respectively, for myocarditis, and 15.78 [13.52-18.42] and 27.03 [21.58-33.87], respectively, for pericarditis. Furthermore, most cases were ≤30 years or male. The period from vaccination to onset was ≤8 days, corresponding to early failure type based on analysis using the Weibull distribution. Outcomes were recovery or remission for most cases; however, they were severe or caused death in some cases.Conclusion: In the Japanese population, SARS-CoV-2 mRNA vaccination was significantly associated with the onset of myocarditis/pericarditis. The influencing factors included age of ≤30 years and male. Furthermore, although most adverse events occurred early after vaccination, overall outcomes were good.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postprandial hypoglycemia caused by the combination of clarithromycin and rifampicin in a patient with nontuberculous mycobacterial pulmonary disease. 一名非结核分枝杆菌肺病患者因克拉霉素和利福平联合用药而导致餐后低血糖。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-08-02 DOI: 10.1016/j.jiac.2024.07.022

Eriko Mitsutome, Shigehisa Yanagi, Taisuke Uchida, Takanori Horiguchi, Hironobu Tsubouchi, Makoto Sumiyoshi, Akiko Kitamura, Yasuharu Oda, Hiroaki Ueno, Hideki Yamaguchi, Taiga Miyazaki

{"title":"Postprandial hypoglycemia caused by the combination of clarithromycin and rifampicin in a patient with nontuberculous mycobacterial pulmonary disease.","authors":"Eriko Mitsutome, Shigehisa Yanagi, Taisuke Uchida, Takanori Horiguchi, Hironobu Tsubouchi, Makoto Sumiyoshi, Akiko Kitamura, Yasuharu Oda, Hiroaki Ueno, Hideki Yamaguchi, Taiga Miyazaki","doi":"10.1016/j.jiac.2024.07.022","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.07.022","url":null,"abstract":"Most cases of nontuberculous mycobacterial pulmonary disease (NTM-PD) have a progressive clinical course, and initiation of treatment is recommended rather than watchful waiting. The NTM-PD medications are frequently associated with adverse reactions, occasionally serious. Optimization of the methods for monitoring and managing adverse events in NTM-PD treatment is thus an important medical issue. Here we report a first case of postprandial hypoglycemia caused by the combination of clarithromycin (CAM) and rifampicin (RFP) in a patient with NTM-PD. A 73-year-old Japanese woman with NTM-PD was hospitalized for treatment with a combination of oral CAM, RFP, and ethambutol. She took the first doses of antibiotics before breakfast, and 3 h later went into a hypoglycemic state. Postprandial hypoglycemia occurred with high reproducibility and was accompanied by relative insulin excess. Continuous glucose monitoring with or without food and in combination with various patterns of medication revealed that the combination of CAM and RFP specifically induced postprandial hypoglycemia. Shifting the timing of administration of the CAM and RFP combination from morning to before sleep corrected the hypoglycemia and enabled continuation of the antimicrobial treatment. In conclusion, our report suggests the importance of introducing NTM-PD medication under inpatient management in order to closely monitor and early detect postprandial hypoglycemia and other serious adverse events.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic characteristics of invasive pneumococcal disease-derived Streptococcus pneumoniae of serogroup 24 isolated in Tokyo, Japan. 在日本东京分离到的侵袭性肺炎链球菌疾病衍生的血清 24 型肺炎链球菌的遗传特征。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-07-31 DOI: 10.1016/j.jiac.2024.07.024

Yumi Uchitani, Rumi Okuno, Tsukasa Ariyoshi, Hiroaki Kubota, Jun Suzuki, Kenji Sadamasu

{"title":"Genetic characteristics of invasive pneumococcal disease-derived Streptococcus pneumoniae of serogroup 24 isolated in Tokyo, Japan.","authors":"Yumi Uchitani, Rumi Okuno, Tsukasa Ariyoshi, Hiroaki Kubota, Jun Suzuki, Kenji Sadamasu","doi":"10.1016/j.jiac.2024.07.024","DOIUrl":"10.1016/j.jiac.2024.07.024","url":null,"abstract":"Background: Since the introduction of the national routine vaccination program against Streptococcus pneumoniae in Japan from the early 2010s, the incidence of invasive pneumococcal disease (IPD) caused by non-vaccine serotypes has increased. This study focused on non-vaccine serogroup 24 strains derived from IPD and aimed to clarify their genetic characteristics.Methods: Between 2013 and 2022, 121 strains identified as serogroup 24 in patients with IPD were collected and applied to multilocus sequence typing and next-generation sequencing. Whole-genome data were used to delineate phylogenetic relationships and to identify virulence and antimicrobial resistance-associated genes.Results: Recent trends in sequence types (STs) were characterized by an increase in the proportion of ST162 and ST2754 for 24F and 24B, respectively, after 2018. Whole-genome phylogenetic analysis demonstrated that serogroup 24 strains were organized into three clades, closely related to STs but not with serotypes. All ST162 strains were classified as Global Pneumococcal Sequence Cluster (GPSC) 6 and harbored the virulence-associated rlrA islet, with co-trimoxazole-resistance mutations in folA and folP genes. Two ST162 strains with different serotypes 24F and 24B from the same patient were phylogenetically indistinguishable, showing that these strains were derived by serotype conversion during infection.Conclusion: The recent changes in predominant STs were similar to those previously reported throughout Japan, except Tokyo. Little correlation between whole-genome phylogeny and serotypes and the observed serotype conversion in one patient indicate potentially variable immunogenicity of this serogroup.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nurse-led multifaceted intervention for the optimal use of indwelling urinary catheters at a tertiary care center: A before-after trial. 在一家三级医疗中心，为优化留置导尿管的使用，开展了一项由护士主导的多方面干预：前后对比试验。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-07-31 DOI: 10.1016/j.jiac.2024.07.019

Shimpei Harita, Shutaro Murakami, Yasuaki Tagashira, Hitoshi Honda

{"title":"A nurse-led multifaceted intervention for the optimal use of indwelling urinary catheters at a tertiary care center: A before-after trial.","authors":"Shimpei Harita, Shutaro Murakami, Yasuaki Tagashira, Hitoshi Honda","doi":"10.1016/j.jiac.2024.07.019","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.07.019","url":null,"abstract":"Background: Few interventional studies of catheter-associated urinary tract infection (CAUTI) have been conducted to optimize indwelling urinary catheter (IUC) use in Japan.Methods: The nurse-led, before-after study was conducted at a tertiary care center from June 2018 through May 2022. The intervention included 1) the provision of appropriate indications for IUC use, 2) prospective feedback to the primary care providers by ward nurses on unnecessary/inappropriate IUC use with two, separate interventional phases, the first involving intensive care units (ICU) only, the second involving ICU and general wards, and 3) proactive feedback by Infectious diseases physicians in the Infection Control department to the primary care providers regarding IUC discontinuation upon discharge from the ICU.Results: During the first phase involving the implementation of the intervention only in the ICU, the indwelling urinary catheter-device utilization ratio (IUC-DUR) trend in the general wards decreased by 1.5 % (P = 0.01). However, the addition of the intervention to the general wards in the second phase led to a 2 % increase in the trend (P = 0.010). The CAUTI incidence in neither the ICU nor the general wards changed significantly.Conclusions: Although providing feedback on IUC removal at discharge from the ICU and appropriate indications for urinary catheter insertion can reduce inappropriate urinary catheter use, the nurse-led intervention alone was inadequate for reducing the CAUTI incidence.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal effects of lascufloxacin on human gut and salivary microbiota: Analysis using next-generation sequencing method. 拉氟沙星对人体肠道和唾液微生物群的时间影响：利用新一代测序方法进行分析。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-07-30 DOI: 10.1016/j.jiac.2024.07.023

Kengo Mukuda, Ryo Inoue, Miyako Takata, Kenji Takazawa, Hisashi Noma, So Morishima, Machi Oda, Athok Shofiudin Ma'arif, Yusuke Endo, Hiroshi Sunada, Ayumu Doi, Risa Matsuda, Yukari Nishikawa, Kensaku Okada, Tsuyoshi Kitaura, Masaki Nakamoto, Akira Yamasaki, Hiroki Chikumi

{"title":"Temporal effects of lascufloxacin on human gut and salivary microbiota: Analysis using next-generation sequencing method.","authors":"Kengo Mukuda, Ryo Inoue, Miyako Takata, Kenji Takazawa, Hisashi Noma, So Morishima, Machi Oda, Athok Shofiudin Ma'arif, Yusuke Endo, Hiroshi Sunada, Ayumu Doi, Risa Matsuda, Yukari Nishikawa, Kensaku Okada, Tsuyoshi Kitaura, Masaki Nakamoto, Akira Yamasaki, Hiroki Chikumi","doi":"10.1016/j.jiac.2024.07.023","DOIUrl":"10.1016/j.jiac.2024.07.023","url":null,"abstract":"Introduction: Antimicrobial treatment disrupts human microbiota. The effects of lascufloxacin (LSFX), a new fluoroquinolone, on human microbiota remains unknown. Therefore, in this study, we aimed to evaluate the effects of LSFX administration on the gut and salivary microbiota of healthy participants and those with pneumonia.Methods: LSFX (75 mg, once a day, orally) was administered to healthy adults (healthy group) and adult patients with pneumonia (pneumonia group), and fecal and saliva samples were collected at five time points (Days 0, 3, 7, 14, and 28). Using the collected samples, α- and β-diversity indices, as well as bacterial composition of the gut microbiota and salivary microbiota were analyzed using next-generation sequencing.Results: In the healthy group, α-diversity indices of the gut and salivary microbiota were reduced and the lowest values on Day 3. For the gut microbiota, the Chao1 index (richness) recovered on Day 28, whereas the Shannon index (evenness) did not. In the salivary microbiota, the Chao1 and Shannon indices did not recover within the 28 day period. The β-diversity indices changed after LSFX administration and subsequently recovered on Day 28. After LSFX administration, the abundance of the Lachnospiraceae family decreased in the gut microbiota, and the abundance of Granulicatella, Streptococcus, Prevotella, Absconditabacteriales(SR1), and Saccharimonadales decreased in the salivary microbiota. In the pneumonia group, the α-diversity indices were lowest on Day 14 after LSFX administration.Conclusions: We elucidated that LSFX administration differentially affected the gut and salivary microbiota; however, the richness and beta diversity recovered within 28 days.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precautionary findings on the utilization of FilmArray® to detect human astroviruses in fecal and sewage samples 利用 FilmArray® 检测粪便和污水样本中人类天花病毒的预防性结论。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-07-29 DOI: 10.1016/j.jiac.2024.07.021

Jonghyun Bae , Chika Takano , Sheikh Ariful Hoque , Hiroyuki Saito , Wakako Akino , Shuichi Nishimura , Yuko Onda , Shoko Okitsu , Satoshi Hayakawa , Shihoko Komine-Aizawa , Hiroshi Ushijima

{"title":"Precautionary findings on the utilization of FilmArray® to detect human astroviruses in fecal and sewage samples","authors":"Jonghyun Bae , Chika Takano , Sheikh Ariful Hoque , Hiroyuki Saito , Wakako Akino , Shuichi Nishimura , Yuko Onda , Shoko Okitsu , Satoshi Hayakawa , Shihoko Komine-Aizawa , Hiroshi Ushijima","doi":"10.1016/j.jiac.2024.07.021","DOIUrl":"10.1016/j.jiac.2024.07.021","url":null,"abstract":"<div><div>The FilmArray® Gastrointestinal (GI) Panel is a modern, sensitive, and comprehensive stool testing technique for identifying common gastrointestinal pathogens, including viruses, bacteria, and parasites. Its increasing demand is due to ease of operation and automation. Pathogens, particularly viruses, undergo constant genetic evolution. For instance, human astrovirus (HAstV), which causes gastroenteritis in children, the elderly, and immune-compromised individuals, can be identified by the GI Panel. HAstV has evolved into several clades, including the classic (HAstV1-8), novel Melbourne (MLB1-3), and Virginia (VA1-5) clades. This study investigated whether the GI Panel accurately detects all HAstV clades. A total of 12 stool and three sewage water (SW) samples were selected post-confirmation of distinct HAstV strains using conventional RT-PCR and sequence-based genotyping for reassessment by the GI Panel. The GI Panel accurately detected the classic HAstV in stool and SW samples. However, our results confirm the GI Panel's inability to detect the novel MLB (MLB1-3) and VA (VA2) clades in fecal samples, raising the possibility of false-negative results in HAstV testing. Although the GI Panel is useful for identifying a variety of gastrointestinal pathogens in stool and SW samples in a single test, our findings highlight the need to exercise caution when interpreting HAstV results from the GI Panel.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"30 12","pages":"Pages 1327-1329"},"PeriodicalIF":1.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four successive cases of human fasciolosis in Japan. 日本连续出现四例人类筋膜炎病例。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-07-25 DOI: 10.1016/j.jiac.2024.07.020

Ayako Kumabe, Asako Doi, Tsuyoshi Kitaura, Atsushi Katayama, Takanori Harada, Michimasa Ueda, Risa Matsuda, Madoka Ichikawa-Seki, Mio Tanaka, Chiho Kaneko, Ayako Yoshida, Hiroki Chikumi, Haruhiko Maruyama

{"title":"Four successive cases of human fasciolosis in Japan.","authors":"Ayako Kumabe, Asako Doi, Tsuyoshi Kitaura, Atsushi Katayama, Takanori Harada, Michimasa Ueda, Risa Matsuda, Madoka Ichikawa-Seki, Mio Tanaka, Chiho Kaneko, Ayako Yoshida, Hiroki Chikumi, Haruhiko Maruyama","doi":"10.1016/j.jiac.2024.07.020","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.07.020","url":null,"abstract":"Fasciolosis is a food-borne parasitic disease, caused by the large liver fluke, Fasciola. Humans acquire infection by ingesting fresh or undercooked water plants, on which infective metacercaria encyst. In spite of the rarity of the disease in Japan, we encountered four successive fasciolosis patients within a short period, who were all living in the same area. The patients were 70-82 years old, three females and the husband of one of the female patients. They started complaining of non-specific symptoms, such as fever, general fatigue, appetite loss, and abdominal pain, almost at the same time. All patients showed prominent peripheral blood eosinophilia, and the medical imaging indicated multiple hepatic lesions. No parasite eggs or worms were detected in any of the patients. Diagnosis was made serologically and they were treated with praziquantel and/or triclabendazole. No cattle or sheep were farmed in the area, but the wild sika deer, Cervus nippon, inhabited adjacent to the residential area. The intermediate host snail, Austropeplea ollula, were found near the residence of the patients, and one of the collected snails was positive for F. hepatica/gigantica hybrid type rediae. Our report should alarm the medical professionals for this rare and unfamiliar parasitic disease.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of isavuconazole in invasive cerebral aspergillosis during hematopoietic stem cell transplantation in a pediatric patient with myelodysplastic syndrome: A case report. 在骨髓增生异常综合征儿科患者接受造血干细胞移植期间，异武唑对侵袭性脑曲霉菌病的疗效：病例报告。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-07-22 DOI: 10.1016/j.jiac.2024.07.018

Hajime Nemoto, Moeko Hino, Takahiro Aoki, Yoshiharu Yamashita, Tomoko Okunushi, Koo Nagasawa, Naruhiko Ishiwada, Akira Watanabe, Shingo Yamazaki, Hiromichi Hamada

{"title":"Effectiveness of isavuconazole in invasive cerebral aspergillosis during hematopoietic stem cell transplantation in a pediatric patient with myelodysplastic syndrome: A case report.","authors":"Hajime Nemoto, Moeko Hino, Takahiro Aoki, Yoshiharu Yamashita, Tomoko Okunushi, Koo Nagasawa, Naruhiko Ishiwada, Akira Watanabe, Shingo Yamazaki, Hiromichi Hamada","doi":"10.1016/j.jiac.2024.07.018","DOIUrl":"10.1016/j.jiac.2024.07.018","url":null,"abstract":"Pediatric myelodysplasia syndrome is often characterized by hypoplastic bone marrow morphology and predisposition to infection. Invasive aspergillosis during hematopoietic stem cell transplantation poses a significant threat and often requires voriconazole (VRCZ) therapy. However, difficulties in achieving appropriate VRCZ blood levels due to drug interactions have prompted the exploration of alternative treatments, such as isavuconazole (ISCZ). We present the case of a 4-year-old boy with myelodysplasia syndrome who developed multiple abscesses, including a brain abscess caused by Aspergillus fumigatus, and was successfully treated with ISCZ. Despite initial treatment with liposomal amphotericin B and VRCZ, the patient's condition deteriorated. Transitioning to ISCZ treatment resulted in significant clinical improvement, resolution of the abscesses, and reduced antigen levels. Although ISCZ induced hepatic enzyme elevation, supportive care improved without discontinuation of treatment. This case highlights the potential of ISCZ in cases of pediatric invasive aspergillosis where traditional therapies fail, underscoring the need for further research and formulation development to optimize its use in this population. As more cases accumulate, ISCZ may become a promising option for treating severe invasive aspergillosis in pediatric patients undergoing hematopoietic stem cell transplantation.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological impact of human adenovirus as causative agent of respiratory infections: An Italian multicentre retrospective study, 2022–2023 人类腺病毒作为呼吸道感染病原体的流行病学影响：一项意大利多中心回顾性研究，2022-2023 年。

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-07-21 DOI: 10.1016/j.jiac.2024.07.017

Federica A.M. Giardina , Laura Pellegrinelli , Federica Novazzi , Elisa Vian , Valeria Biscaro , Cristina Russo , Stefania Ranno , Elisabetta Pagani , Elisa Masi , Claudia Tiberio , Martina Esposito , Sara Uceda Renteria , Annapaola Callegaro , Giulia Piccirilli , Tiziana Lazzarotto , Francesca Rovida , Cristina Galli , Eleonora Lalle , Fabrizio Maggi , Nicasio Mancini , Elena Pariani

{"title":"Epidemiological impact of human adenovirus as causative agent of respiratory infections: An Italian multicentre retrospective study, 2022–2023","authors":"Federica A.M. Giardina , Laura Pellegrinelli , Federica Novazzi , Elisa Vian , Valeria Biscaro , Cristina Russo , Stefania Ranno , Elisabetta Pagani , Elisa Masi , Claudia Tiberio , Martina Esposito , Sara Uceda Renteria , Annapaola Callegaro , Giulia Piccirilli , Tiziana Lazzarotto , Francesca Rovida , Cristina Galli , Eleonora Lalle , Fabrizio Maggi , Nicasio Mancini , Elena Pariani","doi":"10.1016/j.jiac.2024.07.017","DOIUrl":"10.1016/j.jiac.2024.07.017","url":null,"abstract":"<div>Human adenoviruses are the causative agents of 5–7% of viral respiratory infections, mainly caused by species B and C. They can infect all age groups, but children are usually at high risk of infections. Adenovirus epidemiology is well documented in East-Asian countries but little is known about adenovirus circulation in Europe in recent years. This multicentre retrospective study aimed to investigate the circulation and molecular epidemiology of hAdVs. This surveillance collected a total of 54463 respiratory specimens between January 1, 2022 and June 20, 2023 were tested for the presence of respiratory viruses. Our results showed that adenovirus was detected in 6.6 % of all cases of acute respiratory infection included in the study and the median age of positive patients was 3 years, with male children in 1–2 years age group being the most affected. 43.5 % of adenovirus cases were co-infected with at least one other respiratory virus, and rhinovirus was co-detected in 54 % of cases. Genotyping of adenovirus allowed the identification of 6 different genotypes circulating in Italy, among which type B3 was the most frequently detected.</div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"30 11","pages":"Pages 1097-1103"},"PeriodicalIF":1.9,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1341321X24001958/pdfft?md5=12b3c94dbb37305a898c4e352c1d5197&pid=1-s2.0-S1341321X24001958-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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