Journal of Infection and Chemotherapy最新文献

{"title":"Emergence of a methicillin-resistant Staphylococcus aureus strains with an unusual susceptibility antibiotic pattern in Tunisia","authors":"Sana Ferjani ,&nbsp;Zaineb Hamzaoui ,&nbsp;Lamia Kanzari ,&nbsp;Ahmed Fakhfekh ,&nbsp;Asma Ferjani ,&nbsp;Ilhem Boutiba Ben Boubaker","doi":"10.1016/j.jiac.2025.102677","DOIUrl":"10.1016/j.jiac.2025.102677","url":null,"abstract":"<div><div>Typically, methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) strains exhibit concurrent resistance to numerous commonly used antibiotics. Between June and December 2023, five MRSA strains with an unusual antibiotic susceptibility pattern (susceptible to all antibiotics tested, except cefoxitin) were isolated at Charles Nicolle Hospital of Tunis. Isolates were characterized by whole genome sequencing using the Illumina DNA Prep kit. All isolates carried the <em>mec</em>A gene [SCC<em>mec</em> types IVa (2B) (n = 4) and V (n = 1)]. Virulence genes, including leukocidin genes (<em>luk</em>D, <em>luk</em>E), enterotoxin genes (<em>sea</em>, <em>seg</em>, <em>sei</em>, <em>sem</em>, <em>sen</em>, <em>seo</em>, <em>seu</em>), and immune evasion genes (<em>sak</em>, <em>scn</em>). They were identified as ST97/CC97 (n = 2), ST149/CC5 (n = 2), and ST5/CC4 (n = 1). This study highlights the emergence of MRSA clones with an unusual susceptible antibiotic pattern, emphasizing the importance of continued molecular surveillance to monitor both antimicrobial resistance and virulence traits and track the spread of newly introduced clones, thereby improving infection control strategies.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102677"},"PeriodicalIF":1.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and challenges of health economic evaluations related to antimicrobial stewardship in Japan: A scoping review up to 2023","authors":"Ryota Goto ,&nbsp;Ryo Inose ,&nbsp;Tomokazu Shoji ,&nbsp;Manabu Akazawa ,&nbsp;Yuichi Muraki","doi":"10.1016/j.jiac.2025.102657","DOIUrl":"10.1016/j.jiac.2025.102657","url":null,"abstract":"<div><h3>Background</h3><div>Antimicrobial resistance is a major global threat, and the promotion of antimicrobial stewardship (AS) is critical. Although AS is recognized for its economic benefits, the situation in Japan has not yet been thoroughly summarized. This scoping review summarizes the current landscape of health economic evaluations related to AS in Japan, considering challenges and prospects for the future.</div></div><div><h3>Methods</h3><div>Articles related to AS and economic evaluations were extracted from PubMed, Scopus, and Ichushi-Web using search formulas. After performing primary screening based on titles and abstracts, secondary screening of full texts was conducted to identify suitable studies.</div></div><div><h3>Results</h3><div>This review identified 41 single-institution studies, primarily from special functioning hospitals, regional medical care support hospitals, and hospitals with more than 500 beds. The most frequently reported AS activities were prospective audits and feedback (48.8 %, 20 of 41 articles). Among the economic evaluations, 39 articles demonstrated reductions in drug costs, ranging from 3.74 % to 100 % for the evaluated drugs. Furthermore, no worsening trends were observed in the outcome measures, including mortality, which was evaluated along with drug and healthcare costs. However, few studies have considered the costs associated with AS operations.</div></div><div><h3>Conclusion</h3><div>This scoping review indicates that AS may offer economic benefits in terms of drug and healthcare costs in Japan. In the future, promoting research on the economic impact of AS in small- or medium-sized hospitals, along with broader economic evaluations that consider the operational costs of AS, will be necessary to facilitate comparisons with data from other countries.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 3","pages":"Article 102657"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of meningitis treated with intraventricular vancomycin in an infant","authors":"Yuya Uezato ,&nbsp;Wataru Uehara ,&nbsp;Shingo Kurokawa ,&nbsp;Naoya Nishiyama ,&nbsp;Sadao Nakamura ,&nbsp;Masashi Nakamatsu ,&nbsp;Koichi Nakanishi ,&nbsp;Kazuko Yamamoto ,&nbsp;Hideo Shiohira ,&nbsp;Katsunori Nakamura","doi":"10.1016/j.jiac.2025.102674","DOIUrl":"10.1016/j.jiac.2025.102674","url":null,"abstract":"<div><div>There is limited evidence for vancomycin (VCM) ventriculoperitoneal (VP) administration. We report a 3-month-old female with congenital hydrocephalus who developed a fever and was admitted to the hospital with a suspected VP shunt infection; she was being managed as an outpatient following VP shunt placement. Methicillin-resistant <em>Staphylococcus aureus</em> was detected on the removed catheter tip, and VCM treatment was initiated. Intravenous administration was ineffective, so intraventricular administration was initiated. Therapeutic drug monitoring (TDM) of cerebrospinal fluid (CSF) drug concentration showed a high trough level (30.9–50.0 μg/mL) at 2 mg daily dosing. Dose adjustment was implemented considering CSF drainage volume, and administration was changed to every other day. This case suggests that performing TDM and considering the amount of CSF drainage when establishing a detailed dosing regimen are important when administering VCM intraventricularly.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102674"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial prescriptions for older patients in dental medicine: A four-year retrospective study in Japan","authors":"Akira Kurishima ,&nbsp;Yasuhiro Sasaki ,&nbsp;Yusuke Kuwai ,&nbsp;Mari Irie ,&nbsp;Satoshi Miyata ,&nbsp;Yoshiharu Fukuda","doi":"10.1016/j.jiac.2025.102675","DOIUrl":"10.1016/j.jiac.2025.102675","url":null,"abstract":"<div><h3>Background</h3><div>Antimicrobial use (AMU) in Japan is characterized by a high prevalence of oral third-generation cephalosporin prescriptions, especially in dental medicine. However, few studies have examined the time trends and factors influencing AMU in older individuals seeking dental care. Therefore, in this study, we aimed to investigate AMU, particularly third-generation cephalosporin, in a cohort of older adults.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed the dental prescription health insurance claims data of patients aged ≥75 years in one metropolitan area from 2018 to 2021. The antimicrobials were categorized, and the number of defined daily doses (DDDs) per 1000 inhabitants per day (DID) was calculated to assess trends over this period. Multivariate logistic regression analysis was performed to identify factors associated with third-generation cephalosporin prescriptions.</div></div><div><h3>Results</h3><div>This database contains 58,655 patients, of whom 15,038 were prescribed antimicrobials from dentistry. Our findings suggest that third-generation cephalosporins accounted for 44.8 % of all antimicrobial prescriptions, with a noticeable decreasing trend in DID over the study period. Factors significantly associated with third-generation cephalosporin prescriptions included dental association membership (adjusted odds ratio [AOR] 0.72, 95 % confidence interval [CI] 0.63–0.82), fiscal year (AOR 0.86, 95 % CI 0.83–0.89), and their interaction.</div></div><div><h3>Conclusions</h3><div>The findings suggest that the pattern of prescribing third-generation cephalosporins in dental medicine might be shifting owing to heightened awareness of antimicrobial resistance (AMR) and educational initiatives by groups, such as dental associations. Effective educational and policy interventions by professional associations could reduce inappropriate antimicrobial prescriptions, thereby mitigating AMR on a large scale.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102675"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of post-outbreak acute hepatitis a in a Japanese man who have sex with men infected with RIVM-HAV16-090 strain","authors":"Miho Kozuki ,&nbsp;Satoshi Tanaka ,&nbsp;Tatsuya Shirai ,&nbsp;Naomi Sakon ,&nbsp;Satoshi Harada ,&nbsp;Ayaka Kitagawa ,&nbsp;Kensuke Matsushima ,&nbsp;Yutaro Abe ,&nbsp;Nobuyasu Fukutake ,&nbsp;Hiroko Hasegawa ,&nbsp;Shunsuke Yamamoto ,&nbsp;Yuko Sakakibara ,&nbsp;Ryotaro Sakamori","doi":"10.1016/j.jiac.2025.102673","DOIUrl":"10.1016/j.jiac.2025.102673","url":null,"abstract":"<div><h3>Aim</h3><div>Hepatitis A outbreaks among men who have sex with men (MSM) are a growing global concern. We present a case report of acute hepatitis A in a Japanese MSM who acquired the infection after the conclusion of a recent hepatitis A outbreak in Japan during his subsequent visit to Taiwan.</div></div><div><h3>Case presentation</h3><div>A 27-year-old male had experienced fever, headache, and loss of appetite over the previous eight days. After his jaundiced skin was noted during a routine health examination, he visited our outpatient department that same day. The severe liver dysfunction detected in blood tests necessitated hospitalization for acute hepatitis. Subsequent tests revealed positive HA-IgM antibodies, confirming acute hepatitis A. Further inquiry revealed the patient's MSM status and recent sexual encounter one and a half months earlier during a visit to Taiwan. With conservative treatment, his condition improved and he was discharged after 12 days. Phylogenetic analysis extracted from his stool sample confirmed that the hepatitis A virus (HAV) strain was RIVM-HAV16-090, consistent with strains observed in previous hepatitis outbreaks among MSM populations.</div></div><div><h3>Conclusion</h3><div>To the best of our knowledge, this is the first case report of acute hepatitis A in a Japanese MSM sporadically infected with the RIVM-HAV16-090 strain since the end of the outbreak. This case underscores the persistent risk of hepatitis A transmission among MSM despite the cessation of the outbreak, emphasizing the importance of targeted vaccination campaigns, sexual health education, and ongoing vigilance in mitigating the risk of hepatitis A transmission among MSM.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102673"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic findings among healthy adults with asymptomatic norovirus infection in Japan: A single-center cross-sectional study","authors":"Kyoko Yokota ,&nbsp;Hisashi Masugata ,&nbsp;Shizuka Yamagata-Uyama ,&nbsp;Kazuki Yamamoto ,&nbsp;Katsunori Masuda ,&nbsp;Mayuko Saito ,&nbsp;Daiki Kobayashi","doi":"10.1016/j.jiac.2025.102672","DOIUrl":"10.1016/j.jiac.2025.102672","url":null,"abstract":"<div><h3>Introduction</h3><div>Norovirus infection, a major cause of acute viral gastroenteritis, is commonly reported during the winter season. Norovirus invades the upper intestinal tract, causing inflammation. In severe cases, endoscopic findings and complications, including duodenal perforation, have been reported. However endoscopic findings in patients with asymptomatic infections have rarely been reported. Therefore, this study aimed to investigate the upper endoscopic findings of patients with asymptomatic norovirus infection.</div></div><div><h3>Methods</h3><div>Healthy adults (aged ≥18 years) who participated in voluntary health examinations between February 2017 and January 2018 were recruited twice a week. Only the individuals who had undergone esophagogastroduodenoscopy (EGD) were included. The primary outcome measure was the presence of any gross findings of EGD.</div></div><div><h3>Results</h3><div>The norovirus genogroup I (GI)-positive group had more duodenal scarring than the norovirus negative group (16.3 % vs 5.9 %, respectively). After adjustment for age category, sex, and alcohol consumption status, duodenal ulcer scarring exhibited a significant association with GI-positive status (adjusted odds ratio: 3.11; 95 % confidence interval: 1.42–6.82; p = 0.005, Bonferroni-corrected, p = 0.015).</div></div><div><h3>Conclusions</h3><div>Healthy adults with asymptomatic norovirus (GI-positive) infection showed predominantly more duodenal ulcer scarring than the norovirus-negative group on EGD.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102672"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The time to return-to-work in healthcare workers with COVID-19 treated with ensitrelvir, a novel oral inhibitor of 3C-like protease of SARS-CoV-2: An observational study utilizing pre-existing data from a single hospital","authors":"Makoto Katsuta ,&nbsp;Masatoshi Kitazono ,&nbsp;Naohito Nagai ,&nbsp;Hiroto Karibe ,&nbsp;Yusaku Takahashi ,&nbsp;Yasuko Ariwa ,&nbsp;Takuhiro Sonoyama ,&nbsp;Tomoyoshi Yamaguchi","doi":"10.1016/j.jiac.2025.102669","DOIUrl":"10.1016/j.jiac.2025.102669","url":null,"abstract":"<div><div>While treatment with anti-SARS-CoV-2 agents holds promise for managing healthcare workers with COVID-19, studies on this topic are limited. This study evaluated the time to return-to-work and remaining symptoms among healthcare workers with COVID-19 who received ensitrelvir and those who did not receive anti-SARS-CoV-2 drugs. This observational cohort study included healthcare workers diagnosed with COVID-19 between June and September 2023 at a single facility in Japan. Participants returned to work if they met all the following criteria: ≥5 days post-COVID-19 onset, fever resolution, and negative antigen test. The primary endpoint was the days from disease onset to return-to-work. We also evaluated the persistence of each symptom on the date of return-to-work, and the clinical and virological outcomes on the first scheduled date of return-to-work (Trial registration: UMIN000054128). The study enrolled 60 participants in the ensitrelvir group and 42 in the non-antiviral group. The mean number of days (SD) to return-to-work was 6.9 days (±1.6) in the ensitrelvir group and 7.7 days (±1.9) in the non-antiviral group. On the date of return-to-work, 4 participants in the non-antiviral group had taste disorders and 2 had smell disorders. On the first scheduled date of return-to-work (i.e. the date of first antigen test after onset), 56.7 % of participants in the ensitrelvir group and 33.3 % in the non-antiviral group had recovered, with the antigen test negativity in 76.7 % and 52.4 %, respectively. Ensitrelvir treatment for healthcare workers experiencing COVID-19 appeared to be associated with early symptom amelioration with viral load reduction, and shorter time to return-to-work.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102669"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between severe acute respiratory syndrome coronavirus 2 omicron variant epidemic and acute myocardial infarction: A self-controlled case series study","authors":"Jun Suzuki ,&nbsp;Tomoki Mizuno ,&nbsp;Shota Takahashi ,&nbsp;Haruka Imai ,&nbsp;Hideya Itagaki ,&nbsp;Tomohiro Akaba ,&nbsp;Makiko Yoshida ,&nbsp;Shiro Endo","doi":"10.1016/j.jiac.2025.102666","DOIUrl":"10.1016/j.jiac.2025.102666","url":null,"abstract":"<div><h3>Background</h3><div>The coronavirus disease 2019 (COVID-19) pandemic has led to various complications, including cardiovascular events. Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant in 2022, no studies have evaluated the relationship between the Omicron variant epidemic and acute myocardial infarction (AMI).</div></div><div><h3>Methods</h3><div>We utilized a Japanese claims database to identify patients diagnosed with COVID-19 between January 1, 2022, and December 31, 2022. We also identified patients who developed AMI within 90 days before and after their COVID-19 diagnosis. A self-controlled case series (SCCS) analysis evaluated the incidence rate ratio (IRR) for AMI.</div></div><div><h3>Results</h3><div>Of the 360,589 patients with COVID-19, 759 were diagnosed with AMI. Excluding the day of exposure, the SCCS analysis showed an IRR for AMI of 6.65 (95 % confidence interval [CI]: 4.66–9.48, P &lt; 0.001) for the 1st week, 1.90 (95 % CI: 1.05–3.50, P = 0.03) for the 2 nd week, and 0.95 (95 % CI: 0.52–1.72, P = 0.87) for the 3rd and 4th weeks following COVID-19. Including the day of exposure, the IRR was 77.4 (95 % CI: 63.2–94.9, P &lt; 0.001) for the 1st week, 1.90 (95 % CI: 1.05–3.50, P = 0.03) for the 2 nd week, and 0.95 (95 % CI: 0.52–1.72, P = 0.87) for the 3rd and 4th weeks following COVID-19.</div></div><div><h3>Conclusions</h3><div>This study showed that the SARS-CoV-2 Omicron variant epidemic increased AMI incidence. These findings highlight AMI as a COVID-19 characteristic, emphasize the importance of SARS-CoV-2 vaccination, and underline the need for continued vigilance, even with variant changes.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102666"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a school-based tutorial about the HPV vaccine for female middle school students on the HPV vaccination rate in Japan: A prospective cohort study","authors":"Yo Murata ,&nbsp;Yuya Saito ,&nbsp;Toshimasa Obonai","doi":"10.1016/j.jiac.2025.102671","DOIUrl":"10.1016/j.jiac.2025.102671","url":null,"abstract":"<div><h3>Background</h3><div>In Japan, the Ministry of Health, Labour and Welfare (MHLW) rescinded recommendations for including the HPV vaccine in the national immunization program in 2013, which led to a drop in the vaccination rate to &lt; 1 %. Despite the MHLW's decision to reinstate the recommendations in 2022, the vaccination rate has remained low. The present study aimed to assess the effect of a school-based vaccine tutorial on the HPV vaccination rate in female middle-school students in Japan.</div></div><div><h3>Methods</h3><div>This prospective cohort study, conducted in Higashimurayama, Tokyo from September 2023 to March 2024, enrolled female students aged 13–14 years in seven middle schools. Four and three schools formed a tutorial group and control group, respectively. The difference between the pre- and post-intervention vaccination rates was assessed using a questionnaire. Additionally, knowledge about the HPV vaccine and the rate of students’ discussion of the vaccine with their family were analyzed.</div></div><div><h3>Results</h3><div>In total, 123 and 175 students from the tutorial and control group, respectively, were analyzed. The pre-intervention vaccination rate was 9.8 % and 7.4 % (p = 0.476), and the post-intervention vaccination rate was 16.3 % and 9.7 %, indicating a corresponding increase of 7.2 % and 2.5 % (p = 0.075). The knowledge increased to a greater degree in the tutorial group.</div></div><div><h3>Conclusion</h3><div>Our study revealed an increasing trend in the HPV vaccination rate resulting from the school-based tutorial although the difference was not statistically significant. School-based tutorials can increase students’ knowledge about the vaccine and enable them to make informed decisions about vaccination.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102671"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous bacterial peritonitis due to Brucella in an HBV-positive cirrhotic patient","authors":"Yasemin Çakır Kıymaz ,&nbsp;Sümeyye Kara Yeşildağ ,&nbsp;Sevgi Baltacı ,&nbsp;Ayşenur Çömez Baysal ,&nbsp;Cihad Baysal ,&nbsp;Ertuğrul Keskin ,&nbsp;Suna Bozkurt ,&nbsp;Mürşit Hasbek ,&nbsp;Seyit Ali Büyüktuna ,&nbsp;Nazif Elaldı","doi":"10.1016/j.jiac.2025.102663","DOIUrl":"10.1016/j.jiac.2025.102663","url":null,"abstract":"<div><div>Spontaneous bacterial peritonitis (SBP) is a severe complication of cirrhosis, occurring in approximately 15 % of cirrhotic patients. The most common causative pathogens of SBP are <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em>. Although brucellosis can cause various complications, it is a rare cause of peritonitis. Herein, we report a case of a 30-year-old male with chronic hepatitis B who presented with fever, night sweats, weight loss, abdominal pain, and distension. <em>Brucella</em> spp. was isolated from blood and peritoneal fluid cultures. The patient fully recovered following six weeks of treatment with oral doxycycline (100 mg twice daily) and rifampicin (600 mg/day). No relapses or complications were observed during follow-up.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102663"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}