Journal of Infection and Chemotherapy最新文献

Clinical and microbiological characteristics of granulomatous mastitis caused by Corynebacterium species: a case series.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2025-01-03 DOI: 10.1016/j.jiac.2025.102605

Toshinori Hara, Hiroki Kitagawa, Kayoko Tadera, Rie Nagaoka, Yumiko Koba, Seiya Kashiyama, Yuta Kuhara, Takuji Omoto, Toshihito Nomura, Keitaro Omori, Norifumi Shigemoto, Sho Mokuda, Hiroki Ohge

{"title":"Clinical and microbiological characteristics of granulomatous mastitis caused by Corynebacterium species: a case series.","authors":"Toshinori Hara, Hiroki Kitagawa, Kayoko Tadera, Rie Nagaoka, Yumiko Koba, Seiya Kashiyama, Yuta Kuhara, Takuji Omoto, Toshihito Nomura, Keitaro Omori, Norifumi Shigemoto, Sho Mokuda, Hiroki Ohge","doi":"10.1016/j.jiac.2025.102605","DOIUrl":"https://doi.org/10.1016/j.jiac.2025.102605","url":null,"abstract":"Corynebacterium species are an important cause of granulomatous mastitis (GM). Although there have been worldwide reports of infections caused by Corynebacterium kroppenstedtii, few cases of C. tuberculostearicum GM have been reported. We conducted a retrospective study to investigate the clinical and microbiological characteristics of GM caused by Corynebacterium spp. between January 1, 2014, and May 31, 2024. During the study period, six patients with GM were identified, including four cases of C. kroppenstedtii GM and two cases of C. tuberculostearicum GM. All patients were female with a median age of 32 years (range: 18-50 years). All patients underwent surgical drainage and were treated with clarithromycin. The minimum inhibitory concentration (MIC) values for various antimicrobial agents, including azithromycin, clarithromycin, ciprofloxacin, clindamycin, and trimethoprim-sulfamethoxazole, were higher for C. tuberculostearicum than for C. kroppenstedtii. Additionally, MALDI-TOF MS and 16s rRNA gene sequencing accurately identified C. kroppenstedtii and C. tuberculostearicum. Accurate identification of lipophilic Corynebacterium spp. is important for antibiotic treatment selection. If clinicians suspect lipophilic Corynebacterium spp. infection, particularly GM, they should ask the microbiology laboratory to test for lipophilic Corynebacterium spp.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102605"},"PeriodicalIF":1.9,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro to clinical efficacy: Neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 strains.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-30 DOI: 10.1016/j.jiac.2024.102604

Masaki Kakimoto, Toshihito Nomura, Tanuza Nazmul, Akima Yamamoto, Kotaro Ikeda, Daisuke Miyamori, Akifumi Higashiura, Yuki Kaiki, Hiroki Kitagawa, Keitaro Omori, Norifumi Shigemoto, Masanori Ito, Takemasa Sakaguchi, Hiroki Ohge

{"title":"In vitro to clinical efficacy: Neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 strains.","authors":"Masaki Kakimoto, Toshihito Nomura, Tanuza Nazmul, Akima Yamamoto, Kotaro Ikeda, Daisuke Miyamori, Akifumi Higashiura, Yuki Kaiki, Hiroki Kitagawa, Keitaro Omori, Norifumi Shigemoto, Masanori Ito, Takemasa Sakaguchi, Hiroki Ohge","doi":"10.1016/j.jiac.2024.102604","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.102604","url":null,"abstract":"Introduction: Neutralizing antibodies have been approved for coronavirus disease 2019 (COVID-19) treatment; however, no study has clarified the link among their neutralizing effect in vitro, the period of infectious virus shedding, and symptoms in the acute phase. Here, we aimed to assess the duration of virus shed and fever in patients with mild COVID-19 stratified by their characteristics and type of neutralizing antibody administered.Methods: We evaluated the efficacy of neutralizing antibodies in terms of the duration of infectious virus excretion and fever in three groups: patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta strain treated with REGEN-CoV2 (REGN-CoV2 group) and patients infected with Omicron strain treated with S309 (S309 group) or untreated (untreated group).Results: REGN-CoV2 was significantly more effective in reducing viral load than S309; furthermore, S309 treatment did not show a significant reduction in fever duration when compared to no treatment. Mutations in the spike protein receptor-binding domain may reduce the binding ability of REGN-CoV2 and S309: the 50% inhibitory concentration (IC50) of REGN-CoV2 for the conventional and Delta strains was 0.013 and 0.019 μg/mL, respectively, and that of S309 for the Omicron strain was 53.1 μg/mL.Conclusion: Laboratory evaluations are helpful for analyzing the clinical efficacy of neutralizing antibodies, and this study will help in not only considering effective treatments for COVID-19 but also addressing the threat of future unknown viral infections.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102604"},"PeriodicalIF":1.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting recurrent Clostridioides difficile infection by assessing antimicrobial treatment based on days of antibiotic spectrum coverage and ATLAS scores.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-27 DOI: 10.1016/j.jiac.2024.102603

Hiroki Nagaoka, Yuma Morita, Tomonori Ohya, Kazuo Takahashi, Junya Sato, Momoyo Miyata, Saori Iwashita, Yuta Arai, Shuntaro Kiuchi, Hiroaki Ozone, Tetsuya Matsumoto

{"title":"Predicting recurrent Clostridioides difficile infection by assessing antimicrobial treatment based on days of antibiotic spectrum coverage and ATLAS scores.","authors":"Hiroki Nagaoka, Yuma Morita, Tomonori Ohya, Kazuo Takahashi, Junya Sato, Momoyo Miyata, Saori Iwashita, Yuta Arai, Shuntaro Kiuchi, Hiroaki Ozone, Tetsuya Matsumoto","doi":"10.1016/j.jiac.2024.102603","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.102603","url":null,"abstract":"Introduction: We aimed to determine the impact of prior antimicrobial treatment on recurrent Clostridioides difficile infection (CDI) based on days of antibiotic spectrum coverage (DASC) and predict the risk of recurrence to guide the selection of appropriate initial therapeutic agents.Methods: We assessed the antimicrobial treatment administered to 195 patients with a history of CDI for 28 days before testing positive for C. difficile using DASC and illness severity using ATLAS scores. We determined DASC cutoff values and combined them with relevant factors in ATLAS to determine an association with CDI recurrence.Results: Forty-four patients had recurrences of C. difficile infection. The median (interquartile range, IQR) DASC value was significantly higher in the group with recurrent CDI (78 [50-128]) than without (48 [12-99]; p = 0.01). Cutoff values of 36 and 66 for DASC were determined using receiver operating characteristic (ROC) curves. Age and serum creatinine were associated with CDI recurrence according to ATLAS scores. We assessed the risk of recurrence by combining age, serum creatinine, and DASC scores. A scoring system was created by assigning each variable a score from 0 to 2. The area under the ROC curve for this scoring system was 0.70.Conclusion: Assessing antimicrobial treatment using DASC before CDI can predict recurrence and should facilitate the selection of initial therapy for CDI.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102603"},"PeriodicalIF":1.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Coronavirus Disease 2019 Emergency Declarations on Surgeries for Deep Neck Infection Incidence in Japan.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-26 DOI: 10.1016/j.jiac.2024.102601

Kensuke Uraguchi, Naomi Matsumoto, Shohei Fujimoto, Takashi Yorifuji, Mizuo Ando

{"title":"Impact of Coronavirus Disease 2019 Emergency Declarations on Surgeries for Deep Neck Infection Incidence in Japan.","authors":"Kensuke Uraguchi, Naomi Matsumoto, Shohei Fujimoto, Takashi Yorifuji, Mizuo Ando","doi":"10.1016/j.jiac.2024.102601","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.102601","url":null,"abstract":"Introduction: Deep neck infections are lethal diseases; however, factors related to their prevention remain unclear. The national emergency declaration in April 2020, in response to COVID-19, spurred widespread adoption of nonpharmaceutical interventions (NPIs) such as hand washing, mask wearing, and social distancing.Methods: This retrospective cohort study examines the impact of these interventions on the incidence of deep neck infections in Japan through interrupted time series analysis using National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data. Aggregated yearly and monthly data from fiscal year 2014 to 2021 were analyzed. This study aimed to examine the time series changes in Japan, including the impact of COVID-19, by focusing on retropharyngeal, peritonsillar, and deep neck abscess surgeries.Results: A significant seasonal variation was observed in peritonsillar abscesses, with a peak in July. We assessed changes in surgery for deep neck infections before and after the emergency declaration. Interrupted time series analysis revealed changes in surgery for retropharyngeal abscess (level change, 0.59; 95% confidence interval [CI], 0.40-0.86; slope change, 0.98; 95% CI, 0.94-1.02), peritonsillar abscess (level change, 0.84; 95% CI, 0.75-0.94; slope change, 1.00; 95% CI, 0.99-1.01), and deep neck abscess (level change, 0.91; 95% CI, 0.77-1.08; slope change, 0.99; 95% CI, 0.97-1.01).Conclusions: These findings suggest that the NPIs implemented due to the emergency declaration are effective in reducing the need for surgical intervention in retropharyngeal and peritonsillar abscess cases, highlighting the potential for these measures to prevent serious infections.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102601"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro neuraminidase inhibitory concentrations (IC₅₀) of four neuraminidase inhibitors in the Japanese 2023-24 season: Comparison with the 2010-11 to 2022-23 seasons.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-26 DOI: 10.1016/j.jiac.2024.102602

Takeyuki Goto, Naoki Kawai, Takuma Bando, Tomonori Sato, Naoki Tani, Yong Chong, Hideyuki Ikematsu

{"title":"In vitro neuraminidase inhibitory concentrations (IC50) of four neuraminidase inhibitors in the Japanese 2023-24 season: Comparison with the 2010-11 to 2022-23 seasons.","authors":"Takeyuki Goto, Naoki Kawai, Takuma Bando, Tomonori Sato, Naoki Tani, Yong Chong, Hideyuki Ikematsu","doi":"10.1016/j.jiac.2024.102602","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.102602","url":null,"abstract":"Introduction: To assess the susceptibility of epidemic influenza viruses to the four most used neuraminidase inhibitors (NAIs) during the 2023-24 influenza season in Japan, we measured the 50% inhibitory concentration (IC50) of oseltamivir, peramivir, zanamivir, and laninamivir in virus isolates from the sample of 100 patients.Methods: Viral isolation was done using specimens obtained before and after treatment, with the type/subtype determined by RT-PCR using type- and subtype-specific primers. IC50 values were determined by a neuraminidase inhibition assay using a fluorescent substrate.Results: The virus isolates included 16 A(H1N1)pdm09, 19 A(H3N2), and 65 B/Victoria-lineage. The geometric mean (GM) IC50 values of pre-treatment samples for oseltamivir, peramivir, zanamivir, and laninamivir were 0.90 nM, 0.62 nM, 1.09 nM, and 2.77 nM for A(H1N1)pdm09; 0.86 nM, 0.67 nM, 1.64 nM, and 3.61 nM for A(H3N2); and 16.12 nM, 1.84 nM, 3.87 nM, and 11.35 nM for B/Victoria, respectively. These values were comparable to those from the previous eleven seasons, and no virus with significantly reduced susceptibility to any of the NAIs was found either before or after drug administration in the 2023-24 season.Conclusions: These results indicate that susceptibility to these four NAIs has been maintained across the three influenza types/subtypes over the past fourteen seasons in Japan.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102602"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switch to amoxicillin-clavulanate oral therapy in urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: Assessment by chronic phase technetium-99m dimercaptosuccinic acid renal Scintigraphy images.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-24 DOI: 10.1016/j.jiac.2024.102599

Yuhi Takagi, Yuji Fujita, Yuji Kano, Hideaki Shiraishi

{"title":"Switch to amoxicillin-clavulanate oral therapy in urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: Assessment by chronic phase technetium-99m dimercaptosuccinic acid renal Scintigraphy images.","authors":"Yuhi Takagi, Yuji Fujita, Yuji Kano, Hideaki Shiraishi","doi":"10.1016/j.jiac.2024.102599","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.102599","url":null,"abstract":"The incidence of urinary tract infection (UTI) caused by extensive beta-lactamase-producing Escherichia coli (ESBL-EC) is increasing, including in children. However, the available oral antibiotic treatment options for ESBL-EC are limited. Herein, we report the cases of two children diagnosed with UTI caused by ESBL-EC (ESBL-UTI) who were switched from empirical intravenous antibiotics in UTI to amoxicillin-clavulanic acid (AMPC/CVA) (14:1) after the causative organism was found to be ESBL-EC. A 3-month-old infant and an 8-month-old infant were admitted to our hospital with the chief complaint of fever. In both cases, UTI was suspected based on urinalysis results, and intravenous cefotaxime was started as an empiric antibiotic. In both cases, ESBL-EC was detected in urine culture, and the diagnosis of ESBL-UTI was confirmed. Results of antimicrobial susceptibility testing showed resistance to cefotaxime, but fever resolution was obtained in both cases following administration of intravenous cefotaxime. Since fever resolution was achieved, the antimicrobial was switched to oral AMPC/CVA (14:1) monotherapy with reference to antimicrobial susceptibility testing, and the two patients were discharged on days 5-6 of hospitalization. Antimicrobials were administered intravenously and orally for a total of 2 weeks. Chronic-phase technetium-99m dimercaptosuccinic acid renal scintigraphy showed no renal scarring. ESBL-UTI may require 2 weeks of intravenous antibacterial therapy, but in this case, both patients could be treated without renal scarring after conversion to oral AMPC/CVA alone. Since this is important to shorten the length of hospital stay, we will study the effect of this treatment modality in more cases in the future.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102599"},"PeriodicalIF":1.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subsequent bacteremia associated with intravascular catheter colonization with Staphylococcus aureus, Gram-negative rods, and Candida species in children.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-24 DOI: 10.1016/j.jiac.2024.102600

Hina Hisano, Kensuke Shoji, Toshihiro Matsui, Hiroki Kato, Kana Fukui, Motohiro Kano, Yuji Yamada, Yoshihiro Gocho, Akira Ishiguro

引用次数: 0

Brucella anthropi bacteremia: persistent bacteremia with minimal symptoms.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-20 DOI: 10.1016/j.jiac.2024.102595

Sho Yokota, Toshibumi Taniguchi, Shin Takayanagi

引用次数: 0

Long-term follow-up of chronic osteomyelitis after bone tumor resection^.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-20 DOI: 10.1016/j.jiac.2024.102597

Hiroaki Kimura, Hisaki Aiba, Shiro Saito, Takao Sakai, Hideki Murakami

{"title":"Long-term follow-up of chronic osteomyelitis after bone tumor resection.","authors":"Hiroaki Kimura, Hisaki Aiba, Shiro Saito, Takao Sakai, Hideki Murakami","doi":"10.1016/j.jiac.2024.102597","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.102597","url":null,"abstract":"The standard treatment for chronic osteomyelitis after trauma is affected bone resection and bone and soft tissue defect reconstruction. However, few reports exist regarding chronic osteomyelitis after bone tumor surgery. We retrospectively reviewed five cases of chronic infection after bone tumor surgery, including their treatment strategy and clinical course. We reviewed three cases of giant cell tumors of bone and two cases of osteosarcoma. Reconstruction was performed after tumor resection in all cases. Despite careful management, fistula formation and chronic infection occurred. Two patients underwent radical surgery for chronic infection. After the infection subsided, reconstruction was performed again. However, in one case, the infection recurred, and consequently, amputation was performed. When radical surgery is performed, implant replacement is essential due to biofilm formation. Controlling soft tissue infection, besides bone and implant infection, is important. In some cases, however, radical surgery is undesirable, and patients choose to live with the chronic infection instead. Even when methicillin-resistant S. aureus (MRSA) was detected, anti-MRSA drugs were used only in the early stages, after which the infection was managed by switching to oral antibiotics, such as minocycline and sulfamethoxazole-trimethoprim combination drugs. Careful follow-up is necessary due to the risk of fistula cancer in conservative management.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102597"},"PeriodicalIF":1.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-tuberculous mycobacterial shoulder arthritis with acute exacerbation soon after initiation of immune checkpoint inhibitor: A case report.

IF 1.9 4区医学

Journal of Infection and Chemotherapy Pub Date : 2024-12-20 DOI: 10.1016/j.jiac.2024.102596

Shugo Inada, Keitaro Omori, Toshihito Nomura, Hiroki Kitagawa, Norifumi Shigemoto, Noboru Hattori, Hiroki Ohge

{"title":"Non-tuberculous mycobacterial shoulder arthritis with acute exacerbation soon after initiation of immune checkpoint inhibitor: A case report.","authors":"Shugo Inada, Keitaro Omori, Toshihito Nomura, Hiroki Kitagawa, Norifumi Shigemoto, Noboru Hattori, Hiroki Ohge","doi":"10.1016/j.jiac.2024.102596","DOIUrl":"https://doi.org/10.1016/j.jiac.2024.102596","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have been approved for treating various cancers; however, they can cause immune-related adverse events. Generally, ICIs are not associated with an increased risk of infection, however, several reports demonstrated infections caused by nontuberculous mycobacterium (NTM) during ICI therapy. Here, we report a case of NTM shoulder arthritis with acute exacerbation immediately after ICI initiation. A 75-year-old man was diagnosed with left shoulder arthritis caused by Mycobacterium intracellulare eight months before receiving ICI treatment and was treated with clarithromycin and ethambutol. However, the mild redness, swelling, heat, and shoulder pain persisted. The patient was diagnosed with hepatocellular carcinoma and atezolizumab and bevacizumab treatment was initiated; one day after the initiation of therapy, the patient presented with a fever and worsened shoulder symptoms. Considering the suspected worsening of NTM arthritis, sitafloxacin was additionally administered, and surgical debridement was performed. M. intracellulare was isolated through culturing shoulder synovial tissue; immunohistochemical staining analysis revealed programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) expression in granulation tissue cells. After the arthritis symptoms decreased, atezolizumab plus bevacizumab was resumed and continued with no recurrence of arthritis. The NTM exacerbation on the day after ICI administration suggests the potential involvement of the PD-1/PD-L1 pathway in the pathogenesis of NTM; moreover, adverse inflammatory reactions to NTM were possibly triggered through the blockade of this pathway.","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":" ","pages":"102596"},"PeriodicalIF":1.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0