加强疫苗接种对欧微米波期间住院的轻中度COVID-19日本合并症患者治疗后氧恶化的影响

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-06-26 DOI:10.1016/j.jiac.2025.102764

Shunsaku Hayai , Kensuke Fukumitsu , Atsushi Suzuki , Jun Fukihara , Takuma Katano , Toshiyuki Yonezawa , Tomoyuki Ogisu , Hiroyuki Tanaka , Takahiro Inoue , Hisashi Kako , Yuri Maeda , Makoto Ishii , Akio Niimi , Kazuyoshi Imaizumi , Etsuro Yamaguchi

{"title":"加强疫苗接种对欧微米波期间住院的轻中度COVID-19日本合并症患者治疗后氧恶化的影响","authors":"Shunsaku Hayai , Kensuke Fukumitsu , Atsushi Suzuki , Jun Fukihara , Takuma Katano , Toshiyuki Yonezawa , Tomoyuki Ogisu , Hiroyuki Tanaka , Takahiro Inoue , Hisashi Kako , Yuri Maeda , Makoto Ishii , Akio Niimi , Kazuyoshi Imaizumi , Etsuro Yamaguchi","doi":"10.1016/j.jiac.2025.102764","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Although the emergence of the Omicron variant has decreased overall mortality from Coronavirus Disease 2019 (COVID-19) compared to the Delta variant, elderly individuals with comorbidities remain at increased risk of adverse outcomes. While vaccination and antiviral treatments have reduced the severity of COVID-19, data on the impact of booster vaccination on post-hospitalization oxygen deterioration in the Japanese population remain limited.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of hospitalized mild-to-moderate COVID-19 Japanese patients during the Omicron variant wave (December 2021 to October 2022). Both vaccinated and unvaccinated patients were included and categorized into three groups based on their vaccination status: unvaccinated (0–1 vaccine dose), primary series (2 vaccine doses), and booster group (3–4 vaccine doses). Demographic and clinical data were collected, and the frequency and time to post-hospitalization oxygen deterioration were evaluated among the three groups.</div></div><div><h3>Results</h3><div>A total of 596 patients were analyzed (141 unvaccinated, 180 primary series, and 275 booster group). The booster group showed significantly lower rates of oxygen deterioration and a longer time to deterioration compared to the other groups, despite being older and having more comorbidities. A multivariate analysis, adjusted for age and gender, revealed that booster vaccination was significantly associated with a reduced risk of oxygen deterioration after initial treatment. Similar results were observed in the subgroup analysis of elderly patients aged 65 years and older.</div></div><div><h3>Conclusion</h3><div>Our study demonstrated the effectiveness of booster vaccination on preventing post-treatment oxygen deterioration in hospitalized mild-to-moderate COVID-19 Japanese patients with comorbidities during the Omicron wave.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 8","pages":"Article 102764"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of booster vaccination on post-treatment oxygen deterioration in hospitalized mild-to-moderate COVID-19 Japanese patients with comorbidities during the Omicron wave\",\"authors\":\"Shunsaku Hayai , Kensuke Fukumitsu , Atsushi Suzuki , Jun Fukihara , Takuma Katano , Toshiyuki Yonezawa , Tomoyuki Ogisu , Hiroyuki Tanaka , Takahiro Inoue , Hisashi Kako , Yuri Maeda , Makoto Ishii , Akio Niimi , Kazuyoshi Imaizumi , Etsuro Yamaguchi\",\"doi\":\"10.1016/j.jiac.2025.102764\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Although the emergence of the Omicron variant has decreased overall mortality from Coronavirus Disease 2019 (COVID-19) compared to the Delta variant, elderly individuals with comorbidities remain at increased risk of adverse outcomes. While vaccination and antiviral treatments have reduced the severity of COVID-19, data on the impact of booster vaccination on post-hospitalization oxygen deterioration in the Japanese population remain limited.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of hospitalized mild-to-moderate COVID-19 Japanese patients during the Omicron variant wave (December 2021 to October 2022). Both vaccinated and unvaccinated patients were included and categorized into three groups based on their vaccination status: unvaccinated (0–1 vaccine dose), primary series (2 vaccine doses), and booster group (3–4 vaccine doses). Demographic and clinical data were collected, and the frequency and time to post-hospitalization oxygen deterioration were evaluated among the three groups.</div></div><div><h3>Results</h3><div>A total of 596 patients were analyzed (141 unvaccinated, 180 primary series, and 275 booster group). The booster group showed significantly lower rates of oxygen deterioration and a longer time to deterioration compared to the other groups, despite being older and having more comorbidities. A multivariate analysis, adjusted for age and gender, revealed that booster vaccination was significantly associated with a reduced risk of oxygen deterioration after initial treatment. Similar results were observed in the subgroup analysis of elderly patients aged 65 years and older.</div></div><div><h3>Conclusion</h3><div>Our study demonstrated the effectiveness of booster vaccination on preventing post-treatment oxygen deterioration in hospitalized mild-to-moderate COVID-19 Japanese patients with comorbidities during the Omicron wave.</div></div>\",\"PeriodicalId\":16103,\"journal\":{\"name\":\"Journal of Infection and Chemotherapy\",\"volume\":\"31 8\",\"pages\":\"Article 102764\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Infection and Chemotherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1341321X25001618\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection and Chemotherapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1341321X25001618","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

虽然与Delta变异相比，Omicron变异的出现降低了2019冠状病毒病（COVID-19）的总死亡率，但患有合共病的老年人发生不良后果的风险仍然增加。虽然疫苗接种和抗病毒治疗降低了COVID-19的严重程度，但关于加强疫苗接种对日本人群住院后氧气恶化影响的数据仍然有限。方法：我们对在Omicron变异波（2021年12月至2022年10月）期间住院的轻中度COVID-19日本患者进行回顾性研究。接种疫苗和未接种疫苗的患者均纳入研究，并根据其疫苗接种状况分为三组：未接种疫苗（0-1剂疫苗）、初级系列（2剂疫苗）和加强组（3-4剂疫苗）。收集人口学和临床资料，评估三组患者住院后氧恶化的频率和时间。结果：共分析了596例患者（141例未接种疫苗，180例初级系列，275例加强组）。与其他组相比，助推器组表现出明显较低的氧气恶化率和较长的恶化时间，尽管年龄较大且有更多的合并症。一项针对年龄和性别进行调整的多变量分析显示，加强疫苗接种与初始治疗后氧气恶化风险降低显著相关。在65岁及以上老年患者的亚组分析中也观察到类似的结果。结论：我们的研究证实了加强疫苗接种对住院的轻至中度COVID-19日本患者治疗后氧恶化的有效性，这些患者在欧米ron波期间有合并症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effects of booster vaccination on post-treatment oxygen deterioration in hospitalized mild-to-moderate COVID-19 Japanese patients with comorbidities during the Omicron wave

Introduction

Although the emergence of the Omicron variant has decreased overall mortality from Coronavirus Disease 2019 (COVID-19) compared to the Delta variant, elderly individuals with comorbidities remain at increased risk of adverse outcomes. While vaccination and antiviral treatments have reduced the severity of COVID-19, data on the impact of booster vaccination on post-hospitalization oxygen deterioration in the Japanese population remain limited.

Methods

We conducted a retrospective study of hospitalized mild-to-moderate COVID-19 Japanese patients during the Omicron variant wave (December 2021 to October 2022). Both vaccinated and unvaccinated patients were included and categorized into three groups based on their vaccination status: unvaccinated (0–1 vaccine dose), primary series (2 vaccine doses), and booster group (3–4 vaccine doses). Demographic and clinical data were collected, and the frequency and time to post-hospitalization oxygen deterioration were evaluated among the three groups.

Results

A total of 596 patients were analyzed (141 unvaccinated, 180 primary series, and 275 booster group). The booster group showed significantly lower rates of oxygen deterioration and a longer time to deterioration compared to the other groups, despite being older and having more comorbidities. A multivariate analysis, adjusted for age and gender, revealed that booster vaccination was significantly associated with a reduced risk of oxygen deterioration after initial treatment. Similar results were observed in the subgroup analysis of elderly patients aged 65 years and older.

Conclusion

Our study demonstrated the effectiveness of booster vaccination on preventing post-treatment oxygen deterioration in hospitalized mild-to-moderate COVID-19 Japanese patients with comorbidities during the Omicron wave.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.