Characteristics of Kawasaki disease in children with a history of COVID-19.

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-06-13 DOI:10.1016/j.jiac.2025.102755

Hikaru Tabakotani, Masahiro Ishii, Masato Ogawa, Kazuyoshi Mizuki, Takayuki Hoshina

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引用次数: 0

Abstract

Objective: To investigate the characteristics of Kawasaki disease (KD) patients with a history of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, including asymptomatic cases.

Methods: This retrospective study included 63 patients in whom KD was diagnosed between April 2021 and March 2024. We compared demographic and clinical characteristics of patients with KD who did and did not have a history of COVID-19 (KD-COVID-19 vs. KD-non-COVID-19). We also compared these characteristics in the patients who tested positive for the anti-SARS-CoV-2 spike protein antibody in the two groups (antibody-positive KD-COVID-19 vs. antibody-positive KD-non-COVID-19).

Results: Of the 63 patients with KD, 13 had a history of COVID-19. Resistance to initial intravenous immunoglobulin therapy was higher among patients who had had COVID-19 (62%) than among those without COVID-19 (24%; P = 0.017), as were median serum B-type natriuretic peptide (BNP) levels (59.1 vs. 16.0 pg/mL, respectively; P = 0.017). Eight patients (62%) who had had COVID-19 and 16 (32%) who had not had COVID-19 tested positive for the anti-SARS-CoV-2 spike protein antibody. Among patients who were antibody-positive, median serum BNP levels were significantly higher in the patients who had had COVID-19 (76.6 pg/mL) than in those who had not had COVID-19 (14.5 pg/mL; P < 0.001).

Conclusion: Patients with KD who had a history of symptomatic SARS-CoV-2 infection are prone to elevated serum BNP levels, which may indicate potential ventricular dysfunction.

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有COVID-19病史的儿童川崎病的特点

目的：了解有严重急性呼吸综合征-冠状病毒2 （SARS-CoV-2）感染史的川崎病（KD）患者的特点，包括无症状病例。方法：本回顾性研究纳入了2021年4月至2024年3月诊断为KD的63例患者。我们比较了有和没有COVID-19病史的KD患者的人口学和临床特征（KD-COVID-19与KD-非COVID-19）。我们还比较了两组中抗sars - cov -2刺突蛋白抗体检测阳性的患者（抗体阳性的KD-COVID-19与抗体阳性的kd -非covid -19）的这些特征。结果：63例KD患者中，13例有COVID-19病史。感染COVID-19的患者（62%）对初始静脉注射免疫球蛋白治疗的耐药率高于未感染COVID-19的患者(24%；P = 0.017)，血清b型利钠肽（BNP）水平中位数分别为59.1和16.0 pg/mL；P = 0.017)。8名感染COVID-19的患者（62%）和16名未感染COVID-19的患者（32%）的抗sars - cov -2刺突蛋白抗体检测呈阳性。在抗体阳性的患者中，患有COVID-19的患者血清BNP水平中位数（76.6 pg/mL）显著高于未患有COVID-19的患者(14.5 pg/mL；P < 0.001)。结论：有症状性SARS-CoV-2感染史的KD患者血清BNP水平易升高，可能提示潜在的心室功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.