Emergence of a methicillin-resistant Staphylococcus aureus strains with an unusual susceptibility antibiotic pattern in Tunisia

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-03-05 DOI:10.1016/j.jiac.2025.102677

Sana Ferjani , Zaineb Hamzaoui , Lamia Kanzari , Ahmed Fakhfekh , Asma Ferjani , Ilhem Boutiba Ben Boubaker

{"title":"Emergence of a methicillin-resistant Staphylococcus aureus strains with an unusual susceptibility antibiotic pattern in Tunisia","authors":"Sana Ferjani , Zaineb Hamzaoui , Lamia Kanzari , Ahmed Fakhfekh , Asma Ferjani , Ilhem Boutiba Ben Boubaker","doi":"10.1016/j.jiac.2025.102677","DOIUrl":null,"url":null,"abstract":"<div><div>Typically, methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit concurrent resistance to numerous commonly used antibiotics. Between June and December 2023, five MRSA strains with an unusual antibiotic susceptibility pattern (susceptible to all antibiotics tested, except cefoxitin) were isolated at Charles Nicolle Hospital of Tunis. Isolates were characterized by whole genome sequencing using the Illumina DNA Prep kit. All isolates carried the mecA gene [SCCmec types IVa (2B) (n = 4) and V (n = 1)]. Virulence genes, including leukocidin genes (lukD, lukE), enterotoxin genes (sea, seg, sei, sem, sen, seo, seu), and immune evasion genes (sak, scn). They were identified as ST97/CC97 (n = 2), ST149/CC5 (n = 2), and ST5/CC4 (n = 1). This study highlights the emergence of MRSA clones with an unusual susceptible antibiotic pattern, emphasizing the importance of continued molecular surveillance to monitor both antimicrobial resistance and virulence traits and track the spread of newly introduced clones, thereby improving infection control strategies.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102677"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection and Chemotherapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1341321X25000741","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Typically, methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit concurrent resistance to numerous commonly used antibiotics. Between June and December 2023, five MRSA strains with an unusual antibiotic susceptibility pattern (susceptible to all antibiotics tested, except cefoxitin) were isolated at Charles Nicolle Hospital of Tunis. Isolates were characterized by whole genome sequencing using the Illumina DNA Prep kit. All isolates carried the mecA gene [SCCmec types IVa (2B) (n = 4) and V (n = 1)]. Virulence genes, including leukocidin genes (lukD, lukE), enterotoxin genes (sea, seg, sei, sem, sen, seo, seu), and immune evasion genes (sak, scn). They were identified as ST97/CC97 (n = 2), ST149/CC5 (n = 2), and ST5/CC4 (n = 1). This study highlights the emergence of MRSA clones with an unusual susceptible antibiotic pattern, emphasizing the importance of continued molecular surveillance to monitor both antimicrobial resistance and virulence traits and track the spread of newly introduced clones, thereby improving infection control strategies.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.