Emergence of a methicillin-resistant Staphylococcus aureus strains with an unusual susceptibility antibiotic pattern in Tunisia

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-03-05 DOI:10.1016/j.jiac.2025.102677

Sana Ferjani , Zaineb Hamzaoui , Lamia Kanzari , Ahmed Fakhfekh , Asma Ferjani , Ilhem Boutiba Ben Boubaker

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Abstract

Typically, methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit concurrent resistance to numerous commonly used antibiotics. Between June and December 2023, five MRSA strains with an unusual antibiotic susceptibility pattern (susceptible to all antibiotics tested, except cefoxitin) were isolated at Charles Nicolle Hospital of Tunis. Isolates were characterized by whole genome sequencing using the Illumina DNA Prep kit. All isolates carried the mecA gene [SCCmec types IVa (2B) (n = 4) and V (n = 1)]. Virulence genes, including leukocidin genes (lukD, lukE), enterotoxin genes (sea, seg, sei, sem, sen, seo, seu), and immune evasion genes (sak, scn). They were identified as ST97/CC97 (n = 2), ST149/CC5 (n = 2), and ST5/CC4 (n = 1). This study highlights the emergence of MRSA clones with an unusual susceptible antibiotic pattern, emphasizing the importance of continued molecular surveillance to monitor both antimicrobial resistance and virulence traits and track the spread of newly introduced clones, thereby improving infection control strategies.

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出现耐甲氧西林金黄色葡萄球菌菌株与不寻常的敏感性抗生素模式在突尼斯

通常，耐甲氧西林金黄色葡萄球菌（MRSA）菌株对许多常用抗生素同时表现出耐药性。2023年6月至12月期间，在突尼斯Charles Nicolle医院分离出5株具有不同寻常抗生素敏感性的MRSA菌株（对除头孢西丁外的所有测试抗生素均敏感）。采用Illumina DNA Prep试剂盒对分离株进行全基因组测序。所有分离株均携带mecA基因[SCCmec型IVa (2B) （n = 4）和V (n = 1)]。毒力基因，包括杀白细胞素基因（lukD、lukE）、肠毒素基因（sea、seg、sei、sem、sen、seo、seu）和免疫逃避基因（sak、scn）。他们被鉴定为ST97/CC97 (n = 2), ST149/CC5 （n = 2）和ST5/CC4 （n = 1）。本研究强调了MRSA克隆的出现具有不同寻常的敏感抗生素模式，强调了持续分子监测的重要性，以监测抗菌素耐药性和毒力特征，并跟踪新引入克隆的传播，从而改进感染控制策略。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.