Diagnostic value of sTREM-1, sCD25, sCD40L and sCD130 in late-onset neonatal sepsis

Introduction

Neonatal sepsis represents a major public health challenge worldwide, presenting serious risks to the health and survival of infants. The identification of novel and efficient serum biomarkers to replace traditional blood cultures is critical for the timely diagnosis and management of this condition. Our objective is to evaluate the diagnostic value of sTREM-1, sCD25, sCD40L, and sCD130 in cases of late-onset neonatal sepsis.

Methods

This prospective case-control study comprised 80 infants, 40 suspected of having LOS and 40 serving as the control group. Venous anticoagulated blood was collected to measure sTREM-1, sCD25,sCD40L,sCD130, CRP, and PCT levels.

Results

The LOS group exhibited a notably higher occurrence of premature labor, low birth weight, chorioamnionitis, and longer inpatient stays compared to the control group(P < 0.05). CRP, PCT, sTREM-1, and sCD130 were identified as independent predictors of LOS. At the sTREM-1 cutoff value of 42.64 pg/ml, the sensitivity and specificity were 93.20 % and 89.70 %, respectively; at the sCD130 cutoff value of 131165.85 pg/ml, the sensitivity was 91.40 %, and the specificity was 86.20 %. Furthermore, CRP and PCT demonstrated a positive correlation with serum sTREM-1, whereas sCD130 exhibited a negative correlation with both CRP and PCT.

Conclusion

Compared to conventional markers,sTREM-1 and sCD130 exhibit higher sensitivity and specificity, making them reliable indicators for diagnosing LOS.