A case of meningitis treated with intraventricular vancomycin in an infant

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-03-01 DOI:10.1016/j.jiac.2025.102674

Yuya Uezato , Wataru Uehara , Shingo Kurokawa , Naoya Nishiyama , Sadao Nakamura , Masashi Nakamatsu , Koichi Nakanishi , Kazuko Yamamoto , Hideo Shiohira , Katsunori Nakamura

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引用次数: 0

Abstract

There is limited evidence for vancomycin (VCM) ventriculoperitoneal (VP) administration. We report a 3-month-old female with congenital hydrocephalus who developed a fever and was admitted to the hospital with a suspected VP shunt infection; she was being managed as an outpatient following VP shunt placement. Methicillin-resistant Staphylococcus aureus was detected on the removed catheter tip, and VCM treatment was initiated. Intravenous administration was ineffective, so intraventricular administration was initiated. Therapeutic drug monitoring (TDM) of cerebrospinal fluid (CSF) drug concentration showed a high trough level (30.9–50.0 μg/mL) at 2 mg daily dosing. Dose adjustment was implemented considering CSF drainage volume, and administration was changed to every other day. This case suggests that performing TDM and considering the amount of CSF drainage when establishing a detailed dosing regimen are important when administering VCM intraventricularly.

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.