Journal of Human Hypertension最新文献

{"title":"Adaptive-Lag approach for assessing baroreflex functions: validation with the eurobavar dataset","authors":"Manish Goyal, Arun Goel, Narsingh Verma, Yogesh Singh","doi":"10.1038/s41371-026-01140-x","DOIUrl":"10.1038/s41371-026-01140-x","url":null,"abstract":"The arterial baroreflex is a fundamental short-term feedback mechanism stabilizing arterial pressure through autonomic modulation of heart rate and vascular tone. Conventional sequence method for Baroreflex sensitivity (BRS) assessment assumes a fixed delay between systolic pressure and cardiac interval responses, overlooking the physiological variability in reflex latency that arises from differences in neural conduction and effector kinetics. We developed and validated an Adaptive Lag (AL) Baroreflex Sensitivity method that accommodates variable delays, thereby quantifying both reflex gain and lag in response. Using 42 recordings from the EuroBaVar dataset, we compared the AL-BRS method (incorporating variable lags of 0–10 beats), to conventional sequence and spectral methods. The AL approach identified 34% more baroreflex sequences and demonstrated excellent agreement (r = 0.99) with fixed lag BRS. Also, Baroreflex Response Lag (BRL) was also determined which was significantly longer in subjects with impaired baroreflex function (supine: 2.35 vs. 1.16 beats). AL-BRS and BRL, showed superior diagnostic performance for identifying baroreflex impairment (AUC = 0.86 and 0.87, respectively), with BRL being excellent during standing (AUC = 0.95). These findings demonstrate that incorporating variable response time into BRS assessment not only refines sensitivity estimation but also reveals BRL as a temporal feature of baroreflex control, which carries diagnostic and potentially prognostic value in autonomic regulation. Thus AL-BRS method provides a more physiologically complete assessment of baroreflex function. This work advances the field by offering a refined, publicly available tool (implemented in MATLAB and R) for research and clinical applications.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 5","pages":"382-390"},"PeriodicalIF":3.4,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural analysis of causal pathways between adherence, satisfaction and clinical outcomes in hypertensive patients using a mobile adherence intervention: A SEM–NCA–cIPMA approach","authors":"Rajat Rana, Baharudin Bin Ibrahim, Hasniza Binti Zaman Huri, Izyan Binti A. Wahab, Kayatri Govindaraju, Mohd. Syamir Mohamad Shukeri, Siew Chin Ong","doi":"10.1038/s41371-026-01132-x","DOIUrl":"10.1038/s41371-026-01132-x","url":null,"abstract":"Poor medication adherence remains a major barrier to effective hypertension control, particularly in low-resource settings. This study aimed to explore causal pathways, necessity conditions and optimization priorities of the CareAide mobile application for improving medication adherence and clinical outcomes among hypertensive patients. A prospective, randomised, open-label, two-arm trial was conducted at University Malaya Medical Centre. Adults (N = 275) with hypertension and low Morisky Medication Adherence Scale (MMAS-8) scores were randomised to CareAide plus usual care or usual care alone for six months. Primary outcome was adherence (MMAS-8) at third (F1) and sixth month (F2); secondary outcomes included systolic/diastolic blood pressure (Hypertension F1, F2) and application satisfaction via Mobile Adherence Satisfaction Scale (MASS). Structural Equation Modelling (SEM), Necessary Condition Analysis (NCA) and Combined Importance–Performance Map Analysis (cIPMA) tested hypotheses from an integrated theoretical framework. Intervention showed large positive effects on adherence at (F1 β = 0.58, F2 β = 0.79, P < 0.001). Six-month adherence mediated the intervention’s impact on blood pressure (indirect β = −0.16, P = 0.006) and together with early adherence, formed a sequential mediation chain (β = −0.05, P = 0.01). NCA showed the intervention (d = 0.18) and early adherence (d = 0.28) were necessary for high F2 adherence; the intervention (CE-FDH = 100%) and prior blood pressure control (CE-FDH = 48.58%) were necessary for optimal F2 blood pressure. Feature satisfaction (FS) was both sufficient (β = 0.20, P < 0.001) and necessary (d = 0.29) for sustained adherence. cIPMA identified the intervention, early adherence and FS as high-importance, low-performance targets. CareAide significantly improves adherence and blood pressure via a temporally sequenced behavioral pathway with early adherence gains and FS are critical, actionable factors. Trial registration: CAREAide Trial (ClinicalTrials.gov identifier: NCT06068309).","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 5","pages":"370-381"},"PeriodicalIF":3.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41371-026-01132-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147530046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific advances in post-exercise hypotension: a bibliometric review","authors":"Samara Sezana-Costa, Eduardo Amadeu Dutra Moresi, Thiago dos Santos Rosa, Clarcson Placido Conceição Santos, Fernando Ribeiro, Alexandre Sergio Silva, Herbert Gustavo Simões, Marcos Doederlein Polito, Paulo Farinatti, Linda S. Pescatello, Hugo de Luca Correa, Milton Rocha Moraes","doi":"10.1038/s41371-026-01129-6","DOIUrl":"10.1038/s41371-026-01129-6","url":null,"abstract":"This study aimed to perform a bibliometric review to map scientific advances and research trends related to post-exercise hypotension (PEH), a transient blood pressure reduction following physical exercise, increasingly recognized as a non-pharmacological strategy for hypertension management. A comprehensive search was conducted on Scopusdatabase to identify publications on PEH from 1985 to 2024. Metadata from 440 selected articles were analyzed using VOSviewer™ and Gephi™ software to construct keyword co-occurrence networks and identify emerging research topics, influential authors, and leading institutions. Bibliometric analysis revealed an increasing trend in PEH publications over the past decade, with Brazil and the United States leading in research output. High-intensity interval training, isometric resistance exercise and nutritional interventions emerged as key topics. Findings emphasized exercise intensity, recovery posture, and dietary strategies modulate PEH magnitude and duration. Complex autonomic and vascular factors were consistently implicated as physiological mechanisms of PEH, supporting the importance of individualized exercise prescriptions. This review highlights the growing clinical and scientific importance of PEH research. Notable gaps include the need for standardized assessment methodologies, greater biomarker utilization, and further evaluation of multimodal exercise–nutrition strategies to improve clinical translation. Future studies should expand PEH research in clinically high-risk and underrepresented groups (e.g., older adults and individuals with cardiometabolic or renal comorbidities), using harmonized protocols to enhance comparability and applicability.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 5","pages":"349-353"},"PeriodicalIF":3.4,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41371-026-01129-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do patients with primary hypertension assess different endpoints of their treatment? a survey using analytic hierarchy process","authors":"Charalabos-Markos Dintsios, Nadezda Chernyak","doi":"10.1038/s41371-026-01135-8","DOIUrl":"10.1038/s41371-026-01135-8","url":null,"abstract":"Effects of antihypertensive therapy are estimated in clinical trials. There is a need to prioritize the endpoints according to patients’ preferences. 26 patients from two regions of Germany rated in 2019 their preferences regarding the importance of various endpoints of hypertension treatment (Mortality, Myocardial infarction, Stroke, Heart failure, and subdivided Adverse events) by a pairwise comparison of individual endpoints. Analytic Hierarchy Process (AHP), a multi-criteria decision analysis method was used to generate relative weights for each endpoint. The robustness of the results was defined by means of consistency. The elicitation yielded the following aggregated group weights: Stroke 0.320, Mortality 0.297, Myocardial infarction 0.202, Heart failure 0.119, and Adverse events 0.062, subdivided in Dyspnea, Pain, Edema, and Cough. The overall consistency reached for efficacy endpoints a consistency ratio below 0.1 (safety endpoints = 0.04) without exceeding established limits. In all sensitivity analyses but one, no rank reversal was observed, and Stroke was rated highest. Individual weights varied extensively. Some participants weighted Mortality (0.021–0.686) higher than Stroke (0.078–0.615) and Heart failure (0,021–0,469) higher than Myocardial infarction (0,047–0.431). Individual inconsistency exceeded the limits in almost half of the cases, with gender, therapy duration, and therapeutic scheme being explaining variables for inconsistency within binary logistic regression models. AHP can be used to obtain preferences of patients with primary hypertension for effectiveness and safety endpoints. Preference elicitation could provide important information for drug assessment (group weights) and shared decision-making (individual weights) following the concept of patient-centeredness at system and patient level.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 4","pages":"333-341"},"PeriodicalIF":3.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41371-026-01135-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical characteristics of secondary hypertension in young hypertensive tertiary care patients","authors":"Jasmin Vesamo, Teemu J. Niiranen, Karri Suvila","doi":"10.1038/s41371-026-01133-w","DOIUrl":"10.1038/s41371-026-01133-w","url":null,"abstract":"Current European guidelines recommend screening <30-year-old hypertensive patients for secondary hypertension, but the evidence behind this recommendation is limited. Our objective was to assess secondary hypertension prevalence and etiology among young adults and to determine the characteristics linked with secondary hypertension in these patients. We retrospectively studied 243 Finnish hypertensive adults aged 16–30 years (mean age 25.5 years; 49% women) evaluated at a tertiary care hospital in Finland between 2002 and 2023. Data were collected from electronic health records. Patients were classified under three hypertension subtypes: primary, secondary, or exogenic hypertension. We examined the association between participants characteristics and hypertension subtype (primary versus secondary) using logistic regression. A total of 133 patients had primary hypertension, while 98 patients had secondary hypertension. The most common causes of secondary hypertension were renal disease (n = 77) and sleep apnea (n = 13), whereas other causes were limited to 1–2 cases. Individuals with diabetes mellitus had odds of 2.79 (95% confidence interval [95% CI], 1.21-6.43; P = 0.02) for having secondary versus primary hypertension. A plasma creatinine increase of 1 mmol/l was associated with 1.03-fold (95% CI 1.01–1.04; P = 0.002) odds of secondary hypertension. Apart from renal disease and sleep apnea, other forms of secondary hypertension are extremely rare in young adults with hypertension. In this population, renal parenchymal disease and diabetes mellitus emerged as the most important risk factors for secondary hypertension. Extensive universal screening for secondary hypertension without suspicion of such condition for all hypertensive patients <30 years may be unnecessary.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 4","pages":"324-332"},"PeriodicalIF":3.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41371-026-01133-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-centre study of prescribing patterns for the management of resistant hypertension amongst cardiologists","authors":"Prabhakar Dorairaj, Shanmugasundaram Somasundaram, Sunny Anand Nesan, Asha Mahilmaran, KP Sureshkumar, Harikrishnan Parthasarathy, Srikant Natarajan, Ilayaraja Uthirapathi, Associates for Cardiology Education and Research in Tamilnadu (ACERT)","doi":"10.1038/s41371-026-01128-7","DOIUrl":"10.1038/s41371-026-01128-7","url":null,"abstract":"Resistant hypertension is conventionally defined as failure to achieve blood pressure control despite treatment with optimal or maximally tolerated doses of three antihypertensive drugs, typically including a renin–angiotensin system blocker, a calcium channel blocker, and a diuretic. In real-world practice, however, many patients receive four or more antihypertensive agents without necessarily fulfilling classical resistant hypertension criteria, and data describing such prescribing patterns among cardiologists are limited. We conducted a prospective, multicentre, cross-sectional observational study across 10 cardiology outpatient centres enrolling consecutive adult patients (≥ 18 years) receiving more than three antihypertensive drugs. Patients with renal denervation, renal transplantation, known renal artery stenosis, or incomplete data were excluded. Demographic characteristics, blood pressure, comorbidities, and antihypertensive prescriptions were recorded, with a predefined analysis of mineralocorticoid receptor antagonist (MRA) use in the overall cohort and in patients meeting guideline criteria for resistant hypertension. A total of 420 patients were included (mean age 65.2 years; male-to-female ratio 1:0.8). Renin–angiotensin system inhibitors, calcium channel blockers, and diuretics were prescribed in 89, 85, and 82% of patients, respectively, while beta-blocker use was high at 85%. Overall MRA use was low at 39%. Among patients fulfilling criteria for resistant hypertension (n = 273), MRA use was 27%, increasing to only 38% when serum potassium was ≤4.5 mEq/L. Serum potassium ≤4.5 mEq/L was the only independent predictor of MRA prescription. These findings highlight substantial underutilization of MRAs in real-world practice and an important opportunity to improve guideline-directed management of resistant hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 4","pages":"319-323"},"PeriodicalIF":3.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure trends and disparities across the COVID-19 pandemic in a large diverse urban population","authors":"Vincent Zhang, Stephen H. Wang, Kevin Fiori, Wei Hou, Katie S. Duong, Sonya S. Henry, Lili Zhang, Tim Q. Duong","doi":"10.1038/s41371-026-01130-z","DOIUrl":"10.1038/s41371-026-01130-z","url":null,"abstract":"The COVID-19 pandemic disrupted healthcare systems, daily routines, and socioeconomic conditions, potentially increasing systolic blood pressure (SBP) at the population level. Understanding long-term SBP trends is critical to inform hypertension management and address pandemic-exacerbated disparities. We performed a retrospective study using interrupted time series analyses of electronic medical records from the Montefiore Health System (January 2017–August 2024). Adults with in-person outpatient visits were included in the primary analysis of comparing SBP trends post-onset of pandemic to pre-pandemic. Secondary analyses stratified by age, sex, race/ethnicity, and neighborhood-level socioeconomic indicators. Among 789,897 patients with 8,207,177 outpatient SBP measurements (55.0 ± 18.4 years old; 66.5% female), SBP increased by 1.69 mmHg (95% CI, 1.59-1.78; P < 0.001), and did not return to pre-pandemic levels until 16 months later. Racial/ethnic minorities experienced larger pandemic-related SBP increases (P < 0.05). Patients from lower socioeconomic neighborhoods had greater SBP increases than residents of higher socioeconomic neighborhoods (P < 0.05). The COVID-19 pandemic was associated with sustained population-level increases in SBP, disproportionately affecting racial/ethnic minorities and lower socioeconomic groups. These findings highlight the need for targeted interventions to mitigate long-term cardiovascular risks and reduce exacerbated health disparities.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 4","pages":"311-318"},"PeriodicalIF":3.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41371-026-01130-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein and residual cardiovascular risk in hypertension: a prospective cohort study","authors":"Anping Cai, Junguo Zhang, Stephen A. Clarkson, Gregory Y. H. Lip, Aletta E. Schutte, Yingling Zhou, Zhaoyan Liu, Gianfranco Parati","doi":"10.1038/s41371-026-01118-9","DOIUrl":"10.1038/s41371-026-01118-9","url":null,"abstract":"Control of systolic blood pressure (SBP) is important to prevent major adverse cardiovascular events (MACE) in hypertension. However, many individuals with controlled SBP still experience MACE, and the mechanisms remain relatively unknown. We sought to investigate whether elevated C-reactive protein (CRP), indicator of systemic inflammation, was associated with residual MACE risk in hypertensive individuals with controlled SBP. Community hypertensive individuals without cardiovascular disease (CVD) at baseline were included from UK Biobank study (n = 200243; mean age 58.3 years; females 50.3%; median CRP 1.6 mg/L). Baseline CRP was categorized into < 2 mg/L (normal) and ≥ 2 mg/L (elevated); and baseline SBP was categorized into < 120, 120–129, 130–139 and ≥ 140 mmHg. Primary outcome was MACE, a composite of coronary heart disease, myocardial infarction, stroke and cardiovascular death. Among included individuals, 40.4% had CRP ≥ 2 mg/L. During a median follow-up of 12.4 years, incidence rates of MACE were higher in CRP ≥ 2 mg/L group (12.01 vs 9.27 per 1000 person-years; P < 0.0001). CRP ≥ 2 mg/L in reference to CRP < 2 mg/L was associated with 17% (95% CI 14–22%) higher adjusted risk of MACE. This association was attenuated when SBP was below 120 mmHg but remained significant when SBP was at the range of 120–139 mmHg (P-interaction=0.004), irrespective of baseline antihypertensive therapy status. Elevated CRP was significantly associated with residual MACE risk in community hypertensive individuals with controlled SBP. Future studies may be warranted to evaluate whether CRP is a potential therapeutic target to reduce residual MACE risk.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 4","pages":"301-310"},"PeriodicalIF":3.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41371-026-01118-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68Ga-Pentixafor PET/CT complements AVS deficiencies in bilateral aldosterone-producing adenomas: Lessons from unexpected sequential partial adrenalectomy","authors":"Yi Yang, Kai Cheng, Tingting Long, Yao He, Longfei Liu, Yu Gan","doi":"10.1038/s41371-026-01131-y","DOIUrl":"10.1038/s41371-026-01131-y","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 4","pages":"342-344"},"PeriodicalIF":3.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hemoglobin and all-cause mortality in patients with obstructive sleep apnea and hypertension: insights from an observational study","authors":"Chen Guo, Jia-hao Dou, Fan-shun Guo, Dan-ni Li, Tuo Han, Jin Wei","doi":"10.1038/s41371-026-01127-8","DOIUrl":"10.1038/s41371-026-01127-8","url":null,"abstract":"Obstructive sleep apnea (OSA) is a widespread disorder impacting more than one billion individuals globally. Hypertension, a frequent cardiovascular comorbidity associated with OSA, can exacerbate and advance the condition. Recent research has identified a synergistic effect between anemia and OSA concerning the development of hypertension. This study explores the relationship between hemoglobin (Hb) and follow-up and 365-day all-cause mortality in individuals suffering from OSA and hypertension. Data were obtained from the MIMIC-IV database. Kaplan-Meier (KM) analyses and Cox proportional hazards models were utilized to assess associations with outcomes. Restricted cubic spline (RCS) models were selected to assess nonlinear relationships. A total of 6155 patients with first-time hospitalization for OSA and hypertension were included in this study. The KM survival curves demonstrated that the survival rate for the lowest Hb quartile (Q1) was significantly lower than that of the other quartiles. Findings from the multivariable Cox regression analysis revealed that elevated Hb correlates with a significant decrease in mortality risk. The RCS analysis demonstrated an L-shaped nonlinear relationship between Hb and outcome events (P-Nonlinear < 0.05). The relationship between Hb and outcome events remained consistent across all subgroups, further supporting the robustness of the conclusions drawn in this study. Hemoglobin is closely associated with all-cause mortality in patients with OSA and hypertension and can serve as an effective biomarker for risk management and prognostic assessment upon admission. Monitoring Hb in patients with OSA and hypertension and actively correcting anemia when present may improve prognostic survival.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"40 4","pages":"288-297"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}