Journal of Human Hypertension最新文献_第3页

Multiethnic norms for blood pressure response to submaximal exercise testing in young-to-middle adulthood and associations with hypertension: The NHANES dataset.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-23 DOI: 10.1038/s41371-025-00993-y

João L Marôco

{"title":"Multiethnic norms for blood pressure response to submaximal exercise testing in young-to-middle adulthood and associations with hypertension: The NHANES dataset.","authors":"João L Marôco","doi":"10.1038/s41371-025-00993-y","DOIUrl":"https://doi.org/10.1038/s41371-025-00993-y","url":null,"abstract":"The blood pressure (BP) response during exercise testing is a robust correlate of hypertension in middle-to-older White people, but whether this extends to a healthy, young-to-middle-aged multiethnic population is unknown. Moreover, it is unclear what constitutes an exaggerated BP to submaximal exercise, which is a more reliable and stronger correlate of hypertension than maximal testing. The NHANES dataset was used to interrogate the association of submaximal exercise BP with current hypertension and to provide multiethnic norms for BP responses in young-to-middle-aged adults. The analyses combined NHANES cycles wherein treadmill exercise testing was conducted with an analytic sample of 2544 participants aged 12-49 years (Female: White = 467; Black = 324; Hispanic = 439; Male: White = 493, Black = 351; Hispanic = 470). Weighted logistic models were fitted to test associations between exercise BP and hypertension. Age, sex, and race-specific percentiles were estimated. Exaggerated systolic BP (SBP) responses to exercise testing were defined as readings ≥90th percentile, and ≥ROC-derived cutoff. Regardless of race, sex, exercise workload, clinical and socioeconomic characteristics, a 5-mmHg increase in SBP and diastolic BP during stage 1 of exercise testing was associated with a 15% (aOR: 1.15, 95% CI: 1.08-1.21), and 31% (aOR: 1.31, 95% CI: 1.22-1.40) higher odds for hypertension, respectively. Black males had the highest proportion of exaggerated SBP responses (44%, 95% CI: 36-53%) when defined only via ROC-derived cutoffs. BP responses during submaximal exercise were associated with hypertension, irrespective of race in young-to-middle adulthood. Still, the exaggerated SBP response to exercise of Black males suggests uncontrolled high BP not detected at rest.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-22 DOI: 10.1038/s41371-025-00992-z

Zhe Chen, Dongming Guo, Lifeng Xiao, Honghui Su, Yirun Chen

{"title":"Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China.","authors":"Zhe Chen, Dongming Guo, Lifeng Xiao, Honghui Su, Yirun Chen","doi":"10.1038/s41371-025-00992-z","DOIUrl":"https://doi.org/10.1038/s41371-025-00992-z","url":null,"abstract":"This study investigated the association between fat-to-muscle ratio (FMR) and hypertension. A total of 1592 participants aged ≥ 40 years were included. Participants were divided into four groups by quartiles of FMR. Odds ratio (OR) and 95% confidence interval (CI) was calculated using logistic regression models. Restricted cubic spline was applied to examine the correlation of FMR and hypertension. Of 1592 participants, 943 (59.2%) participants had hypertension. Hypertension risk rose with FMR quartiles. Compared to FMR quartile 1, ORs were 1.496 (95% CI: 1.115-2.006), 2.445 (95% CI: 1.840-3.249), and 5.415 (95% CI: 3.993-7.344) for quartiles 2, 3, and 4, respectively (P for trend < 0.001). Adjusted OR in quartile 4 was 3.015 (95% CI: 2.083-4.365). Restricted cubic spline showed a linear relationship between FMR and hypertension. Adding FMR improved hypertension risk model performance (P = 0.006). Subgroup analysis revealed FMR interactions with sex (P = 0.010) and BMI (P < 0.016), with a higher hypertension risk in females and non-obese individuals. Additionally, versus FMR quartile 1, hypertensive individuals in quartiles 2 (OR: 1.370, 95% CI: 0.900-2.085), 3 (OR: 2.055, 95% CI: 1.374-3.073) and 4 (OR: 3.102, 95% CI: 2.055-4.682) exhibited a significantly elevated risk of atherosclerotic cardiovascular disease (ASCVD). In summary, Elevated FMR independently correlated with hypertension risk, especially in women, or even in non-obese individuals. FMR is a valuable tool for identifying populations with higher hypertension risk and assessing ASCVD risk in hypertensive individuals. Body composition warrants consideration in future hypertension risk studies.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we detect masked hypertension and masked uncontrolled hypertension using simple metrics? A novel clinical model for latino population

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-22 DOI: 10.1038/s41371-025-00996-9

Camila Ponce-Acosta, Neftali Eduardo Antonio-Villa

引用次数: 0

Recurrence of primary aldosteronism 20 years after surgery: a case report

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-20 DOI: 10.1038/s41371-025-00994-x

Jie Wang, Cai-Ni Fan, Guo-Xi Wei, Xiao-Jian Zhao, Kai Liu, Meng-Lin Wang, Ling Li, Min Liu, Hai-Ying Zhao

引用次数: 0

Adherence to lifestyle modifications and its associated factors among adult hypertensive patients attending their follow-up at public hospitals in West Shoa, Oromia, Ethiopia, 2023

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-17 DOI: 10.1038/s41371-025-00991-0

Demessie Diriba, Dereje Guta

{"title":"Adherence to lifestyle modifications and its associated factors among adult hypertensive patients attending their follow-up at public hospitals in West Shoa, Oromia, Ethiopia, 2023","authors":"Demessie Diriba, Dereje Guta","doi":"10.1038/s41371-025-00991-0","DOIUrl":"10.1038/s41371-025-00991-0","url":null,"abstract":"Hypertension is a serious public health concern, disturbing millions of lives worldwide. Effective lifestyle modifications are the foundation for the prevention and control of hypertension. The aim of this study is to assess adherence to lifestyle modifications and associated factors among adult hypertensive patients in West Shoa, Oromia, Ethiopia. An institutional-based cross-sectional study design was employed from August 20 to September 20, 2023. A systematic random sampling technique was employed to select study participants. A binary logistic regression model was used to check the association between independent and outcome variables. The strength of the association was stated using an adjusted odds ratio with a 95% confidence interval and a p-value of < 0.05. The study included 316 study participants, with a 98.8% response rate. The magnitude of adherence to lifestyle modifications was 31% (95%CI: 25.7–36.1%). Age (AOR = 2.71, 95% CI: 1.19–6.19), residence (AOR = 0.19, 95%CI: 0.09–0.39), duration of treatment (AOR = 2.17, 95%CI: 1.14–4.13), attitude (AOR = 2.14, 95%CI: 1.06–4.30), perceived social support (AOR = 6.23, 95%CI: 3.18–12.22) and self-efficacy (AOR = 2.66, 95%CI: 1.25–5.69) were the independent predictors of lifestyle modifications adherence. This study found that adherence to lifestyle modifications was low among hypertensive patients.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"192-198"},"PeriodicalIF":2.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00991-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spotlight on hypertension in the African Continent

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-04 DOI: 10.1038/s41371-025-00989-8

Zakirullah Khan, Sunil K. Nadar

引用次数: 0

Call for candidates: Editor-in-Chief for the Journal of Human Hypertension

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-03 DOI: 10.1038/s41371-025-00988-9

引用次数: 0

The pulsatile brain, pulse pressure, cognition, and antihypertensive treatments in older adults: a functional NIRS study

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-01-30 DOI: 10.1038/s41371-024-00985-4

Hanieh Mohammadi, Florent Besnier, Thomas Vincent, Sarah Fraser, Anil Nigam, Frédéric Lesage, Louis Bherer

{"title":"The pulsatile brain, pulse pressure, cognition, and antihypertensive treatments in older adults: a functional NIRS study","authors":"Hanieh Mohammadi, Florent Besnier, Thomas Vincent, Sarah Fraser, Anil Nigam, Frédéric Lesage, Louis Bherer","doi":"10.1038/s41371-024-00985-4","DOIUrl":"10.1038/s41371-024-00985-4","url":null,"abstract":"Age-related arterial stiffness increases pulsatility that reaches the cerebral microcirculation, compromises cerebrovascular health and lead to cognitive decline. The presence of cardiovascular risk factors (CVRFs) such as high blood pressure can exacerbate this effect. Despite extensive research on the impact of antihypertensive treatments on reducing arterial stiffness, little is known about the impact of antihypertensive treatments on pulsatility in cerebral microcirculation. This study investigated the impact of antihypertensive treatments on cerebral pulsatility and cognition in older adults with CVRFs. Participants were 42 older adults with diverse CVRFs in two groups of untreated (n = 21, mean 67.2 ± 5.9 years old, 57.1% female) and treated with antihypertensive medications (n = 21, mean 67.2 ± 5.5 years old, 61.1% female). Cognitive scores of processing speed and executive functions were evaluated behaviorally using the four subsets of the Stroop test. A near-infrared spectroscopy (NIRS) device recorded hemodynamics data from the frontal and motor cortex subregions. The data were then used to extract an optical index of cerebral pulsatility. Results indicated that after controlling for CVRFs, the antihypertensive treatment was associated with lower cerebral pulsatility (untreated 33.99 ± 6.68 vs. treated 28.88 ± 5.39 beats/min, p = 0.009). In both groups cerebral pulsatility was associated with pulse pressure (p < 0.05). Also, treated group had significantly higher cognitive scores in executive functions compared with the untreated group (p < 0.05). These results suggest that beyond its known effect on blood pressure, antihypertensive treatments might also favor cerebrovascular health by reducing pulsatility in the cerebral microcirculation.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"217-225"},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red cell distribution width as a cardiovascular risk predictor in adults with hypertension in sub-Saharan Africa 红细胞分布宽度作为撒哈拉以南非洲成人高血压患者心血管风险预测因子

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-01-11 DOI: 10.1038/s41371-025-00987-w

Olayinka Rasheed Ibrahim, Kojo Awotwi Hutton-Mensah, Funmi Temidayo Adeniyi, George Bediako Nketiah, Adaku M. Nwankwo, Abukari Yakubu Natogmah, James Ayodele Ogunmodede, Dike Ojji, Adesola Olumide, Biodun Sulyman Alabi, Daniel F. Sarpong, Olugbenga Ayodeji Mokuolu

{"title":"Red cell distribution width as a cardiovascular risk predictor in adults with hypertension in sub-Saharan Africa","authors":"Olayinka Rasheed Ibrahim, Kojo Awotwi Hutton-Mensah, Funmi Temidayo Adeniyi, George Bediako Nketiah, Adaku M. Nwankwo, Abukari Yakubu Natogmah, James Ayodele Ogunmodede, Dike Ojji, Adesola Olumide, Biodun Sulyman Alabi, Daniel F. Sarpong, Olugbenga Ayodeji Mokuolu","doi":"10.1038/s41371-025-00987-w","DOIUrl":"10.1038/s41371-025-00987-w","url":null,"abstract":"Red cell distribution width (RDW) quantifies the degree of variation in erythrocyte size, is identified as a potential marker of adverse cardiovascular events, and may be a surrogate marker for assessing cardiovascular disease (CVD) risk in low-resource settings. We evaluated RDW as a predictor of CVD risk compared to the World Health Organization (WHO) CVD risk score among adults with hypertension attending primary healthcare centers (PHCs) in Ghana and Nigeria. Adults with hypertension attending selected PHCs in Ghana and Nigeria participated in a cross-sectional study. Each participant underwent blood pressure (BP) measurement and laboratory evaluation (RDW, total cholesterol, and fasting blood sugar) following standard methods. We recruited 319 adults aged 40–74 years from the study sites. The mean (standard deviation) RDW was 13.96 (1.1%). The median CVD risk score was 8.11% [interquartile range (IQR) 4.00 to 11.00]. For participants with hemoglobin (Hb) levels ≥ 12 g/dL, RDW showed positive correlations with age (r = 0.136; p = 0.042); systolic BP (r = 0.183; p = 0.006), diastolic BP (r = 0.206, p = 0.002) and WHO CVD risk scores (r = 0.166, p = 0.013). Multiple linear regression showed an independent association between RDW and WHO CVD risk scores with an upward gradient, and was most significant at 3rd quartiles. Using receiver operating characteristic curve, the C-statistic was 0.673 (95% confidence interval: 0.618 to 0.724), p = 0.031. With a cut-off of >14, the RDW demonstrated a sensitivity of 81.82% and specificity of 55.84%. This study shows that at Hb levels ≥ 12 g/dL, RDW modestly predicted CVD risk in adults with hypertension in sub-Saharan Africa.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 2","pages":"171-176"},"PeriodicalIF":2.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin type 1 and type 2 receptors-induced mitochondrial dysfunction promotes ferroptosis in cardiomyocytes 血管紧张素1型和2型受体诱导的线粒体功能障碍促进心肌细胞铁下垂。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-01-09 DOI: 10.1038/s41371-024-00982-7

Hong Fang, Omer Cavdar, Zhiping Yao, Xuewei Zhu, Yi Shen, Chi Liu

{"title":"Angiotensin type 1 and type 2 receptors-induced mitochondrial dysfunction promotes ferroptosis in cardiomyocytes","authors":"Hong Fang, Omer Cavdar, Zhiping Yao, Xuewei Zhu, Yi Shen, Chi Liu","doi":"10.1038/s41371-024-00982-7","DOIUrl":"10.1038/s41371-024-00982-7","url":null,"abstract":"Previous studies suggest that ferroptosis is involved in cardiovascular diseases. The aim of the present study is to investigate the causal relationship between angiotensin II type 1 and type 2 receptors (AT1/2R) activities and mitochondrial dysfunction in induction of cardiomyocyte ferroptosis. Human AC16 cardiomyocytes were first pre-treated with an AT1/2R blockers, before stimulated with angiotensin II (Ang II) for 24 h. The redox status of the cardiomyocytes were assessed by measuring the cellular malondialdehyde (MDA), superoxide dismutase (SOD), and Nicotinamide-adenine dinucleotide phosphate, (NADPH) levels using biochemical methods. Mitochondrial reactive oxygen specifics (mitROS), mitochondrial memebrane potential, and Fe2+ levels were determined using flow cytometry. The signaling pathways, including the glutathione peroxidase 4 (GPX4), heme oxygenase-1 (HO-1), sirtuin1, and ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10) pathways, were evaluated using western blotting. Our results demonstrated that Ang II significantly elevated the levels of MDA, Fe2+, mitoROS, and FtMt and markedly reduced SOD, NADPH, mitochondrial membrane potential, GPX4, HO-1, Sirt1, SFXN1, Nrf2, and FSP1 levels in cardiomyocyte, which were reversed by blockade of AT1/2R. Our results suggest that AT1/2R signaling can induce myocardial ferroptosis by impairing mitochondrial function via multiple signaling pathways, including the cyst (e)ine /GSH/GPX4 axis and FSP1/coenzyme Q10 (CoQ10) axis.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"226-236"},"PeriodicalIF":2.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0