Journal of Human Hypertension最新文献

{"title":"Population-based surveillance for hypertension awareness, treatment, and control in nine districts - India Hypertension Control Initiative, 2018–19","authors":"Prabhdeep Kaur, Kamaraj Pattabi, Amirthammal Gunasekaran, Vettrichelvan Venkatasamy, Azhagendran Sivalingam, Sabarinathan Ramasamy, Sailaja Bitragunta, Tapas Chakma, Sampada D. Bangar, Meenakshi Sharma, Abhishek Kunwar, Kiran Durgad, Anupam K. Pathni, Sandeep S. Gill, Padmaja Jogewar, Madhavi Mallela, Ashish Saxsena, Bipin Gopal, Bidisha Das, Vishwajit Bharadwaj, Pooja Gaigaware, Sreedhar Chintala, Chakshu Joshi, Rupali Bharadwaj, Suyesh Shrivastava, Pankaj Uike, Yannick P. Puthussery, Gopinath T Sambandam, RS Dhaliwal, Balram Bhargava","doi":"10.1038/s41371-025-01005-9","DOIUrl":"10.1038/s41371-025-01005-9","url":null,"abstract":"Hypertension control is the crucial indicator for cardiovascular disease programs. We conducted a baseline cross-sectional survey to estimate hypertension awareness, treatment, and control in the selected districts in 2018–19, where the India Hypertension Control Initiative is being implemented. We conducted cross-sectional surveys in nine project districts for 18–69 years age group. The sample size was 624 per district. The study population was individuals with raised BP/diagnosed HT. We estimated the proportion and 95% confidence intervals (CI) for each district’s awareness, treatment, and control. We computed unadjusted and adjusted prevalence ratios (APR) with 95% CI for factors associated with BP control. Hypertension was defined as systolic blood pressure (SBP) > = 140 or diastolic blood pressure (DBP) > = 90 mmHg or treatment in the previous two weeks. Control was defined as SBP < 140 and DBP < 90 mmHg. Among 7047 who had hypertension, 52.4% were aware, 40.8% were on treatment, and 14.5% had BP control. BP control was below 5% in two districts, 5–15% in three districts, and more than 15% in four districts. Among hypertensives aware of the diagnosis, the factors (APR with 95% CI) associated with control were lack of alcohol consumption [1.28 (1.09–1.52)], recent visit to government [1.98 (1.57–2.50)] or private facility [1.99 (1.61–2.46)] and treatment with single drug [2.40 (1.98–2.90)] or multiple drugs [2.84 (2.27–3.55)]. The simple, rapid population-based surveys can document awareness, treatment, and control changes. Improving access to treatment for hypertension through the public or private sector should be a high priority for India.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"376-386"},"PeriodicalIF":2.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01005-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERSPECTIVE – The Growing Global Benefits of Limiting Salt Intake: an urgent call from the World Hypertension League for more effective policy and public health initiatives","authors":"Brent M. Egan, Daniel T. Lackland, Susan E. Sutherland, Michael K. Rakotz, Janet Williams, Yvonne Commodore-Mensah, Daniel W. Jones, Sverre-Erik Kjeldsen, Norm R. C. Campbell, Gianfranco Parati, Feng J. He, Graham A. MacGregor, Michael A. Weber, Paul K. Whelton","doi":"10.1038/s41371-025-00990-1","DOIUrl":"10.1038/s41371-025-00990-1","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"241-245"},"PeriodicalIF":2.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00990-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home versus routine dialysis-unit blood pressure recordings among patients on hemodialysis","authors":"Kallistheni Leonidou, Panagiotis I. Georgianos, Anastasios Kollias, Ioannis Kontogiorgos, Vasilios Vaios, Konstantinos Leivaditis, Apostolos Karligkiotis, Eleni Stamellou, Elias V. Balaskas, George S. Stergiou, Vassilios Liakopoulos","doi":"10.1038/s41371-025-01007-7","DOIUrl":"10.1038/s41371-025-01007-7","url":null,"abstract":"The optimal method for the diagnosis of hypertension among patients on hemodialysis remains a controversial issue. Using 44-h ambulatory blood pressure (BP) monitoring (ABPM) as the reference-standard, we assessed the diagnostic performance of home BP monitoring (HBPM) versus routine dialysis-unit BP recordings in hemodialysis patients. Over a period of 2 weeks, the following methods were used for the assessment of hypertension: (i) routine predialysis and postdialysis BP recordings averaged over 6 consecutive dialysis sessions; (ii) HBPM for 7 days (duplicate morning and evening measurements, Microlife WatchBP Home N); (iii) 44-h ABPM (20-min intervals over an entire interdialytic interval, Microlife WatchBPO3). The study included 70 patients (mean age: 65.3 ± 13.2 years; treated hypertensives: 87.1%; 44-h ambulatory systolic/diastolic BP: 120.6 ± 15.2/66.3 ± 10.1 mmHg). Mean (standard deviation) of the differences between ambulatory daytime systolic BP (SBP) and routine predialysis SBP was −11.4 (13.4) mmHg, routine postdialysis SBP −4.0 (15.1) mmHg and home SBP −8.6 (10.7) mmHg. The area under the receiver-operating-characteristic-curve (AUC) for the detection of an ambulatory daytime SBP ≥ 135 mmHg was higher for home SBP [AUC: 0.934; 95% confidence interval (CI): 0.871–0.996] relative to predialysis SBP (AUC: 0.778; 95% CI: 0.643–0.913) and postdialysis SBP (AUC: 0.766; 95% CI: 0.623–0.909) (P = 0.02 for both comparisons). Home SBP at the cut-off point of 141.0 mmHg provided the best combination of sensitivity (85.7%) and specificity (92.9%) in diagnosing hypertension. In conclusion, the present study shows that among hemodialysis patients, HBPM for 1 week is superior to 2-week averaged routine predialysis or postdialysis BP in predicting ambulatory hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"355-361"},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index modifies genetic susceptibility to high systolic blood pressure in adolescents and young adults: results from an 18-year longitudinal study","authors":"Teodora Riglea, Tatiana Dessy, Jodi Kalubi, Danick Goulet, Fiston Ikwa Ndol Mbutiwi, Scott M. Williams, James C. Engert, Hao Yu Chen, Jennifer O’Loughlin, Marie-Pierre Sylvestre","doi":"10.1038/s41371-025-01003-x","DOIUrl":"10.1038/s41371-025-01003-x","url":null,"abstract":"Genome-wide association studies (GWAS) in adults have identified single nucleotide polymorphisms (SNPs) associated with systolic blood pressure (SBP), but it is unclear whether the findings apply in youth. Further, the role of body mass index (BMI) in these associations is understudied. Our objective was to determine whether BMI modifies genetic susceptibility to high SBP in young people. The sample comprised 714 participants of European ancestry recruited in 1999–2000 from 10 Montreal-area high schools for a longitudinal study. SBP was measured at ages 12, 15, 17, 24, and 30. Blood and saliva samples were collected at ages 14, 20, and 25. Two evidence-based genetic risk scores (GRS) were constructed based on GWAS results in adults: GRS22 used 22 SNPs and GRS182 added 160 additional SNPs to GRS22. Sex-specific associations between each GRS and repeated measures of SBP were estimated using linear mixed models including BMI and a GRS*BMI product term. GRS182 explained a greater proportion of SBP variance than GRS22, and a greater proportion in females than males. The associations increased monotonically with BMI values between 22 kg/m2 and 35 kg/m2. Results indicate that BMI modifies the association between a GRS and SBP levels from adolescence to adulthood.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"334-342"},"PeriodicalIF":2.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between epicardial adipose tissue thickness and sedentary time, physical activity level, and physical performance in patients with hypertension","authors":"Emine Tunc Suygun, Naciye Vardar Yagli, Hakan Suygun","doi":"10.1038/s41371-025-01002-y","DOIUrl":"10.1038/s41371-025-01002-y","url":null,"abstract":"Epicardial adipose tissue is associated with the development of cardiovascular disease and its increase is positively correlated with blood pressure elevation in hypertensive individuals. In the literature, being physically active has been shown to be effective in the treatment of hypertension and reduction of epicardial adipose tissue thickness. The aim of this study was to evaluate the relationship between epicardial adipose tissue thickness and sedentary time, physical activity level and physical performance in patients with hypertension. The physical and demographic characteristics of the 40 patients with hypertension were collected with sociodemographic form. Waist/hip circumference was measured with tape measure and epicardial adipose tissue thickness with echocardiography device. Physical activity levels and sedentary time were recorded via IPAQ-7. Physical performance was determined using the 30-s sit-and-stand test. There was a moderate negative correlation between epicardial adipose tissue thickness and IPAQ-7 score (rho: −0.568 p < 0.001) and a high negative correlation between epicardial adipose tissue thickness and sit-and-stand test score (rho: −0.794 p < 0.001). There was no relationship between epicardial adipose tissue thickness and daily sitting time, BMI, or hip circumference. There was moderate positive correlation between epicardial adipose tissue thickness and age (rho: 0.504 p: 0.001) and low positive correlation between waist circumference (rho: 0.322 p < 0.05).This study demonstrated that the epicardial adipose tissue thickness was negatively associated with activity and performance in hypertensive patients, but not with daily sitting time. These results underscore the importance of physical activity in the management and prevention of chronic diseases.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"274-278"},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01002-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the quality and reliability of youtube information on hypertension: a comprehensive analysis","authors":"Geethiikha Jammula, Juhi Ardeshna-Chovatiya, Nadia Djahanshahi, Marina Samuel Basta, Krishna Amarlal Katariya, Iorwuese Ali Daniel, Saumya Joshi","doi":"10.1038/s41371-025-00999-6","DOIUrl":"10.1038/s41371-025-00999-6","url":null,"abstract":"Patient education is an important aspect in the management of hypertension and YouTube has become a popular platform for sharing hypertension-related information, but concerns persist regarding the accuracy and reliability of such content in the context of patient education. To address this issue, this cross-sectional type of observational study aims to assess YouTube’s information on hypertension using the Global Quality Score (GQS) and Reliability Score (DISCERN SCORE), which evaluate the quality and trustworthiness of the YouTube content, and the Video Power Index (VPI). Majority of the videos are uploaded by physicians (26, 33.3 percent) and most give information about causes/etiology, treatment, complications (n = 51, 65.38%) each. The median GQS for all the videos is 4. The median reliability score is 4. The statistical test used is Kruskal - Wallis Test. The p value of VPI, GQS, and Reliability score among various types of uploader are 0.264, 0.347 and 0.452. Hence, there is no statistical significance (p value > 0.05). The analysis therefore suggests that the quality of these videos is moderate. Although they usually provide accurate information, they lack comprehensiveness and may have a biased perspective.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"308-312"},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and resting heart rate influence the relation between arterial stiffness and cardiac structure and function – insights from the general population","authors":"Anna Sista, Till Ittermann, Stefan Gross, Marcello R. P. Markus, Keeron Stone, Lee Stoner, Nele Friedrich, Marcus Dörr, Martin Bahls","doi":"10.1038/s41371-025-01000-0","DOIUrl":"10.1038/s41371-025-01000-0","url":null,"abstract":"Arterial stiffness, a risk factor for cardiovascular disease, can be measured using pulse wave velocity (PWV) and augmentation index (AIx). We studied sex-specific associations between carotid-femoral PWV (cfPWV), brachial-ankle PWV (baPWV), aortic PWV (aoPWV), aortic (aoAIx), and brachial (baAIx) AIx with echocardiographic parameters. Data of 1150 participants of the Study of Health in Pomerania (SHIP-Trend 1; 530 men; median age 53 years; inter quartile range (IQR) 44 to 64) were used. Echocardiography assessed common structural and functional cardiac parameters. PWV and AIx were measured using the Vascular Explorer. Multivariable linear regression models were applied. In men, a higher brAIx was related to a greater right ventricular diameter (RV) (β 0.037; CI 0.003 to 0.148). A one m/s higher baPWV was associated with a smaller RV (β −0.037; CI −0.168 to −0.021) and right ventricular outflow tract (RVOT; β −0.029; CI −0.141 to −0.026). In men, a higher aoAIx (β 0.028; CI 0.01 to 0.122) and brAIx (β 0.029; CI 0.017 to 0.13) were associated with a greater RVOT. In women, a one m/s higher aoPWV (β 0.025; CI 0.006 to 0.105) was associated with a larger RV and a one m/s higher baPWV (β −0.031; CI −0.124 to −0.001) was inversely related to RVOT. In women, PWV associated with right ventricular dimensions, while in men, baPWV and AIx were related to right ventricular parameters. This suggests potentially sex-specific relations between PWV and cardiac structure and function.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"254-261"},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01000-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines","authors":"Caitlin Greenlees, Christian Delles","doi":"10.1038/s41371-025-01001-z","DOIUrl":"10.1038/s41371-025-01001-z","url":null,"abstract":"Globally prevalent conditions such as hypertension, heart failure, ischaemic heart disease (IHD) and chronic kidney disease (CKD) are frequently and effectively treated with blockers of the renin-angiotensin-aldosterone system (RAAS) as a first line treatment in the UK and worldwide. RAAS blockers are prohibited in pregnancy due to their adverse fetal effects. We reviewed clinical guidelines from the National Institute of Health and Care Excellence (NICE) on the management of cardiovascular and kidney disease with RAAS blockers in pregnancy, with other UK, European and American guidance as comparators. Whilst guidelines agree on the strict avoidance of RAAS blockers in pregnancy, nuanced considerations regarding prescription in women of childbearing potential, contraception, timing of RAAS blocker withdrawal and breastfeeding are not consistently addressed in clinical guidelines. We call for consistent wording and more explicit advice on RAAS blocker prescription in women of childbearing potential, in pregnancy and in the postpartum period in future iterations of clinical guidelines.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"315-319"},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01001-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure variability in CKD patients with and without nocturnal hypertension","authors":"Artemios G. Karagiannidis, Marieta P. Theodorakopoulou, Fotini Iatridi, Maria Schoina, Erasmia Sampani, Ioannis Mykoniatis, Konstantinos Stavropoulos, Vasileios Kamperidis, Mehmet Kanbay, Pantelis Sarafidis","doi":"10.1038/s41371-025-00998-7","DOIUrl":"10.1038/s41371-025-00998-7","url":null,"abstract":"Nocturnal hypertension is highly prevalent in patients with chronic kidney disease (CKD) and represents a strong predictor of cardiovascular events. Increased blood pressure variability (BPV) is also independently associated with cardiovascular events in these patients. Differences in short-term BPV indices between CKD patients with and without nocturnal hypertension have not been previously studied. This study included 96 patients (73 with and 23 without nocturnal hypertension) who underwent 24-h ambulatory BP measurement. Standard deviation (SD), weighted SD (wSD), coefficient of variation (CV), and average real variability (ARV) of systolic (SBP) and diastolic blood pressure (DBP) were calculated using validated formulas for the 24-h and the respective daytime (07:00–23:00) and nighttime (23:00–07:00) periods. 24-h, daytime and nighttime SBP and DBP were higher in patients with nocturnal hypertension. During the 24-h period, wSD and ARV for 24-h SBP (wSD, 14.0 ± 3.8 vs 11.7 ± 3.1 mmHg, p = 0.009; ARV, 10.5 ± 2.7 vs 9.2 ± 1.9 mmHg, p = 0.035) and 24-h DBP were higher in patients with nocturnal hypertension. Regarding the daytime period, patients with nocturnal hypertension presented higher daytime SD and ARV for SBP (SD, 14.8 ± 4.0 vs 13.0 ± 3.6 mmHg, p = 0.008; ARV; 10.5 ± 3.2 vs 9.1 ± 2.0 mmHg, p = 0.016) and DBP, with daytime SBP and DBP CV being numerically but not significantly higher (p = 0.110 and p = 0.08 respectively). During the nighttime period, no significant differences between groups were present for all nighttime BPV indices. In conclusion, CKD patients with nocturnal hypertension have higher systolic and diastolic BPV indices during the 24-h and daytime periods, but not the nighttime period. These findings signify that increased BPV may be responsible for higher cardiovascular risk in CKD patients with compared to those without nocturnal hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"286-292"},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CITED2 is highly-expressed and PRX4 is poorly-expressed in preeclampsia and have diagnostic values","authors":"Caixia Yang, Zhiying Song","doi":"10.1038/s41371-025-00995-w","DOIUrl":"10.1038/s41371-025-00995-w","url":null,"abstract":"This study aims to investigate the differential level of CITED2 and PRX4 in the serum of preeclampsia (PE) patients and to explore their clinical value in PE diagnosis, severity assessment, and pregnancy outcomes. A total of 110 singleton pregnant women with PE were included, consisting of 57 cases of mild PE and 53 cases of severe PE, with 110 healthy singleton pregnant women enrolled as the normal control. The baseline clinical characteristics were analyzed using chi-square test and independent samples t-test. CITED2 and PRX4 concentrations were measured by ELISA and their diagnostic efficacy for PE was evaluated through ROC curves. Multivariate logistic regression analysis was conducted to identify factors associated with adverse pregnancy outcomes in PE patients. Compared to the healthy group, CITED2 serum levels in PE patients were significantly increased, while PRX4 levels were significantly decreased. CITED2 and PRX4 can diagnose PE, distinguish between mild and severe PE, and be associate with adverse pregnancy outcomes in PE patients. The diagnostic efficacy was better when CITED2 and PRX4 were combined. The serum levels of CITED2 were further elevated and PRX4 levels were further reduced in patients with severe PE and adverse pregnancy outcomes. CITED2 was an independent risk factor and PRX4 was a protective factor for adverse pregnancy outcomes in PE patients. In conclusion, CITED2 and PRX4 can diagnose PE, assess PE severity, and are associated with PE outcomes.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"293-300"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}