Journal of Human Hypertension最新文献

Variations in the hypertension care cascade across districts and the factors influencing it among Indian adults: findings from the National Family Health Survey -5. 不同地区高血压护理的差异及其在印度成年人中的影响因素：来自全国家庭健康调查的结果-5

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-07-09 DOI: 10.1038/s41371-025-01039-z

Vaitheeswaran Kulothungan, Kavyashree Seenappa, Rohith Mohan

{"title":"Variations in the hypertension care cascade across districts and the factors influencing it among Indian adults: findings from the National Family Health Survey -5.","authors":"Vaitheeswaran Kulothungan, Kavyashree Seenappa, Rohith Mohan","doi":"10.1038/s41371-025-01039-z","DOIUrl":"https://doi.org/10.1038/s41371-025-01039-z","url":null,"abstract":"Hypertension, a leading cause of cardiovascular diseases, accounts for 7.5 million deaths annually, affecting over 1.3 billion people globally, with significant burdens in low- and middle-income countries like India. It significantly impacts India's population, with low rates of awareness, diagnosis, and treatment. This study examines the hypertension care cascade and its key determinants at the national, state, and district levels in India. The analysis was conducted using data from the NFHS-5 survey, involving a total of 743,067 adults aged 18-54 years. From this group, 118,231 individuals with hypertension were identified, and the hypertension care cascade was constructed. A color-coded map was generated to visually depict geographic disparities in prevalence rates across different regions of India. Multivariate logistic regression was employed at the district, state, and national levels, with significance set at p < 0.05. Hypertension awareness varied significantly across districts, with an average rate of 46.0%, ranging from 89.6-6.1%. Treatment rates were 18.7%, with considerable disparity among districts. Blood pressure control was achieved in 32.9% of individuals with hypertension. Older age, female gender, higher socioeconomic status, urban residence, and obesity were associated with better attainment of cascade steps. Conversely, younger age and alcohol consumption were linked to lower attainment, while educated individuals showed lower treatment-seeking behavior despite better awareness. Poor-performing districts were identified in Gujarat, Chhattisgarh, and Madhya Pradesh. These findings highlight the need for targeted, evidence-based interventions to address regional disparities, enhance hypertension care, and reduce the cardiovascular disease burden in India.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nocturnal systolic and diastolic blood pressure across gestational periods and the risk of preeclampsia. 妊娠期夜间收缩压和舒张压与先兆子痫的风险。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-07-09 DOI: 10.1038/s41371-025-01046-0

Martin R Salazar, Walter G Espeche, Julián Minetto, Gustavo Cerri, Soledad Torres, Florencia Grassi, Claudia Santillan, Romina Tizzano, Juan Todoroff, Lautaro Reitovich, Rosario Ramallo, Horacio A Carbajal

{"title":"Nocturnal systolic and diastolic blood pressure across gestational periods and the risk of preeclampsia.","authors":"Martin R Salazar, Walter G Espeche, Julián Minetto, Gustavo Cerri, Soledad Torres, Florencia Grassi, Claudia Santillan, Romina Tizzano, Juan Todoroff, Lautaro Reitovich, Rosario Ramallo, Horacio A Carbajal","doi":"10.1038/s41371-025-01046-0","DOIUrl":"https://doi.org/10.1038/s41371-025-01046-0","url":null,"abstract":"To investigate the relationship between blood pressure (BP) components (daytime vs. nocturnal BP and systolic vs. diastolic BP) and preeclampsia (PE) across gestational stages. We conducted a historical cohort study involving 1363 high-risk pregnant women (mean age, 30 ± 7 years). Ambulatory BP monitoring (ABPM) was performed at 12-19 weeks (n = 389), 20-27 weeks (n = 798), and 28-36 weeks (n = 1176); 59.9, 25.0, and 15.1% of the participants underwent one, two, and three ABPM evaluations, respectively. PE occurred in 15.4, 18.9, and 20.2% of the women evaluated at 12-19, 20-27, and 28-36 weeks, respectively. In the second half of pregnancy, sustained (daytime and nighttime) and isolated nocturnal hypertension were strong predictors of PE. Conversely, before the 20th week of gestation, only sustained hypertension (but not isolated nocturnal hypertension) increased PE risk, with lower odds ratios (ORs). Moreover, the areas under the curve (AUCs) for all ABPM components increased markedly after the 20th week of gestation. In late pregnancy, systolic and diastolic ABPM levels as well as all forms of nocturnal hypertension (isolated systolic, isolated diastolic, and combined systodiastolic) were significantly associated with PE risk, with ORs remaining significant after adjusting for daytime ABPM and maternal covariates. Patients with systodiastolic nocturnal hypertension had the highest risk. Conversely, neither daytime hypertension nor daytime ABPM levels remained statistically significant after adjusting for nocturnal ABPM levels. In conclusion, the association between PE and systolic, diastolic, and systodiastolic nocturnal hypertension emerges in the second half of pregnancy, suggesting a relationship with abnormal placentation.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incremental prognostic value of combined information of arterial stiffness and the result of treadmill exercise test in patients with suspected coronary artery disease. 动脉僵硬度与跑步机运动试验结果联合信息对疑似冠状动脉疾病患者的增量预后价值

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-07-09 DOI: 10.1038/s41371-025-01044-2

Jaehoon Chung, Hack-Lyoung Kim, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim

{"title":"Incremental prognostic value of combined information of arterial stiffness and the result of treadmill exercise test in patients with suspected coronary artery disease.","authors":"Jaehoon Chung, Hack-Lyoung Kim, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim","doi":"10.1038/s41371-025-01044-2","DOIUrl":"https://doi.org/10.1038/s41371-025-01044-2","url":null,"abstract":"The effectiveness of diagnostic tools can be enhanced by their combination. This study aimed to investigate whether total arterial stiffness data, obtained by brachial-ankle pulse wave velocity (baPWV) measurement, could improve prognostic value to exercise treadmill test (ETT) to predict future cardiovascular events. A total of 1 610 consecutive subjects (mean age 56.3 ± 9.8 years, 59.4% men) with suspected of having coronary artery disease (CAD), who underwent ETT and baPWV on the same day were prospectively recruited. The study outcome was major adverse cardiovascular event (MACE), a composite of cardiac death, non-fatal myocardial infarction, and coronary revascularization. During a mean follow-up period of 938 days (interquartile range, 125-2 252 days), there were 61 cases of MACE (3.8%). The elevated baPWV (≥1 526 cm/s) (hazard ratio [HR] 2.99, 95% confidence interval [CI] 1.64-5.46, P < 0.001) and positive ETT result (HR 4.18, 95% CI 2.48-7.06, P < 0.001) were associated with MACE even after adjustment for potential confounders. The combination of baPWV to traditional risk factors and ETT result further stratified the subjects' risk (low baPWV and negative ETT result vs high baPWV and positive ETT result; HR 14.11, 95% CI 5.74-34.69, P < 0.001). Total arterial stiffness, assessed by baPWV, had incremental prognostic value to ETT result in patients with suspected of CAD. Combined information of baPWV and ETT result can serve as a useful clinical tool for risk stratification in this high-risk patient population.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of home doppler blood pressure measurement to minimise unnecessary investigations in children with suspected hypertension. 家庭多普勒血压测量的效用，以尽量减少不必要的调查，儿童怀疑高血压。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-07-09 DOI: 10.1038/s41371-025-01038-0

Manson Chon In Kuok, Joanna Newton, Cheentan Singh, Manish D Sinha

{"title":"Utility of home doppler blood pressure measurement to minimise unnecessary investigations in children with suspected hypertension.","authors":"Manson Chon In Kuok, Joanna Newton, Cheentan Singh, Manish D Sinha","doi":"10.1038/s41371-025-01038-0","DOIUrl":"https://doi.org/10.1038/s41371-025-01038-0","url":null,"abstract":"An accurate measurement of blood pressure (BP) is essential in making a diagnosis of hypertension, however lack of reference values in children <5 years old makes out-of-office BP measurement using ambulatory blood pressure monitoring difficult in this age group. We conducted a retrospective analysis in children aged under 5 years referred to our hypertension service for suspected hypertension. We included those who underwent home doppler blood pressure measurement (HDBPM) for hypertension diagnosis confirmation, and evaluated the investigations performed for suspected hypertension before the diagnosis was confirmed using out-of-office BP measurements. Children receiving anti-hypertensive medication at the time of initial review were excluded. Fifty-five children (62% male) with a median age of 1.6 years completed HDBPM and were included. Nearly 90% of them referred for hypertension were found to be normotensive following out-of-office BP assessment using HDBPM. In these normotensive patients, different investigations for secondary hypertension, including blood tests (creatinine, renin, aldosterone, cortisol, thyroid function tests, and catecholamine levels), doppler kidney ultrasound, and echocardiograms were performed before referral, most of which yielded unremarkable results. Our finding suggested that whilst some initial investigations were essential, second-line tests for less common secondary causes of hypertension are often unnecessary before hypertension is confirmed. We recommend deferring some of these investigations in asymptomatic children until hypertension is verified by home blood pressure measurements.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of ventricular-arterial coupling in early stage middle-aged hypertensives. 早期中年高血压患者心室-动脉耦合的评估。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-07-08 DOI: 10.1038/s41371-025-01042-4

Andrea Vitali, Giuseppe Biondi Zoccai, George W Booz, Raffaele Altara

{"title":"Assessment of ventricular-arterial coupling in early stage middle-aged hypertensives.","authors":"Andrea Vitali, Giuseppe Biondi Zoccai, George W Booz, Raffaele Altara","doi":"10.1038/s41371-025-01042-4","DOIUrl":"https://doi.org/10.1038/s41371-025-01042-4","url":null,"abstract":"Ventricular-arterial coupling (VAC) is altered by aging and cardiovascular comorbidities, indicating myocardial dysfunction and/or arterial stiffness. Our aim was to demonstrate whether lifestyle changes and anti-hypertensive drug treatment would improve VAC in recently diagnosed, early stage middle-aged hypertensives (HTN) without organ damage. Arterial elastance (Ea), carotid-femoral pulse wave velocity (cfPWV), global longitudinal strain (GLS), and myocardial work (MW) [global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE)] were investigated. This retrospective observational study involved 126 individuals (mean age 40 years; 55% female), divided into HTN and normotensives (NT). Clinical, echocardiographic and echo vascular parameters were assessed. Lifestyle changes were recommended for HTN. If blood pressure (BP) values still remained high, anti-hypertensive drug treatment was administered. Higher values of systolic blood pressure (SBP), mean arterial pressure (MAP), heart rate (HR), GWI, GCW, and GWW were observed in HTN. By following lifestyle changes, BP [diastolic blood pressure (DBP) and MAP], HR, VAC, Ea, cfPWV, GWE, and GLS were changed in HTN; after 6 months of anti-hypertensive drug treatment, BP (SBP, DBP and MAP), HR, VAC, Ea, cfPWV, GWI, GCW, GWW, GWE, and GLS were found to be changed. VAC was linearly related to cfPWV and GLS at two follow ups. No statistically significant difference in VAC between HTN and NT was found. Along with a decrease in BP, smoking cessation, and HR control highlighted a significant role in cardiovascular prevention by improvement of VAC, Ea, cfPWV, GLS and MW.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in systolic blood pressure response to exercise testing: a real-world clinical analysis. 收缩压对运动测试反应的性别差异：现实世界的临床分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-06-30 DOI: 10.1038/s41371-025-01037-1

Shengming Li, Tianjing Zhang, Jia He, Chen He, Fang Liu, Yan Yao, Xiaofei Li, Rutai Hui, Xiaohan Fan

{"title":"Sex differences in systolic blood pressure response to exercise testing: a real-world clinical analysis.","authors":"Shengming Li, Tianjing Zhang, Jia He, Chen He, Fang Liu, Yan Yao, Xiaofei Li, Rutai Hui, Xiaohan Fan","doi":"10.1038/s41371-025-01037-1","DOIUrl":"https://doi.org/10.1038/s41371-025-01037-1","url":null,"abstract":"The American Heart Association recommends sex-specific thresholds for defining exaggerated systolic blood pressure response to exercise (ESBPR), primarily based on data from young healthy populations. However, their applicability and the sex differences in systolic blood pressure (SBP) response to exercise in real-world clinical settings remain unclear. We conducted a cross-sectional study of 44 418 adults (40.6% female) with a mean age of 49, who underwent treadmill exercise testing at Fuwai Hospital from 2016-2022. ESBPR was defined as peak SBP during exercise ≥ 210 mmHg for males and ≥ 190 mmHg for females. Multivariate regression models stratified by sex were used to explore whether sex modifies age-related patterns in SBP response to exercise. ESBPR was over five times more prevalent in females than males (10.1 vs. 1.9%, P < 0.001). While the mean, 90th, and 95th percentiles of peak SBP were at least 12 mmHg higher in males than females in younger age groups (18-44), the gap narrowed to less than 4 mmHg in older age groups (≥45). Stratified multivariate analysis revealed that age was a strong predictor of ESBPR in females but not in males. Using age ≥ 51 as a proxy for menopause, females older than 51 had significantly higher odds of ESBPR compared to younger females (adjusted OR: 1.904, 95% CI: 1.683-2.155, P < 0.001). Our findings reveal that females and males display distinct age-related patterns in SBP response to exercise. The lower threshold for females may disproportionately classify postmenopausal females as abnormal.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Meta-analysis of White Coat Hypertension and Mortality. 白大衣高血压与死亡率的最新荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-06-30 DOI: 10.1038/s41371-025-01041-5

Alavi Hossain, Raymond R Townsend, Jordana B Cohen

引用次数: 0

The effect of health anxiety on attitudes toward disease prevention in individuals with and without a family history of hypertension. 健康焦虑对有和无高血压家族史个体疾病预防态度的影响

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-06-24 DOI: 10.1038/s41371-025-01036-2

Yasemin Karacan, Ayşe Gül Parlak

{"title":"The effect of health anxiety on attitudes toward disease prevention in individuals with and without a family history of hypertension.","authors":"Yasemin Karacan, Ayşe Gül Parlak","doi":"10.1038/s41371-025-01036-2","DOIUrl":"https://doi.org/10.1038/s41371-025-01036-2","url":null,"abstract":"This study aims to examine how health anxiety and demographic characteristics influence attitudes toward hypertension prevention in individuals with and without a family history of hypertension (family HHT). This cross-sectional study included 1,139 individuals over the age of 18. Data were collected through an online survey and analyzed using the Attitudes Scale Towards Prevention of HT (ASPH) and the Health Anxiety Scale (HAS). In addition to scale scores, demographic characteristics and family history of hypertension were also collected. The survey link was shared via social media, allowing participants to distribute it within their networks. The mean ASPH score was 98.31 ± 21.91, highest in prevention and control (31.55 ± 7.28). Age correlated with mental and physical activity (p = 0.026) and nutritional behavior (p = 0.041), while BMI was linked to hypertension attitudes (p = 0.006). Regression analysis showed that gender (B = -6.609, p < 0.001) and a family HHT (B = -0.574, p = 0.013) significantly influenced attitudes toward hypertension prevention, with men and those with a family HHT scoring lower than their counterparts. Scatter plots revealed higher health anxiety and stronger hypertension attitudes in those with hypertensive parents, while attitudes were more varied among individuals with hypertensive siblings or grandparents. These findings highlight the impact of family hypertension history and demographics on hypertension attitudes and health anxiety, emphasizing early awareness, targeted health education for gender differences, and preventive strategies for high-risk groups.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertensive urgencies and emergencies in the cardiology emergency department: epidemiology, patient profile, and management. 心脏病急诊科的高血压急症和急诊：流行病学、患者概况和管理。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-06-20 DOI: 10.1038/s41371-025-01033-5

Panagiotis Theofilis, Nikolaos Nakas, Thomais Lamprou, Kalliopi Touchantzidou, Aikaterini Vordoni, Vasilios Thimis, Despina Smirloglou, Athanasios Kotsakis, Rigas G Kalaitzidis

{"title":"Hypertensive urgencies and emergencies in the cardiology emergency department: epidemiology, patient profile, and management.","authors":"Panagiotis Theofilis, Nikolaos Nakas, Thomais Lamprou, Kalliopi Touchantzidou, Aikaterini Vordoni, Vasilios Thimis, Despina Smirloglou, Athanasios Kotsakis, Rigas G Kalaitzidis","doi":"10.1038/s41371-025-01033-5","DOIUrl":"10.1038/s41371-025-01033-5","url":null,"abstract":"Hypertensive urgencies (HU) and hypertensive emergencies (HE) are common conditions in the cardiology emergency department (ED), often requiring urgent intervention. Despite their clinical significance, data on patient characteristics, etiologies, and management strategies remain limited. This study aimed to assess the epidemiology, clinical profile, and management of HU and HE in a tertiary cardiology ED. A single-center, observational study was conducted over 12 months, enrolling patients diagnosed with HU/HE (BP ≥ 180/120 mmHg). Demographic data, medical history, symptoms, etiologic factors, and antihypertensive treatments were recorded. Serial blood pressure (BP) measurements were taken to assess BP reduction during the ED stay. Of 4010 cardiology ED visits, 83 patients (2.1%) had HU/HE (median age 65 years, 45.8% male). Most had a history of hypertension (73.5%), with frequent coexisting smoking (56.6%) and dyslipidemia (43.4%). Common symptoms included dyspnea (19.3%) and chest pain (25.3%). Stress (26.8%) and increased salt intake (15.9%) were common etiologic factors. HE was diagnosed in 18 cases (21.7%), and 12.7% of HU cases required hospitalization. Mean BP on admission was 200/100 mmHg, with SBP and DBP reductions of 41 mmHg (-21%) and 18 mmHg (-17%), respectively. Nitrates, anxiolytics, and combination therapies resulted in the greatest BP reductions. In conclusion, HU and HE are frequently observed in hypertensive patients with additional cardiovascular risk factors. Target-organ damage is not solely related to BP levels, emphasizing the need for individualized management strategies.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients with Essential Hypertension: A Phase III, Multicenter, Double-Blind, Parallel-Group, Randomised study. 阿利沙坦异丙醇/氨氯地平治疗原发性高血压的疗效和安全性：一项多中心、双盲、平行组、随机研究

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-06-17 DOI: 10.1038/s41371-025-01035-3

Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yuanyuan Chen, Yan Chen, Hao Tang, Zichen Liu, Peng Mi, Xiangmin Lin

{"title":"Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients with Essential Hypertension: A Phase III, Multicenter, Double-Blind, Parallel-Group, Randomised study.","authors":"Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yuanyuan Chen, Yan Chen, Hao Tang, Zichen Liu, Peng Mi, Xiangmin Lin","doi":"10.1038/s41371-025-01035-3","DOIUrl":"https://doi.org/10.1038/s41371-025-01035-3","url":null,"abstract":"This multicenter, double-blind, parallel-group, randomised controlled phase III study evaluated the efficacy and safety of the Allisartan Isoproxil 240 mg /Amlodipine 5 mg (ALI/AML) combination compared with ALI 240 mg monotherapy in patients with mild-to-moderate essential hypertension. Patients aged 18 to 70 years with mean sitting systolic blood pressure (msSBP) between 140 and <180 mmHg and mean sitting diastolic blood pressure (msDBP) between 90 and <110 mmHg were randomised 1:1 to receive ALI/AML or ALI once-daily for 12 weeks after a 4-week treatment with ALI, followed by an open-label extension period with ALI/AML up to week 52. A total of 199 patients were randomised (ALI/AML: n = 99, ALI: n = 100) with 169 completing the study. Baseline characteristics were comparable between groups. After 12 weeks of randomisation, the reduction in msSBP (primary endpoint) was significantly greater in the ALI/AML group vs the ALI group (-18.3 vs. -9.3 mmHg, p < 0.001). Reductions in msDBP (-6.0 vs. -1.9 mmHg, p < 0.001) and 24-hour mean ambulatory systolic/diastolic blood pressure (-19.9/-10.1 vs. -6.9/-4.2 mmHg) were more pronounced in the ALI/AML group. Additionally, a greater proportion of patients achieved the BP response and target office BP in the ALI/AML group compared to the ALI group (53.6% vs. 25.5%, p < 0.001; 40.2% vs. 20.4%, p=0.0026). AML/ALI combination was generally safe and well tolerated, with sustained efficacy up to 52 weeks. The study concluded that ALI/AML offers a convenient, single-pill option for effective BP reduction in hypertensive patients.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0