Journal of Human Hypertension最新文献

Sleep quality and hypertension in an indigenous African population: a cross-sectional investigation from the COMBAT-CVDs study. 非洲原住民的睡眠质量与高血压：COMBAT-CVDs 研究的横断面调查。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-11-04 DOI: 10.1038/s41371-024-00971-w

Oluwafemi Gbolahan Aremu, Osahon Jeffery Asowata, David Kadan Danladi, Akinkunmi Paul Okekunle, Onoja Matthew Akpa

{"title":"Sleep quality and hypertension in an indigenous African population: a cross-sectional investigation from the COMBAT-CVDs study.","authors":"Oluwafemi Gbolahan Aremu, Osahon Jeffery Asowata, David Kadan Danladi, Akinkunmi Paul Okekunle, Onoja Matthew Akpa","doi":"10.1038/s41371-024-00971-w","DOIUrl":"10.1038/s41371-024-00971-w","url":null,"abstract":"Hypertension is a major risk factor for cardiovascular events worldwide, and little is known about its association with sleep quality (SQ) among Africans. We evaluated the association of SQ with hypertension among adults in Ibadan, Nigeria. In Ibadan and its suburbs, we identified 3635 participants in the door-to-door Community-based Investigation of the Risk Factors for Cardiovascular Diseases (COMBAT-CVDs) study. SQ was self-reported, and SQ scores were classified by the tertile distribution in this sample as good (<9), moderate (10-18), and poor (≥19), and hypertension was defined as one of the following conditions: systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg or prior diagnosis by a certified health professional or current use of blood pressure-lowering drugs. Using good SQ as a reference, logistic regression models were used to estimate the multivariable-adjusted odds ratio and 95% confidence interval (CI) for odds of hypertension by tertiles of SQ scores in a two-sided test at p < 0.05. In all, 1182 (32.5%) had poor SQ, 903 (24.8%) had hypertension, and the mean(±SD) age was 35.3 ± 15.2 years in this sample. The multivariable-adjusted odds of hypertension by tertiles of SQ scores (using good SQ as reference) were OR: 1.13 (95% CI: 0.92, 1.38) for moderate SQ, and OR: 1.29 (95% CI: 1.05, 1.59) for poor SQ; P for trend = 0.06 after adjusting for relevant covariates. Poor SQ is associated with higher odds of hypertension in this sample. The imperative of culturally sensitive interventions to improve SQ would be promising in managing poor sleep-associated hypertension burden in this population.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Course of brain damage following malignant hypertension. 恶性高血压的脑损伤过程。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-11-01 DOI: 10.1038/s41371-024-00968-5

Jean Sebastien Liegey, Antoine Cremer, Ludovic Lucas, Philippe Gosse, Stéphane Debeugny, Sebastien Rubin, Julien Doublet, Igor Sibon, Romain Boulestreau

{"title":"Course of brain damage following malignant hypertension.","authors":"Jean Sebastien Liegey, Antoine Cremer, Ludovic Lucas, Philippe Gosse, Stéphane Debeugny, Sebastien Rubin, Julien Doublet, Igor Sibon, Romain Boulestreau","doi":"10.1038/s41371-024-00968-5","DOIUrl":"https://doi.org/10.1038/s41371-024-00968-5","url":null,"abstract":"Malignant hypertension (MHT) crisis triggers widespread microvascular damage, particularly in the brain. Despite recent MRI evidence highlighting acute cerebral injuries during MHT crises, follow-up data remain scarce. This study seeks to fill this gap by exploring how brain MRI markers evolve following acute MHT crisis management. We conducted a retrospective analysis of brain MRI data from MHT patients admitted to Bordeaux University Hospital between 2008 and 2022. Eligible patients had at least one follow-up MRI. Analysis blinded to clinical data was performed to identify markers of posterior reversible encephalopathy syndrome (PRES), acute stroke, cerebral hemorrhage, and microangiopathy. Out of 149 patients, 47 had follow-up MRIs. Most were male (72.3%) with a mean age of 48.2 ± 10.8 years. The median interval between initial and follow-up MRI was 228 days. Follow-up MRIs revealed new strokes in 10.6% of patients, cerebral hemorrhages in 4.3%, and no cases of PRES. Additionally, more patients exhibited chronic lacunar infarcts and/or microbleeds, with overall Fazekas scores remaining stable in 66.0%, improving in 31.9%, and worsening in 2.1%. Subgroup analyses based on blood pressure control or follow-up duration showed no significant differences in MRI markers. This study sheds light on the risk of new cerebrovascular events and the dynamic changes in brain MRI markers following acute MHT crisis management. Understanding these changes could lead to improved diagnosis, personalized treatment strategies, and proactive patient care for individuals with MHT.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood indices of inflammation and their association with hypertension in smokers: analysis using data mining approaches. 血液中的炎症指数及其与吸烟者高血压的关系：利用数据挖掘方法进行分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-29 DOI: 10.1038/s41371-024-00975-6

Sahar Ghoflchi, Amin Mansoori, Muhammad Islampanah, Sahar Arab Yousefabadi, Mohadeseh Poudineh, Elahe Derakhshan-Nezhad, Amirhosein Zardast, Marzyeh Azmon, Fatemeh Asgharian Rezae, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan

{"title":"Blood indices of inflammation and their association with hypertension in smokers: analysis using data mining approaches.","authors":"Sahar Ghoflchi, Amin Mansoori, Muhammad Islampanah, Sahar Arab Yousefabadi, Mohadeseh Poudineh, Elahe Derakhshan-Nezhad, Amirhosein Zardast, Marzyeh Azmon, Fatemeh Asgharian Rezae, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan","doi":"10.1038/s41371-024-00975-6","DOIUrl":"https://doi.org/10.1038/s41371-024-00975-6","url":null,"abstract":"Although there have been reports on the association between smoking and increased level of inflammatory markers in hypertensive this has not been assessed prospectively in a large, modern cohort using data mining approaches. We conducted a cross-sectional analysis of the Mashad trial which was a prospective. 2085 smokers aged 35 to 65 years was studied. Inflammatory indices measured included: Hemoglobin-Platelet Ratio (HPR), Uric acid-high Density Lipoprotein (HDL) Ratio (UHR), Neutrophil-Lymphocyte Ratio (NLR), Systemic Immune Inflammation (SII) index, WBC, Platelet-Lymphocyte Ratio (PLR), and RBC Distribution Width (RDW). The association between these parameters and smoking in hypertensive individuals was examined. Over the course of the 6-year monitoring period, 585 peoples had HTN of whom the majority was female (59%). As per the LR analysis, there was a significant association between hypertension and age, WBC, SII, PLR in female smokers, as well as age and PLR in male smokers. (p-value < 0.05). PLR (OR = 0.993, CI 95% (0.987, 0.999)) and age (1.080 (1.058, 1.102)) for male and WBC (1.340 (1.139, 1.577)) and age (1.091 (1.070, 1.113)) for female exhibits the most appropriate estimate. Using the DT model for male individuals, those with, age ≥ 64 years, and SII < 336 had the correlated with hypertension prevalence (76%). For females, those with age ≥ 62 years, WBC ≥ 6.1, and SII < 445.634 had the highest risk of HTN. Age and SII for smoker males and age and WBC for smoker females showed the strongest correlation with hypertension. Age and WBC were the most significant indicators for predicting HTN.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JHH Young Investigator Award 2023: interview with the winner Andrew O. Agbaje 2023 年 JHH 青年研究员奖：采访获奖者 Andrew O. Agbaje。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-29 DOI: 10.1038/s41371-024-00974-7

Andrew O. Agbaje

引用次数: 0

Correction: The association of leptin and incident hypertension in the reasons for geographic and racial differences in stroke (REGARDS) cohort 更正：中风的地域和种族差异原因（REGARDS）队列中瘦素与高血压发病率的关系。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-28 DOI: 10.1038/s41371-024-00970-x

S. E. Sherman, E. Stoutenburg, D. L. Long, S. P. Juraschek, M. Cushman, V. J. Howard, R. P. Tracy, S. E. Judd, D. Kamin Mukaz, N. A. Zakai, T. B. Plante

引用次数: 0

True-resistant hypertension and serum fibrinogen; much more than a marriage of convenience? 真性耐药高血压与血清纤维蛋白原；不仅仅是权宜之计？

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-25 DOI: 10.1038/s41371-024-00973-8

Alvaro Hermida-Ameijeiras, Nestor Vazquez-Agra, Antonio Pose-Reino

引用次数: 0

Post-exercise hypotension after different volumes of combined calisthenic and walking exercises in older adults with hypertension: a randomized controlled trial. 患有高血压的老年人进行不同运动量的综合健身和步行锻炼后出现的运动后低血压：随机对照试验。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-23 DOI: 10.1038/s41371-024-00972-9

Vinícius Mallmann Schneider, Rodrigo Flores de Abreu, Hirofumi Tanaka, Rodrigo Ferrari

{"title":"Post-exercise hypotension after different volumes of combined calisthenic and walking exercises in older adults with hypertension: a randomized controlled trial.","authors":"Vinícius Mallmann Schneider, Rodrigo Flores de Abreu, Hirofumi Tanaka, Rodrigo Ferrari","doi":"10.1038/s41371-024-00972-9","DOIUrl":"https://doi.org/10.1038/s41371-024-00972-9","url":null,"abstract":"This study aimed to analyze the acute effects of combined calisthenic and walking exercises using different volumes on blood pressure (BP) in aging adults with primary hypertension. A total of 48 participants with primary hypertension aged 50-80 years were randomly assigned into two groups that performed two experimental sessions each: a non-exercising CONTROL session and a LOW (group 1) or HIGH (group 2) volume exercise session. The order of these sessions was randomized. The exercise protocols lasted 30 min (LOW) or 60 min (HIGH) and consisted of calisthenic exercises combined with continuous walking or jogging. Exercise intensity was controlled using a rating of perceived exertion (RPE) scale. BP was measured at baseline and after each session for 60 min. Results showed that systolic BP was lower after the HIGH session at post 30' (p = 0.03), post 40' (p = 0.03), post 50' (p = 0.04), and post 60' (p < 0.02), and after the LOW session at post 30' (p = 0.02), post 40' (p < 0.01), post 50' (p < 0.01), and post 60' (p < 0.01) when compared to the corresponding CONTROL at the same time point. There were no significant differences in systolic and diastolic BP between the HIGH and LOW sessions. In conclusion, a pragmatic combined training session using different volumes acutely reduces BP in older adults with primary hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic performance of single-lead electrocardiograms for arterial hypertension diagnosis: a machine learning approach. 单导联心电图在动脉高血压诊断中的诊断性能：一种机器学习方法。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-18 DOI: 10.1038/s41371-024-00969-4

Eleni Angelaki, Georgios D Barmparis, Konstantinos Fragkiadakis, Spyros Maragkoudakis, Evangelos Zacharis, Anthi Plevritaki, Emmanouil Kampanieris, Petros Kalomoirakis, Spyros Kassotakis, George Kochiadakis, Giorgos P Tsironis, Maria E Marketou

{"title":"Diagnostic performance of single-lead electrocardiograms for arterial hypertension diagnosis: a machine learning approach.","authors":"Eleni Angelaki, Georgios D Barmparis, Konstantinos Fragkiadakis, Spyros Maragkoudakis, Evangelos Zacharis, Anthi Plevritaki, Emmanouil Kampanieris, Petros Kalomoirakis, Spyros Kassotakis, George Kochiadakis, Giorgos P Tsironis, Maria E Marketou","doi":"10.1038/s41371-024-00969-4","DOIUrl":"https://doi.org/10.1038/s41371-024-00969-4","url":null,"abstract":"Awareness and early identification of hypertension is crucial in reducing the burden of cardiovascular disease (CVD). Artificial intelligence-based analysis of 12-lead electrocardiograms (ECGs) can already detect arrhythmias and hypertension. We performed an observational two-center study in order to develop a machine learning algorithm to proactively detect arterial hypertension from single-lead ECGs. This could serve as proof of concept with an eye towards todays wearables that record single-lead ECGs. In a prospective observational study, we enrolled 1254 consecutive subjects (539 male, aged 60.22 ± 12.46 years), with and without essential hypertension, and no indications of CVD. A 12-lead ECG of 10 seconds duration in resting position was performed on each subject using a digital electrocardiograph and lead I was isolated for analysis using a calibrated Random Forest (RF). Our RF model classified hypertensive from normotensive subjects on a hold-out test set, with 75% accuracy, ROC/AUC 0.831 (95%CI: 0.781-0.871), sensitivity 72%, and specificity 82% (sensitivity and specificity calculated using a threshold of 0.675). Increasing age, larger values of body mass index, the area under the T wave divided by the QRS complex area, and the area under QRS segment adjusted for BMI, were the four most important features that drove the classification decisions of our model. This study demonstrates the potential to opportunistically detect an undiagnosed hypertension, using a single-lead ECG. While studies with data from wearables are required to translate our findings to actual smartwatch settings, our results could pave the way to innovative technologies for hypertension awareness.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterial stiffness as a novel tool for the early prediction of preeclampsia: a perspective 动脉僵化作为子痫前期早期预测的新工具：透视。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-16 DOI: 10.1038/s41371-024-00967-6

Mekayla Forrest, Maria Matossian, Brenda Valdes Sustaita, Helena Papacostas Quintanilla, Bart Spronck, James Sharman, Stella S. Daskalopoulou

引用次数: 0

Development of quality indicators for hypertension management at the primary health care level in South Africa. 为南非初级医疗保健机构的高血压管理制定质量指标。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-10-14 DOI: 10.1038/s41371-024-00966-7

Enos Muisaphanda Rampamba, Johanna Catharina Meyer, Brian Godman, Ntodeni Norah Ndwamato, Stephen Mark Campbell

{"title":"Development of quality indicators for hypertension management at the primary health care level in South Africa.","authors":"Enos Muisaphanda Rampamba, Johanna Catharina Meyer, Brian Godman, Ntodeni Norah Ndwamato, Stephen Mark Campbell","doi":"10.1038/s41371-024-00966-7","DOIUrl":"https://doi.org/10.1038/s41371-024-00966-7","url":null,"abstract":"Despite many quality initiatives at the primary health care (PHC) level, little is known about the actual quality of care of patients diagnosed with hypertension in South Africa. This study aimed to develop quality indicators for hypertension management at the PHC level to improve the quality of care and patient outcomes. The RAND/UCLA Appropriateness Method, comprising two rounds, was used to develop clear, appropriate, and feasible evidence-based quality indicators for hypertension. In Round 1, a 9-point scale was used by a panel of 11 members to rate clarity and appropriateness of 102 hypertension quality indicator statements, grouped under 9 dimensions of quality hypertension management, using an online MS Excel® spreadsheet. In Round 2, 9 of the same panellists discussed all indicators and rated their appropriateness and feasibility during a remote online, interactive face-to-face MS Teams® meeting. Statements rated ≥7-9 with agreement were defined as either appropriate or feasible. The panel rated 46 hypertension quality indicator statements ≥7-9 with agreement for the appropriate and feasible measurement of the management of hypertension: monitoring (n = 16), review (n = 5), lifestyle advice (n = 9), tests (n = 7), intermediate outcomes (n = 6), referrals (n = 2) and practice/facility structures (n = 1). No indicator statements were rated both appropriate and feasible for measuring blood pressure levels and treatment. If applied, these indicators would improve monitoring and management of patients with hypertension, patient outcomes, and data quality in South Africa and result in more efficient use of scarce resources. This study can be replicable for improving care of other non-communicable diseases across Africa.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0