Journal of Human Hypertension最新文献

{"title":"The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis.","authors":"Minako Kinuta, Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Noriko Nakahata, Hideyuki Kanda","doi":"10.1038/s41371-025-01014-8","DOIUrl":"https://doi.org/10.1038/s41371-025-01014-8","url":null,"abstract":"<p><p>Few studies have examined the association of objectively measured habitual physical activity (PA) and sedentary behavior with out-of-office blood pressure (BP). We investigated the associations of objectively measured PA intensity time, sedentary time, and step count with at-home BP. Using accelerometer-recorded PA indices and self-measured BP in 368 participants (mean age, 53.8 years; 58.7% women), we analyzed 115,575 records of each parameter between May 2019 and April 2024. PA intensities were categorized as light (2.0-2.9 metabolic equivalents [METs]); moderate (3.0-5.9 METs); vigorous (≥6.0 METs), or sedentary (<2.0 METs): the median [interquartile ranges] for these variables was 188 [146-232], 83 [59-114], 1 [0-2], 501 [428-579] minutes, respectively, and for step count, was 6040 [4164-8457]. Means [standard deviations] for systolic and diastolic BP were 116.4 [14.2] and 75.2 [9.3] mmHg, respectively. A mixed-effect model adjusted for possible confounders showed that 1-h longer in vigorous PA was associated with lower systolic and diastolic BP (-1.69 and -1.09 mmHg, respectively). A 1000-step increase in step count was associated with lower systolic and diastolic BP (-0.05 and -0.02 mmHg, respectively). Associations were more pronounced among men and participants aged <60 years. Sedentary time was positively associated with BP in men and participants aged <60 years, but inversely associated with BP in women and participants aged ≥60 years. Our findings suggest that more PA and less sedentary behavior were associated with BP reduction, particularly among men and participants aged <60 years. However, the clinical relevance of this effect remains uncertain because of its modest magnitude.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of elevated blood pressure (prehypertension) and hypertension among undergraduate university students in the UAE: a serious health concern.","authors":"Yasser Amer Abd Alsamad, Bessan Musa Saleh Jaffal, Khaleel Rajaee Ibrahim Shuhait, Reem Khudoum Khamis Khudoum Alzaabi, Sari Mohammad Mahmoud Lataifeh, Tahsina Tajnin Sadia, Amal Hussein, Adel B Elmoselhi","doi":"10.1038/s41371-025-01015-7","DOIUrl":"https://doi.org/10.1038/s41371-025-01015-7","url":null,"abstract":"<p><p>Hypertension, often referred to as a \"silent killer,\" due to its lack of obvious symptoms but can lead to devastating complications such as cardiovascular disease and stroke, particularly when left unmanaged. This highlights the importance of early screening of elevated blood pressure. The aim of this study is to determine the prevalence of elevated blood pressure (prehypertension) and hypertension among undergraduate university students, along with the associated risk factors. We recruited 344 randomly selected undergraduate students for a cross-sectional study. Blood pressure (BP) measurements were taken following best practice guidelines. In addition, body mass index (BMI) was measured, while other risk factors were collected through a questionnaire. Out of all participants, 36% exhibited elevated blood pressure, with the following breakdown: 15% (n = 51) had prehypertension, 18% (n = 62) had stage 1 hypertension, and 3% (n = 10) had stage 2 hypertension. The prevalence of hypertension and prehypertension was significantly higher among male students (52.7 and 100%, respectively) compared to female students (47.3, and 0% respectively). Significant correlations were found between blood pressure, BMI, and physical activity levels (P ≤ 0.001 and P ≤ 0.011, respectively). Our findings reveal a concerning prevalence of prehypertension and, to a greater extent, hypertension among undergraduate university students. Elevated blood pressure levels were strongly correlated with male gender, BMI, and physical activity levels. These results warrant further large-scale investigation and underscore the urgent need to raise awareness about this significant health risk in the younger population.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A salty symphony: unraveling the tale of uromodulin and sodium sensitivity.","authors":"Artemios G Karagiannidis, Marieta P Theodorakopoulou, Fotini Iatridi, Alberto Ortiz, Pantelis Sarafidis","doi":"10.1038/s41371-025-01013-9","DOIUrl":"10.1038/s41371-025-01013-9","url":null,"abstract":"<p><p>Uromodulin is a kidney-specific glycoprotein which is uniquely synthesized by the epithelial cells lining the thick ascending limb and early distal convoluted tubule. Among multiple roles in complex physiological and pathological processes, uromodulin mediates renal sodium handling through modulating tubular sodium transporters that reabsorb sodium and therefore is putatively linked to hypertension through generating sodium sensitivity of blood pressure. This review aims to present an updated overview of the role of uromodulin in sodium renal handling and summarize the existing evidence originating from preclinical, genetic, and clinical studies that support a relationship between uromodulin and sodium-sensitive hypertension.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between antihypertensive drug use and the risk of depression: a systematic review and network meta-analysis","authors":"Jay Tewari,&nbsp;Khalid Ahmad Qidwai,&nbsp;Ajoy Tewari,&nbsp;Anadika Rana,&nbsp;Vineeta Tewari,&nbsp;Vanshika Singh,&nbsp;Rishabh Tiwari,&nbsp;Anuj Maheshwari,&nbsp;Narsingh Verma,&nbsp;Hemali Jha,&nbsp;Savneet Kaur","doi":"10.1038/s41371-025-01011-x","DOIUrl":"10.1038/s41371-025-01011-x","url":null,"abstract":"Hypertension is the biggest and most prevalent risk factor for cardiovascular diseases. Depression is the most common psychiatric illness worldwide. Many studies have linked the development of new depression to the use of antihypertensive drugs. This meta-analysis was done to ascertain the relationship. Using standard reporting techniques a literature search was undertaken in Pubmed from inception till 10 May 2024. The risk bias assessment was done using the ROBINS-I tool. Data for the odds ratio were combined using Revman 5.4 using a random or fixed effects model. Our analysis found a significant association between beta blockers and calcium channel blockers use and the risk of developing new depression. Results for other classes of antihypertensives were not significant. The findings highlight the importance of taking into account the potential psychiatric side effects of antihypertensive drugs in people with hypertension. Physicians should stay vigilant and screen their patients for these conditions regularly.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"246-253"},"PeriodicalIF":2.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01011-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Close relationship between electrocardiogram QRS duration and the risk of developing hypertension.","authors":"Hiroyuki Takase, Sumiyo Yamashita, Naomi Kawakatsu, Kazusa Hayashi, Fumihiko Kin, Takeru Isogaki, Yasuaki Dohi","doi":"10.1038/s41371-025-01012-w","DOIUrl":"https://doi.org/10.1038/s41371-025-01012-w","url":null,"abstract":"<p><p>Electrocardiogram QRS duration is associated with cardiovascular events and all-cause death. The present study was conducted to investigate the hypothesis that the QRS duration predicts the future development of hypertension in the Japanese general population with normal blood pressure. Overall, 13,382 individuals without bundle branch block, Wolff-Parkinson-White syndrome, complete atrioventricular block, pacemaker implantation, or old myocardial infarction on electrocardiogram were enrolled. The cross-sectional analysis indicated that the QRS duration was longer in hypertensive than in normotensive participants. After excluding the participants with hypertension, the remaining 9293 participants with normal blood pressure (male = 5425, 50.2 ± 11.7 years) were followed up for the median of 4 years with an endpoint of hypertension development. During the follow-up period, 1953 participants developed hypertension (50.6 per 1000 person-year). Kaplan-Meier analysis revealed that the incidence of hypertension increased across the quartiles of participants based on QRS duration at baseline as 39.0, 48.6, 53.7, and 62.4 per 1000 person-years in the first, second, third, and fourth quartiles, respectively. Univariate analysis confirmed a significant impact of QRS duration on the development of hypertension. In the multivariate Cox hazard regression analysis adjusted for possible confounding variables, QRS duration was an independent predictor of the development of hypertension. These results suggest the close association between electrocardiogram QRS duration and the future development of hypertension in the Japanese general population. Moreover, alterations in the intraventricular conduction may precede clinically apparent hypertension.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambulatory blood pressure monitoring before and after resection of catecholamine-secreting pheochromocytoma or paraganglioma.","authors":"Jordana B Cohen, Liann Abu Salman, Bonita J Bennett, Debbie L Cohen","doi":"10.1038/s41371-025-01008-6","DOIUrl":"https://doi.org/10.1038/s41371-025-01008-6","url":null,"abstract":"<p><p>Pheochromocytomas/paragangliomas are catecholamine-secreting tumors that are a rare cause of hypertension and associated with high cardiovascular risk. We aimed to evaluate changes in 24-h ambulatory blood pressure (BP) monitoring (ABPM) following tumor resection. Individuals with evidence of pheochromocytoma/paraganglioma prospectively underwent 24-h ABPM and plasma and urine catecholamine measurement 2-3 weeks before and 6-8 weeks after pathologically-confirmed tumor resection. Patients with metastatic disease were excluded. Changes in office, 24-h, daytime, and nighttime mean systolic and diastolic BP and heart rate, 24-h BP and heart rate average real variability, and rates of controlled, sustained, white coat, and masked hypertension were assessed in paired analyses. There were 34 participants who completed 24-h ABPM before and after tumor resection. Mean age was 55 ± 13 years, with 21 (62%) women, median duration of hypertension of 3 years, and 6 (18%) participants with coronary artery disease. Serum and urine catecholamines normalized following tumor resection and participants were prescribed 1 ± 0.2 fewer antihypertensive medications. Office BP declined by a mean 10 ± 16/7 ± 9 mmHg, 24-h BP declined by 8 ± 14/4 ± 10 mmHg, with greater improvement in nighttime (9 ± 18/5 ± 13 mmHg) than daytime (7 ± 14/4 ± 9) ambulatory BP. Systolic BP variability and heart rate variability significantly improved. While the frequency of controlled hypertension increased (4 [12%] to 11 [32%]; p = 0.008), there was no significant change in masked hypertension (9 [26%] to 12 [35%]; p = 0.366). In conclusion, pheochromocytoma/paraganglioma resection was associated with improvement in 24-h BP and BP variability, particularly nighttime BP. ABPM may be useful following tumor resection to identify patients with unrecognized residual cardiovascular risk.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"sFlt-1/PlGF ratio combined with endocan-1 serum levels improves the predictive values for the occurrence and prognosis of preeclampsia in a single centre study.","authors":"Shanshan Tian, Libin He, Ahuang Pan, Lina Zhang, Jielin Wang","doi":"10.1038/s41371-025-01009-5","DOIUrl":"https://doi.org/10.1038/s41371-025-01009-5","url":null,"abstract":"<p><p>This retrospective study evaluated diagnostic and prognostic values of sFlt-1/PlGF ratio combined with serum endocan-1 for preeclampsia (PE). This study included 105 patients with PE admitted at Xiamen University Affiliated Xiang'an Hospital from January 2020 to September 2023, with 90 healthy pregnant women receiving routine check-ups during the same period as controls. sFlt-1, PlGF, and endocan-1 levels were measured, and sFlt-1/PlGF ratio was calculated. The correlation of sFlt-1/PlGF ratio with serum endocan-1 levels was analysed, and influencing factors for poor prognosis of PE patients were screened. Diagnostic and prognostic values of sFlt-1/PlGF ratio combined with serum endocan-1 were assessed. Results showed an increase in sFlt-1/PlGF ratio and serum endocan-1 levels in PE patients and a positive correlation between them. For assisting in the diagnosis of PE, the AUC of the sFlt-1/PlGF ratio combined with serum endocan-1 was 0.874 (95%CI: 0.819 - 0.917; sensitivity, 75.24%; specificity, 100.00%), which was superior over that of sFlt-1/PlGF ratio (P = 0.025) and endocan-1 (P = 0.047) alone. Elevated sFlt-1/PlGF ratio and serum endocan-1 levels were independent risk factors for poor prognosis of PE patients. For assisting in predicting poor prognosis of PE, the AUC of sFlt-1/PlGF ratio with serum endocan-1 was 0.955 (95%CI: 0.896 - 0.986; sensitivity, 82.61%; specificity, 100.00%), which was higher than that of sFlt-1/PlGF ratio (P = 0.023) or serum endocan-1 (P = 0.010) alone. Altogether, sFlt-1/PlGF ratio combined with serum endocan-1 is advantageous over sFlt-1/PlGF ratio and serum endocan-1 alone for predicting PE occurrence and prognosis.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between different types of obesity and hypertension in perimenopausal working women.","authors":"Huaiqin Zhong, Yan Qiu, Xvping Zhu, Jinyu Li, Mei Liu, Zhuoqun Zou","doi":"10.1038/s41371-025-01010-y","DOIUrl":"https://doi.org/10.1038/s41371-025-01010-y","url":null,"abstract":"<p><p>Hypertension (HTN) can lead to a series of target organ damage and is associated with increased cardiovascular disease incidence and mortality. Perimenopause implies an important physiological transition. Previous studies have confirmed that obesity is a risk factor for the development of HTN. Nevertheless, few studies have investigated the prevalence of HTN in perimenopausal women and the relationships between peripheral or abdominal obesity and HTN. Therefore, we analysed the influencing factors of HTN in perimenopausal working women and the correlation between different types of obesity and HTN to provide evidence for the need to prevent HTN in perimenopausal women. Perimenopausal women who underwent physical examination at Shanghai Health and Medical Center from January 2021 to October 2021 were selected as subjects. A multivariate logistic regression model was used to analyse the associations between different types of obesity and HTN in perimenopausal women. Five hundred eighty-two perimenopausal women were included in this study; 124 cases of HTN were detected (incidence rate 21.31%), 23 of which were isolated systolic HTN (18.55% of total HTN cases). Multivariate logistic regression analysis revealed that age and BMI were the influencing factors of HTN in perimenopausal women. Compared with that of perimenopausal women without peripheral obesity, HTN in overweight (OR = 1.84, 95% CI: 1.13-2.98) and peripheral obesity (OR = 4.36, 95% CI: 1.52-12.54) women increased with increasing body weight. Perimenopausal women with abdominal obesity had a greater risk of developing HTN (OR = 2.69, 95% CI: 1.16-6.21) (P < 0.05). Age and BMI are risk factors for the development of HTN in perimenopausal working women. Both abdominal obesity and peripheral obesity are positively associated with HTN in perimenopausal women. The BMI and abdominal circumference of perimenopausal women need to be monitored as early as possible to prevent obesity and reduce the occurrence of HTN.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-based surveillance for hypertension awareness, treatment, and control in nine districts - India Hypertension Control Initiative, 2018-19.","authors":"Prabhdeep Kaur, Kamaraj Pattabi, Amirthammal Gunasekaran, Vettrichelvan Venkatasamy, Azhagendran Sivalingam, Sabarinathan Ramasamy, Sailaja Bitragunta, Tapas Chakma, Sampada D Bangar, Meenakshi Sharma, Abhishek Kunwar, Kiran Durgad, Anupam K Pathni, Sandeep S Gill, Padmaja Jogewar, Madhavi Mallela, Ashish Saxsena, Bipin Gopal, Bidisha Das, Vishwajit Bharadwaj, Pooja Gaigaware, Sreedhar Chintala, Chakshu Joshi, Rupali Bharadwaj, Suyesh Shrivastava, Pankaj Uike, Yannick P Puthussery, Gopinath T Sambandam, R S Dhaliwal, Balram Bhargava","doi":"10.1038/s41371-025-01005-9","DOIUrl":"https://doi.org/10.1038/s41371-025-01005-9","url":null,"abstract":"<p><p>Hypertension control is the crucial indicator for cardiovascular disease programs. We conducted a baseline cross-sectional survey to estimate hypertension awareness, treatment, and control in the selected districts in 2018-19, where the India Hypertension Control Initiative is being implemented. We conducted cross-sectional surveys in nine project districts for 18-69 years age group. The sample size was 624 per district. The study population was individuals with raised BP/diagnosed HT. We estimated the proportion and 95% confidence intervals (CI) for each district's awareness, treatment, and control. We computed unadjusted and adjusted prevalence ratios (APR) with 95% CI for factors associated with BP control. Hypertension was defined as systolic blood pressure (SBP) > = 140 or diastolic blood pressure (DBP) > = 90 mmHg or treatment in the previous two weeks. Control was defined as SBP < 140 and DBP < 90 mmHg. Among 7047 who had hypertension, 52.4% were aware, 40.8% were on treatment, and 14.5% had BP control. BP control was below 5% in two districts, 5-15% in three districts, and more than 15% in four districts. Among hypertensives aware of the diagnosis, the factors (APR with 95% CI) associated with control were lack of alcohol consumption [1.28 (1.09-1.52)], recent visit to government [1.98 (1.57-2.50)] or private facility [1.99 (1.61-2.46)] and treatment with single drug [2.40 (1.98-2.90)] or multiple drugs [2.84 (2.27-3.55)]. The simple, rapid population-based surveys can document awareness, treatment, and control changes. Improving access to treatment for hypertension through the public or private sector should be a high priority for India.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERSPECTIVE – The Growing Global Benefits of Limiting Salt Intake: an urgent call from the World Hypertension League for more effective policy and public health initiatives","authors":"Brent M. Egan,&nbsp;Daniel T. Lackland,&nbsp;Susan E. Sutherland,&nbsp;Michael K. Rakotz,&nbsp;Janet Williams,&nbsp;Yvonne Commodore-Mensah,&nbsp;Daniel W. Jones,&nbsp;Sverre-Erik Kjeldsen,&nbsp;Norm R. C. Campbell,&nbsp;Gianfranco Parati,&nbsp;Feng J. He,&nbsp;Graham A. MacGregor,&nbsp;Michael A. Weber,&nbsp;Paul K. Whelton","doi":"10.1038/s41371-025-00990-1","DOIUrl":"10.1038/s41371-025-00990-1","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"241-245"},"PeriodicalIF":2.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00990-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}