Annabel X Tan, Andrew Y Chang, Daichi Shimbo, Adam Bress, Mario Sims, Michelle C Odden
{"title":"Association of ambient temperature and blood pressure in the Jackson Heart Study.","authors":"Annabel X Tan, Andrew Y Chang, Daichi Shimbo, Adam Bress, Mario Sims, Michelle C Odden","doi":"10.1038/s41371-025-01026-4","DOIUrl":"https://doi.org/10.1038/s41371-025-01026-4","url":null,"abstract":"<p><p>Extreme temperature events related to climate change may impact blood pressure (BP). African American populations are disproportionately affected by temperature extremes due to structural inequities. We examined the association between ambient outdoor temperature and BP among participants in JHS, a cohort of African American adults residing in the tri-county area of Jackson, Mississippi. Our primary hypothesis is that daily higher outdoor ambient temperatures would be associated with lower BP. We used a linear-mixed effects model to determine the relationship between temperature and systolic and diastolic blood pressure (SBP and DBP) at three visits (N = 5296). Participants had BP readings across three visits: Visit 1 (2000-2004), Visit 2 (2005-2008), Visit 3 (2009-2013). Cardiovascular disease (CVD), diabetes, BP medication, sex, age, and visit number were included as adjustment variables. For every 1-degree Celsius higher average temperature from the mean, SBP was 0.11 mm Hg lower (95% CI: -0.14, -0.07, p < 0.001) in adjusted models. Similarly, for every 1-degree Celsius higher average temperature from the mean, DBP was 0.06 mm Hg lower (95% CI: -0.08, -0.04) in adjusted models. The associations were weakly curvilinear (inverted U-shape) with significant quadratic terms. This relationship was not modified by markers of socioeconomic status. This is the first study in the Jackson Heart Study (JHS) to investigate the association between temperature and blood pressure. Further research is needed to explore this relationship in vulnerable populations living in areas prone to extreme temperatures.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The mislaid clue to APOL1 kidney disease prevention in blacks.","authors":"Constance B Hilliard","doi":"10.1038/s41371-025-01024-6","DOIUrl":"https://doi.org/10.1038/s41371-025-01024-6","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helen Shi, Allison Stark, Aloke Maity, Abhishek Shah, Joseph Manganelli, Paula Baichoo, Svetlana Korchevsky, Pooja Suthar, Chenshu Zhang, Sharon Rikin
{"title":"Assessment of clinical pharmacist outreach and medication titration in remote patient monitoring program for hypertension.","authors":"Helen Shi, Allison Stark, Aloke Maity, Abhishek Shah, Joseph Manganelli, Paula Baichoo, Svetlana Korchevsky, Pooja Suthar, Chenshu Zhang, Sharon Rikin","doi":"10.1038/s41371-025-01025-5","DOIUrl":"https://doi.org/10.1038/s41371-025-01025-5","url":null,"abstract":"<p><p>In this implementation science study evaluating the feasibility and effectiveness of a remote patient monitoring program for hypertension, we found that most, but not all of patients received the intended program components of clinical pharmacist outreach and medication titration. Despite feasibility challenges, remote-patient monitoring for hypertension was effective at reducing systolic blood pressure by ≥ 5 mmHg in (64%) and 346 (71%) patients by 3 and 6 months of enrollment respectively. Unexpectedly, chi-square and multivariate logistic regressions analysis showed that the clinical pharmacist outreach, was not associated with blood pressure improvement, but that patient engagement and medication titration were associated with blood pressure improvement. These results suggest that other unmeasured behavioral and lifestyle changes may be a large driver of BP improvement and that while RPM-HTN is a worthwhile intervention, it may not require all ancillary components to deliver meaningful results.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabella Kharraziha, Ensieh Memarian, Örjan Ekblom, Anders Gottsäter, Gunnar Engström, Viktor Hamrefors
{"title":"The relationship between physical activity, orthostatic blood pressure reactions and subclinical atherosclerosis: the Swedish CArdioPulmonary bioImage Study (SCAPIS).","authors":"Isabella Kharraziha, Ensieh Memarian, Örjan Ekblom, Anders Gottsäter, Gunnar Engström, Viktor Hamrefors","doi":"10.1038/s41371-025-01022-8","DOIUrl":"https://doi.org/10.1038/s41371-025-01022-8","url":null,"abstract":"<p><p>An abnormal blood pressure (BP) response on standing is associated with atherosclerotic cardiovascular disease (CVD). The role of physical activity (PA) on orthostatic BP-reactions and its relation to subclinical atherosclerosis is unclear. We aimed to assess the association between PA and orthostatic BP-reactions, and whether PA modifies the relationship between orthostatic BP-reactions and subclinical atherosclerosis. A total of 5,396 middle aged subjects from the population-based SCAPIS-study were included. Associations between orthostatic BP-response and accelerometer-derived PA were studied using linear regression. Interaction analyses were performed to study modifying effects of PA on the relationship between orthostatic BP-response and subclinical coronary atherosclerosis, assessed by coronary artery calcium score (CACS). Moderate to vigorous PA (MVPA) was associated with less pronounced orthostatic systolic BP (SBP) increase but more pronounced orthostatic diastolic BP increase after adjusting for age, sex, total wear time, proportion weekend days and season (Beta per 1%-increase(mmHg):0.12; p = <0.01 and -0.06; p = 0.02, respectively). Subjects with high MVPA were less likely to have orthostatic hypertension (OHTN), but more likely to have orthostatic hypotension (OH; p = 0.002 for both). Individuals with higher CACS were more likely to have OH (p = 0.041) but not OHTN (p = 0.276). There were no interactions of PA on the association between orthostatic BP-response and CACS. In conclusion, physically active middle-aged individuals are less likely to show inappropriate SBP-increase upon standing, but more likely to have excessive SBP-decrease. PA does not modify the association between orthostatic BP-response and subclinical atherosclerosis. The relationship between PA, orthostatic BP and CVD is likely to be complex.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of various legwear during arterial stiffness measurement.","authors":"Taha A Alhalimi, Tianyu Wang, Hirofumi Tanaka","doi":"10.1038/s41371-025-01023-7","DOIUrl":"https://doi.org/10.1038/s41371-025-01023-7","url":null,"abstract":"<p><p>Carotid-femoral pulse wave velocity (cfPWV) is widely used to measure arterial stiffness. The type of legwear worn by participants during the measurement may introduce variabilities because different fabric materials and thicknesses may disturb arterial waveforms. Therefore, we investigated the impact of common legwear on cfPWV measured using tonometry and oscillometry. We studied 50 adults (36 women) varying widely in age (19-78 years). We evaluated cfPWV using two commonly used devices that detect femoral pulses using tonometric and cuff-based oscillometric sensors. The participants wore thin medical shorts as the reference condition, khaki pants, sweatpants, and athletic shorts, with an optional bare skin condition (optimum control) with 10 min of rest between measurements. Both devices produced similar cfPWV among different legwear with no significant systematic differences. The range of cfPWV was 647-649 cm/s for the tonometric device and 482-500 cm/s for the oscillometric device across different types of legwear. Mean values of cfPWV measured with a bare skin condition did not differ significantly from other legwear. No data output rates were 13% for khaki, 6% for sweatpants, 3% for medical shorts, athletic shorts, and bare skin using the tonometry while the oscillometric device had a 0% no data output rate among all conditions. We concluded that relatively thin legwear did not appear to affect arterial stiffness as assessed by cfPWV. However, stiffer legwear, such as khaki pants, presents a challenge to detect femoral pulses when using a tonometric sensor.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Rita Leite, António Angélico-Gonçalves, Adelino Leite-Moreira, João Sérgio Neves, João Pedro Ferreira
{"title":"Blood pressure response to mineralocorticoid receptor antagonists or aldosterone synthase inhibitors according to baseline renin levels.","authors":"Ana Rita Leite, António Angélico-Gonçalves, Adelino Leite-Moreira, João Sérgio Neves, João Pedro Ferreira","doi":"10.1038/s41371-025-01021-9","DOIUrl":"https://doi.org/10.1038/s41371-025-01021-9","url":null,"abstract":"<p><p>Plasma renin is a surrogate marker of sodium retention in hypertension, and its levels are suppressed in conditions of heightened aldosterone production. We performed a random-effects meta-analysis of randomized clinical trials focusing on the impact of mineralocorticoid receptor antagonists (MRA) and aldosterone synthase inhibitors (ASi) on blood pressure according to baseline renin levels. We included four randomized clinical trials, and we found that the response to MRA or ASi was independent of baseline plasma renin levels.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ABSTRACTS FROM THE 6<sup>th</sup> WORLD HYPERTENSION CONGRESS CHENNAI, INDIA.","authors":"","doi":"10.1038/s41371-025-01016-6","DOIUrl":"10.1038/s41371-025-01016-6","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":"1-22"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Healthy lifestyle knowledge and age at hypertension diagnosis: a primary health care based survey in Bangladesh.","authors":"Md Monirul Islam, Md Safayet Hossain, Md Mizanur Rahman, Ryota Nakamura, Motohiro Sato","doi":"10.1038/s41371-025-01019-3","DOIUrl":"https://doi.org/10.1038/s41371-025-01019-3","url":null,"abstract":"<p><p>This study examined the relationship between knowledge of healthy lifestyles and the age of hypertension diagnosis among hypertensive individuals within Bangladeshi rural population. This cross-section study was conducted among hypertensive adults (18-80 years) in a rural population. We obtained data from 3600 adults with hypertension from 40 randomly selected community pharmacies. We gathered data on demographics, health knowledge, and measured vital signs, including hypertension diagnosis year. Multinomial logistic regression analysis was used to identify the lifestyle and knowledge factors about hypertension with the age of diagnosis of hypertension. The mean age of hypertension diagnosis was 45.84 years. The mean age of hypertension diagnosis of male participants was higher than female (48.1 vs 44.4 years). Our study found that males and individuals with primary education are more likely to receive a later hypertension diagnosis (odds ratio = 2.32; 95% confidence interval: 1.75-3.10 and odds ratio = 5.96; 95% confidence interval: 3.09-11.48 respectively) for those aged ≥65. The poorest and those lacking physical exercise faced higher odds of later diagnosis (odds ratio = 2.20; 95% confidence interval: 1.53-3.15 and odds ratio = 2.37; 95% confidence interval: 1.78-3.17 respectively). Conversely, a family history of hypertension reduces the odds (odds ratio = 0.38; 95% confidence interval: 0.27-0.55). Increased knowledge of healthy lifestyle factors and engagement with health-related media correlate with later diagnosis, highlighting the influence of education and awareness on hypertension detection age. Our study reveals that knowledge of a healthy lifestyle is associated with the age of hypertension diagnosis. Targeting specific age groups based on health education programs may reduce hypertension-related complications.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luca Faconti, Louise Abrams, Bernadette Jenner, Eduard Shantsila, Sarah Partridge, Ian B. Wilkinson
{"title":"British and Irish Hypertension Society response to ‘RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines’","authors":"Luca Faconti, Louise Abrams, Bernadette Jenner, Eduard Shantsila, Sarah Partridge, Ian B. Wilkinson","doi":"10.1038/s41371-025-01004-w","DOIUrl":"10.1038/s41371-025-01004-w","url":null,"abstract":"In their review of clinical practice guidelines on the use of renin-angiotensin-aldosterone system (RAAS) inhibitors, Greenlees and Delles call for more explicit advice on the use of these drugs among women of childbearing potential, during pregnancy and breastfeeding. In response, the British and Irish Hypertension Society (BIHS) highlight the key issues for clinicians to consider when prescribing RAAS inhibitors to hypertensive women and suggest areas where further research is needed.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"313-314"},"PeriodicalIF":2.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01004-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Prognostic significance of hypertension at the onset of lupus nephritis in Chinese patients: prevalence and clinical outcomes","authors":"Rong Rong, Qiong Wen, Yating Wang, Qian Zhou, Yagui Qiu, Miaoqing Lu, Xiaotian Liu, Wei Chen, Xueqing Yu","doi":"10.1038/s41371-025-01020-w","DOIUrl":"10.1038/s41371-025-01020-w","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"387-388"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01020-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}