Journal of Human Hypertension最新文献_第10页

Correction: The impact of renal artery stenting on therapeutic aims 更正：肾动脉支架植入术对治疗目标的影响。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-16 DOI: 10.1038/s41371-024-00893-7

Ben Edgar, Robert Pearson, Ram Kasthuri, Keith Gillis, Colin Geddes, Maggie Rostron, Adrian Brady, Keith Hussey, Giles Roditi, Christian Delles, Linsay McCallum, Patrick Mark, David Kingsmore

引用次数: 0

Efficacy and safety of mineralocorticoid receptor antagonists for the treatment of low-renin hypertension: a systematic review and meta-analysis 矿物皮质激素受体拮抗剂治疗低肾素高血压的有效性和安全性：系统回顾和荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-11 DOI: 10.1038/s41371-023-00891-1

Sonali S. Shah, Jinghong Zhang, Stella May Gwini, Morag J. Young, Peter J. Fuller, Jun Yang

{"title":"Efficacy and safety of mineralocorticoid receptor antagonists for the treatment of low-renin hypertension: a systematic review and meta-analysis","authors":"Sonali S. Shah, Jinghong Zhang, Stella May Gwini, Morag J. Young, Peter J. Fuller, Jun Yang","doi":"10.1038/s41371-023-00891-1","DOIUrl":"10.1038/s41371-023-00891-1","url":null,"abstract":"Hypertension is the leading risk factor for premature death. The optimal treatment of low-renin hypertension (LRH), present in 30% of hypertensive individuals, is not known. LRH likely reflects a state of excess salt, expanded volume and/or mineralocorticoid receptor (MR) activation. Therefore, targeted treatment with MR antagonists (MRA) may be beneficial. The objective of this systematic review was to assess the efficacy of MRA therapy in LRH. MEDLINE, Embase and Cochrane databases were searched for randomised controlled trials of adults with LRH that compared the efficacy of MRA to placebo or other antihypertensive treatments. Risk of bias was assessed using the Cochrane risk of bias tool. A meta-analysis was performed using a random-effects model to estimate the difference in blood pressure and the certainty of evidence was assessed using the GRADE approach. The protocol is registered on PROSPERO (CRD42022318763). From the 1612 records identified, 17 studies met the inclusion criteria with a total sample size of 1043 participants. Seven studies (n = 345) were assessed as having a high risk of bias. Meta-analysis indicated that MRA reduced systolic blood pressure by −6.8 mmHg (95% confidence interval −9.6 to −4.1) and −4.8 mmHg (95% confidence interval −11.9 to 2.4) compared to angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARB) and diuretics. The certainty of the evidence was assessed as moderate and very low, respectively. The findings of this systematic review suggest that MRA is effective in lowering blood pressure in LRH and may be better than ACEi/ARB. Translation to clinical practice is limited by the uncertainty of evidence.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"38 5","pages":"383-392"},"PeriodicalIF":2.7,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-023-00891-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity 24 小时动态血压监测中的节律成分在对合并心血管疾病的慢性肾病患者进行风险分层时的预后作用

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-11 DOI: 10.1038/s41371-023-00884-0

Nadim El Jamal, Thomas G. Brooks, Jordana Cohen, Raymond R. Townsend, Giselle Rodriguez de Sosa, Vallabh Shah, Chronic Renal Insufficiency Cohort Study (CRIC) Consortium, Robert G. Nelson, Paul E. Drawz, Panduranga Rao, Zeenat Bhat, Alexander Chang, Wei Yang, Garret A. FitzGerald, Carsten Skarke

{"title":"Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity","authors":"Nadim El Jamal, Thomas G. Brooks, Jordana Cohen, Raymond R. Townsend, Giselle Rodriguez de Sosa, Vallabh Shah, Chronic Renal Insufficiency Cohort Study (CRIC) Consortium, Robert G. Nelson, Paul E. Drawz, Panduranga Rao, Zeenat Bhat, Alexander Chang, Wei Yang, Garret A. FitzGerald, Carsten Skarke","doi":"10.1038/s41371-023-00884-0","DOIUrl":"10.1038/s41371-023-00884-0","url":null,"abstract":"Chronic kidney disease (CKD) represents a significant global burden. Hypertension is a modifiable risk factor for rapid progression of CKD. We extend the risk stratification by introducing the non-parametric determination of rhythmic components in 24-h profiles of ambulatory blood pressure monitoring (ABPM) in the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study for Kidney Disease and Hypertension (AASK) cohort using Cox proportional hazards models. We find that rhythmic profiling of BP through JTK_CYCLE analysis identifies subgroups of CRIC participants that were more likely to die due to cardiovascular causes. While our fully adjusted model shows a trend towards a significant association between absent cyclic components and cardiovascular death in the full CRIC cohort (HR: 1.71,95% CI: 0.99–2.97, p = 0.056), CRIC participants with a history of cardiovascular disease (CVD) and absent cyclic components in their BP profile had at any time a 3.4-times higher risk of cardiovascular death than CVD patients with cyclic components present in their BP profile (HR: 3.37, 95% CI: 1.45–7.87, p = 0.005). This increased risk was not explained by the dipping or non-dipping pattern in ABPM. Due to the large differences in patient characteristics, the results do not replicate in the AASK cohort. This study suggests rhythmic blood pressure components as a potential novel biomarker to unmask excess risk among CKD patients with prior cardiovascular disease.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"38 5","pages":"420-429"},"PeriodicalIF":2.7,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-023-00884-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139420525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis 日本出生队列联合会的不孕症治疗与妊娠高血压疾病之间的关系：一项荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-10 DOI: 10.1038/s41371-023-00890-2

Mami Ishikuro, Tomoko Nishimura, Hiroyoshi Iwata, Hirohito Metoki, Taku Obara, Noriyuki Iwama, Keiko Murakami, Md. Shafiur Rahman, Maki Tojo, Sumitaka Kobayashi, Chihiro Miyashita, Keiko Tanaka, Yoshihiro Miyake, Kazue Ishitsuka, Reiko Horikawa, Naho Morisaki, Midori Yamamoto, Kenichi Sakurai, Chisato Mori, Atsushi Shimizu, Fumihiro Sata, Kenji J. Tsuchiya, Reiko Kishi, Shinichi Kuriyama, the Japan Birth Cohort Consortium

引用次数: 0

Adult hypertension referral pathway and therapeutic management: British and Irish Hypertension Society position statement 成人高血压转诊途径和治疗管理：英国和爱尔兰高血压学会立场声明。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-09 DOI: 10.1038/s41371-023-00882-2

Philip Lewis, Jacob George, Vikas Kapil, Neil R. Poulter, Sarah Partridge, James Goodman, Luca Faconti, Terry McCormack, Ian B. Wilkinson

引用次数: 0

Efficacy and safety of esaxerenone (CS-3150) in primary hypertension: a meta-analysis 埃沙塞酮（CS-3150）对原发性高血压的疗效和安全性：一项荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-04 DOI: 10.1038/s41371-023-00889-9

Ran Sun, Yali Li, Lei Lv, Weiliang Zhang, Xiaoxia Guo

引用次数: 0

Trends in antihypertensive use among privately insured hypertensive clients in Ghana 加纳私人投保的高血压患者使用降压药的趋势

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-02 DOI: 10.1038/s41371-023-00885-z

Afia Frimpomaa Asare Marfo, John Serbe Marfo, Jacob Plange-Rhule, Samantha Hollingworth

{"title":"Trends in antihypertensive use among privately insured hypertensive clients in Ghana","authors":"Afia Frimpomaa Asare Marfo, John Serbe Marfo, Jacob Plange-Rhule, Samantha Hollingworth","doi":"10.1038/s41371-023-00885-z","DOIUrl":"https://doi.org/10.1038/s41371-023-00885-z","url":null,"abstract":"<p>The objective of the study was to describe the patterns of antihypertensive medicines (AHM) in a selected national population in Ghana. The claims data for all privately insured patients in Ghana over three years to 2018 were analysed. The classes of medicines used, the dose by time, gender and age, and generic status were examined. In addition, the use in Defined Daily Dose (DDD) per 1000 population per day was estimated. Classes of AHM prescribed were CCB, ARB, ACEI, diuretics, and BB. Amlodipine, nifedipine, losartan, lisinopril, and bendroflumethiazide accounted for 74% of all use. The most widely used single CCB was amlodipine 3.92 DDD/1,000 population/day in 2016, 3.92 DDD/1,000 population/day in 2017, and 4.92 DDD/1,000 population/day in 2018. In those aged 51–60 years, use of CCB in women (74.0 DDD/1,000 population/day) was almost twice that of men (38.3 DDD/1,000 population/day). The top ten medicines accounted for 93% of all single medicine products in 2018. Most single medicine products was generic (76.5% in 2016; 79.9% in 2017 and 83.1% in 2018) whiles most fixed combination products were branded (73.0% in 2016; 89.7% in 2017 and 91.3% in 2018). The patterns of AHM use are clinically expected although the Ghana Standard Treatment guidelines are not directive about lines of treatment.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"6 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139078294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application value of serum S100B combined with glucose metabolism indexes in predicting adverse pregnancy outcomes of patients with severe preeclampsia 血清 S100B 结合糖代谢指标在预测重度子痫前期患者不良妊娠结局中的应用价值

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2023-12-30 DOI: 10.1038/s41371-023-00887-x

Aiqin Yan

{"title":"Application value of serum S100B combined with glucose metabolism indexes in predicting adverse pregnancy outcomes of patients with severe preeclampsia","authors":"Aiqin Yan","doi":"10.1038/s41371-023-00887-x","DOIUrl":"10.1038/s41371-023-00887-x","url":null,"abstract":"S100 calcium-binding protein B (S100B) and glucose control are reflective of maternal-fetal risks. We investigated the value of serum S100B combined with fasting blood glucose (FBG)/hemoglobin A1c (HbA1c) in evaluating the pregnancy outcomes of patients with severe preeclampsia (SPE). The clinical characteristics of SPE patients/controls were collected. FBG/HbA1c and serum S100B levels were measured, with their correlations analyzed. SPE patients were subdivided into adverse/non-adverse outcome groups based on follow-up results. The value of different indexes in predicting pregnancy outcomes was analyzed. SPE patients showed higher systolic blood pressure, diastolic blood pressure, urine protein, and body mass index and lower platelets, gestational age at delivery, and infant birth weight than healthy controls. FBG and HbA1c were positively correlated with serum S100B. SPE patients with adverse outcomes exhibited increased serum S100B and FBG/HbA1c levels. The area under the curve of serum S100B + FBG/HbA1c in evaluating adverse pregnancy outcomes of SPE patients was 0.8412 (77.05% sensitivity/84.21% specificity), higher than either alone. Serum S100B and FBG/HbA1c were independent risk factors for adverse outcomes of SPE patients. Overall, serum S100B positively-correlates with FBG/HbA1c in SPE patients. Serum S100B and FBG/HbA1c are independent risk factors, and their combination has high value on predicting adverse pregnancy outcomes of SPE patients.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"38 3","pages":"232-237"},"PeriodicalIF":2.7,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139071913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inter-arm blood pressure difference in post-stroke patients with hemiparesis 中风后偏瘫患者手臂间的血压差异。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2023-12-27 DOI: 10.1038/s41371-023-00886-y

Hai-ping PENG, Liang TAO, Min TANG, Hai SU

引用次数: 0

Spot urinary sodium-to-potassium ratio is associated with blood pressure levels in healthy adolescents: the Wakayama Study 斑尿钠钾比值与健康青少年的血压水平有关：和歌山研究

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2023-12-19 DOI: 10.1038/s41371-023-00883-1

Yan Zhang, Nobuyuki Miyai, Miyoko Utsumi, Kazuhisa Miyashita, Mikio Arita

{"title":"Spot urinary sodium-to-potassium ratio is associated with blood pressure levels in healthy adolescents: the Wakayama Study","authors":"Yan Zhang, Nobuyuki Miyai, Miyoko Utsumi, Kazuhisa Miyashita, Mikio Arita","doi":"10.1038/s41371-023-00883-1","DOIUrl":"10.1038/s41371-023-00883-1","url":null,"abstract":"The spot urinary sodium-to-potassium (Na/K) ratio is a simple measure of salt loading and has been shown to be associated with elevated blood pressure (BP) in middle-aged and older adults. This study aimed to evaluate the association between the spot urinary Na/K ratio and BP in 457 healthy adolescents aged 12–15 years in a school-based setting. The mean urinary Na/K ratio was 4.99 ± 2.76, and no significant difference was found between the boys and girls. When the participants were stratified based on urinary Na/K ratio quartile, age- and sex-adjusted systolic and diastolic BP gradually increased as Na/K ratio increased (systolic BP: 106.1, 106.9, 108.2, and 111.5 mmHg, Ptrend < 0.001; diastolic BP: 62.0, 62.4, 63.1, 64.3 mmHg, Ptrend = 0.022). The systolic and diastolic BP were more closely associated with urinary Na/K ratio than with Na and K levels, as well as estimated daily salt intake. In the multiple regression analysis, the urinary Na/K ratio was significantly associated with systolic BP (β = 0.144, P < 0.001) and diastolic BP (β = 0.114, P = 0.015) independent of potential confounding factors. An additional subgroup analysis revealed that the BP of the group with both high salt intake (≥8.5 g/day) and high Na/K ratio (≥6.60) was significantly higher than that of the group with high salt intake alone (systolic BP, 115.0 vs. 109.1 mmHg, P < 0.001; diastolic BP, 66.0 vs. 62.5 mmHg, P = 0.017). These results suggest that the urinary Na/K ratio is associated with BP levels in healthy adolescents and may be useful for assessing salt loading and its effects on BP elevation.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"38 3","pages":"238-244"},"PeriodicalIF":2.7,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138744711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0