Journal of Human Hypertension最新文献

{"title":"Blood pressure variability in CKD patients with and without nocturnal hypertension","authors":"Artemios G. Karagiannidis, Marieta P. Theodorakopoulou, Fotini Iatridi, Maria Schoina, Erasmia Sampani, Ioannis Mykoniatis, Konstantinos Stavropoulos, Vasileios Kamperidis, Mehmet Kanbay, Pantelis Sarafidis","doi":"10.1038/s41371-025-00998-7","DOIUrl":"10.1038/s41371-025-00998-7","url":null,"abstract":"Nocturnal hypertension is highly prevalent in patients with chronic kidney disease (CKD) and represents a strong predictor of cardiovascular events. Increased blood pressure variability (BPV) is also independently associated with cardiovascular events in these patients. Differences in short-term BPV indices between CKD patients with and without nocturnal hypertension have not been previously studied. This study included 96 patients (73 with and 23 without nocturnal hypertension) who underwent 24-h ambulatory BP measurement. Standard deviation (SD), weighted SD (wSD), coefficient of variation (CV), and average real variability (ARV) of systolic (SBP) and diastolic blood pressure (DBP) were calculated using validated formulas for the 24-h and the respective daytime (07:00–23:00) and nighttime (23:00–07:00) periods. 24-h, daytime and nighttime SBP and DBP were higher in patients with nocturnal hypertension. During the 24-h period, wSD and ARV for 24-h SBP (wSD, 14.0 ± 3.8 vs 11.7 ± 3.1 mmHg, p = 0.009; ARV, 10.5 ± 2.7 vs 9.2 ± 1.9 mmHg, p = 0.035) and 24-h DBP were higher in patients with nocturnal hypertension. Regarding the daytime period, patients with nocturnal hypertension presented higher daytime SD and ARV for SBP (SD, 14.8 ± 4.0 vs 13.0 ± 3.6 mmHg, p = 0.008; ARV; 10.5 ± 3.2 vs 9.1 ± 2.0 mmHg, p = 0.016) and DBP, with daytime SBP and DBP CV being numerically but not significantly higher (p = 0.110 and p = 0.08 respectively). During the nighttime period, no significant differences between groups were present for all nighttime BPV indices. In conclusion, CKD patients with nocturnal hypertension have higher systolic and diastolic BPV indices during the 24-h and daytime periods, but not the nighttime period. These findings signify that increased BPV may be responsible for higher cardiovascular risk in CKD patients with compared to those without nocturnal hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"286-292"},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CITED2 is highly-expressed and PRX4 is poorly-expressed in preeclampsia and have diagnostic values","authors":"Caixia Yang, Zhiying Song","doi":"10.1038/s41371-025-00995-w","DOIUrl":"10.1038/s41371-025-00995-w","url":null,"abstract":"This study aims to investigate the differential level of CITED2 and PRX4 in the serum of preeclampsia (PE) patients and to explore their clinical value in PE diagnosis, severity assessment, and pregnancy outcomes. A total of 110 singleton pregnant women with PE were included, consisting of 57 cases of mild PE and 53 cases of severe PE, with 110 healthy singleton pregnant women enrolled as the normal control. The baseline clinical characteristics were analyzed using chi-square test and independent samples t-test. CITED2 and PRX4 concentrations were measured by ELISA and their diagnostic efficacy for PE was evaluated through ROC curves. Multivariate logistic regression analysis was conducted to identify factors associated with adverse pregnancy outcomes in PE patients. Compared to the healthy group, CITED2 serum levels in PE patients were significantly increased, while PRX4 levels were significantly decreased. CITED2 and PRX4 can diagnose PE, distinguish between mild and severe PE, and be associate with adverse pregnancy outcomes in PE patients. The diagnostic efficacy was better when CITED2 and PRX4 were combined. The serum levels of CITED2 were further elevated and PRX4 levels were further reduced in patients with severe PE and adverse pregnancy outcomes. CITED2 was an independent risk factor and PRX4 was a protective factor for adverse pregnancy outcomes in PE patients. In conclusion, CITED2 and PRX4 can diagnose PE, assess PE severity, and are associated with PE outcomes.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"293-300"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of semi-quantitative gold nanoparticle-based quick cortisol assay with and without adrenocorticotropic hormone infusion during adrenal vein sampling","authors":"Felicity Stringer, Pamela Franco, Landy M. Wu, Christopher A. Preston, Maresa M. Derbyshire, Richard J. MacIsaac, Eric X. Z. Yong, Benjamin Marginson, Nirupa Sachithanandan","doi":"10.1038/s41371-025-00997-8","DOIUrl":"10.1038/s41371-025-00997-8","url":null,"abstract":"Adrenal vein sampling (AVS) is the gold standard for diagnosing unilateral primary aldosteronism. Point-of-care rapid cortisol assays such as the gold nanoparticle based quick cortisol assay (QCA) are used to confirm accurate cannulation of the adrenal veins during the procedure and have improved AVS success rates. In this retrospective cohort study, we reviewed the results of consecutive AVS procedures (n = 37) performed with and without ACTH (synacthen) infusion between October 2020 and December 2022 at our institution. We compared (1) the accuracy of point-of-care QCA at semi-quantitatively assessing successful adrenal vein cannulation before and after ACTH infusion when compared with selectivity index based on laboratory cortisol measurements, (2) accuracy of QCA based on peripheral and adrenal vein cortisol levels and (3) the impact of time of day on the accuracy of QCA. We found the accuracy of QCA compared with formal laboratory cortisol measurements was 71% pre-ACTH and 100% post-ACTH (p-value < 0.001). Pre-ACTH, the accuracy of QCA was higher in the lowest (28–257 nmol/L) and highest (466–25130 nmol/L) adrenal vein cortisol tertiles compared to the mid-tertile. Post-ACTH, the accuracy of QCA remained high regardless of adrenal vein cortisol levels. Time of day did not affect the accuracy of the QCA. We conclude that during basal AVS subjective, visual estimates of adrenal vein cortisol levels using the QCA semi-quantitively should not be solely relied upon to guide catheter placement. These results will help guide clinicians in the appropriate clinical situations in which QCA should be used during AVS.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"279-285"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00997-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported hypertension prevalence, risk factors, and knowledge among South Africans aged 24 to 40 years old","authors":"Asanda Mtintsilana, Witness Mapanga, Ashleigh Craig, Siphiwe N. Dlamini, Shane A. Norris","doi":"10.1038/s41371-024-00957-8","DOIUrl":"10.1038/s41371-024-00957-8","url":null,"abstract":"Although hypertension is a significant public health burden in South Africa (SA), less is known about its prevalence, risk factors, and possible preventative strategies among young adults. We assessed the prevalence, possible risk factors, and knowledge associated with self-reported hypertension among young adults from SA. A cross-sectional online survey was conducted among 1000 young South African adults (24–40 years; 51.0% women). We administered a socio-demographic questionnaire and collected information on measures of socio-economic status (SES) (e.g. asset wealth index), self-reported medical history, and lifestyle risk factors. Furthermore, a modified version of the hypertension evaluation of lifestyle and management questionnaire was used to assess participants’ hypertension knowledge. The overall prevalence of self-reported hypertension was 24.0%, with significant differences between women and men (27.5% and 20.4% respectively, p = 0.033). Only 16.8% of the respondents had good hypertension knowledge. There was a positive association between good knowledge of hypertension and being hypertensive (OR = 1.43 CI:1.23–3.12), monthly blood pressure check-ups (OR = 2.03 CI:1.78–3.23), knowing the side effects of uncontrolled blood pressure (OR = 1.28 CI:1.07–1.89) and having a biological mother with hypertension (OR = 1.79 CI:1.53–2.21). Being employed full-time (OR = 0.74 CI:0.69–0.80), having a higher SES (wealth index 4 (OR = 0.70 CI:0.59–0.97) and 5 (OR = 0.65 CI:0.48–0.81)), exercising 6 to 7 days per week (OR = 0.83 CI:0.71–0.94), and not consuming alcohol at all (OR = 0.73 CI:0.67–0.89), were all found to be protective against hypertension. The high hypertension prevalence, lack of hypertension knowledge, and reported risk factors among this group highlight the need for early robust preventative strategies to mitigate hypertension risk among this population.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 2","pages":"177-187"},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-024-00957-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiethnic norms for blood pressure response to submaximal exercise testing in young-to-middle adulthood and associations with hypertension: The NHANES dataset","authors":"João L. Marôco","doi":"10.1038/s41371-025-00993-y","DOIUrl":"10.1038/s41371-025-00993-y","url":null,"abstract":"The blood pressure (BP) response during exercise testing is a robust correlate of hypertension in middle-to-older White people, but whether this extends to a healthy, young-to-middle-aged multiethnic population is unknown. Moreover, it is unclear what constitutes an exaggerated BP to submaximal exercise, which is a more reliable and stronger correlate of hypertension than maximal testing. The NHANES dataset was used to interrogate the association of submaximal exercise BP with current hypertension and to provide multiethnic norms for BP responses in young-to-middle-aged adults. The analyses combined NHANES cycles wherein treadmill exercise testing was conducted with an analytic sample of 2544 participants aged 12–49 years (Female: White = 467; Black = 324; Hispanic = 439; Male: White = 493, Black = 351; Hispanic = 470). Weighted logistic models were fitted to test associations between exercise BP and hypertension. Age, sex, and race-specific percentiles were estimated. Exaggerated systolic BP (SBP) responses to exercise testing were defined as readings ≥90th percentile, and ≥ROC-derived cutoff. Regardless of race, sex, exercise workload, clinical and socioeconomic characteristics, a 5-mmHg increase in SBP and diastolic BP during stage 1 of exercise testing was associated with a 15% (aOR: 1.15, 95% CI: 1.08–1.21), and 31% (aOR: 1.31, 95% CI: 1.22–1.40) higher odds for hypertension, respectively. Black males had the highest proportion of exaggerated SBP responses (44%, 95% CI: 36–53%) when defined only via ROC-derived cutoffs. BP responses during submaximal exercise were associated with hypertension, irrespective of race in young-to-middle adulthood. Still, the exaggerated SBP response to exercise of Black males suggests uncontrolled high BP not detected at rest.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"262-273"},"PeriodicalIF":2.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China","authors":"Zhe Chen, Dongming Guo, Lifeng Xiao, Honghui Su, Yirun Chen","doi":"10.1038/s41371-025-00992-z","DOIUrl":"10.1038/s41371-025-00992-z","url":null,"abstract":"This study investigated the association between fat-to-muscle ratio (FMR) and hypertension. A total of 1592 participants aged ≥ 40 years were included. Participants were divided into four groups by quartiles of FMR. Odds ratio (OR) and 95% confidence interval (CI) was calculated using logistic regression models. Restricted cubic spline was applied to examine the correlation of FMR and hypertension. Of 1592 participants, 943 (59.2%) participants had hypertension. Hypertension risk rose with FMR quartiles. Compared to FMR quartile 1, ORs were 1.496 (95% CI: 1.115–2.006), 2.445 (95% CI: 1.840–3.249), and 5.415 (95% CI: 3.993–7.344) for quartiles 2, 3, and 4, respectively (P for trend < 0.001). Adjusted OR in quartile 4 was 3.015 (95% CI: 2.083–4.365). Restricted cubic spline showed a linear relationship between FMR and hypertension. Adding FMR improved hypertension risk model performance (P = 0.006). Subgroup analysis revealed FMR interactions with sex (P = 0.010) and BMI (P < 0.016), with a higher hypertension risk in females and non-obese individuals. Additionally, versus FMR quartile 1, hypertensive individuals in quartiles 2 (OR: 1.370, 95% CI: 0.900–2.085), 3 (OR: 2.055, 95% CI: 1.374–3.073) and 4 (OR: 3.102, 95% CI: 2.055–4.682) exhibited a significantly elevated risk of atherosclerotic cardiovascular disease (ASCVD). In summary, Elevated FMR independently correlated with hypertension risk, especially in women, or even in non-obese individuals. FMR is a valuable tool for identifying populations with higher hypertension risk and assessing ASCVD risk in hypertensive individuals. Body composition warrants consideration in future hypertension risk studies.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"301-307"},"PeriodicalIF":2.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we detect masked hypertension and masked uncontrolled hypertension using simple metrics? A novel clinical model for latino population","authors":"Camila Ponce-Acosta, Neftali Eduardo Antonio-Villa","doi":"10.1038/s41371-025-00996-9","DOIUrl":"10.1038/s41371-025-00996-9","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"189-191"},"PeriodicalIF":2.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of primary aldosteronism 20 years after surgery: a case report","authors":"Jie Wang, Cai-Ni Fan, Guo-Xi Wei, Xiao-Jian Zhao, Kai Liu, Meng-Lin Wang, Ling Li, Min Liu, Hai-Ying Zhao","doi":"10.1038/s41371-025-00994-x","DOIUrl":"10.1038/s41371-025-00994-x","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"237-239"},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to lifestyle modifications and its associated factors among adult hypertensive patients attending their follow-up at public hospitals in West Shoa, Oromia, Ethiopia, 2023","authors":"Demessie Diriba, Dereje Guta","doi":"10.1038/s41371-025-00991-0","DOIUrl":"10.1038/s41371-025-00991-0","url":null,"abstract":"Hypertension is a serious public health concern, disturbing millions of lives worldwide. Effective lifestyle modifications are the foundation for the prevention and control of hypertension. The aim of this study is to assess adherence to lifestyle modifications and associated factors among adult hypertensive patients in West Shoa, Oromia, Ethiopia. An institutional-based cross-sectional study design was employed from August 20 to September 20, 2023. A systematic random sampling technique was employed to select study participants. A binary logistic regression model was used to check the association between independent and outcome variables. The strength of the association was stated using an adjusted odds ratio with a 95% confidence interval and a p-value of < 0.05. The study included 316 study participants, with a 98.8% response rate. The magnitude of adherence to lifestyle modifications was 31% (95%CI: 25.7–36.1%). Age (AOR = 2.71, 95% CI: 1.19–6.19), residence (AOR = 0.19, 95%CI: 0.09–0.39), duration of treatment (AOR = 2.17, 95%CI: 1.14–4.13), attitude (AOR = 2.14, 95%CI: 1.06–4.30), perceived social support (AOR = 6.23, 95%CI: 3.18–12.22) and self-efficacy (AOR = 2.66, 95%CI: 1.25–5.69) were the independent predictors of lifestyle modifications adherence. This study found that adherence to lifestyle modifications was low among hypertensive patients.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"192-198"},"PeriodicalIF":2.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00991-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotlight on hypertension in the African Continent","authors":"Zakirullah Khan, Sunil K. Nadar","doi":"10.1038/s41371-025-00989-8","DOIUrl":"10.1038/s41371-025-00989-8","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 2","pages":"80-82"},"PeriodicalIF":2.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00989-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}