Journal of Human Hypertension最新文献_第9页

Individual versus integration of multiple components of central blood pressure and aortic stiffness in predicting cardiovascular mortality in end-stage renal diseases 在预测终末期肾病患者心血管死亡率时，中心血压和主动脉僵硬度多个组成部分的单独预测与综合预测的比较

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-20 DOI: 10.1038/s41371-023-00888-w

Nadège Côté, Catherine Fortier, Louis-Charles Desbiens, János Nemcsik, Mohsen Agharazii

{"title":"Individual versus integration of multiple components of central blood pressure and aortic stiffness in predicting cardiovascular mortality in end-stage renal diseases","authors":"Nadège Côté, Catherine Fortier, Louis-Charles Desbiens, János Nemcsik, Mohsen Agharazii","doi":"10.1038/s41371-023-00888-w","DOIUrl":"10.1038/s41371-023-00888-w","url":null,"abstract":"Aortic stiffness, measured by carotid-femoral pulse wave velocity (PWV), is a predictor of cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD). Aortic stiffness increases aortic systolic and pulse pressures (cSBP, cPP) and augmentation index adjusted for a heart rate of 75 beats per minute (AIx@75). In this study, we examined if the integration of multiple components of central blood pressure and aortic stiffness (ICPS) into risk score categories could improve CV mortality prediction in ESRD. In a prospective cohort of 311 patients with ESRD on dialysis who underwent vascular assessment at baseline, 118 CV deaths occurred after a median follow-up of 3.1 years. The relationship between hemodynamic parameters and CV mortality was analyzed through Kaplan–Meier and Cox survival analysis. ICPS risk score from 0 to 5 points were calculated from points given to tertiles, and were regrouped into three risk categories (Average, High, Very-High). A strong association was found between the ICPS risk categories and CV mortality (High risk HR = 2.20, 95% CI: 1.05–4.62, P = 0.036); Very-High risk (HR = 4.44, 95% CI: 2.21–8.92, P < 0.001) as compared to the Average risk group. The Very-High risk category remained associated with CV mortality (HR = 3.55, 95% CI: 1.37–9.21, P = 0.009) after adjustment for traditional CV risk factors as compared to the Average risk group. While higher C-statistics value of ICPS categories (C: 0.627, 95% CI: 0.578–0.676, P = 0.001) was not statistically superior to PWV, cPP or AIx@75, the use of ICPS categories resulted in a continuous net reclassification index of 0.56 (95% CI: 0.07–0.99). In conclusion, integration of multiple components of central blood pressure and aortic stiffness may potentially be useful for better prediction of CV mortality in this cohort.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139510374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incremental health care expenditures associated with hypertension in South Korea 韩国与高血压相关的医疗支出递增。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-16 DOI: 10.1038/s41371-024-00892-8

Minji Hong, Bomgyeol Kim, Hyuk-Jae Chang, Tae Hyun Kim

{"title":"Incremental health care expenditures associated with hypertension in South Korea","authors":"Minji Hong, Bomgyeol Kim, Hyuk-Jae Chang, Tae Hyun Kim","doi":"10.1038/s41371-024-00892-8","DOIUrl":"10.1038/s41371-024-00892-8","url":null,"abstract":"Hypertension is a significant risk factor for cardiovascular disease and the number of deaths due to hypertension increases annually. The increasing healthcare costs of hypertension are a major societal and personal issue. By estimating the medical expenses incurred by patients with hypertension, this study aimed to provide information on the additional costs of hypertension and emphasize the importance of blood pressure management. Health Panel data from 2014 to 2018 were used to calculate incremental out-of-pocket healthcare costs associated with hypertension. First, we compared the mean annual differences in medical expenditure of people with and without hypertension each year. Second, we analyzed five-year panel data from 2014 to 2018 using random Generalized Least Squares. In a cross-sectional mean difference analysis, we found that as of 2018, individuals with hypertension spent an average of 545,489 won more per year on healthcare than those without hypertension. In a five-year panel data analysis, hypertension was associated with an average of 338,799 won in medical expenses per year for the same sex, age, income groups, number of cormorbility and other lifestyle factor. Hypertension incurs incremental costs in treating the condition and its complications. This study aimed to provide information on out-of-pocket healthcare costs associated with hypertension. We highlight the importance of ongoing disease management by discussing the financial burden of chronic diseases on individuals. Managing blood pressure at a young age can reduce healthcare costs throughout an individual’s lifetime.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: The impact of renal artery stenting on therapeutic aims 更正：肾动脉支架植入术对治疗目标的影响。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-16 DOI: 10.1038/s41371-024-00893-7

Ben Edgar, Robert Pearson, Ram Kasthuri, Keith Gillis, Colin Geddes, Maggie Rostron, Adrian Brady, Keith Hussey, Giles Roditi, Christian Delles, Linsay McCallum, Patrick Mark, David Kingsmore

引用次数: 0

Efficacy and safety of mineralocorticoid receptor antagonists for the treatment of low-renin hypertension: a systematic review and meta-analysis 矿物皮质激素受体拮抗剂治疗低肾素高血压的有效性和安全性：系统回顾和荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-11 DOI: 10.1038/s41371-023-00891-1

Sonali S. Shah, Jinghong Zhang, Stella May Gwini, Morag J. Young, Peter J. Fuller, Jun Yang

{"title":"Efficacy and safety of mineralocorticoid receptor antagonists for the treatment of low-renin hypertension: a systematic review and meta-analysis","authors":"Sonali S. Shah, Jinghong Zhang, Stella May Gwini, Morag J. Young, Peter J. Fuller, Jun Yang","doi":"10.1038/s41371-023-00891-1","DOIUrl":"10.1038/s41371-023-00891-1","url":null,"abstract":"Hypertension is the leading risk factor for premature death. The optimal treatment of low-renin hypertension (LRH), present in 30% of hypertensive individuals, is not known. LRH likely reflects a state of excess salt, expanded volume and/or mineralocorticoid receptor (MR) activation. Therefore, targeted treatment with MR antagonists (MRA) may be beneficial. The objective of this systematic review was to assess the efficacy of MRA therapy in LRH. MEDLINE, Embase and Cochrane databases were searched for randomised controlled trials of adults with LRH that compared the efficacy of MRA to placebo or other antihypertensive treatments. Risk of bias was assessed using the Cochrane risk of bias tool. A meta-analysis was performed using a random-effects model to estimate the difference in blood pressure and the certainty of evidence was assessed using the GRADE approach. The protocol is registered on PROSPERO (CRD42022318763). From the 1612 records identified, 17 studies met the inclusion criteria with a total sample size of 1043 participants. Seven studies (n = 345) were assessed as having a high risk of bias. Meta-analysis indicated that MRA reduced systolic blood pressure by −6.8 mmHg (95% confidence interval −9.6 to −4.1) and −4.8 mmHg (95% confidence interval −11.9 to 2.4) compared to angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARB) and diuretics. The certainty of the evidence was assessed as moderate and very low, respectively. The findings of this systematic review suggest that MRA is effective in lowering blood pressure in LRH and may be better than ACEi/ARB. Translation to clinical practice is limited by the uncertainty of evidence.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-023-00891-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity 24 小时动态血压监测中的节律成分在对合并心血管疾病的慢性肾病患者进行风险分层时的预后作用

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-11 DOI: 10.1038/s41371-023-00884-0

Nadim El Jamal, Thomas G. Brooks, Jordana Cohen, Raymond R. Townsend, Giselle Rodriguez de Sosa, Vallabh Shah, Chronic Renal Insufficiency Cohort Study (CRIC) Consortium, Robert G. Nelson, Paul E. Drawz, Panduranga Rao, Zeenat Bhat, Alexander Chang, Wei Yang, Garret A. FitzGerald, Carsten Skarke

{"title":"Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity","authors":"Nadim El Jamal, Thomas G. Brooks, Jordana Cohen, Raymond R. Townsend, Giselle Rodriguez de Sosa, Vallabh Shah, Chronic Renal Insufficiency Cohort Study (CRIC) Consortium, Robert G. Nelson, Paul E. Drawz, Panduranga Rao, Zeenat Bhat, Alexander Chang, Wei Yang, Garret A. FitzGerald, Carsten Skarke","doi":"10.1038/s41371-023-00884-0","DOIUrl":"10.1038/s41371-023-00884-0","url":null,"abstract":"Chronic kidney disease (CKD) represents a significant global burden. Hypertension is a modifiable risk factor for rapid progression of CKD. We extend the risk stratification by introducing the non-parametric determination of rhythmic components in 24-h profiles of ambulatory blood pressure monitoring (ABPM) in the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study for Kidney Disease and Hypertension (AASK) cohort using Cox proportional hazards models. We find that rhythmic profiling of BP through JTK_CYCLE analysis identifies subgroups of CRIC participants that were more likely to die due to cardiovascular causes. While our fully adjusted model shows a trend towards a significant association between absent cyclic components and cardiovascular death in the full CRIC cohort (HR: 1.71,95% CI: 0.99–2.97, p = 0.056), CRIC participants with a history of cardiovascular disease (CVD) and absent cyclic components in their BP profile had at any time a 3.4-times higher risk of cardiovascular death than CVD patients with cyclic components present in their BP profile (HR: 3.37, 95% CI: 1.45–7.87, p = 0.005). This increased risk was not explained by the dipping or non-dipping pattern in ABPM. Due to the large differences in patient characteristics, the results do not replicate in the AASK cohort. This study suggests rhythmic blood pressure components as a potential novel biomarker to unmask excess risk among CKD patients with prior cardiovascular disease.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-023-00884-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139420525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis 日本出生队列联合会的不孕症治疗与妊娠高血压疾病之间的关系：一项荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-10 DOI: 10.1038/s41371-023-00890-2

Mami Ishikuro, Tomoko Nishimura, Hiroyoshi Iwata, Hirohito Metoki, Taku Obara, Noriyuki Iwama, Keiko Murakami, Md. Shafiur Rahman, Maki Tojo, Sumitaka Kobayashi, Chihiro Miyashita, Keiko Tanaka, Yoshihiro Miyake, Kazue Ishitsuka, Reiko Horikawa, Naho Morisaki, Midori Yamamoto, Kenichi Sakurai, Chisato Mori, Atsushi Shimizu, Fumihiro Sata, Kenji J. Tsuchiya, Reiko Kishi, Shinichi Kuriyama, the Japan Birth Cohort Consortium

引用次数: 0

Adult hypertension referral pathway and therapeutic management: British and Irish Hypertension Society position statement 成人高血压转诊途径和治疗管理：英国和爱尔兰高血压学会立场声明。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-09 DOI: 10.1038/s41371-023-00882-2

Philip Lewis, Jacob George, Vikas Kapil, Neil R. Poulter, Sarah Partridge, James Goodman, Luca Faconti, Terry McCormack, Ian B. Wilkinson

引用次数: 0

Efficacy and safety of esaxerenone (CS-3150) in primary hypertension: a meta-analysis 埃沙塞酮（CS-3150）对原发性高血压的疗效和安全性：一项荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-04 DOI: 10.1038/s41371-023-00889-9

Ran Sun, Yali Li, Lei Lv, Weiliang Zhang, Xiaoxia Guo

引用次数: 0

Trends in antihypertensive use among privately insured hypertensive clients in Ghana 加纳私人投保的高血压患者使用降压药的趋势

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2024-01-02 DOI: 10.1038/s41371-023-00885-z

Afia Frimpomaa Asare Marfo, John Serbe Marfo, Jacob Plange-Rhule, Samantha Hollingworth

{"title":"Trends in antihypertensive use among privately insured hypertensive clients in Ghana","authors":"Afia Frimpomaa Asare Marfo, John Serbe Marfo, Jacob Plange-Rhule, Samantha Hollingworth","doi":"10.1038/s41371-023-00885-z","DOIUrl":"https://doi.org/10.1038/s41371-023-00885-z","url":null,"abstract":"<p>The objective of the study was to describe the patterns of antihypertensive medicines (AHM) in a selected national population in Ghana. The claims data for all privately insured patients in Ghana over three years to 2018 were analysed. The classes of medicines used, the dose by time, gender and age, and generic status were examined. In addition, the use in Defined Daily Dose (DDD) per 1000 population per day was estimated. Classes of AHM prescribed were CCB, ARB, ACEI, diuretics, and BB. Amlodipine, nifedipine, losartan, lisinopril, and bendroflumethiazide accounted for 74% of all use. The most widely used single CCB was amlodipine 3.92 DDD/1,000 population/day in 2016, 3.92 DDD/1,000 population/day in 2017, and 4.92 DDD/1,000 population/day in 2018. In those aged 51–60 years, use of CCB in women (74.0 DDD/1,000 population/day) was almost twice that of men (38.3 DDD/1,000 population/day). The top ten medicines accounted for 93% of all single medicine products in 2018. Most single medicine products was generic (76.5% in 2016; 79.9% in 2017 and 83.1% in 2018) whiles most fixed combination products were branded (73.0% in 2016; 89.7% in 2017 and 91.3% in 2018). The patterns of AHM use are clinically expected although the Ghana Standard Treatment guidelines are not directive about lines of treatment.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139078294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application value of serum S100B combined with glucose metabolism indexes in predicting adverse pregnancy outcomes of patients with severe preeclampsia 血清 S100B 结合糖代谢指标在预测重度子痫前期患者不良妊娠结局中的应用价值

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2023-12-30 DOI: 10.1038/s41371-023-00887-x

Aiqin Yan

{"title":"Application value of serum S100B combined with glucose metabolism indexes in predicting adverse pregnancy outcomes of patients with severe preeclampsia","authors":"Aiqin Yan","doi":"10.1038/s41371-023-00887-x","DOIUrl":"10.1038/s41371-023-00887-x","url":null,"abstract":"S100 calcium-binding protein B (S100B) and glucose control are reflective of maternal-fetal risks. We investigated the value of serum S100B combined with fasting blood glucose (FBG)/hemoglobin A1c (HbA1c) in evaluating the pregnancy outcomes of patients with severe preeclampsia (SPE). The clinical characteristics of SPE patients/controls were collected. FBG/HbA1c and serum S100B levels were measured, with their correlations analyzed. SPE patients were subdivided into adverse/non-adverse outcome groups based on follow-up results. The value of different indexes in predicting pregnancy outcomes was analyzed. SPE patients showed higher systolic blood pressure, diastolic blood pressure, urine protein, and body mass index and lower platelets, gestational age at delivery, and infant birth weight than healthy controls. FBG and HbA1c were positively correlated with serum S100B. SPE patients with adverse outcomes exhibited increased serum S100B and FBG/HbA1c levels. The area under the curve of serum S100B + FBG/HbA1c in evaluating adverse pregnancy outcomes of SPE patients was 0.8412 (77.05% sensitivity/84.21% specificity), higher than either alone. Serum S100B and FBG/HbA1c were independent risk factors for adverse outcomes of SPE patients. Overall, serum S100B positively-correlates with FBG/HbA1c in SPE patients. Serum S100B and FBG/HbA1c are independent risk factors, and their combination has high value on predicting adverse pregnancy outcomes of SPE patients.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139071913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0