Journal of Human Hypertension最新文献

{"title":"sFlt-1/PlGF ratio combined with endocan-1 serum levels improves the predictive values for the occurrence and prognosis of preeclampsia in a single centre study","authors":"Shanshan Tian, Libin He, Ahuang Pan, Lina Zhang, Jielin Wang","doi":"10.1038/s41371-025-01009-5","DOIUrl":"10.1038/s41371-025-01009-5","url":null,"abstract":"This retrospective study evaluated diagnostic and prognostic values of sFlt-1/PlGF ratio combined with serum endocan-1 for preeclampsia (PE). This study included 105 patients with PE admitted at Xiamen University Affiliated Xiang’an Hospital from January 2020 to September 2023, with 90 healthy pregnant women receiving routine check-ups during the same period as controls. sFlt-1, PlGF, and endocan-1 levels were measured, and sFlt-1/PlGF ratio was calculated. The correlation of sFlt-1/PlGF ratio with serum endocan-1 levels was analysed, and influencing factors for poor prognosis of PE patients were screened. Diagnostic and prognostic values of sFlt-1/PlGF ratio combined with serum endocan-1 were assessed. Results showed an increase in sFlt-1/PlGF ratio and serum endocan-1 levels in PE patients and a positive correlation between them. For assisting in the diagnosis of PE, the AUC of the sFlt-1/PlGF ratio combined with serum endocan-1 was 0.874 (95%CI: 0.819 − 0.917; sensitivity, 75.24%; specificity, 100.00%), which was superior over that of sFlt-1/PlGF ratio (P = 0.025) and endocan-1 (P = 0.047) alone. Elevated sFlt-1/PlGF ratio and serum endocan-1 levels were independent risk factors for poor prognosis of PE patients. For assisting in predicting poor prognosis of PE, the AUC of sFlt-1/PlGF ratio with serum endocan-1 was 0.955 (95%CI: 0.896 − 0.986; sensitivity, 82.61%; specificity, 100.00%), which was higher than that of sFlt-1/PlGF ratio (P = 0.023) or serum endocan-1 (P = 0.010) alone. Altogether, sFlt-1/PlGF ratio combined with serum endocan-1 is advantageous over sFlt-1/PlGF ratio and serum endocan-1 alone for predicting PE occurrence and prognosis.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"348-354"},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between different types of obesity and hypertension in perimenopausal working women","authors":"Huaiqin Zhong, Yan Qiu, Xvping Zhu, Jinyu Li, Mei Liu, Zhuoqun Zou","doi":"10.1038/s41371-025-01010-y","DOIUrl":"10.1038/s41371-025-01010-y","url":null,"abstract":"Hypertension (HTN) can lead to a series of target organ damage and is associated with increased cardiovascular disease incidence and mortality. Perimenopause implies an important physiological transition. Previous studies have confirmed that obesity is a risk factor for the development of HTN. Nevertheless, few studies have investigated the prevalence of HTN in perimenopausal women and the relationships between peripheral or abdominal obesity and HTN. Therefore, we analysed the influencing factors of HTN in perimenopausal working women and the correlation between different types of obesity and HTN to provide evidence for the need to prevent HTN in perimenopausal women. Perimenopausal women who underwent physical examination at Shanghai Health and Medical Center from January 2021 to October 2021 were selected as subjects. A multivariate logistic regression model was used to analyse the associations between different types of obesity and HTN in perimenopausal women. Five hundred eighty-two perimenopausal women were included in this study; 124 cases of HTN were detected (incidence rate 21.31%), 23 of which were isolated systolic HTN (18.55% of total HTN cases). Multivariate logistic regression analysis revealed that age and BMI were the influencing factors of HTN in perimenopausal women. Compared with that of perimenopausal women without peripheral obesity, HTN in overweight (OR = 1.84, 95% CI: 1.13–2.98) and peripheral obesity (OR = 4.36, 95% CI: 1.52–12.54) women increased with increasing body weight. Perimenopausal women with abdominal obesity had a greater risk of developing HTN (OR = 2.69, 95% CI: 1.16–6.21) (P < 0.05). Age and BMI are risk factors for the development of HTN in perimenopausal working women. Both abdominal obesity and peripheral obesity are positively associated with HTN in perimenopausal women. The BMI and abdominal circumference of perimenopausal women need to be monitored as early as possible to prevent obesity and reduce the occurrence of HTN.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"343-347"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-based surveillance for hypertension awareness, treatment, and control in nine districts - India Hypertension Control Initiative, 2018–19","authors":"Prabhdeep Kaur, Kamaraj Pattabi, Amirthammal Gunasekaran, Vettrichelvan Venkatasamy, Azhagendran Sivalingam, Sabarinathan Ramasamy, Sailaja Bitragunta, Tapas Chakma, Sampada D. Bangar, Meenakshi Sharma, Abhishek Kunwar, Kiran Durgad, Anupam K. Pathni, Sandeep S. Gill, Padmaja Jogewar, Madhavi Mallela, Ashish Saxsena, Bipin Gopal, Bidisha Das, Vishwajit Bharadwaj, Pooja Gaigaware, Sreedhar Chintala, Chakshu Joshi, Rupali Bharadwaj, Suyesh Shrivastava, Pankaj Uike, Yannick P. Puthussery, Gopinath T Sambandam, RS Dhaliwal, Balram Bhargava","doi":"10.1038/s41371-025-01005-9","DOIUrl":"10.1038/s41371-025-01005-9","url":null,"abstract":"Hypertension control is the crucial indicator for cardiovascular disease programs. We conducted a baseline cross-sectional survey to estimate hypertension awareness, treatment, and control in the selected districts in 2018–19, where the India Hypertension Control Initiative is being implemented. We conducted cross-sectional surveys in nine project districts for 18–69 years age group. The sample size was 624 per district. The study population was individuals with raised BP/diagnosed HT. We estimated the proportion and 95% confidence intervals (CI) for each district’s awareness, treatment, and control. We computed unadjusted and adjusted prevalence ratios (APR) with 95% CI for factors associated with BP control. Hypertension was defined as systolic blood pressure (SBP) > = 140 or diastolic blood pressure (DBP) > = 90 mmHg or treatment in the previous two weeks. Control was defined as SBP < 140 and DBP < 90 mmHg. Among 7047 who had hypertension, 52.4% were aware, 40.8% were on treatment, and 14.5% had BP control. BP control was below 5% in two districts, 5–15% in three districts, and more than 15% in four districts. Among hypertensives aware of the diagnosis, the factors (APR with 95% CI) associated with control were lack of alcohol consumption [1.28 (1.09–1.52)], recent visit to government [1.98 (1.57–2.50)] or private facility [1.99 (1.61–2.46)] and treatment with single drug [2.40 (1.98–2.90)] or multiple drugs [2.84 (2.27–3.55)]. The simple, rapid population-based surveys can document awareness, treatment, and control changes. Improving access to treatment for hypertension through the public or private sector should be a high priority for India.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"376-386"},"PeriodicalIF":2.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01005-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERSPECTIVE – The Growing Global Benefits of Limiting Salt Intake: an urgent call from the World Hypertension League for more effective policy and public health initiatives","authors":"Brent M. Egan, Daniel T. Lackland, Susan E. Sutherland, Michael K. Rakotz, Janet Williams, Yvonne Commodore-Mensah, Daniel W. Jones, Sverre-Erik Kjeldsen, Norm R. C. Campbell, Gianfranco Parati, Feng J. He, Graham A. MacGregor, Michael A. Weber, Paul K. Whelton","doi":"10.1038/s41371-025-00990-1","DOIUrl":"10.1038/s41371-025-00990-1","url":null,"abstract":"","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"241-245"},"PeriodicalIF":2.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00990-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home versus routine dialysis-unit blood pressure recordings among patients on hemodialysis","authors":"Kallistheni Leonidou, Panagiotis I. Georgianos, Anastasios Kollias, Ioannis Kontogiorgos, Vasilios Vaios, Konstantinos Leivaditis, Apostolos Karligkiotis, Eleni Stamellou, Elias V. Balaskas, George S. Stergiou, Vassilios Liakopoulos","doi":"10.1038/s41371-025-01007-7","DOIUrl":"10.1038/s41371-025-01007-7","url":null,"abstract":"The optimal method for the diagnosis of hypertension among patients on hemodialysis remains a controversial issue. Using 44-h ambulatory blood pressure (BP) monitoring (ABPM) as the reference-standard, we assessed the diagnostic performance of home BP monitoring (HBPM) versus routine dialysis-unit BP recordings in hemodialysis patients. Over a period of 2 weeks, the following methods were used for the assessment of hypertension: (i) routine predialysis and postdialysis BP recordings averaged over 6 consecutive dialysis sessions; (ii) HBPM for 7 days (duplicate morning and evening measurements, Microlife WatchBP Home N); (iii) 44-h ABPM (20-min intervals over an entire interdialytic interval, Microlife WatchBPO3). The study included 70 patients (mean age: 65.3 ± 13.2 years; treated hypertensives: 87.1%; 44-h ambulatory systolic/diastolic BP: 120.6 ± 15.2/66.3 ± 10.1 mmHg). Mean (standard deviation) of the differences between ambulatory daytime systolic BP (SBP) and routine predialysis SBP was −11.4 (13.4) mmHg, routine postdialysis SBP −4.0 (15.1) mmHg and home SBP −8.6 (10.7) mmHg. The area under the receiver-operating-characteristic-curve (AUC) for the detection of an ambulatory daytime SBP ≥ 135 mmHg was higher for home SBP [AUC: 0.934; 95% confidence interval (CI): 0.871–0.996] relative to predialysis SBP (AUC: 0.778; 95% CI: 0.643–0.913) and postdialysis SBP (AUC: 0.766; 95% CI: 0.623–0.909) (P = 0.02 for both comparisons). Home SBP at the cut-off point of 141.0 mmHg provided the best combination of sensitivity (85.7%) and specificity (92.9%) in diagnosing hypertension. In conclusion, the present study shows that among hemodialysis patients, HBPM for 1 week is superior to 2-week averaged routine predialysis or postdialysis BP in predicting ambulatory hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"355-361"},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index modifies genetic susceptibility to high systolic blood pressure in adolescents and young adults: results from an 18-year longitudinal study","authors":"Teodora Riglea, Tatiana Dessy, Jodi Kalubi, Danick Goulet, Fiston Ikwa Ndol Mbutiwi, Scott M. Williams, James C. Engert, Hao Yu Chen, Jennifer O’Loughlin, Marie-Pierre Sylvestre","doi":"10.1038/s41371-025-01003-x","DOIUrl":"10.1038/s41371-025-01003-x","url":null,"abstract":"Genome-wide association studies (GWAS) in adults have identified single nucleotide polymorphisms (SNPs) associated with systolic blood pressure (SBP), but it is unclear whether the findings apply in youth. Further, the role of body mass index (BMI) in these associations is understudied. Our objective was to determine whether BMI modifies genetic susceptibility to high SBP in young people. The sample comprised 714 participants of European ancestry recruited in 1999–2000 from 10 Montreal-area high schools for a longitudinal study. SBP was measured at ages 12, 15, 17, 24, and 30. Blood and saliva samples were collected at ages 14, 20, and 25. Two evidence-based genetic risk scores (GRS) were constructed based on GWAS results in adults: GRS22 used 22 SNPs and GRS182 added 160 additional SNPs to GRS22. Sex-specific associations between each GRS and repeated measures of SBP were estimated using linear mixed models including BMI and a GRS*BMI product term. GRS182 explained a greater proportion of SBP variance than GRS22, and a greater proportion in females than males. The associations increased monotonically with BMI values between 22 kg/m2 and 35 kg/m2. Results indicate that BMI modifies the association between a GRS and SBP levels from adolescence to adulthood.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"334-342"},"PeriodicalIF":2.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between epicardial adipose tissue thickness and sedentary time, physical activity level, and physical performance in patients with hypertension","authors":"Emine Tunc Suygun, Naciye Vardar Yagli, Hakan Suygun","doi":"10.1038/s41371-025-01002-y","DOIUrl":"10.1038/s41371-025-01002-y","url":null,"abstract":"Epicardial adipose tissue is associated with the development of cardiovascular disease and its increase is positively correlated with blood pressure elevation in hypertensive individuals. In the literature, being physically active has been shown to be effective in the treatment of hypertension and reduction of epicardial adipose tissue thickness. The aim of this study was to evaluate the relationship between epicardial adipose tissue thickness and sedentary time, physical activity level and physical performance in patients with hypertension. The physical and demographic characteristics of the 40 patients with hypertension were collected with sociodemographic form. Waist/hip circumference was measured with tape measure and epicardial adipose tissue thickness with echocardiography device. Physical activity levels and sedentary time were recorded via IPAQ-7. Physical performance was determined using the 30-s sit-and-stand test. There was a moderate negative correlation between epicardial adipose tissue thickness and IPAQ-7 score (rho: −0.568 p < 0.001) and a high negative correlation between epicardial adipose tissue thickness and sit-and-stand test score (rho: −0.794 p < 0.001). There was no relationship between epicardial adipose tissue thickness and daily sitting time, BMI, or hip circumference. There was moderate positive correlation between epicardial adipose tissue thickness and age (rho: 0.504 p: 0.001) and low positive correlation between waist circumference (rho: 0.322 p < 0.05).This study demonstrated that the epicardial adipose tissue thickness was negatively associated with activity and performance in hypertensive patients, but not with daily sitting time. These results underscore the importance of physical activity in the management and prevention of chronic diseases.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"274-278"},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01002-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the quality and reliability of youtube information on hypertension: a comprehensive analysis","authors":"Geethiikha Jammula, Juhi Ardeshna-Chovatiya, Nadia Djahanshahi, Marina Samuel Basta, Krishna Amarlal Katariya, Iorwuese Ali Daniel, Saumya Joshi","doi":"10.1038/s41371-025-00999-6","DOIUrl":"10.1038/s41371-025-00999-6","url":null,"abstract":"Patient education is an important aspect in the management of hypertension and YouTube has become a popular platform for sharing hypertension-related information, but concerns persist regarding the accuracy and reliability of such content in the context of patient education. To address this issue, this cross-sectional type of observational study aims to assess YouTube’s information on hypertension using the Global Quality Score (GQS) and Reliability Score (DISCERN SCORE), which evaluate the quality and trustworthiness of the YouTube content, and the Video Power Index (VPI). Majority of the videos are uploaded by physicians (26, 33.3 percent) and most give information about causes/etiology, treatment, complications (n = 51, 65.38%) each. The median GQS for all the videos is 4. The median reliability score is 4. The statistical test used is Kruskal - Wallis Test. The p value of VPI, GQS, and Reliability score among various types of uploader are 0.264, 0.347 and 0.452. Hence, there is no statistical significance (p value > 0.05). The analysis therefore suggests that the quality of these videos is moderate. Although they usually provide accurate information, they lack comprehensiveness and may have a biased perspective.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"308-312"},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and resting heart rate influence the relation between arterial stiffness and cardiac structure and function – insights from the general population","authors":"Anna Sista, Till Ittermann, Stefan Gross, Marcello R. P. Markus, Keeron Stone, Lee Stoner, Nele Friedrich, Marcus Dörr, Martin Bahls","doi":"10.1038/s41371-025-01000-0","DOIUrl":"10.1038/s41371-025-01000-0","url":null,"abstract":"Arterial stiffness, a risk factor for cardiovascular disease, can be measured using pulse wave velocity (PWV) and augmentation index (AIx). We studied sex-specific associations between carotid-femoral PWV (cfPWV), brachial-ankle PWV (baPWV), aortic PWV (aoPWV), aortic (aoAIx), and brachial (baAIx) AIx with echocardiographic parameters. Data of 1150 participants of the Study of Health in Pomerania (SHIP-Trend 1; 530 men; median age 53 years; inter quartile range (IQR) 44 to 64) were used. Echocardiography assessed common structural and functional cardiac parameters. PWV and AIx were measured using the Vascular Explorer. Multivariable linear regression models were applied. In men, a higher brAIx was related to a greater right ventricular diameter (RV) (β 0.037; CI 0.003 to 0.148). A one m/s higher baPWV was associated with a smaller RV (β −0.037; CI −0.168 to −0.021) and right ventricular outflow tract (RVOT; β −0.029; CI −0.141 to −0.026). In men, a higher aoAIx (β 0.028; CI 0.01 to 0.122) and brAIx (β 0.029; CI 0.017 to 0.13) were associated with a greater RVOT. In women, a one m/s higher aoPWV (β 0.025; CI 0.006 to 0.105) was associated with a larger RV and a one m/s higher baPWV (β −0.031; CI −0.124 to −0.001) was inversely related to RVOT. In women, PWV associated with right ventricular dimensions, while in men, baPWV and AIx were related to right ventricular parameters. This suggests potentially sex-specific relations between PWV and cardiac structure and function.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"254-261"},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01000-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines","authors":"Caitlin Greenlees, Christian Delles","doi":"10.1038/s41371-025-01001-z","DOIUrl":"10.1038/s41371-025-01001-z","url":null,"abstract":"Globally prevalent conditions such as hypertension, heart failure, ischaemic heart disease (IHD) and chronic kidney disease (CKD) are frequently and effectively treated with blockers of the renin-angiotensin-aldosterone system (RAAS) as a first line treatment in the UK and worldwide. RAAS blockers are prohibited in pregnancy due to their adverse fetal effects. We reviewed clinical guidelines from the National Institute of Health and Care Excellence (NICE) on the management of cardiovascular and kidney disease with RAAS blockers in pregnancy, with other UK, European and American guidance as comparators. Whilst guidelines agree on the strict avoidance of RAAS blockers in pregnancy, nuanced considerations regarding prescription in women of childbearing potential, contraception, timing of RAAS blocker withdrawal and breastfeeding are not consistently addressed in clinical guidelines. We call for consistent wording and more explicit advice on RAAS blocker prescription in women of childbearing potential, in pregnancy and in the postpartum period in future iterations of clinical guidelines.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"315-319"},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01001-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}