Journal of Human Hypertension最新文献_第7页

British and Irish Hypertension Society response to ‘RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines’ 英国和爱尔兰高血压学会对《妊娠、母乳喂养和生育潜力妇女的RAAS抑制剂：国家和国际临床实践指南综述》的回应

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-04-24 DOI: 10.1038/s41371-025-01004-w

Luca Faconti, Louise Abrams, Bernadette Jenner, Eduard Shantsila, Sarah Partridge, Ian B. Wilkinson

引用次数: 0

Correction: Prognostic significance of hypertension at the onset of lupus nephritis in Chinese patients: prevalence and clinical outcomes 修正：中国狼疮性肾炎患者发病时高血压的预后意义：患病率和临床结果

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-04-23 DOI: 10.1038/s41371-025-01020-w

Rong Rong, Qiong Wen, Yating Wang, Qian Zhou, Yagui Qiu, Miaoqing Lu, Xiaotian Liu, Wei Chen, Xueqing Yu

引用次数: 0

Association of self-perceived physical condition with cardiovascular parameters: data analysis from the EVasCu study 自我感知身体状况与心血管参数的关联：来自EVasCu研究的数据分析

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-04-15 DOI: 10.1038/s41371-025-01018-4

Marta Fenoll-Morante, Iván Cavero-Redondo, Carla Geovanna Lever-Megina, Nerea Moreno-Herraiz, Iris Otero-Luis, Alicia Saz-Lara

{"title":"Association of self-perceived physical condition with cardiovascular parameters: data analysis from the EVasCu study","authors":"Marta Fenoll-Morante, Iván Cavero-Redondo, Carla Geovanna Lever-Megina, Nerea Moreno-Herraiz, Iris Otero-Luis, Alicia Saz-Lara","doi":"10.1038/s41371-025-01018-4","DOIUrl":"10.1038/s41371-025-01018-4","url":null,"abstract":"Cardiovascular diseases (CVDs) represent a significant global health burden, with risk factors such as age, sex, smoking, and metabolic disorders contributing to their prevalence. While preventive measures focus on lifestyle interventions and pharmacotherapy, attention has increasingly turned to hemodynamic parameters, including arterial stiffness, as prognostic markers for CVD risk. A total of 390 healthy adults from the EVasCu were included. Cardiovascular parameters were measured by oscillometric techniques using Mobil-O-Graph equipment. Self-perceived physical fitness was measured with the IFIS questionnaire. The EVasCu study revealed significant associations between general physical fitness and cardiovascular parameters, such as HR, SV and AIx 75 (p < 0.01). Similarly, significant associations were shown between cardiorespiratory fitness (p < 0.001), muscular strength (p < 0.001) and speed-agility (p < 0.01) and HR, SV and AIx 75. A positive self-perception of fitness was related to more favourable cardiovascular profiles (p < 0.05). The findings of this study revealed associations between cardiovascular parameters (HR, SV and AIx 75) and cardiorespiratory fitness, muscle strength and speed-agility. However, further research is needed in this field.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 6","pages":"406-414"},"PeriodicalIF":2.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hidden role of left atrial strain: insights into end-organ damage in dipper and nondipper hypertension 左心房劳损的隐藏作用：对斗和非斗高血压终末器官损害的认识。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-04-12 DOI: 10.1038/s41371-025-01017-5

Özden Seçkin, Serkan Ünlü, Mehmet Rıdvan Yalçın

{"title":"The hidden role of left atrial strain: insights into end-organ damage in dipper and nondipper hypertension","authors":"Özden Seçkin, Serkan Ünlü, Mehmet Rıdvan Yalçın","doi":"10.1038/s41371-025-01017-5","DOIUrl":"10.1038/s41371-025-01017-5","url":null,"abstract":"Hypertension is a major global health concern associated with significant morbidity and mortality due to its effects on target organs such as the heart, kidneys, and brain. Non-dipper hypertension, characterized by insufficient nocturnal blood pressure reduction leading to sustained hemodynamic load, is linked to higher risks of end-organ damage. This study evaluates the impact of hypertension on LA anatomy and physiomechanics and explores the association of LA strain parameters with hypertensive heart disease and nephropathy. This prospective, single-center cohort study included 135 participants: 35 healthy controls, 50 dipper hypertension, and 50 non-dipper hypertension patients. All participants underwent 24-h ABPM, biochemical analysis, and transthoracic echocardiography, including speckle-tracking echocardiography, a novel technique for LA strain analysis. LA diameter,LASr, and LAVI maximum were identified as significant parameters associated with hypertensive end-organ damage. Non-dipper hypertension was associated with significantly higher 24-h blood pressure values and reduced nocturnal dipping compared to dipper hypertension. LA strain parameters(LASr, LAScd, LASct) were significantly lower in the non-dipper group. These reductions indicate impaired left atrial mechanics and early cardiac dysfunction. Logistic regression revealed that LA diameter, LASr, and LAVI maximum were significant variables associated with hypertensive heart disease, whereas only LASr was significantly associated with hypertensive nephropathy. LA strain analysis provides valuable insights into the pathophysiology of hypertension and its complications. The findings support the use of LA parameters as cost-effective, noninvasive biomarkers for assessing associations with hypertensive heart disease and nephropathy, enabling early risk stratification. This emphasizes the importance of enhanced monitoring and tailored interventions for high-risk patients.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 6","pages":"425-431"},"PeriodicalIF":2.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01017-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis 客观测量的身体活动和家庭血压之间的关系：基于人群的现实世界数据分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-04-03 DOI: 10.1038/s41371-025-01014-8

Minako Kinuta, Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Noriko Nakahata, Hideyuki Kanda

{"title":"The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis","authors":"Minako Kinuta, Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Noriko Nakahata, Hideyuki Kanda","doi":"10.1038/s41371-025-01014-8","DOIUrl":"10.1038/s41371-025-01014-8","url":null,"abstract":"Few studies have examined the association of objectively measured habitual physical activity (PA) and sedentary behavior with out-of-office blood pressure (BP). We investigated the associations of objectively measured PA intensity time, sedentary time, and step count with at-home BP. Using accelerometer-recorded PA indices and self-measured BP in 368 participants (mean age, 53.8 years; 58.7% women), we analyzed 115,575 records of each parameter between May 2019 and April 2024. PA intensities were categorized as light (2.0–2.9 metabolic equivalents [METs]); moderate (3.0–5.9 METs); vigorous (≥6.0 METs), or sedentary (<2.0 METs): the median [interquartile ranges] for these variables was 188 [146–232], 83 [59–114], 1 [0–2], 501 [428–579] minutes, respectively, and for step count, was 6040 [4164–8457]. Means [standard deviations] for systolic and diastolic BP were 116.4 [14.2] and 75.2 [9.3] mmHg, respectively. A mixed-effect model adjusted for possible confounders showed that 1-h longer in vigorous PA was associated with lower systolic and diastolic BP (−1.69 and −1.09 mmHg, respectively). A 1000-step increase in step count was associated with lower systolic and diastolic BP (−0.05 and −0.02 mmHg, respectively). Associations were more pronounced among men and participants aged <60 years. Sedentary time was positively associated with BP in men and participants aged <60 years, but inversely associated with BP in women and participants aged ≥60 years. Our findings suggest that more PA and less sedentary behavior were associated with BP reduction, particularly among men and participants aged <60 years. However, the clinical relevance of this effect remains uncertain because of its modest magnitude.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 6","pages":"400-405"},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01014-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High prevalence of elevated blood pressure (prehypertension) and hypertension among undergraduate university students in the UAE: a serious health concern 阿联酋大学本科生中血压升高（高血压前期）和高血压的高发率：一个严重的健康问题。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-04-03 DOI: 10.1038/s41371-025-01015-7

Yasser Amer Abd Alsamad, Bessan Musa Saleh Jaffal, Khaleel Rajaee Ibrahim Shuhait, Reem Khudoum Khamis Khudoum Alzaabi, Sari Mohammad Mahmoud Lataifeh, Tahsina Tajnin Sadia, Amal Hussein, Adel B. Elmoselhi

{"title":"High prevalence of elevated blood pressure (prehypertension) and hypertension among undergraduate university students in the UAE: a serious health concern","authors":"Yasser Amer Abd Alsamad, Bessan Musa Saleh Jaffal, Khaleel Rajaee Ibrahim Shuhait, Reem Khudoum Khamis Khudoum Alzaabi, Sari Mohammad Mahmoud Lataifeh, Tahsina Tajnin Sadia, Amal Hussein, Adel B. Elmoselhi","doi":"10.1038/s41371-025-01015-7","DOIUrl":"10.1038/s41371-025-01015-7","url":null,"abstract":"Hypertension, often referred to as a “silent killer,” due to its lack of obvious symptoms but can lead to devastating complications such as cardiovascular disease and stroke, particularly when left unmanaged. This highlights the importance of early screening of elevated blood pressure. The aim of this study is to determine the prevalence of elevated blood pressure (prehypertension) and hypertension among undergraduate university students, along with the associated risk factors. We recruited 344 randomly selected undergraduate students for a cross-sectional study. Blood pressure (BP) measurements were taken following best practice guidelines. In addition, body mass index (BMI) was measured, while other risk factors were collected through a questionnaire. Out of all participants, 36% exhibited elevated blood pressure, with the following breakdown: 15% (n = 51) had prehypertension, 18% (n = 62) had stage 1 hypertension, and 3% (n = 10) had stage 2 hypertension. The prevalence of hypertension and prehypertension was significantly higher among male students (52.7 and 100%, respectively) compared to female students (47.3, and 0% respectively). Significant correlations were found between blood pressure, BMI, and physical activity levels (P ≤ 0.001 and P ≤ 0.011, respectively). Our findings reveal a concerning prevalence of prehypertension and, to a greater extent, hypertension among undergraduate university students. Elevated blood pressure levels were strongly correlated with male gender, BMI, and physical activity levels. These results warrant further large-scale investigation and underscore the urgent need to raise awareness about this significant health risk in the younger population.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 6","pages":"442-447"},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A salty symphony: unraveling the tale of uromodulin and sodium sensitivity 一首咸交响乐：解开尿调素和钠敏感性的故事。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-31 DOI: 10.1038/s41371-025-01013-9

Artemios G. Karagiannidis, Marieta P. Theodorakopoulou, Fotini Iatridi, Alberto Ortiz, Pantelis Sarafidis

引用次数: 0

Association between antihypertensive drug use and the risk of depression: a systematic review and network meta-analysis 抗高血压药物使用与抑郁症风险之间的关系：系统回顾和网络荟萃分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-29 DOI: 10.1038/s41371-025-01011-x

Jay Tewari, Khalid Ahmad Qidwai, Ajoy Tewari, Anadika Rana, Vineeta Tewari, Vanshika Singh, Rishabh Tiwari, Anuj Maheshwari, Narsingh Verma, Hemali Jha, Savneet Kaur

{"title":"Association between antihypertensive drug use and the risk of depression: a systematic review and network meta-analysis","authors":"Jay Tewari, Khalid Ahmad Qidwai, Ajoy Tewari, Anadika Rana, Vineeta Tewari, Vanshika Singh, Rishabh Tiwari, Anuj Maheshwari, Narsingh Verma, Hemali Jha, Savneet Kaur","doi":"10.1038/s41371-025-01011-x","DOIUrl":"10.1038/s41371-025-01011-x","url":null,"abstract":"Hypertension is the biggest and most prevalent risk factor for cardiovascular diseases. Depression is the most common psychiatric illness worldwide. Many studies have linked the development of new depression to the use of antihypertensive drugs. This meta-analysis was done to ascertain the relationship. Using standard reporting techniques a literature search was undertaken in Pubmed from inception till 10 May 2024. The risk bias assessment was done using the ROBINS-I tool. Data for the odds ratio were combined using Revman 5.4 using a random or fixed effects model. Our analysis found a significant association between beta blockers and calcium channel blockers use and the risk of developing new depression. Results for other classes of antihypertensives were not significant. The findings highlight the importance of taking into account the potential psychiatric side effects of antihypertensive drugs in people with hypertension. Physicians should stay vigilant and screen their patients for these conditions regularly.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"246-253"},"PeriodicalIF":2.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01011-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Close relationship between electrocardiogram QRS duration and the risk of developing hypertension 心电图QRS持续时间与高血压发病风险密切相关。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-28 DOI: 10.1038/s41371-025-01012-w

Hiroyuki Takase, Sumiyo Yamashita, Naomi Kawakatsu, Kazusa Hayashi, Fumihiko Kin, Takeru Isogaki, Yasuaki Dohi

{"title":"Close relationship between electrocardiogram QRS duration and the risk of developing hypertension","authors":"Hiroyuki Takase, Sumiyo Yamashita, Naomi Kawakatsu, Kazusa Hayashi, Fumihiko Kin, Takeru Isogaki, Yasuaki Dohi","doi":"10.1038/s41371-025-01012-w","DOIUrl":"10.1038/s41371-025-01012-w","url":null,"abstract":"Electrocardiogram QRS duration is associated with cardiovascular events and all-cause death. The present study was conducted to investigate the hypothesis that the QRS duration predicts the future development of hypertension in the Japanese general population with normal blood pressure. Overall, 13,382 individuals without bundle branch block, Wolff–Parkinson–White syndrome, complete atrioventricular block, pacemaker implantation, or old myocardial infarction on electrocardiogram were enrolled. The cross-sectional analysis indicated that the QRS duration was longer in hypertensive than in normotensive participants. After excluding the participants with hypertension, the remaining 9293 participants with normal blood pressure (male = 5425, 50.2 ± 11.7 years) were followed up for the median of 4 years with an endpoint of hypertension development. During the follow-up period, 1953 participants developed hypertension (50.6 per 1000 person-year). Kaplan–Meier analysis revealed that the incidence of hypertension increased across the quartiles of participants based on QRS duration at baseline as 39.0, 48.6, 53.7, and 62.4 per 1000 person-years in the first, second, third, and fourth quartiles, respectively. Univariate analysis confirmed a significant impact of QRS duration on the development of hypertension. In the multivariate Cox hazard regression analysis adjusted for possible confounding variables, QRS duration was an independent predictor of the development of hypertension. These results suggest the close association between electrocardiogram QRS duration and the future development of hypertension in the Japanese general population. Moreover, alterations in the intraventricular conduction may precede clinically apparent hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"362-368"},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambulatory blood pressure monitoring before and after resection of catecholamine-secreting pheochromocytoma or paraganglioma 儿茶酚胺分泌嗜铬细胞瘤或副神经节瘤切除术前后动态血压监测。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-26 DOI: 10.1038/s41371-025-01008-6

Jordana B. Cohen, Liann Abu Salman, Bonita J. Bennett, Debbie L. Cohen

{"title":"Ambulatory blood pressure monitoring before and after resection of catecholamine-secreting pheochromocytoma or paraganglioma","authors":"Jordana B. Cohen, Liann Abu Salman, Bonita J. Bennett, Debbie L. Cohen","doi":"10.1038/s41371-025-01008-6","DOIUrl":"10.1038/s41371-025-01008-6","url":null,"abstract":"Pheochromocytomas/paragangliomas are catecholamine-secreting tumors that are a rare cause of hypertension and associated with high cardiovascular risk. We aimed to evaluate changes in 24-h ambulatory blood pressure (BP) monitoring (ABPM) following tumor resection. Individuals with evidence of pheochromocytoma/paraganglioma prospectively underwent 24-h ABPM and plasma and urine catecholamine measurement 2–3 weeks before and 6–8 weeks after pathologically-confirmed tumor resection. Patients with metastatic disease were excluded. Changes in office, 24-h, daytime, and nighttime mean systolic and diastolic BP and heart rate, 24-h BP and heart rate average real variability, and rates of controlled, sustained, white coat, and masked hypertension were assessed in paired analyses. There were 34 participants who completed 24-h ABPM before and after tumor resection. Mean age was 55 ± 13 years, with 21 (62%) women, median duration of hypertension of 3 years, and 6 (18%) participants with coronary artery disease. Serum and urine catecholamines normalized following tumor resection and participants were prescribed 1 ± 0.2 fewer antihypertensive medications. Office BP declined by a mean 10 ± 16/7 ± 9 mmHg, 24-h BP declined by 8 ± 14/4 ± 10 mmHg, with greater improvement in nighttime (9 ± 18/5 ± 13 mmHg) than daytime (7 ± 14/4 ± 9) ambulatory BP. Systolic BP variability and heart rate variability significantly improved. While the frequency of controlled hypertension increased (4 [12%] to 11 [32%]; p = 0.008), there was no significant change in masked hypertension (9 [26%] to 12 [35%]; p = 0.366). In conclusion, pheochromocytoma/paraganglioma resection was associated with improvement in 24-h BP and BP variability, particularly nighttime BP. ABPM may be useful following tumor resection to identify patients with unrecognized residual cardiovascular risk.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 5","pages":"369-375"},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-01008-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0