抗高血压药物使用与抑郁症风险之间的关系：系统回顾和网络荟萃分析。

IF 2.7 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Human Hypertension Pub Date : 2025-03-29 DOI:10.1038/s41371-025-01011-x

Jay Tewari, Khalid Ahmad Qidwai, Ajoy Tewari, Anadika Rana, Vineeta Tewari, Vanshika Singh, Rishabh Tiwari, Anuj Maheshwari, Narsingh Verma, Hemali Jha, Savneet Kaur

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引用次数: 0

摘要

高血压是心血管疾病最大和最普遍的危险因素。抑郁症是世界上最常见的精神疾病。许多研究已经将新型抑郁症的发展与抗高血压药物的使用联系起来。本荟萃分析是为了确定两者之间的关系。使用标准报告技术，从Pubmed成立到2024年5月10日进行了文献检索。风险偏倚评估采用ROBINS-I工具。比值比数据采用Revman 5.4合并，采用随机或固定效应模型。我们的分析发现，受体阻滞剂和钙通道阻滞剂的使用与新发抑郁症的风险之间存在显著关联。其他类型的抗高血压药物的结果无统计学意义。研究结果强调了考虑降压药对高血压患者潜在的精神副作用的重要性。医生应保持警惕，并定期对患者进行这些情况的筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Association between antihypertensive drug use and the risk of depression: a systematic review and network meta-analysis

查看原文本刊更多论文

Association between antihypertensive drug use and the risk of depression: a systematic review and network meta-analysis

Hypertension is the biggest and most prevalent risk factor for cardiovascular diseases. Depression is the most common psychiatric illness worldwide. Many studies have linked the development of new depression to the use of antihypertensive drugs. This meta-analysis was done to ascertain the relationship. Using standard reporting techniques a literature search was undertaken in Pubmed from inception till 10 May 2024. The risk bias assessment was done using the ROBINS-I tool. Data for the odds ratio were combined using Revman 5.4 using a random or fixed effects model. Our analysis found a significant association between beta blockers and calcium channel blockers use and the risk of developing new depression. Results for other classes of antihypertensives were not significant. The findings highlight the importance of taking into account the potential psychiatric side effects of antihypertensive drugs in people with hypertension. Physicians should stay vigilant and screen their patients for these conditions regularly.

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来源期刊

Journal of Human Hypertension 医学-外周血管病

CiteScore

5.20

自引率

3.70%

发文量

126

审稿时长

6-12 weeks

期刊介绍： Journal of Human Hypertension is published monthly and is of interest to health care professionals who deal with hypertension (specialists, internists, primary care physicians) and public health workers. We believe that our patients benefit from robust scientific data that are based on well conducted clinical trials. We also believe that basic sciences are the foundations on which we build our knowledge of clinical conditions and their management. Towards this end, although we are primarily a clinical based journal, we also welcome suitable basic sciences studies that promote our understanding of human hypertension. The journal aims to perform the dual role of increasing knowledge in the field of high blood pressure as well as improving the standard of care of patients. The editors will consider for publication all suitable papers dealing directly or indirectly with clinical aspects of hypertension, including but not limited to epidemiology, pathophysiology, therapeutics and basic sciences involving human subjects or tissues. We also consider papers from all specialties such as ophthalmology, cardiology, nephrology, obstetrics and stroke medicine that deal with the various aspects of hypertension and its complications.