A salty symphony: unraveling the tale of uromodulin and sodium sensitivity

IF 2.7 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Human Hypertension Pub Date : 2025-03-31 DOI:10.1038/s41371-025-01013-9

Artemios G. Karagiannidis, Marieta P. Theodorakopoulou, Fotini Iatridi, Alberto Ortiz, Pantelis Sarafidis

引用次数: 0

Abstract

Uromodulin is a kidney-specific glycoprotein which is uniquely synthesized by the epithelial cells lining the thick ascending limb and early distal convoluted tubule. Among multiple roles in complex physiological and pathological processes, uromodulin mediates renal sodium handling through modulating tubular sodium transporters that reabsorb sodium and therefore is putatively linked to hypertension through generating sodium sensitivity of blood pressure. This review aims to present an updated overview of the role of uromodulin in sodium renal handling and summarize the existing evidence originating from preclinical, genetic, and clinical studies that support a relationship between uromodulin and sodium-sensitive hypertension.

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一首咸交响乐：解开尿调素和钠敏感性的故事。

尿调蛋白是一种肾特异性糖蛋白，由厚升肢和早期远曲小管上皮细胞合成。在复杂的生理和病理过程中，尿调素通过调节再吸收钠的小管钠转运体介导肾脏钠处理，因此被认为通过产生血压钠敏感性与高血压有关。本综述旨在介绍尿调素在钠肾处理中的作用的最新概述，并总结来自临床前、遗传和临床研究的现有证据，这些证据支持尿调素与钠敏感性高血压之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Human Hypertension 医学-外周血管病

CiteScore

5.20

自引率

3.70%

发文量

126

审稿时长

6-12 weeks

期刊介绍： Journal of Human Hypertension is published monthly and is of interest to health care professionals who deal with hypertension (specialists, internists, primary care physicians) and public health workers. We believe that our patients benefit from robust scientific data that are based on well conducted clinical trials. We also believe that basic sciences are the foundations on which we build our knowledge of clinical conditions and their management. Towards this end, although we are primarily a clinical based journal, we also welcome suitable basic sciences studies that promote our understanding of human hypertension. The journal aims to perform the dual role of increasing knowledge in the field of high blood pressure as well as improving the standard of care of patients. The editors will consider for publication all suitable papers dealing directly or indirectly with clinical aspects of hypertension, including but not limited to epidemiology, pathophysiology, therapeutics and basic sciences involving human subjects or tissues. We also consider papers from all specialties such as ophthalmology, cardiology, nephrology, obstetrics and stroke medicine that deal with the various aspects of hypertension and its complications.