Journal of Human Hypertension最新文献_第2页

Relationship between epicardial adipose tissue thickness and sedentary time, physical activity level, and physical performance in patients with hypertension.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-11 DOI: 10.1038/s41371-025-01002-y

Emine Tunc Suygun, Naciye Vardar Yagli, Hakan Suygun

{"title":"Relationship between epicardial adipose tissue thickness and sedentary time, physical activity level, and physical performance in patients with hypertension.","authors":"Emine Tunc Suygun, Naciye Vardar Yagli, Hakan Suygun","doi":"10.1038/s41371-025-01002-y","DOIUrl":"10.1038/s41371-025-01002-y","url":null,"abstract":"Epicardial adipose tissue is associated with the development of cardiovascular disease and its increase is positively correlated with blood pressure elevation in hypertensive individuals. In the literature, being physically active has been shown to be effective in the treatment of hypertension and reduction of epicardial adipose tissue thickness. The aim of this study was to evaluate the relationship between epicardial adipose tissue thickness and sedentary time, physical activity level and physical performance in patients with hypertension. The physical and demographic characteristics of the 40 patients with hypertension were collected with sociodemographic form. Waist/hip circumference was measured with tape measure and epicardial adipose tissue thickness with echocardiography device. Physical activity levels and sedentary time were recorded via IPAQ-7. Physical performance was determined using the 30-s sit-and-stand test. There was a moderate negative correlation between epicardial adipose tissue thickness and IPAQ-7 score (rho: -0.568 p < 0.001) and a high negative correlation between epicardial adipose tissue thickness and sit-and-stand test score (rho: -0.794 p < 0.001). There was no relationship between epicardial adipose tissue thickness and daily sitting time, BMI, or hip circumference. There was moderate positive correlation between epicardial adipose tissue thickness and age (rho: 0.504 p: 0.001) and low positive correlation between waist circumference (rho: 0.322 p < 0.05).This study demonstrated that the epicardial adipose tissue thickness was negatively associated with activity and performance in hypertensive patients, but not with daily sitting time. These results underscore the importance of physical activity in the management and prevention of chronic diseases.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the quality and reliability of youtube information on hypertension: a comprehensive analysis. 评估youtube上有关高血压信息的质量和可靠性：一项综合分析。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-07 DOI: 10.1038/s41371-025-00999-6

Geethiikha Jammula, Juhi Ardeshna-Chovatiya, Nadia Djahanshahi, Marina Samuel Basta, Krishna Amarlal Katariya, Iorwuese Ali Daniel, Saumya Joshi

{"title":"Assessing the quality and reliability of youtube information on hypertension: a comprehensive analysis.","authors":"Geethiikha Jammula, Juhi Ardeshna-Chovatiya, Nadia Djahanshahi, Marina Samuel Basta, Krishna Amarlal Katariya, Iorwuese Ali Daniel, Saumya Joshi","doi":"10.1038/s41371-025-00999-6","DOIUrl":"10.1038/s41371-025-00999-6","url":null,"abstract":"Patient education is an important aspect in the management of hypertension and YouTube has become a popular platform for sharing hypertension-related information, but concerns persist regarding the accuracy and reliability of such content in the context of patient education. To address this issue, this cross-sectional type of observational study aims to assess YouTube's information on hypertension using the Global Quality Score (GQS) and Reliability Score (DISCERN SCORE), which evaluate the quality and trustworthiness of the YouTube content, and the Video Power Index (VPI). Majority of the videos are uploaded by physicians (26, 33.3 percent) and most give information about causes/etiology, treatment, complications (n = 51, 65.38%) each. The median GQS for all the videos is 4. The median reliability score is 4. The statistical test used is Kruskal - Wallis Test. The p value of VPI, GQS, and Reliability score among various types of uploader are 0.264, 0.347 and 0.452. Hence, there is no statistical significance (p value > 0.05). The analysis therefore suggests that the quality of these videos is moderate. Although they usually provide accurate information, they lack comprehensiveness and may have a biased perspective.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and resting heart rate influence the relation between arterial stiffness and cardiac structure and function - insights from the general population.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-07 DOI: 10.1038/s41371-025-01000-0

Anna Sista, Till Ittermann, Stefan Gross, Marcello R P Markus, Keeron Stone, Lee Stoner, Nele Friedrich, Marcus Dörr, Martin Bahls

{"title":"Sex and resting heart rate influence the relation between arterial stiffness and cardiac structure and function - insights from the general population.","authors":"Anna Sista, Till Ittermann, Stefan Gross, Marcello R P Markus, Keeron Stone, Lee Stoner, Nele Friedrich, Marcus Dörr, Martin Bahls","doi":"10.1038/s41371-025-01000-0","DOIUrl":"https://doi.org/10.1038/s41371-025-01000-0","url":null,"abstract":"Arterial stiffness, a risk factor for cardiovascular disease, can be measured using pulse wave velocity (PWV) and augmentation index (AIx). We studied sex-specific associations between carotid-femoral PWV (cfPWV), brachial-ankle PWV (baPWV), aortic PWV (aoPWV), aortic (aoAIx), and brachial (baAIx) AIx with echocardiographic parameters. Data of 1150 participants of the Study of Health in Pomerania (SHIP-Trend 1; 530 men; median age 53 years; inter quartile range (IQR) 44 to 64) were used. Echocardiography assessed common structural and functional cardiac parameters. PWV and AIx were measured using the Vascular Explorer. Multivariable linear regression models were applied. In men, a higher brAIx was related to a greater right ventricular diameter (RV) (β 0.037; CI 0.003 to 0.148). A one m/s higher baPWV was associated with a smaller RV (β -0.037; CI -0.168 to -0.021) and right ventricular outflow tract (RVOT; β -0.029; CI -0.141 to -0.026). In men, a higher aoAIx (β 0.028; CI 0.01 to 0.122) and brAIx (β 0.029; CI 0.017 to 0.13) were associated with a greater RVOT. In women, a one m/s higher aoPWV (β 0.025; CI 0.006 to 0.105) was associated with a larger RV and a one m/s higher baPWV (β -0.031; CI -0.124 to -0.001) was inversely related to RVOT. In women, PWV associated with right ventricular dimensions, while in men, baPWV and AIx were related to right ventricular parameters. This suggests potentially sex-specific relations between PWV and cardiac structure and function.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-03-05 DOI: 10.1038/s41371-025-01001-z

Caitlin Greenlees, Christian Delles

{"title":"RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines.","authors":"Caitlin Greenlees, Christian Delles","doi":"10.1038/s41371-025-01001-z","DOIUrl":"https://doi.org/10.1038/s41371-025-01001-z","url":null,"abstract":"Globally prevalent conditions such as hypertension, heart failure, ischaemic heart disease (IHD) and chronic kidney disease (CKD) are frequently and effectively treated with blockers of the renin-angiotensin-aldosterone system (RAAS) as a first line treatment in the UK and worldwide. RAAS blockers are prohibited in pregnancy due to their adverse fetal effects. We reviewed clinical guidelines from the National Institute of Health and Care Excellence (NICE) on the management of cardiovascular and kidney disease with RAAS blockers in pregnancy, with other UK, European and American guidance as comparators. Whilst guidelines agree on the strict avoidance of RAAS blockers in pregnancy, nuanced considerations regarding prescription in women of childbearing potential, contraception, timing of RAAS blocker withdrawal and breastfeeding are not consistently addressed in clinical guidelines. We call for consistent wording and more explicit advice on RAAS blocker prescription in women of childbearing potential, in pregnancy and in the postpartum period in future iterations of clinical guidelines.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood pressure variability in CKD patients with and without nocturnal hypertension.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-28 DOI: 10.1038/s41371-025-00998-7

Artemios G Karagiannidis, Marieta P Theodorakopoulou, Fotini Iatridi, Maria Schoina, Erasmia Sampani, Ioannis Mykoniatis, Konstantinos Stavropoulos, Vasileios Kamperidis, Mehmet Kanbay, Pantelis Sarafidis

{"title":"Blood pressure variability in CKD patients with and without nocturnal hypertension.","authors":"Artemios G Karagiannidis, Marieta P Theodorakopoulou, Fotini Iatridi, Maria Schoina, Erasmia Sampani, Ioannis Mykoniatis, Konstantinos Stavropoulos, Vasileios Kamperidis, Mehmet Kanbay, Pantelis Sarafidis","doi":"10.1038/s41371-025-00998-7","DOIUrl":"https://doi.org/10.1038/s41371-025-00998-7","url":null,"abstract":"Nocturnal hypertension is highly prevalent in patients with chronic kidney disease (CKD) and represents a strong predictor of cardiovascular events. Increased blood pressure variability (BPV) is also independently associated with cardiovascular events in these patients. Differences in short-term BPV indices between CKD patients with and without nocturnal hypertension have not been previously studied. This study included 96 patients (73 with and 23 without nocturnal hypertension) who underwent 24-h ambulatory BP measurement. Standard deviation (SD), weighted SD (wSD), coefficient of variation (CV), and average real variability (ARV) of systolic (SBP) and diastolic blood pressure (DBP) were calculated using validated formulas for the 24-h and the respective daytime (07:00-23:00) and nighttime (23:00-07:00) periods. 24-h, daytime and nighttime SBP and DBP were higher in patients with nocturnal hypertension. During the 24-h period, wSD and ARV for 24-h SBP (wSD, 14.0 ± 3.8 vs 11.7 ± 3.1 mmHg, p = 0.009; ARV, 10.5 ± 2.7 vs 9.2 ± 1.9 mmHg, p = 0.035) and 24-h DBP were higher in patients with nocturnal hypertension. Regarding the daytime period, patients with nocturnal hypertension presented higher daytime SD and ARV for SBP (SD, 14.8 ± 4.0 vs 13.0 ± 3.6 mmHg, p = 0.008; ARV; 10.5 ± 3.2 vs 9.1 ± 2.0 mmHg, p = 0.016) and DBP, with daytime SBP and DBP CV being numerically but not significantly higher (p = 0.110 and p = 0.08 respectively). During the nighttime period, no significant differences between groups were present for all nighttime BPV indices. In conclusion, CKD patients with nocturnal hypertension have higher systolic and diastolic BPV indices during the 24-h and daytime periods, but not the nighttime period. These findings signify that increased BPV may be responsible for higher cardiovascular risk in CKD patients with compared to those without nocturnal hypertension.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CITED2 is highly-expressed and PRX4 is poorly-expressed in preeclampsia and have diagnostic values.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-27 DOI: 10.1038/s41371-025-00995-w

Caixia Yang, Zhiying Song

{"title":"CITED2 is highly-expressed and PRX4 is poorly-expressed in preeclampsia and have diagnostic values.","authors":"Caixia Yang, Zhiying Song","doi":"10.1038/s41371-025-00995-w","DOIUrl":"https://doi.org/10.1038/s41371-025-00995-w","url":null,"abstract":"This study aims to investigate the differential level of CITED2 and PRX4 in the serum of preeclampsia (PE) patients and to explore their clinical value in PE diagnosis, severity assessment, and pregnancy outcomes. A total of 110 singleton pregnant women with PE were included, consisting of 57 cases of mild PE and 53 cases of severe PE, with 110 healthy singleton pregnant women enrolled as the normal control. The baseline clinical characteristics were analyzed using chi-square test and independent samples t-test. CITED2 and PRX4 concentrations were measured by ELISA and their diagnostic efficacy for PE was evaluated through ROC curves. Multivariate logistic regression analysis was conducted to identify factors associated with adverse pregnancy outcomes in PE patients. Compared to the healthy group, CITED2 serum levels in PE patients were significantly increased, while PRX4 levels were significantly decreased. CITED2 and PRX4 can diagnose PE, distinguish between mild and severe PE, and be associate with adverse pregnancy outcomes in PE patients. The diagnostic efficacy was better when CITED2 and PRX4 were combined. The serum levels of CITED2 were further elevated and PRX4 levels were further reduced in patients with severe PE and adverse pregnancy outcomes. CITED2 was an independent risk factor and PRX4 was a protective factor for adverse pregnancy outcomes in PE patients. In conclusion, CITED2 and PRX4 can diagnose PE, assess PE severity, and are associated with PE outcomes.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of semi-quantitative gold nanoparticle-based quick cortisol assay with and without adrenocorticotropic hormone infusion during adrenal vein sampling.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-26 DOI: 10.1038/s41371-025-00997-8

Felicity Stringer, Pamela Franco, Landy M Wu, Christopher A Preston, Maresa M Derbyshire, Richard J MacIsaac, Eric X Z Yong, Benjamin Marginson, Nirupa Sachithanandan

{"title":"Accuracy of semi-quantitative gold nanoparticle-based quick cortisol assay with and without adrenocorticotropic hormone infusion during adrenal vein sampling.","authors":"Felicity Stringer, Pamela Franco, Landy M Wu, Christopher A Preston, Maresa M Derbyshire, Richard J MacIsaac, Eric X Z Yong, Benjamin Marginson, Nirupa Sachithanandan","doi":"10.1038/s41371-025-00997-8","DOIUrl":"https://doi.org/10.1038/s41371-025-00997-8","url":null,"abstract":"Adrenal vein sampling (AVS) is the gold standard for diagnosing unilateral primary aldosteronism. Point-of-care rapid cortisol assays such as the gold nanoparticle based quick cortisol assay (QCA) are used to confirm accurate cannulation of the adrenal veins during the procedure and have improved AVS success rates. In this retrospective cohort study, we reviewed the results of consecutive AVS procedures (n = 37) performed with and without ACTH (synacthen) infusion between October 2020 and December 2022 at our institution. We compared (1) the accuracy of point-of-care QCA at semi-quantitatively assessing successful adrenal vein cannulation before and after ACTH infusion when compared with selectivity index based on laboratory cortisol measurements, (2) accuracy of QCA based on peripheral and adrenal vein cortisol levels and (3) the impact of time of day on the accuracy of QCA. We found the accuracy of QCA compared with formal laboratory cortisol measurements was 71% pre-ACTH and 100% post-ACTH (p-value < 0.001). Pre-ACTH, the accuracy of QCA was higher in the lowest (28-257 nmol/L) and highest (466-25130 nmol/L) adrenal vein cortisol tertiles compared to the mid-tertile. Post-ACTH, the accuracy of QCA remained high regardless of adrenal vein cortisol levels. Time of day did not affect the accuracy of the QCA. We conclude that during basal AVS subjective, visual estimates of adrenal vein cortisol levels using the QCA semi-quantitively should not be solely relied upon to guide catheter placement. These results will help guide clinicians in the appropriate clinical situations in which QCA should be used during AVS.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-reported hypertension prevalence, risk factors, and knowledge among South Africans aged 24 to 40 years old

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-24 DOI: 10.1038/s41371-024-00957-8

Asanda Mtintsilana, Witness Mapanga, Ashleigh Craig, Siphiwe N. Dlamini, Shane A. Norris

{"title":"Self-reported hypertension prevalence, risk factors, and knowledge among South Africans aged 24 to 40 years old","authors":"Asanda Mtintsilana, Witness Mapanga, Ashleigh Craig, Siphiwe N. Dlamini, Shane A. Norris","doi":"10.1038/s41371-024-00957-8","DOIUrl":"10.1038/s41371-024-00957-8","url":null,"abstract":"Although hypertension is a significant public health burden in South Africa (SA), less is known about its prevalence, risk factors, and possible preventative strategies among young adults. We assessed the prevalence, possible risk factors, and knowledge associated with self-reported hypertension among young adults from SA. A cross-sectional online survey was conducted among 1000 young South African adults (24–40 years; 51.0% women). We administered a socio-demographic questionnaire and collected information on measures of socio-economic status (SES) (e.g. asset wealth index), self-reported medical history, and lifestyle risk factors. Furthermore, a modified version of the hypertension evaluation of lifestyle and management questionnaire was used to assess participants’ hypertension knowledge. The overall prevalence of self-reported hypertension was 24.0%, with significant differences between women and men (27.5% and 20.4% respectively, p = 0.033). Only 16.8% of the respondents had good hypertension knowledge. There was a positive association between good knowledge of hypertension and being hypertensive (OR = 1.43 CI:1.23–3.12), monthly blood pressure check-ups (OR = 2.03 CI:1.78–3.23), knowing the side effects of uncontrolled blood pressure (OR = 1.28 CI:1.07–1.89) and having a biological mother with hypertension (OR = 1.79 CI:1.53–2.21). Being employed full-time (OR = 0.74 CI:0.69–0.80), having a higher SES (wealth index 4 (OR = 0.70 CI:0.59–0.97) and 5 (OR = 0.65 CI:0.48–0.81)), exercising 6 to 7 days per week (OR = 0.83 CI:0.71–0.94), and not consuming alcohol at all (OR = 0.73 CI:0.67–0.89), were all found to be protective against hypertension. The high hypertension prevalence, lack of hypertension knowledge, and reported risk factors among this group highlight the need for early robust preventative strategies to mitigate hypertension risk among this population.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 2","pages":"177-187"},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-024-00957-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiethnic norms for blood pressure response to submaximal exercise testing in young-to-middle adulthood and associations with hypertension: The NHANES dataset.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-23 DOI: 10.1038/s41371-025-00993-y

João L Marôco

{"title":"Multiethnic norms for blood pressure response to submaximal exercise testing in young-to-middle adulthood and associations with hypertension: The NHANES dataset.","authors":"João L Marôco","doi":"10.1038/s41371-025-00993-y","DOIUrl":"https://doi.org/10.1038/s41371-025-00993-y","url":null,"abstract":"The blood pressure (BP) response during exercise testing is a robust correlate of hypertension in middle-to-older White people, but whether this extends to a healthy, young-to-middle-aged multiethnic population is unknown. Moreover, it is unclear what constitutes an exaggerated BP to submaximal exercise, which is a more reliable and stronger correlate of hypertension than maximal testing. The NHANES dataset was used to interrogate the association of submaximal exercise BP with current hypertension and to provide multiethnic norms for BP responses in young-to-middle-aged adults. The analyses combined NHANES cycles wherein treadmill exercise testing was conducted with an analytic sample of 2544 participants aged 12-49 years (Female: White = 467; Black = 324; Hispanic = 439; Male: White = 493, Black = 351; Hispanic = 470). Weighted logistic models were fitted to test associations between exercise BP and hypertension. Age, sex, and race-specific percentiles were estimated. Exaggerated systolic BP (SBP) responses to exercise testing were defined as readings ≥90th percentile, and ≥ROC-derived cutoff. Regardless of race, sex, exercise workload, clinical and socioeconomic characteristics, a 5-mmHg increase in SBP and diastolic BP during stage 1 of exercise testing was associated with a 15% (aOR: 1.15, 95% CI: 1.08-1.21), and 31% (aOR: 1.31, 95% CI: 1.22-1.40) higher odds for hypertension, respectively. Black males had the highest proportion of exaggerated SBP responses (44%, 95% CI: 36-53%) when defined only via ROC-derived cutoffs. BP responses during submaximal exercise were associated with hypertension, irrespective of race in young-to-middle adulthood. Still, the exaggerated SBP response to exercise of Black males suggests uncontrolled high BP not detected at rest.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China.

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-22 DOI: 10.1038/s41371-025-00992-z

Zhe Chen, Dongming Guo, Lifeng Xiao, Honghui Su, Yirun Chen

{"title":"Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China.","authors":"Zhe Chen, Dongming Guo, Lifeng Xiao, Honghui Su, Yirun Chen","doi":"10.1038/s41371-025-00992-z","DOIUrl":"https://doi.org/10.1038/s41371-025-00992-z","url":null,"abstract":"This study investigated the association between fat-to-muscle ratio (FMR) and hypertension. A total of 1592 participants aged ≥ 40 years were included. Participants were divided into four groups by quartiles of FMR. Odds ratio (OR) and 95% confidence interval (CI) was calculated using logistic regression models. Restricted cubic spline was applied to examine the correlation of FMR and hypertension. Of 1592 participants, 943 (59.2%) participants had hypertension. Hypertension risk rose with FMR quartiles. Compared to FMR quartile 1, ORs were 1.496 (95% CI: 1.115-2.006), 2.445 (95% CI: 1.840-3.249), and 5.415 (95% CI: 3.993-7.344) for quartiles 2, 3, and 4, respectively (P for trend < 0.001). Adjusted OR in quartile 4 was 3.015 (95% CI: 2.083-4.365). Restricted cubic spline showed a linear relationship between FMR and hypertension. Adding FMR improved hypertension risk model performance (P = 0.006). Subgroup analysis revealed FMR interactions with sex (P = 0.010) and BMI (P < 0.016), with a higher hypertension risk in females and non-obese individuals. Additionally, versus FMR quartile 1, hypertensive individuals in quartiles 2 (OR: 1.370, 95% CI: 0.900-2.085), 3 (OR: 2.055, 95% CI: 1.374-3.073) and 4 (OR: 3.102, 95% CI: 2.055-4.682) exhibited a significantly elevated risk of atherosclerotic cardiovascular disease (ASCVD). In summary, Elevated FMR independently correlated with hypertension risk, especially in women, or even in non-obese individuals. FMR is a valuable tool for identifying populations with higher hypertension risk and assessing ASCVD risk in hypertensive individuals. Body composition warrants consideration in future hypertension risk studies.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0