Journal of Human Hypertension最新文献

{"title":"Hypertensive urgencies and emergencies in the cardiology emergency department: epidemiology, patient profile, and management.","authors":"Panagiotis Theofilis, Nikolaos Nakas, Thomais Lamprou, Kalliopi Touchantzidou, Aikaterini Vordoni, Vasilios Thimis, Despina Smirloglou, Athanasios Kotsakis, Rigas G Kalaitzidis","doi":"10.1038/s41371-025-01033-5","DOIUrl":"10.1038/s41371-025-01033-5","url":null,"abstract":"<p><p>Hypertensive urgencies (HU) and hypertensive emergencies (HE) are common conditions in the cardiology emergency department (ED), often requiring urgent intervention. Despite their clinical significance, data on patient characteristics, etiologies, and management strategies remain limited. This study aimed to assess the epidemiology, clinical profile, and management of HU and HE in a tertiary cardiology ED. A single-center, observational study was conducted over 12 months, enrolling patients diagnosed with HU/HE (BP ≥ 180/120 mmHg). Demographic data, medical history, symptoms, etiologic factors, and antihypertensive treatments were recorded. Serial blood pressure (BP) measurements were taken to assess BP reduction during the ED stay. Of 4010 cardiology ED visits, 83 patients (2.1%) had HU/HE (median age 65 years, 45.8% male). Most had a history of hypertension (73.5%), with frequent coexisting smoking (56.6%) and dyslipidemia (43.4%). Common symptoms included dyspnea (19.3%) and chest pain (25.3%). Stress (26.8%) and increased salt intake (15.9%) were common etiologic factors. HE was diagnosed in 18 cases (21.7%), and 12.7% of HU cases required hospitalization. Mean BP on admission was 200/100 mmHg, with SBP and DBP reductions of 41 mmHg (-21%) and 18 mmHg (-17%), respectively. Nitrates, anxiolytics, and combination therapies resulted in the greatest BP reductions. In conclusion, HU and HE are frequently observed in hypertensive patients with additional cardiovascular risk factors. Target-organ damage is not solely related to BP levels, emphasizing the need for individualized management strategies.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients with Essential Hypertension: A Phase III, Multicenter, Double-Blind, Parallel-Group, Randomised study.","authors":"Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yuanyuan Chen, Yan Chen, Hao Tang, Zichen Liu, Peng Mi, Xiangmin Lin","doi":"10.1038/s41371-025-01035-3","DOIUrl":"https://doi.org/10.1038/s41371-025-01035-3","url":null,"abstract":"<p><p>This multicenter, double-blind, parallel-group, randomised controlled phase III study evaluated the efficacy and safety of the Allisartan Isoproxil 240 mg /Amlodipine 5 mg (ALI/AML) combination compared with ALI 240 mg monotherapy in patients with mild-to-moderate essential hypertension. Patients aged 18 to 70 years with mean sitting systolic blood pressure (msSBP) between 140 and <180 mmHg and mean sitting diastolic blood pressure (msDBP) between 90 and <110 mmHg were randomised 1:1 to receive ALI/AML or ALI once-daily for 12 weeks after a 4-week treatment with ALI, followed by an open-label extension period with ALI/AML up to week 52. A total of 199 patients were randomised (ALI/AML: n = 99, ALI: n = 100) with 169 completing the study. Baseline characteristics were comparable between groups. After 12 weeks of randomisation, the reduction in msSBP (primary endpoint) was significantly greater in the ALI/AML group vs the ALI group (-18.3 vs. -9.3 mmHg, p < 0.001). Reductions in msDBP (-6.0 vs. -1.9 mmHg, p < 0.001) and 24-hour mean ambulatory systolic/diastolic blood pressure (-19.9/-10.1 vs. -6.9/-4.2 mmHg) were more pronounced in the ALI/AML group. Additionally, a greater proportion of patients achieved the BP response and target office BP in the ALI/AML group compared to the ALI group (53.6% vs. 25.5%, p < 0.001; 40.2% vs. 20.4%, p=0.0026). AML/ALI combination was generally safe and well tolerated, with sustained efficacy up to 52 weeks. The study concluded that ALI/AML offers a convenient, single-pill option for effective BP reduction in hypertensive patients.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiles of echocardiographic features associated with blood pressure in patients with hypertension.","authors":"Wenlang Zhao, Mingdan Wang, Pan Zhou, Ziyu Wang, Xuan Deng, Jiangtao Li, Na Yang, Lizhen Han, Zhao Yang, Yue Qi, Jing Liu","doi":"10.1038/s41371-025-01034-4","DOIUrl":"https://doi.org/10.1038/s41371-025-01034-4","url":null,"abstract":"<p><p>The multidimensional echocardiographic features associated with BP level are unclear. This study aimed to identify the multidimensional echocardiographic features associated with BP. In total, 2 092 adult participants (aged ≥18 years) with hypertension who underwent echocardiography in Beijing between July 2017 and January 2020 as part of the Multi-provincial Cohort for Hypertension study were enrolled. The associations between BP levels and echocardiographic features were investigated by multivariate regression analysis. After multivariable adjustment, a 1 SD (15.4 mmHg) increase in systolic BP was associated with a 0.21-mm increment (95% CI 0.06-0.35) in left atrial diameter, a 2.17-g/m² increment (95% CI 1.46-2.88) in LV mass index, a 0.25-mm increment (95% CI 0.11-0.39) in ascending aorta diameter and a 0.03 decrement (95% CI -0.04, -0.01) in the E/A ratio. A 1 SD (10.1 mmHg) increase in diastolic BP was associated with a 1.51-g/m² increment (95% CI 0.80-2.21) in LV mass index, a 0.46-mm increment (95% CI 0.31-0.61) in aortic root diameter, a 0.77-mm increment (95% CI 0.63-0.91) in ascending aorta diameter, and a 0.05 decrement (95% CI -0.07, -0.04) in E/A ratio. In conclusion, specific echocardiographic features were associated with the BP level. LV structure, ascending aorta diameter, and the E/A ratio were associated with systolic and diastolic BP. Left atrial diameter was positively associated only with systolic BP, and aortic root diameter was positively associated only with diastolic BP. These echocardiographic features may be valuable for early identification of target organ damage caused by elevated BP.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of alcohol-mediated bilateral adrenal artery embolization in patients with idiopathic hyperaldosteronism: a 6-month follow-up of a randomized controlled trial.","authors":"Yaqiong Zhou, Sen Liu, Guo Ji, Changqiang Yang, Lingling Zhang, Tao Luo, Fei Huang, Zongling Chen, Jixin Hou, Peijian Wang","doi":"10.1038/s41371-025-01032-6","DOIUrl":"https://doi.org/10.1038/s41371-025-01032-6","url":null,"abstract":"<p><p>Although unilateral adrenal artery embolization (AAE) has emerged as an alternative treatment for patients with primary aldosteronism (PA), it may be insufficient for treating patients with idiopathic hyperaldosteronism (IHA) due to the bilateral nature of their condition. This study aimed to investigate the safety and efficacy of alcohol-mediated bilateral adrenal artery embolization (Bi-AAE) in patients with idiopathic hyperaldosteronism (IHA). A total of 72 patients were randomly assigned in a (1:1) ratio to receive either Bi-AAE or spironolactone (20-60 mg/day). The primary endpoint was the change in office systolic blood pressure (SBP) from baseline to 6 months. Key secondary endpoints included changes in 24 h blood pressure, aldosterone levels, aldosterone-to-renin ratio (ARR), and serum potassium. At 6 months, Bi-AAE significantly reduced office SBP compared to spironolactone (-18.9 ± 16.4 mmHg vs. -11.6 ± 9.3 mmHg; treatment difference: -7.4 mmHg; P = 0.03), with a greater proportion of Bi-AAE patients achieving target SBP (<140 mmHg; 77.1% vs. 51.5%; P = 0.027). Bi-AAE also resulted in significantly greater reductions in 24 h and home SBP at 1, 3, and 6 months (all P < 0.05). Furthermore, Bi-AAE was more effective in correcting biochemical abnormalities, including hyperaldosteronism and renin suppression (all P < 0.05). Importantly, Bi-AAE preserved zona fasciculata function, as evidenced by normal morning serum cortisol levels and intact responses to ACTH stimulation post-procedure. No serious adverse events occurred during the perioperative or 6-month follow-up period. These findings support Bi-AAE as a safe, minimally invasive, and highly effective alternative to medical therapy for managing IHA. Although the findings support Bi-AAE as a safe, minimally invasive, and highly effective alternative to medical therapy for managing IHA, the need for long-term data before drawing definitive conclusions is emphasized. Future studies with extended follow-up are necessary to confirm its long-term benefits and risks. Trial registration: The trial has been registered at ClinicalTrials.gov (NCT05262660).</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ambulatory blood pressure monitoring among patients with postural orthostatic tachycardia syndrome, autonomic dysfunction, and controls.","authors":"Megan Bach, Joseph Kassab, Ahmed Mohamed Hassan, Nandan Kodur, Luke J Laffin","doi":"10.1038/s41371-025-01031-7","DOIUrl":"https://doi.org/10.1038/s41371-025-01031-7","url":null,"abstract":"<p><p>The utility of ambulatory blood pressure monitoring (ABPM) among patients with various forms of autonomic dysfunction (AD) is unknown. Twenty-four-hour ABPM among patients with postural orthostatic tachycardia syndrome (POTS), AD without POTS, and control patients without AD were compared. Patients with AD without POTS had high rates of uncontrolled blood pressure (76%), whereas 19% of patients with POTS had uncontrolled blood pressure, suggesting ABPM may provide less value among patients with POTS.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea.","authors":"Ana Cristina Tenório da Costa Fernandes, João Carlos Moreno Azevedo, Elizabeth Silaid Muxfeldt, Fabio de Souza","doi":"10.1038/s41371-025-01030-8","DOIUrl":"https://doi.org/10.1038/s41371-025-01030-8","url":null,"abstract":"<p><p>Continuous Positive Airway Pressure (CPAP) is the gold standard treatment for Obstructive Sleep Apnea (OSA). Its long-term effects on Resistant Hypertension (RHT) have not yet been fully established. We conducted a prospective intervention study to evaluate the impact of long-term CPAP therapy on office and ambulatory blood pressure (BP) in patients with RHT and moderate to severe OSA. Patients who used CPAP for a minimum of 12 months were included in the CPAP group and compared with those who declined to use CPAP despite clinical indications (control group). All participants underwent 24-h ambulatory blood pressure monitoring (ABPM) at baseline and at the end of the study. Intergroup comparisons of BP changes were performed using a general linear model, including two per-protocol analyses for patients with optimal CPAP adherence (at least 4 h/night) and those with refractory hypertension. A total of 124 individuals were included (65 in the CPAP group and 59 controls), with a mean age of 60.7 ± 7.8 years. The intention-to-treat analysis found no significant differences in overall BP changes between groups. The per-protocol analyses (50 CPAP users with optimal adherence and 28 with refractory hypertension) showed significant reductions in nighttime systolic BP (-8.1 mmHg (95% CI -14.7 to -1.5) and -25.6 mmHg (95% CI -40.1 - -10.5), respectively) and in nighttime diastolic BP (-5.3 mmHg (95% CI -9.6 to -1.1) and -13.9 mmHg (95% CI -22.5 - -5.3), respectively). These findings suggest that while CPAP benefits adherent patients and refractory hypertensives, its overall long-term effects on resistant hypertension require further investigation.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baroreceptor sensitivity, kidney function and cardiovascular risk in prepubescent boys with normal versus elevated blood pressure.","authors":"Aletta S Uys, Wayne Smith, Annemarie Wentzel, Catharina Mc Mels, Ruan Kruger","doi":"10.1038/s41371-025-01029-1","DOIUrl":"https://doi.org/10.1038/s41371-025-01029-1","url":null,"abstract":"<p><p>In children reduced baroreceptor sensitivity (BRS) has been linked to obesity but not blood pressure (BP). Offspring of hypertensive parents have reduced BRS, with possibly increasing risk for hypertension development and kidney dysfunction. This study aimed to explore the relationships between BRS, kidney function, familial cardiovascular-and lifestyle risk in prepubescent boys with varying BP levels. We included 40 Black and 41 White boys (aged 6-8 years). Anthropometric measurements included calculated body mass index (BMI) and sex-and-age specific BMI z-scores (BMIz). Demographic data was collected with questionnaires and included information on familial cardiovascular-and lifestyle risk. Cardiovascular measures were resting BP and Finometer monitoring for BRS calculation. Kidney function was assessed using urinary albumin-to-creatinine ratio (uACR). Stratification was based on normal or elevated BP status. The elevated BP group had more Black boys (n = 37; 65.5%; p = 0.003). Notably, BRS (p = 0.56) and uACR (p = 0.92) were comparable between normal and elevated BP groups. In the normal BP group, single, partial and fully adjusted models revealed an inverse association between BRS and uACR (β = -0.38; p = 0.009). In the elevated BP group, BRS associated with familial risk (β = -0.52; p = 0.002), BMIz (β = 0.36; p = 0.020) and Black ethnicity (β = -0.37; p = 0.024), yet no association was evident between BRS and uACR. A cardioprotective relationship exists between BRS and kidney function in boys with normal BP. In boys with elevated BP, a positive familial cardiovascular-and lifestyle risk, adiposity and Black ethnicity seems to contribute to cardiovascular disease risk via a relationship with lower BRS.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new approach to interpreting the LF/HF ratio: a study in hypertensive patients.","authors":"Tatiane de Azevedo Rubio, Moacir Fernandes de Godoy, Jéssica Roma Rodrigues Uyemura, José E Tanus-Santos, Tatiana Palotta Minari, José Fernando Vilela-Martin, Juan Carlos Yugar-Toledo, Heitor Moreno Junior","doi":"10.1038/s41371-025-01028-2","DOIUrl":"https://doi.org/10.1038/s41371-025-01028-2","url":null,"abstract":"<p><p>Resistant arterial hypertension (RHTN) has been associated with sympathetic hyperactivity, which represents a significant challenge in the management and treatment of arterial hypertension. In the present study, autonomic modulation was analysed in hypertensive, resistant hypertensive, and refractory hypertensive patients, compared to a group of apparently healthy normotensive individuals. Participants with resistant hypertension were included only after the exclusion of secondary hypertension and pseudo-resistance diagnoses. Heart rate variability (HRV) analysis included parameters from the time domain, frequency domain, and nonlinear methods, providing a comprehensive assessment of global autonomic modulation. The results demonstrated a significant reduction in global HRV across all three hypertensive groups, evidenced by decreases in parameters from the time domain, frequency domain and nonlinear methods. Furthermore, a concomitant reduction in the low- and high-frequency components was observed, with the decrease in the high-frequency component being more pronounced. These findings challenge the traditional view of isolated sympathetic hyperactivity in hypertension. Instead, the results reveal a relative predominance of sympathetic function due to the more marked attenuation of parasympathetic activity. These results underscore the need to reinterpret autonomic dysfunction in arterial hypertension, particularly in its more severe forms, as a global loss of autonomic modulation.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple system biology approaches reveals the role of the hsa-miR-21 in increasing risk of neurological disorders in patients suffering from hypertension","authors":"Sanjana Mishra,&nbsp;Prekshi Garg,&nbsp;Mala Trivedi,&nbsp;Prachi Srivastava","doi":"10.1038/s41371-025-01027-3","DOIUrl":"10.1038/s41371-025-01027-3","url":null,"abstract":"Hypertension is a prevalent disease that substantially elevates the risk of neurological disorders such as dementia, stroke and Parkinson’s disease. MicroRNAs (miRNAs) play a critical role in the regulation of gene expression related to brain function and disorders. Understanding the involvement of miRNAs in these conditions could provide new insights into potential therapeutic targets. The main objective of this study is to target and investigate microRNAs (miRNAs) associated with neurological disorders in patients suffering from hypertension. The genes involved in hypertension were identified from various databases including GeneCard, MalaCard, DisGeNet, OMIM &amp; GEO2R. The key gene for hypertension was identified using a systems biology approach. Also, potent phytochemical for hypertension was determined by computer-aided drug-designing approach. Functional miRNAs were determined for the key target gene using miRNet analytics platform by hypergeometric tests. Further, the gene-miRNA interaction was determined and enrichment analysis was done. RPS27A was identified as a key target gene for hypertension. Naringenin showed effective molecular interaction with RPS27A with a binding energy score (−6.28). Further, a list of miRNAs which were targeting brain disorders was determined from miRNet. A gene-miRNA network was constructed using the PSRR tool for Parkinson’s Disease, Autism Spectrum Disorder, Acute Cerebral Infarction, ACTH-Secreting Pituitary Adenoma, &amp; Ependymoma. Further, miRNA 21 &amp; miRNA 16 were found to be associated with four of the neurological disorders. The study identifies specific miRNAs that may serve as potential biomarkers for brain disorders in hypertensive patients. Targeting these miRNAs could open new avenues for therapeutic strategies aimed at mitigating neurological damage in this patient population.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 6","pages":"432-441"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ambient temperature and blood pressure in the Jackson Heart Study","authors":"Annabel X. Tan,&nbsp;Andrew Y. Chang,&nbsp;Daichi Shimbo,&nbsp;Adam Bress,&nbsp;Mario Sims,&nbsp;Michelle C. Odden","doi":"10.1038/s41371-025-01026-4","DOIUrl":"10.1038/s41371-025-01026-4","url":null,"abstract":"Extreme temperature events related to climate change may impact blood pressure (BP). African American populations are disproportionately affected by temperature extremes due to structural inequities. We examined the association between ambient outdoor temperature and BP among participants in JHS, a cohort of African American adults residing in the tri-county area of Jackson, Mississippi. Our primary hypothesis is that daily higher outdoor ambient temperatures would be associated with lower BP. We used a linear-mixed effects model to determine the relationship between temperature and systolic and diastolic blood pressure (SBP and DBP) at three visits (N = 5296). Participants had BP readings across three visits: Visit 1 (2000–2004), Visit 2 (2005–2008), Visit 3 (2009–2013). Cardiovascular disease (CVD), diabetes, BP medication, sex, age, and visit number were included as adjustment variables. For every 1-degree Celsius higher average temperature from the mean, SBP was 0.11 mm Hg lower (95% CI: −0.14, −0.07, p &lt; 0.001) in adjusted models. Similarly, for every 1-degree Celsius higher average temperature from the mean, DBP was 0.06 mm Hg lower (95% CI: −0.08, −0.04) in adjusted models. The associations were weakly curvilinear (inverted U-shape) with significant quadratic terms. This relationship was not modified by markers of socioeconomic status. This is the first study in the Jackson Heart Study (JHS) to investigate the association between temperature and blood pressure. Further research is needed to explore this relationship in vulnerable populations living in areas prone to extreme temperatures.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 6","pages":"415-421"},"PeriodicalIF":2.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}