Journal of Human Hypertension最新文献_第4页

Accuracy of semi-quantitative gold nanoparticle-based quick cortisol assay with and without adrenocorticotropic hormone infusion during adrenal vein sampling 在肾上腺静脉取样时输注促肾上腺皮质激素，基于金纳米颗粒的半定量快速皮质醇测定的准确性。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-26 DOI: 10.1038/s41371-025-00997-8

Felicity Stringer, Pamela Franco, Landy M. Wu, Christopher A. Preston, Maresa M. Derbyshire, Richard J. MacIsaac, Eric X. Z. Yong, Benjamin Marginson, Nirupa Sachithanandan

{"title":"Accuracy of semi-quantitative gold nanoparticle-based quick cortisol assay with and without adrenocorticotropic hormone infusion during adrenal vein sampling","authors":"Felicity Stringer, Pamela Franco, Landy M. Wu, Christopher A. Preston, Maresa M. Derbyshire, Richard J. MacIsaac, Eric X. Z. Yong, Benjamin Marginson, Nirupa Sachithanandan","doi":"10.1038/s41371-025-00997-8","DOIUrl":"10.1038/s41371-025-00997-8","url":null,"abstract":"Adrenal vein sampling (AVS) is the gold standard for diagnosing unilateral primary aldosteronism. Point-of-care rapid cortisol assays such as the gold nanoparticle based quick cortisol assay (QCA) are used to confirm accurate cannulation of the adrenal veins during the procedure and have improved AVS success rates. In this retrospective cohort study, we reviewed the results of consecutive AVS procedures (n = 37) performed with and without ACTH (synacthen) infusion between October 2020 and December 2022 at our institution. We compared (1) the accuracy of point-of-care QCA at semi-quantitatively assessing successful adrenal vein cannulation before and after ACTH infusion when compared with selectivity index based on laboratory cortisol measurements, (2) accuracy of QCA based on peripheral and adrenal vein cortisol levels and (3) the impact of time of day on the accuracy of QCA. We found the accuracy of QCA compared with formal laboratory cortisol measurements was 71% pre-ACTH and 100% post-ACTH (p-value < 0.001). Pre-ACTH, the accuracy of QCA was higher in the lowest (28–257 nmol/L) and highest (466–25130 nmol/L) adrenal vein cortisol tertiles compared to the mid-tertile. Post-ACTH, the accuracy of QCA remained high regardless of adrenal vein cortisol levels. Time of day did not affect the accuracy of the QCA. We conclude that during basal AVS subjective, visual estimates of adrenal vein cortisol levels using the QCA semi-quantitively should not be solely relied upon to guide catheter placement. These results will help guide clinicians in the appropriate clinical situations in which QCA should be used during AVS.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"279-285"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00997-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-reported hypertension prevalence, risk factors, and knowledge among South Africans aged 24 to 40 years old 24至40岁南非人自我报告的高血压患病率、危险因素和知识

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-24 DOI: 10.1038/s41371-024-00957-8

Asanda Mtintsilana, Witness Mapanga, Ashleigh Craig, Siphiwe N. Dlamini, Shane A. Norris

{"title":"Self-reported hypertension prevalence, risk factors, and knowledge among South Africans aged 24 to 40 years old","authors":"Asanda Mtintsilana, Witness Mapanga, Ashleigh Craig, Siphiwe N. Dlamini, Shane A. Norris","doi":"10.1038/s41371-024-00957-8","DOIUrl":"10.1038/s41371-024-00957-8","url":null,"abstract":"Although hypertension is a significant public health burden in South Africa (SA), less is known about its prevalence, risk factors, and possible preventative strategies among young adults. We assessed the prevalence, possible risk factors, and knowledge associated with self-reported hypertension among young adults from SA. A cross-sectional online survey was conducted among 1000 young South African adults (24–40 years; 51.0% women). We administered a socio-demographic questionnaire and collected information on measures of socio-economic status (SES) (e.g. asset wealth index), self-reported medical history, and lifestyle risk factors. Furthermore, a modified version of the hypertension evaluation of lifestyle and management questionnaire was used to assess participants’ hypertension knowledge. The overall prevalence of self-reported hypertension was 24.0%, with significant differences between women and men (27.5% and 20.4% respectively, p = 0.033). Only 16.8% of the respondents had good hypertension knowledge. There was a positive association between good knowledge of hypertension and being hypertensive (OR = 1.43 CI:1.23–3.12), monthly blood pressure check-ups (OR = 2.03 CI:1.78–3.23), knowing the side effects of uncontrolled blood pressure (OR = 1.28 CI:1.07–1.89) and having a biological mother with hypertension (OR = 1.79 CI:1.53–2.21). Being employed full-time (OR = 0.74 CI:0.69–0.80), having a higher SES (wealth index 4 (OR = 0.70 CI:0.59–0.97) and 5 (OR = 0.65 CI:0.48–0.81)), exercising 6 to 7 days per week (OR = 0.83 CI:0.71–0.94), and not consuming alcohol at all (OR = 0.73 CI:0.67–0.89), were all found to be protective against hypertension. The high hypertension prevalence, lack of hypertension knowledge, and reported risk factors among this group highlight the need for early robust preventative strategies to mitigate hypertension risk among this population.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 2","pages":"177-187"},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-024-00957-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiethnic norms for blood pressure response to submaximal exercise testing in young-to-middle adulthood and associations with hypertension: The NHANES dataset 中青年次最大运动测试血压反应的多民族标准及其与高血压的关系：NHANES数据集

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-23 DOI: 10.1038/s41371-025-00993-y

João L. Marôco

{"title":"Multiethnic norms for blood pressure response to submaximal exercise testing in young-to-middle adulthood and associations with hypertension: The NHANES dataset","authors":"João L. Marôco","doi":"10.1038/s41371-025-00993-y","DOIUrl":"10.1038/s41371-025-00993-y","url":null,"abstract":"The blood pressure (BP) response during exercise testing is a robust correlate of hypertension in middle-to-older White people, but whether this extends to a healthy, young-to-middle-aged multiethnic population is unknown. Moreover, it is unclear what constitutes an exaggerated BP to submaximal exercise, which is a more reliable and stronger correlate of hypertension than maximal testing. The NHANES dataset was used to interrogate the association of submaximal exercise BP with current hypertension and to provide multiethnic norms for BP responses in young-to-middle-aged adults. The analyses combined NHANES cycles wherein treadmill exercise testing was conducted with an analytic sample of 2544 participants aged 12–49 years (Female: White = 467; Black = 324; Hispanic = 439; Male: White = 493, Black = 351; Hispanic = 470). Weighted logistic models were fitted to test associations between exercise BP and hypertension. Age, sex, and race-specific percentiles were estimated. Exaggerated systolic BP (SBP) responses to exercise testing were defined as readings ≥90th percentile, and ≥ROC-derived cutoff. Regardless of race, sex, exercise workload, clinical and socioeconomic characteristics, a 5-mmHg increase in SBP and diastolic BP during stage 1 of exercise testing was associated with a 15% (aOR: 1.15, 95% CI: 1.08–1.21), and 31% (aOR: 1.31, 95% CI: 1.22–1.40) higher odds for hypertension, respectively. Black males had the highest proportion of exaggerated SBP responses (44%, 95% CI: 36–53%) when defined only via ROC-derived cutoffs. BP responses during submaximal exercise were associated with hypertension, irrespective of race in young-to-middle adulthood. Still, the exaggerated SBP response to exercise of Black males suggests uncontrolled high BP not detected at rest.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"262-273"},"PeriodicalIF":2.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China 脂肪-肌肉比与高血压的关系：中国的一项横断面研究。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-22 DOI: 10.1038/s41371-025-00992-z

Zhe Chen, Dongming Guo, Lifeng Xiao, Honghui Su, Yirun Chen

{"title":"Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China","authors":"Zhe Chen, Dongming Guo, Lifeng Xiao, Honghui Su, Yirun Chen","doi":"10.1038/s41371-025-00992-z","DOIUrl":"10.1038/s41371-025-00992-z","url":null,"abstract":"This study investigated the association between fat-to-muscle ratio (FMR) and hypertension. A total of 1592 participants aged ≥ 40 years were included. Participants were divided into four groups by quartiles of FMR. Odds ratio (OR) and 95% confidence interval (CI) was calculated using logistic regression models. Restricted cubic spline was applied to examine the correlation of FMR and hypertension. Of 1592 participants, 943 (59.2%) participants had hypertension. Hypertension risk rose with FMR quartiles. Compared to FMR quartile 1, ORs were 1.496 (95% CI: 1.115–2.006), 2.445 (95% CI: 1.840–3.249), and 5.415 (95% CI: 3.993–7.344) for quartiles 2, 3, and 4, respectively (P for trend < 0.001). Adjusted OR in quartile 4 was 3.015 (95% CI: 2.083–4.365). Restricted cubic spline showed a linear relationship between FMR and hypertension. Adding FMR improved hypertension risk model performance (P = 0.006). Subgroup analysis revealed FMR interactions with sex (P = 0.010) and BMI (P < 0.016), with a higher hypertension risk in females and non-obese individuals. Additionally, versus FMR quartile 1, hypertensive individuals in quartiles 2 (OR: 1.370, 95% CI: 0.900–2.085), 3 (OR: 2.055, 95% CI: 1.374–3.073) and 4 (OR: 3.102, 95% CI: 2.055–4.682) exhibited a significantly elevated risk of atherosclerotic cardiovascular disease (ASCVD). In summary, Elevated FMR independently correlated with hypertension risk, especially in women, or even in non-obese individuals. FMR is a valuable tool for identifying populations with higher hypertension risk and assessing ASCVD risk in hypertensive individuals. Body composition warrants consideration in future hypertension risk studies.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 4","pages":"301-307"},"PeriodicalIF":2.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we detect masked hypertension and masked uncontrolled hypertension using simple metrics? A novel clinical model for latino population 我们能否用简单的指标检测隐匿性高血压和隐匿性未控制高血压？拉丁裔人群的新型临床模型。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-22 DOI: 10.1038/s41371-025-00996-9

Camila Ponce-Acosta, Neftali Eduardo Antonio-Villa

引用次数: 0

Recurrence of primary aldosteronism 20 years after surgery: a case report 原发性醛固酮增多症术后20年复发1例。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-20 DOI: 10.1038/s41371-025-00994-x

Jie Wang, Cai-Ni Fan, Guo-Xi Wei, Xiao-Jian Zhao, Kai Liu, Meng-Lin Wang, Ling Li, Min Liu, Hai-Ying Zhao

引用次数: 0

Adherence to lifestyle modifications and its associated factors among adult hypertensive patients attending their follow-up at public hospitals in West Shoa, Oromia, Ethiopia, 2023 2023年在埃塞俄比亚奥罗米亚州西绍阿公立医院接受随访的成年高血压患者的生活方式改变依从性及其相关因素

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-17 DOI: 10.1038/s41371-025-00991-0

Demessie Diriba, Dereje Guta

{"title":"Adherence to lifestyle modifications and its associated factors among adult hypertensive patients attending their follow-up at public hospitals in West Shoa, Oromia, Ethiopia, 2023","authors":"Demessie Diriba, Dereje Guta","doi":"10.1038/s41371-025-00991-0","DOIUrl":"10.1038/s41371-025-00991-0","url":null,"abstract":"Hypertension is a serious public health concern, disturbing millions of lives worldwide. Effective lifestyle modifications are the foundation for the prevention and control of hypertension. The aim of this study is to assess adherence to lifestyle modifications and associated factors among adult hypertensive patients in West Shoa, Oromia, Ethiopia. An institutional-based cross-sectional study design was employed from August 20 to September 20, 2023. A systematic random sampling technique was employed to select study participants. A binary logistic regression model was used to check the association between independent and outcome variables. The strength of the association was stated using an adjusted odds ratio with a 95% confidence interval and a p-value of < 0.05. The study included 316 study participants, with a 98.8% response rate. The magnitude of adherence to lifestyle modifications was 31% (95%CI: 25.7–36.1%). Age (AOR = 2.71, 95% CI: 1.19–6.19), residence (AOR = 0.19, 95%CI: 0.09–0.39), duration of treatment (AOR = 2.17, 95%CI: 1.14–4.13), attitude (AOR = 2.14, 95%CI: 1.06–4.30), perceived social support (AOR = 6.23, 95%CI: 3.18–12.22) and self-efficacy (AOR = 2.66, 95%CI: 1.25–5.69) were the independent predictors of lifestyle modifications adherence. This study found that adherence to lifestyle modifications was low among hypertensive patients.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"192-198"},"PeriodicalIF":2.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41371-025-00991-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spotlight on hypertension in the African Continent 关注非洲大陆的高血压。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-04 DOI: 10.1038/s41371-025-00989-8

Zakirullah Khan, Sunil K. Nadar

引用次数: 0

Call for candidates: Editor-in-Chief for the Journal of Human Hypertension 招聘候选人：《人类高血压杂志》主编。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-02-03 DOI: 10.1038/s41371-025-00988-9

引用次数: 0

The pulsatile brain, pulse pressure, cognition, and antihypertensive treatments in older adults: a functional NIRS study 老年人搏动脑、脉压、认知和降压治疗：一项功能性近红外光谱研究。

IF 2.7 4区医学

Journal of Human Hypertension Pub Date : 2025-01-30 DOI: 10.1038/s41371-024-00985-4

Hanieh Mohammadi, Florent Besnier, Thomas Vincent, Sarah Fraser, Anil Nigam, Frédéric Lesage, Louis Bherer

{"title":"The pulsatile brain, pulse pressure, cognition, and antihypertensive treatments in older adults: a functional NIRS study","authors":"Hanieh Mohammadi, Florent Besnier, Thomas Vincent, Sarah Fraser, Anil Nigam, Frédéric Lesage, Louis Bherer","doi":"10.1038/s41371-024-00985-4","DOIUrl":"10.1038/s41371-024-00985-4","url":null,"abstract":"Age-related arterial stiffness increases pulsatility that reaches the cerebral microcirculation, compromises cerebrovascular health and lead to cognitive decline. The presence of cardiovascular risk factors (CVRFs) such as high blood pressure can exacerbate this effect. Despite extensive research on the impact of antihypertensive treatments on reducing arterial stiffness, little is known about the impact of antihypertensive treatments on pulsatility in cerebral microcirculation. This study investigated the impact of antihypertensive treatments on cerebral pulsatility and cognition in older adults with CVRFs. Participants were 42 older adults with diverse CVRFs in two groups of untreated (n = 21, mean 67.2 ± 5.9 years old, 57.1% female) and treated with antihypertensive medications (n = 21, mean 67.2 ± 5.5 years old, 61.1% female). Cognitive scores of processing speed and executive functions were evaluated behaviorally using the four subsets of the Stroop test. A near-infrared spectroscopy (NIRS) device recorded hemodynamics data from the frontal and motor cortex subregions. The data were then used to extract an optical index of cerebral pulsatility. Results indicated that after controlling for CVRFs, the antihypertensive treatment was associated with lower cerebral pulsatility (untreated 33.99 ± 6.68 vs. treated 28.88 ± 5.39 beats/min, p = 0.009). In both groups cerebral pulsatility was associated with pulse pressure (p < 0.05). Also, treated group had significantly higher cognitive scores in executive functions compared with the untreated group (p < 0.05). These results suggest that beyond its known effect on blood pressure, antihypertensive treatments might also favor cerebrovascular health by reducing pulsatility in the cerebral microcirculation.","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":"39 3","pages":"217-225"},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0