湖南大学学报(自然科学版)最新文献

{"title":"Dissolution Testing and Content Uniformity Analysis for Metformin Tablets Using Vildagliptin as an Internal Standard","authors":"H. Younes, Sandi Saad Ali Adib, Mohamed Izham Mohamed Ibrahim, Ala’ Ahmad Shalash","doi":"10.55463/issn.1674-2974.50.1.1","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.1","url":null,"abstract":"Poor-quality medicines, brand or generic, do not meet acceptable standards. Further studies must explore the status of generic medicines in Qatar and the region, especially during the GCC crisis. The research goal is to assess whether the multi-sourced antidiabetic medication, Metformin Hydrochloride (MH) tablets marketed in Qatar and other selected worldwide locations fulfill the compendial quality control parameters and in vitro bioequivalence/interchangeability requirements. Could we safely replace branded Glucophage® with generic MH without compromising the patient’s interest? This laboratory experimental study assessed the quality control parameters and in vitro bioequivalence/interchangeability requirements of sixteen marketed products of MH tablets from 11 countries in addition to 33 MH products from Qatar’s market based on the US Pharmacopeia (USP 34) guideline recommendations. Content analysis test showed that the minimum amount was 96.9% in product S10 from the International samples and 97.1% for both Neomet (Q-N.m-1) and Glucophage (Q-G.Ph-2) from Qatar’s samples, while the maximum amount was 103.3% in product S4 (Formit 500) from the international market and 101.8% in product Q-Di-4, which is Dimet -500 from Qatar’s market. The rapid increase in the percentage of the drug release is noticed in products (S2-S6-S8-S9-S10-S12-S13-s15-S16–(Q-N.m-1)-(Q-Di-1)-(Q-Di-3)-(Q-D.ph-1)-(Q-D.ph-3)-(Q-M.ph-1)-(Q-M.ph-2)-(Q-G.m-3)) as they achieved the acceptance limit at the first time point (15 min). However, the products that showed the slowest release are (S4-S11-S14-(Q-D.Ph-3)). But, eventually, at 45 min, all the products passed the dissolution test. similarity factor results revealed that the Glucophage (S15) and (Q- G.Ph-5) were found to be the most similar products to the innovator brand Glucophage® (France) with the highest similarity factors (f2= 91.1%) and (f2 = 90.0%) respectively. This research has confirmed that not all the generics are exchangeable with the reference product Glucophage®.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49291165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skills for Prospective Civil Engineers: Mastery of Current and Future Situations","authors":"M. Ramadhan, Sutarto, S. Widodo, Nurul Anisa","doi":"10.55463/issn.1674-2974.50.1.21","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.21","url":null,"abstract":"This study aims to explore the competency mastery of prospective civil engineers based on the 3rd edition of the Civil Engineering Body of Knowledge and predict the future skills needed for prospective civil engineers in the next 10-20 years. A quantitative approach with a survey method was carried out to answer the first research objective. The questionnaire is filled out by prospective civil engineers who are final-year students of bachelor’s in civil engineering. Next, a descriptive analysis was conducted to provide an overview of the mastery of competencies. Finally, the Systematic Literature Review (SLR) method was carried out to answer the second research objective. The analyzed literature uses the Scopus Database with keywords that describe future work skills and competencies. Then the articles were then filtered using the PRISMA Diagram and analyzed with the help of the R program to produce a word cloud that describes the types of future skills needed. The research results show that 1) civil engineer candidates must increase competence in the application of natural sciences, humanities aspects for Civil Engineering, mechanics and fluids problems, formulation of solutions to problems relevant to Civil Engineering, engineering economics, probability concepts, and statistics. 2) They must develop future skills needed for prospective civil engineers: critical thinking, communication, professionalism, problem-solving, leadership, teamwork, collaboration, and the principle of sustainability. The findings of this study serve as evaluation material and recommendations for civil engineering education providers to prepare prospective civil engineers with a global outlook.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41384699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Crowdshipping Business Opportunity in Air Transportation through the Mobility of Inter-Urban Passengers and the Utilization of Internet in Hang Nadim Airport, Batam","authors":"Moden Purba, H. Aimon, A. Satrianto","doi":"10.55463/issn.1674-2974.50.1.3","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.3","url":null,"abstract":"This study examines logistics business opportunities through air transportation in relation to passenger mobility and internet usage. Data collection was carried out using a survey method by distributing questionnaires involving 100 respondents, and the research was conducted at Hang Nadim airport in Batam, Indonesia. Data analysis uses the Partial Least Square (PLS) approach with the help of SmartPLS 3.0. PLS is a statistical method of Structural Equation Modeling (SEM) based on variance. The results of the study found that there was a significant influence of passenger mobility between cities (X1), air transportation (X2), and internet usage (X3) simultaneously on crowdshipping (Y) with a determination of 0.977. Furthermore, the relationship between inter-city passenger mobility (X1) and air transportation (X2) is determined at 0.954 and inter-city passenger mobility and air transportation (X2) with simultaneous usage (X3) - at 0.954. The novelty of this study is the relationship between the variables of inter-urban population mobility, air transportation, internet usage, and crowdshipping in logistics transportation at Hang Nadim Airport, Batam, Indonesia. The study concluded that through inter-city passenger mobility, air transportation and internet usage had a significant effect on the crowdshipping business at Hang Nadim Airport, Batam.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43155047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Requirements for Applying the Six Sigma Method to Develop the Management Performance of the Employees at the Palestinian Ministry of Youth and Sports","authors":"Omar Nasrallah Qeshta","doi":"10.55463/issn.1674-2974.50.1.6","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.6","url":null,"abstract":"This study aims to identify the requirements for applying the Six Sigma method to develop the management performance of the employees of the Palestinian Ministry of Youth and Sports based on enabling the concept and importance of developing management performance through the areas of Six Sigma: support of senior leadership, feedback and measurement, continuous improvement, processes and systems, and human resources using the descriptive approach. The research population consisted of 125 members of the officials working in the Palestinian Ministry of Youth and Sports, including managers, general managers, district managers, and heads of departments. The research sample consisted of 95 individuals from the Palestinian Ministry of Youth and Sports, and the researcher used the requirements for applying the Six Sigma method to develop the management performance of the workers at the Palestinian Ministry of Youth and Sports to collect data from its preparation and the appropriate statistical treatments. The author describes the obtained results that allow workers in the Ministry to move toward supporting senior leadership, feedback and measurement, continuous improvement, processes and systems, and human resources came at a medium level. Also, the author describes the obtained recommendations, working to improve the quality of the service provided by the Palestinian Ministry of Youth and Sports considering applying the Six Sigma method, assigning specialists to improve the quality of the service provided by the Ministry, developing a clear and defined strategy followed by services provided by the Ministry, holding periodic meetings and continuous training for the workers at sports federations and refining their skills to enhance service quality and improve their interaction with the visitors of the Ministry, and forming a human resource management unit at each federation, such that it can adopt all the requirements to apply the Six Sigma method.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42819252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Proposed Test Set Reduction Hybrid Compaction Schemes for FPGA-Based Designs","authors":"A. R. Khatri","doi":"10.55463/issn.1674-2974.50.1.23","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.23","url":null,"abstract":"Recently, the density and intricacy of Very Large-Scale Integration (VLSI) circuits are grown, and the number of test vectors has increased drastically. Owing to this, the cost of testing is a significant component for consideration. The two main factors that measure the cost of the test are the size of the test vector sets and test data volume. Compression and compaction are the two approaches used to reduce the aforementioned factors. Compaction is a primary process in the test generation procedure, and there are two classes for it, i.e., dynamic and static compaction approaches. In this paper, the author performs testing and obtains the compact test vectors for various FPGA-based designs. The RASP-FIT fault injection testing tool provides the ATPG testing framework. In this paper, the testing is performed on various FPGA benchmark designs written in Verilog HDL, and the results are validated. The ATPG method developed under the RASP-FIT tool contains new hybrid compaction techniques that calculate compaction and fault coverage for the designs. This work is also compared with the previous work and found that the proposed compaction scheme is better at compacting the test vectors.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46846874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communism Issues in Kompas Daily, Transformation from the Old Order to the New Order Era","authors":"Abie Besman, D. Hidayat, A. Bajari, A. Moosmüller","doi":"10.55463/issn.1674-2974.50.1.11","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.11","url":null,"abstract":"The editorials of large national mass media naturally become a part of the history of political power transitions. Such is the case for Kompas Daily, one of the oldest mass media in Indonesia. Despite being banned nationally since 1966, communism is still a topic of discussion within media editorials. This research aims to present new evidence of the role of journalism in raising the issue of communism in the mass media during the regime transition from the Old Order to the New Order in Indonesia. This research uses the historiography method with a constructivist approach and found Kompas Daily editorial dynamics in responding to the issue of communism that occurred during the regime transition. The authors used data collected from the mass media, research studies, publications, online technology, interviews, and academic literature related to the communism issue in the Kompas Daily media practice, supported by a check-list for the classification of research materials, map of writing, and format of research notes. The study results show that when dealing with power, Kompas Daily practices swing journalism that adapts to developing situations and conditions. Swing media allows Kompas Daily to create a position that lets them maintain journalistic independence while remaining politically secure in accommodating the ruling regime.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41758340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiplasmodial and Antioxidant Activity of Garcinia Bancana Extract","authors":"Rifaldi, A. Fadlan, T. Ersam, Adi Setyo Purnomo, S. Fatmawati","doi":"10.55463/issn.1674-2974.50.1.28","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.28","url":null,"abstract":"Malaria caused by Plasmodium parasites is a significant public health issue, particularly in tropical and subtropical regions. There is also resistance to chloroquine-based therapy, which highlights the need for novel therapeutic agents. Therefore, our project in exploring antiplasmodial agents from Garcinia Indonesia continues. This study evaluates the phytochemical content of G. bancana by the total phenolic content (TPC) and total flavonoid content (TFC) and its in vitro antioxidant and antiplasmodial activities. The TPC and TFC values were determined using a UV-VIS spectrophotometer, while the antioxidant activity was determined using the DPPH, ABTS, and FRAP assays. Antiplasmodial activity against a chloroquine-sensitive strain 3D7 was evaluated using the Giemsa staining method. The highest TPC value of 195.75 ± 1.24 mg GAE/g was obtained from methanolic extract, while a TFC value of 82.79 ± 0.34 mg QE/g extract was found from dichloromethane extract. The methanolic extract exhibited the most potent antioxidant activity in the DPPH and FRAP assays with IC50 values of 6.07 ± 0.06 μg/ml and 74.35 ± 3.77 μM Fe2+/g, respectively. The n-hexane extract was found to be the most potent on ABTS antioxidant and antiplasmodial assays with IC50 values of 1.22 ± 0.02 μg/ml and 0.23 ± 0.01 μg/ml, respectively. Furthermore, the DPPH antioxidant was negatively correlated with antiplasmodial significantly at 0.05. These findings suggest that the n-hexane extract of G. bancana has great potential as a source of antioxidant and antiplasmodial compounds. To the best of our knowledge, this study provides microscopic evidence in addition to the strongest antiplasmodial efficacy of Garcinia extract.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43193066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphic Health Warnings on Cigarette Packages: Adolescents’ Emotive Reaction toward Smoking","authors":"Shakir Hafeez, Muhammad Aslam, Muhamamd Wasif Hanif, Mubeen Ahsan, Shoaib Iqbal, Syeda Asmara Nisar, Malik Muhammad Sarmad","doi":"10.55463/issn.1674-2974.50.1.15","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.15","url":null,"abstract":"This study aims to identify the prominent role of graphic health warnings on cigarette packets due to mediating evoked fear in impelling smoking considerations and behavior. The quantitatively designed study deployed a probability (simple random) sampling technique to collect the sample size (Yamane method) of 384 adolescents (smokers or non-smokers) living in the Abbottabad district of Pakistan. The study implemented the Hayes Process model for statistical examining the gathered data in SPSS 20. The empirical findings of the study depicted that perceived visibility of the graphic health warning threats has a positive impact in raising evoking emotions (fear, guilt, disgust), while perceived visibility significantly impacts the emotions (fear, guilt, disgust) of adolescents who smoke. Moreover, smoking status moderates the effects of guilty on the personal consideration of smoking. The results indicated the complete mediation for the indirect effect of the independent variable (perceived visibility) through mediators (fear, guilt, disgust) on dependent variables, i.e., personal and other people's attitudes toward smoking and beliefs about secondhand smoke. The novel empirical findings of the study revealed that adolescents who smoke have a higher level of fear and guilt than non-smokers. The study recommends using graphic warnings about the dangers of smoking to efficiently stimulate emotions in adolescents to manage adult smoking behavior.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41460585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coastal Ecosystem Assessment with an Integrated Approach to Land and Seascape Coastal Ecosystems for Conservation: A Case Study of the Pulo Doro Coast, Malang Regency","authors":"Rudianto, D. Setyohadi, A. Isdianto, K. S. Harahap","doi":"10.55463/issn.1674-2974.50.1.26","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.26","url":null,"abstract":"This research starts from the phenomenon of climate change and increasing land subsidence in the coastal areas. Disasters that often occur due to climate change and subsidence result in the destruction of coastal communities' property, loss of life, agricultural land cannot produce optimally, and tsunamis, tidal floods, and liquefaction are increasingly common. If the incident is not addressed, it will lead to a more severe disaster, and the lives of coastal communities will be threatened. This research aims to assess the condition of coastal ecosystems, both coastal ecosystems, landscapes and seascapes, which are then assessed for the level of usage (economic), conservation (ecology), and the value of local wisdom (social). The method used includes three models: geographic information system (GIS), partial least square (PLS), and total economic value (TEV). GIS is used to assess the presence of landscapes and seascapes. PLS is used to assess public opinion and assessment of the existence of coastal ecosystems. TEV is used to assess the economy. The results of the study show that there are still many Pulo Doro beaches that have not been intervened by anthropogenic processes. The condition of the coastal ecosystem is still intact, although natural processes have begun stressing the coastal area due to the increasing wave height. The results of the PLS show that the community values the landscape as 0.753, the seascape assessment as 0.666, the assessment of the relationship between the landscape and the seascape as 0.841, the assessment of the condition of the Pulo Doro Coastal as 0.693, and efforts to develop a Pulo Doro coastal ecosystem management strategy 0.766. The results of the TEV calculation show that both the landscape and seascape show that the economic value is still not exploited much. The results of this study found a model for managing the coast based on landscape and seascape approaches.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43168344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft Skills Model for Employability in Mexico","authors":"Blanca Angélica de la Concha Solís, Benedicta María Domínguez Valdez, Carlos Enríquez Ramírez, Liliana de Jesús Gordillo Benavente","doi":"10.55463/issn.1674-2974.50.1.14","DOIUrl":"https://doi.org/10.55463/issn.1674-2974.50.1.14","url":null,"abstract":"Nowadays, soft skills are known as skills of the XXI century; in Mexico, it is necessary to promote or promote soft skills to encourage productivity, employability, and improve the quality of life of people or young professionals, so it is essential to know those skills that, in addition to the basic knowledge, employers require since skills necessary to contribute to the same objectives of the companies can be determined [1]. In any organization, certain competencies acquired by employers are required, and that is where soft skills play an important and fundamental role in companies, soft skills are considered a holistic concept of competence that involves the mobilization of knowledge, attitudes, and values to meet complex demands [2]. The objective of this research was to design a model for the employability of companies in Mexico. The methodology used for this research was a quantitative approach, causal correlational scope, and non-experimental, translational, and causal correlational research design [3]. Factor analysis was used to prevent two variables from measuring the same and multiple regression to determine the influence of soft skills on employability [3] in large companies in transformation in the State of Hidalgo, Mexico. The research instrument contains 22 items with a Likert scale from totally agree to strongly disagree, with a Cronbach’s alpha of .830. The results were that the soft skills that influence employability are recognition, control of emotions, creative thinking, understanding of feelings, analytical reflections, own feelings and empathy, and relating and understanding with others; it could be concluded that hard work is needed with the integration of previous soft skills with employers.","PeriodicalId":15926,"journal":{"name":"Journal of Hunan University Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44549810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}