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ANTIMICROBIAL ACTIVITY OF 4{[(7-CHLORO-2-NITRO PHENOTHIAZINE-10-YL)-PHENYL-METHYL]-AMINO}-BENZOIC ACID DERIVATIVES 4{[(7-氯-2-硝基吩噻嗪-10-基)-苯基甲基]-氨基}-苯甲酸衍生物的抗菌活性
Journal of Global Pharma Technology Pub Date : 2011-05-02 DOI: 10.1234/JGPT.V3I1.333
Sharad Kumar, D. Shrivastva, S. Singhal, V. Saini, A. Seth, Y. Yadav, T. Ghelani, Anuj Malik
{"title":"ANTIMICROBIAL ACTIVITY OF 4{[(7-CHLORO-2-NITRO PHENOTHIAZINE-10-YL)-PHENYL-METHYL]-AMINO}-BENZOIC ACID DERIVATIVES","authors":"Sharad Kumar, D. Shrivastva, S. Singhal, V. Saini, A. Seth, Y. Yadav, T. Ghelani, Anuj Malik","doi":"10.1234/JGPT.V3I1.333","DOIUrl":"https://doi.org/10.1234/JGPT.V3I1.333","url":null,"abstract":"The antimicrobial activity of novel synthesized compounds was evaluated by Disc- Diffusion method. Compounds IVc, IVf and IV ­ i showed better, while IVb, IVd and IVh showed moderate and rest showed poor antimicrobial activity. The Disc Diffusion method of assay of drug potency is based on the measurement of the zone of microbial growth inhibition surroundings discs containing various concentrations of test compounds, which are placed on the surface of a solid nutrient previously inoculated with the culture of suitable microorganism. Inhibition produced by the test drug is compared with that produced by known concentration of reference standard. The in vitro screening was carried out using selected microbes like B. subtilis (NCIM) 2063, Gram +ve), S. aureus(NCIM 2079, Gram +ve), E.coli (NCIM 2931, Gram -ve).","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"199 1","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2011-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77462628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDY OF LEAF OF GYMNOSPORIA MONTANA (VIKALO) 蒙大拿裸子菌(gymnosporia Montana)叶片的生药学和植物化学研究
Journal of Global Pharma Technology Pub Date : 2011-05-02 DOI: 10.1234/JGPT.V3I1.332
Bhavita Dhru, M. Zaveri, B. Lakshmi
{"title":"PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDY OF LEAF OF GYMNOSPORIA MONTANA (VIKALO)","authors":"Bhavita Dhru, M. Zaveri, B. Lakshmi","doi":"10.1234/JGPT.V3I1.332","DOIUrl":"https://doi.org/10.1234/JGPT.V3I1.332","url":null,"abstract":"Ethanomedicinal plant like Gymnosporia montana belonging to the family Celeastraceae commonly known as Vikalo in Gujarat. Gymnosporia montana is known as “VIKALO” means VI + KAMALO (jaundice in Gujarati –Kamalo) cure JAUNDICE. Ethanomedicinally fresh leaves of Vikalo are chewed in trible regions of Gujarat to cure jaundice.. Pharmacognostical evaluation including examination of morphological and microscopical characters, determination of quality control parameters such as ash values, extractive values, moisture content, foreign matter, and microbial contamination were carried out. Phytochemical screening including qualitative chemical examinations was also carried out. Hence, the present attempt was undertaken to investigate the Phytopharmacognostical studies of leaf of Gymnosporia montana . The study revealed the presence of biseriate upper and lower epidermis with waxy cuticle and stomata. Mesophyll contains yellowish black colour matter. Phytochemical screening of the plant showed the presence of phytoconstituents like phenol, flavonoids, alkaloids and saponin.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"13 1","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2011-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80381730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
IN-VITRO ANTIOXIDANT POTENTIAL OF STEM AND ROOT BARK OF OROXYLUM INDICUM 白杨茎、根皮体外抗氧化活性研究
Journal of Global Pharma Technology Pub Date : 2011-05-02 DOI: 10.1234/JGPT.V3I1.329
M. Zaveri, Bhavita Dhru
{"title":"IN-VITRO ANTIOXIDANT POTENTIAL OF STEM AND ROOT BARK OF OROXYLUM INDICUM","authors":"M. Zaveri, Bhavita Dhru","doi":"10.1234/JGPT.V3I1.329","DOIUrl":"https://doi.org/10.1234/JGPT.V3I1.329","url":null,"abstract":"Oroxylum indicum is a medicinal plant species known in Gujarat by the common name Syonakh . The free radical scavenging potential of the Oroxylum indicum was studied by using different antioxidant models of screening.  In-vitro antioxidant activity of petroleum ether, ethyl acetate and n- butanol extract of stem and root bark of Oroxylum indicum was determined by ABTS radical cation decolorization assay, Scavenging of nitric oxide radical, Reduction of ferric ions by ortho- phenanthroline colour method, inhibition of lipid peroxide formation. Ascorbic acid was used as standard and positive control for both the analysis. All the analysis was made with the use of UV-Visible Spectrophotometer (Systronics 117, Japan). The n- butanol extracts of stem and root bark of Oroxylum indicum shown very significant scavenging activity as compared to standard. Hence, it is suggested that Oroxylum indicum showed significant antioxidant activity.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"39 1 1","pages":"42-49"},"PeriodicalIF":0.0,"publicationDate":"2011-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90752786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
IN-VITRO AND IN-VIVO RELEASE STUDIES FROM ENTERIC COATED DRUG DELIVERY SYSTEMS UTILIZING MICROBIAL TRIGGERED BIODEGRADABLE GUAR GUM POLYSACCHARIDES FOR COLON SPECIFIC TARGETING 利用微生物触发的可生物降解瓜尔胶多糖进行结肠特异性靶向的肠包膜给药系统的体外和体内释放研究
Journal of Global Pharma Technology Pub Date : 2011-05-02 DOI: 10.1234/JGPT.V3I1.334
S. Lanjhiyana, Debapriya Garabadu, S. Lanjhiyana, A. Arya
{"title":"IN-VITRO AND IN-VIVO RELEASE STUDIES FROM ENTERIC COATED DRUG DELIVERY SYSTEMS UTILIZING MICROBIAL TRIGGERED BIODEGRADABLE GUAR GUM POLYSACCHARIDES FOR COLON SPECIFIC TARGETING","authors":"S. Lanjhiyana, Debapriya Garabadu, S. Lanjhiyana, A. Arya","doi":"10.1234/JGPT.V3I1.334","DOIUrl":"https://doi.org/10.1234/JGPT.V3I1.334","url":null,"abstract":"The present study extensively investigated the colon as an effective drug delivery site for local colorectal cancer treatment using 5-Fluorouracil (5-FU) as model drug based on oral pulsatile release technology. Formulations coated with enteric Eudragit-S100 (EdâS-100) and swellable hydroxyl propyl methyl cellulose (HPMC) to a varying coat thickness of 2:4, 4:2, 3:4 and 4:3, were tested for in-vitro drug dissolution with various simulated fluids of stomach (pH 1.2), small intestine (pH 7.2) and colon (pH 6.8). Guar gum was used as matrix vehicle aimed to delay drug dissolutions and localize in the distal portions of small bowl or colon. The formulation was capable in delaying onset of drug dissolution for a programmed lag time period of 3-5 h in the hostile environment of upper gastrointestinal tract. The optimized enteric coated formulations containing 30% guar gum released only 5-12% approximately of 5-FU during 5 h dissolution studies in hostile physiological environment of stomach (pH 1.2) and small intestine (pH 7.2). The guar gum was found susceptible and encountered by colonic microfloras and released significant amount of 5-FU in simulated colonic fluids containing rat caecal contents (2 and 4% w/v) at the end of 24 h drug dissolution studies under anaerobic atmosphere. Furthermore, in -vivo studies were performed in order to examine the fate/ transit of formulations in gastrointestinal tract of albino rats, to validate the in-vitro methodology. However, these findings confirmed its applicability as a promising device for targeting of 5-FU at desirable site of colon.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"1 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2011-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82254625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TOXICITY STUDIES ON HEPATIC, NEPHRIC AND ENDOCRINE ORGANS OF CITRUS MEDICA SEEDS EXTRACT ON OF FEMALE ALBINO MICE 枸杞子提取物对雌性白化小鼠肝脏、肾脏和内分泌器官的毒性研究
Journal of Global Pharma Technology Pub Date : 2011-05-02 DOI: 10.1234/JGPT.V3I1.331
Sharangouda J. Patil, S. B. Patil
{"title":"TOXICITY STUDIES ON HEPATIC, NEPHRIC AND ENDOCRINE ORGANS OF CITRUS MEDICA SEEDS EXTRACT ON OF FEMALE ALBINO MICE","authors":"Sharangouda J. Patil, S. B. Patil","doi":"10.1234/JGPT.V3I1.331","DOIUrl":"https://doi.org/10.1234/JGPT.V3I1.331","url":null,"abstract":"b Abstract: The present study is an evaluation to determine the toxicity level of benzene and ethanol extracts of Citrus medica seeds in the endocrine organs of female albino Swiss albino mice (Mus musculus) at the dose level of 200mg and 400mg/kg body weight for 15 days. The results exposed that the (administered of extract of C. medica seeds to female mice observed) changes in the gain/loss of body weight, organ weight (Liver, Kidney, Adrenal, Ovary and Uterus) morphological and behavioural studies. The detection of haematotoxicity, haemoglobin concentration, total RBC, WBC counts and total differential count were evaluated. The biochemical (Blood Sugar, Serum Cholesterol, Total Protein and Blood Urea Nitrogen) and histological changes in the liver, ovary and uterus were also determined. All the parameters of benzene extract treated mice were found to be within normal range, when compare to control. The data suggest that the ethanol extract of C. medica seeds at both the dose level administration for 15 days little effective and shown almost significant level of toxicity on liver as well as reproductive organs.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"38 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2011-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79836965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
BENEFICIAL EFFECTS OF GREEN TEA ON EXPERIMENTAL 绿茶对实验的有益作用
Journal of Global Pharma Technology Pub Date : 2011-03-10 DOI: 10.1234/JGPT.V3I07.413
Arun Kumar, V. Juyal
{"title":"BENEFICIAL EFFECTS OF GREEN TEA ON EXPERIMENTAL","authors":"Arun Kumar, V. Juyal","doi":"10.1234/JGPT.V3I07.413","DOIUrl":"https://doi.org/10.1234/JGPT.V3I07.413","url":null,"abstract":"The present study was undertaken to investigate the beneficial effects of green tea in cognitive \u0000dysfunctions of mice. Memory impairment was produced by high fat diet (HFD). Morris water maze, \u0000elevated plus maze and passive avoidance test were employed to assess learning and memory. HFD \u0000significantly impair the learning and memory in mice. Furthermore HFD significantly increase serum nitrite \u0000and cholesterol concentrations. Pretreatment of green tea significantly reversed HFD induced learning and \u0000memory deficits along with attenuation of HFD-induced rise in serum nitrite and cholesterol concentrations.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"69 1","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2011-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90416075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SYNTHESIS AND NEUROPHARMACOLOGICAL EFFECTS OF SOME SUBSTITUTED HYDROXYTRIAZENES 一些取代羟基三氮杂烯的合成及其神经药理作用
Journal of Global Pharma Technology Pub Date : 2011-03-08 DOI: 10.1234/JGPT.V3I6.397
L. Chauhan, C. Jain, R. Chauhan, A. Goswami
{"title":"SYNTHESIS AND NEUROPHARMACOLOGICAL EFFECTS OF SOME SUBSTITUTED HYDROXYTRIAZENES","authors":"L. Chauhan, C. Jain, R. Chauhan, A. Goswami","doi":"10.1234/JGPT.V3I6.397","DOIUrl":"https://doi.org/10.1234/JGPT.V3I6.397","url":null,"abstract":"Hydroxytriazene compounds (HT) were synthesized and the purity of each hydroxytriazene was checked by physical characteristics and elemental analysis. The synthesized hydroxytriazenes were studied on some neuropharmacological paradigms on mice like behavior, locomotion, sleep, and convulsions using standard procedures. The hydroxytriazenes exhibited reduced alertness, reduced spontaneous locomotion activity and potentiated the pentobarbitone induced sleep. Conclusively the compounds showed CNS depressant effects.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"92 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2011-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76672755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SYNTHESIS OF SOME HETERORYL SULFONES DERIVED FROM CARBAZOLE AND AZACARBAZOLE DERIVATIVES AND THEIR BIOLOGICAL EVALUATION 咔唑和氮杂咔唑衍生物杂酰基砜的合成及其生物学评价
Journal of Global Pharma Technology Pub Date : 2011-03-08 DOI: 10.1234/JGPT.V3I6.398
Sonika Jain, Anamika Sharma, R. Sirohi, D. Kishore
{"title":"SYNTHESIS OF SOME HETERORYL SULFONES DERIVED FROM CARBAZOLE AND AZACARBAZOLE DERIVATIVES AND THEIR BIOLOGICAL EVALUATION","authors":"Sonika Jain, Anamika Sharma, R. Sirohi, D. Kishore","doi":"10.1234/JGPT.V3I6.398","DOIUrl":"https://doi.org/10.1234/JGPT.V3I6.398","url":null,"abstract":"Synthesis of new series of heteroryl sulfones 8 (a-l) in which hetryl part is represented by carbazole and azacarbazole derivatives. The key step of this transformation involves the proton catalyzed rearrangement of the sulfonamide derivatives 7 (a-l) to the corresponding sulfones 8 (a-l). All the synthesized compounds were screened for their antibacterial and antifungal activity and they showed good to moderate activity.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"1 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2011-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88201852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
REVIEW ARTICLE ON MOUTH DISSOLVING FILM 口腔溶解膜综述
Journal of Global Pharma Technology Pub Date : 2011-03-02 DOI: 10.1234/JGPT.V3I1.335
D. Vishwkarma, A. Tripathi, P. Yogesh, B. Maddheshiyab
{"title":"REVIEW ARTICLE ON MOUTH DISSOLVING FILM","authors":"D. Vishwkarma, A. Tripathi, P. Yogesh, B. Maddheshiyab","doi":"10.1234/JGPT.V3I1.335","DOIUrl":"https://doi.org/10.1234/JGPT.V3I1.335","url":null,"abstract":"Oral drug delivery is the most widely utilized route of administration among the entire route that has been explored for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The conventional tablet  seems to be most popular because of its ease of transportability and comparatively low manufacturing cost but poor patient compliance in case of pediatrics and geriatrics patients who experienced difficulties in swallowing, in response to this mouth dissolving drugs delivery system(MDDs) were developed as an alternative to tablet, cap & syrups. A variety of MDDs like mouth dissolving tablets and mouth dissolving film (MDFs) were commercialized. MDFs evolved over the past few years from by the confection and oral care market in the form of breath strips & became a novel & widely accepted form by consumers. MDFs were developed based on the technology of transdermal patches. It consist very thin oral strips, which release active ingredients immediately after uptake into oral cavity. Today MDFs are a proven & accepted technology for the systemic delivery of active pharmaceuticals ingredients.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"81 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2011-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83987507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
PRELIMINARY ANTIBACTERIAL AND PHYTOCHEMICAL EVALUATION OF DRYOPTERIS COCHLEATA (D.DON) C.CHR. 竹叶毛蕨抑菌及植物化学初步评价。
Journal of Global Pharma Technology Pub Date : 2011-02-08 DOI: 10.1234/JGPT.V3I6.395
Toji Thomas
{"title":"PRELIMINARY ANTIBACTERIAL AND PHYTOCHEMICAL EVALUATION OF DRYOPTERIS COCHLEATA (D.DON) C.CHR.","authors":"Toji Thomas","doi":"10.1234/JGPT.V3I6.395","DOIUrl":"https://doi.org/10.1234/JGPT.V3I6.395","url":null,"abstract":": ryopteris cochleata Dryopteridaceae is one of the important plants of traditional systems of medicine. Fronds (leaves) of Dryopteris cochleata were evaluated for its antibacterial potential and phytochemical contents in various solvent extracts in increasing polarity towards pathogenic bacterial species. Antibacterial activity was tested by disc diffusion method. Petroleum ether, acetone, methanol and water extracts of Dryopteris cochleata were tested for antibacterial activity towards some pathogenic bacterial strains. Both acetone and methanol extracts exhibited antibacterial activity; maximum activity was shown by acetone extract compared to others. Antibacterial activity was confirmed by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). MIC and MBC values of acetone extract of 12.5mg/ml and 25mg/ml were observed towards Staphyococcus albus while MIC and MBC values of 25mg/ml and 50mg/ml were observed towards Pseudomonas aeruginosa. Flavonoids, phenols, steroids were detected in acetone and methanol extracts. The study proves that Dryopteris cochleata possesses antibacterial principles, soluble in acetone, which hinder the growth and multiplication of some multidrug resistant bacterial strains.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"4 1","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"2011-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76644691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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