SYNTHESIS AND NEUROPHARMACOLOGICAL EFFECTS OF SOME SUBSTITUTED HYDROXYTRIAZENES

Abstract

Hydroxytriazene compounds (HT) were synthesized and the purity of each hydroxytriazene was checked by physical characteristics and elemental analysis. The synthesized hydroxytriazenes were studied on some neuropharmacological paradigms on mice like behavior, locomotion, sleep, and convulsions using standard procedures. The hydroxytriazenes exhibited reduced alertness, reduced spontaneous locomotion activity and potentiated the pentobarbitone induced sleep. Conclusively the compounds showed CNS depressant effects.