SYNTHESIS OF SOME HETERORYL SULFONES DERIVED FROM CARBAZOLE AND AZACARBAZOLE DERIVATIVES AND THEIR BIOLOGICAL EVALUATION

Abstract

Synthesis of new series of heteroryl sulfones 8 (a-l) in which hetryl part is represented by carbazole and azacarbazole derivatives. The key step of this transformation involves the proton catalyzed rearrangement of the sulfonamide derivatives 7 (a-l) to the corresponding sulfones 8 (a-l). All the synthesized compounds were screened for their antibacterial and antifungal activity and they showed good to moderate activity.