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Journal of Global Pharma Technology最新文献

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Evaluation of Tableting Properties of Adhatoda vasica Leaf Powder 水仙花叶粉的压片性能评价
Journal of Global Pharma Technology Pub Date : 2010-09-11 DOI: 10.1234/JGPT.V2I10.273
S. Singh, Subas C. Dinda, C. Patra
{"title":"Evaluation of Tableting Properties of Adhatoda vasica Leaf Powder","authors":"S. Singh, Subas C. Dinda, C. Patra","doi":"10.1234/JGPT.V2I10.273","DOIUrl":"https://doi.org/10.1234/JGPT.V2I10.273","url":null,"abstract":"For Correspondence : Email:singh.satyaprakash@rediffmail.com Abstract: The leaf of Adhatoda vasica Nees is widely used for its antitussive, antiulcer, hepatoprotective, antitubercular and anti-inflammatory activity. The objective of the present research was to study the original flowability, compressibility and compactibility of Adhatoda vasica leaf powder and develop its tablet formulations by wet granulation and direct compression technology. The consolidation behaviors of powder and tablet formulations were studied by using Heckel and Leuenberger equation. Adhatoda vasica leaf powder showed very poor flowability and compactibility. Kawakita analysis revealed improved flowability for formulations prepared by direct compression and wet granulation technique. The Heckel plot showed that Adhatoda vasica leaf powder is soft in nature, poor in die filling. Granules showed higher degree of plasticity and fragmentation than leaf powder and direct compression formulation. The compression susceptibility parameter for compact formed by direct compression and wet granulation technique indicated that the maximum crushing strength is reached faster at lower pressures of compression. Brittle fracture index value revealed that tablets prepared from granules showed lesser fracture tendency than the direct compression formulation. From this study, it is concluded that desired flowability, compressibility and compactibility of Adhatoda vasica leaf powder can be obtained by direct compression and wet granulation technique. Keywords : Adhatoda vasica, Flow ability , Compressibility, Tablets.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"138 1","pages":"34-42"},"PeriodicalIF":0.0,"publicationDate":"2010-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84522835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
LIPID NANOPARTICLES (SLN, NLC): A NOVEL APPROACH FOR COSMETIC AND DERMAL PHARMACEUTICAL 脂质纳米颗粒(sln, nlc):化妆品和真皮药物的新途径
Journal of Global Pharma Technology Pub Date : 2010-08-10 DOI: 10.1234/JGPT.V2I9.249
D. Puri
{"title":"LIPID NANOPARTICLES (SLN, NLC): A NOVEL APPROACH FOR COSMETIC AND DERMAL PHARMACEUTICAL","authors":"D. Puri","doi":"10.1234/JGPT.V2I9.249","DOIUrl":"https://doi.org/10.1234/JGPT.V2I9.249","url":null,"abstract":"","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"117 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2010-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77240460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
SYNTHESIS, ANTIBACTERIAL ACTIVITY, INSILICO METABOLISM AND TOXICITY PREDICTION OF THE PYRAZOLINE DERIVATIVES 吡唑啉衍生物的合成、抗菌活性、硅代谢及毒性预测
Journal of Global Pharma Technology Pub Date : 2010-08-10 DOI: 10.1234/JGPT.V2I9.280
A. Singh
{"title":"SYNTHESIS, ANTIBACTERIAL ACTIVITY, INSILICO METABOLISM AND TOXICITY PREDICTION OF THE PYRAZOLINE DERIVATIVES","authors":"A. Singh","doi":"10.1234/JGPT.V2I9.280","DOIUrl":"https://doi.org/10.1234/JGPT.V2I9.280","url":null,"abstract":"","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"45 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2010-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90523705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
IN VITRO AND IN VIVO ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF MALINKARA ZAPOTA BARK 马来树皮乙醇提取物的体外和体内抗氧化活性
Journal of Global Pharma Technology Pub Date : 2010-07-12 DOI: 10.1234/JGPT.V2I11.312
Md. Ekramul Islam Islam
{"title":"IN VITRO AND IN VIVO ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF MALINKARA ZAPOTA BARK","authors":"Md. Ekramul Islam Islam","doi":"10.1234/JGPT.V2I11.312","DOIUrl":"https://doi.org/10.1234/JGPT.V2I11.312","url":null,"abstract":"Many plants possess antioxidant ingredients that provided efficacy by additive or synergistic activities. Manilkara zapota bark (MZB) has been used for the treatment of fever and diarrhea. Antioxidant activity of the ethanol crude extract of bark of Manilkara zapota was assessed in vitro using DPPH, reducing power capacity, total antioxidant, total phenol and total flavonoid content assays at different concentration. The extract exhibited potent antioxidant activity compared to known antioxidant. The potent extract of MZB was tested for in vivo efficacy by carbon tetrachloride (CCl 4 ) induced liver damage rats in hepatoprotective model. CCl 4 produced significant alteration of serum marker enzymes, total bilirubin, total protein and liver weight. The extract significantly restored of these values towards normal compared to control group. Due to its natural origin and potent free radical scavenging ability MZB could be used as a potential preventive intervention for free radical mediated diseases.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"127 6 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2010-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87761052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE MOUTH DISSOLVING TABLET 盐酸曲马多口腔溶出片的研制及评价
Journal of Global Pharma Technology Pub Date : 2010-07-12 DOI: 10.1234/JGPT.V2I11.308
S. Raval
{"title":"FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE MOUTH DISSOLVING TABLET","authors":"S. Raval","doi":"10.1234/JGPT.V2I11.308","DOIUrl":"https://doi.org/10.1234/JGPT.V2I11.308","url":null,"abstract":"Tramadol is an Opioid pain-killer. It is bitter in taste. In the present study an attempt has been made to prepare bitterless mouth dissolving tablets of Tramadol hydrochloride using ion exchange resin Indion 294 as a taste masking agent. Ion exchange resinates and tasteless granules were prepared with Indion 294 in weight ratio of 1:2. Prepared complex was further examined through U.V. Visible Spectroscopy. The mouth dissolving tablets of both resinates and granules were prepared with different superdisintegrants e.g. cross carmallose sodium, crosspovidone & Indion 234 in different concentration. The blend was examined for their flow properties. The tablets were evaluated for physiochemical properties. The tasteless blends having good flow properties. The prepared zero defect mouth dissolving tablets were passed all the official and non-official parameters. The disintegration time was also tested and was found to be less than one minute. A tablet having resinates shows less time for onset of action of drug due to enhanced and fast release of Tramadol hydrochloride.  It was concluded that tablets prepared by addition of superdisintegrant Indion 234 has less disintegration time, fast and more dug release than those prepared by crosspovidone.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"42 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2010-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72772660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
TOXICITY STUDIES OF SUBSTITUTED HYDROXYTRIAZENES ON RODENTS 取代羟基三氮烯对啮齿动物的毒性研究
Journal of Global Pharma Technology Pub Date : 2010-07-12 DOI: 10.1234/JGPT.V2I11.307
L. S. Chouhan
{"title":"TOXICITY STUDIES OF SUBSTITUTED HYDROXYTRIAZENES ON RODENTS","authors":"L. S. Chouhan","doi":"10.1234/JGPT.V2I11.307","DOIUrl":"https://doi.org/10.1234/JGPT.V2I11.307","url":null,"abstract":"Hydroxytriazene compounds (HT) were synthesized and the purity of each hydroxytriazene was checked by physical characteristics and elemental analysis. The synthesised hydroxytriazenes were studied for acute and sub-acute toxicity in rodents. The acute toxicity study was carried out to determine LD 50 and behavioral activity. The sub-acute toxicity studies were done to investigate the effect of hydroxytriazenes on hematological and biochemical parameters. The results of this study indicate that hydroxytriazenes have no significant influence on hematological parameters, but some biochemical parameters are changed significantly.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"47 1","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2010-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75287577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE 盐酸昂丹西琼掩口溶片的研制与评价
Journal of Global Pharma Technology Pub Date : 2010-07-12 DOI: 10.1234/JGPT.V2I11.310
Prajapati R.H.
{"title":"FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE","authors":"Prajapati R.H.","doi":"10.1234/JGPT.V2I11.310","DOIUrl":"https://doi.org/10.1234/JGPT.V2I11.310","url":null,"abstract":"To overcome difficulty in swallowing tablets or capsules, formulators have considerably dedicated their effort to develop novel drug delivery systems which enhance safety and efficacy of drug molecule and to achieve better patient compliance. One such approach is ‘Mouth Dissolving Tablets’. The purpose of this research was to mask the intensely bitter taste of ondansetron Hcl by complexing with indion204 Resin by the solvent evaporation and to formulate a mouth dissolving tablets of the taste-masked drug. Tablets were formulated by direct compression method using different superdisintegrants like Polyplasdone XL-10 & Sodium starch glycolate (SSG) in different concentration, diluents like Mannitol, Microcrystalline cellulose (MCC 112), sweetening agent Aspartame, Flavoring agents like peppermint and vanilla, lubricant Magnesium Stearate & glidant aerosil. All formulations were evaluated for disintegration time, wetting time, % friability, Content uniformity and in vitro dissolution rate. Formulations with 7% Polyplasdone XL-10 showed the disintegration time 14 seconds and wetting time 25 seconds. In vitro drug release study of taste masked tablet showed complete drug release within 10 minutes & successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"23 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2010-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83610854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
EVALUATION OF ANTIMICROBIAL AND TOXICITY OF DIFFERENT FRACTIONS OF DILLENIA INDICA LINN. BARK EXTRACT 印楝不同部位的抑菌及毒性评价。树皮中提取
Journal of Global Pharma Technology Pub Date : 2010-07-12 DOI: 10.1234/JGPT.V2I11.309
M. Haque
{"title":"EVALUATION OF ANTIMICROBIAL AND TOXICITY OF DIFFERENT FRACTIONS OF DILLENIA INDICA LINN. BARK EXTRACT","authors":"M. Haque","doi":"10.1234/JGPT.V2I11.309","DOIUrl":"https://doi.org/10.1234/JGPT.V2I11.309","url":null,"abstract":"The methanolic extract along with some organic soluble fractions of the bark of Dillenia indica Linn. were tested against four Gram-positive and seven Gram-negative bacteria and against three pathogenic fungi. N-Hexane and dichloromethane fractions showed remarkable activities against all the tested bacteria but n-Hexane fraction showed highest activity against Shigella dysenteriae and its zone of inhibition was 15.51 ± 0.75 mm. Other showed moderate or little activity. Methanol crude extract showed highest activity against fungus Candida albicans with a zone of inhibition 13.13 ± 1.75 mm. Lowest minimum inhibitory concentration (MIC) values were observed in n-Hexane fraction against Shigella dysenteriae  and Staphylococcus aureus and were 0.312 in both cases. Lowest LC 50 value 19.02 ± 1.16 of n-Hexane fraction indicated the highest toxicity incomparison with the other fractions.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"4 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2010-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78534638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
CYCLODEXTRINS IN PHARMACY- AN OVERVIEW 环糊精在药学中的应用综述
Journal of Global Pharma Technology Pub Date : 2010-07-12 DOI: 10.1234/JGPT.V2I11.311
N. KanakaDurgaDevi
{"title":"CYCLODEXTRINS IN PHARMACY- AN OVERVIEW","authors":"N. KanakaDurgaDevi","doi":"10.1234/JGPT.V2I11.311","DOIUrl":"https://doi.org/10.1234/JGPT.V2I11.311","url":null,"abstract":"Cyclodextrins are a group of compounds that enhances permeability through biological membrane, by which they act as permeation enhancers. In this present review article, the history, chemical structure, synthesis,physico-chemical properties,uses,complexation phenomenon, approaches for making inclusion complexes, and its charecterisation, advantages of inclusion complexes,mechanism of drug release,regulatory status,and applications of cyclodextrins have been explained neatly and legibly. The future prospects of CD and its derivatives are quite bright since they possess remarkably unique properties of forming inclusion complexes with drugs. An increasingly number of drugs being developed today have problem of poor solubility, bioavailability and permeability. CDs can serve as useful tools in the hands of pharmaceutical scientists for optimizing the drug delivery.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"29 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2010-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81853936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
MAGNETIC MICROSPHERES: AS A MAGNETICALLY TARGETED DRUG DELIVERY SYSTEM. 磁性微球:作为一种磁性靶向给药系统。
Journal of Global Pharma Technology Pub Date : 2010-07-04 DOI: 10.1234/JGPT.V2I3.103
M. Salim
{"title":"MAGNETIC MICROSPHERES: AS A MAGNETICALLY TARGETED DRUG DELIVERY SYSTEM.","authors":"M. Salim","doi":"10.1234/JGPT.V2I3.103","DOIUrl":"https://doi.org/10.1234/JGPT.V2I3.103","url":null,"abstract":"","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73775584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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