FORMULATION AND EVALUATION OF TASTE MASKED MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE

Abstract

To overcome difficulty in swallowing tablets or capsules, formulators have considerably dedicated their effort to develop novel drug delivery systems which enhance safety and efficacy of drug molecule and to achieve better patient compliance. One such approach is ‘Mouth Dissolving Tablets’. The purpose of this research was to mask the intensely bitter taste of ondansetron Hcl by complexing with indion204 Resin by the solvent evaporation and to formulate a mouth dissolving tablets of the taste-masked drug. Tablets were formulated by direct compression method using different superdisintegrants like Polyplasdone XL-10 & Sodium starch glycolate (SSG) in different concentration, diluents like Mannitol, Microcrystalline cellulose (MCC 112), sweetening agent Aspartame, Flavoring agents like peppermint and vanilla, lubricant Magnesium Stearate & glidant aerosil. All formulations were evaluated for disintegration time, wetting time, % friability, Content uniformity and in vitro dissolution rate. Formulations with 7% Polyplasdone XL-10 showed the disintegration time 14 seconds and wetting time 25 seconds. In vitro drug release study of taste masked tablet showed complete drug release within 10 minutes & successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity.