{"title":"取代羟基三氮烯对啮齿动物的毒性研究","authors":"L. S. Chouhan","doi":"10.1234/JGPT.V2I11.307","DOIUrl":null,"url":null,"abstract":"Hydroxytriazene compounds (HT) were synthesized and the purity of each hydroxytriazene was checked by physical characteristics and elemental analysis. The synthesised hydroxytriazenes were studied for acute and sub-acute toxicity in rodents. The acute toxicity study was carried out to determine LD 50 and behavioral activity. The sub-acute toxicity studies were done to investigate the effect of hydroxytriazenes on hematological and biochemical parameters. The results of this study indicate that hydroxytriazenes have no significant influence on hematological parameters, but some biochemical parameters are changed significantly.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"47 1","pages":"11-16"},"PeriodicalIF":0.0000,"publicationDate":"2010-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TOXICITY STUDIES OF SUBSTITUTED HYDROXYTRIAZENES ON RODENTS\",\"authors\":\"L. S. Chouhan\",\"doi\":\"10.1234/JGPT.V2I11.307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hydroxytriazene compounds (HT) were synthesized and the purity of each hydroxytriazene was checked by physical characteristics and elemental analysis. The synthesised hydroxytriazenes were studied for acute and sub-acute toxicity in rodents. The acute toxicity study was carried out to determine LD 50 and behavioral activity. The sub-acute toxicity studies were done to investigate the effect of hydroxytriazenes on hematological and biochemical parameters. The results of this study indicate that hydroxytriazenes have no significant influence on hematological parameters, but some biochemical parameters are changed significantly.\",\"PeriodicalId\":15889,\"journal\":{\"name\":\"Journal of Global Pharma Technology\",\"volume\":\"47 1\",\"pages\":\"11-16\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Global Pharma Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1234/JGPT.V2I11.307\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Global Pharma Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1234/JGPT.V2I11.307","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
TOXICITY STUDIES OF SUBSTITUTED HYDROXYTRIAZENES ON RODENTS
Hydroxytriazene compounds (HT) were synthesized and the purity of each hydroxytriazene was checked by physical characteristics and elemental analysis. The synthesised hydroxytriazenes were studied for acute and sub-acute toxicity in rodents. The acute toxicity study was carried out to determine LD 50 and behavioral activity. The sub-acute toxicity studies were done to investigate the effect of hydroxytriazenes on hematological and biochemical parameters. The results of this study indicate that hydroxytriazenes have no significant influence on hematological parameters, but some biochemical parameters are changed significantly.
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