Journal of Global Pharma Technology最新文献_第9页

BILE AND ACID TOLERANCE ABILITY OF PROBIOTIC LACTOBACILLUS STRAINS 益生菌乳酸菌菌株的胆汁耐酸能力

Journal of Global Pharma Technology Pub Date : 2010-12-31 DOI: 10.1234/JGPT.V2I12.318

K. Singhal, H. Joshi

{"title":"BILE AND ACID TOLERANCE ABILITY OF PROBIOTIC LACTOBACILLUS STRAINS","authors":"K. Singhal, H. Joshi","doi":"10.1234/JGPT.V2I12.318","DOIUrl":"https://doi.org/10.1234/JGPT.V2I12.318","url":null,"abstract":"Lactobacillus makes up an extremely important group of probiotic bacteria and is used in many probiotic dairy products. Probiotics are live microbial food supplements which beneficially affect the host by improving the intestinal microbial balance. Probiotic bacteria used as food adjuncts are commonly delivered in a food system and their journey starts from the mouth to lower intestinal tract. Therefore probiotic bacteria must overcome physical and chemical barriers such as bile and acid in the gastrointestinal tract. Hence, tolerances to bile and acid are the two most important properties for selection of potential probiotic strains. The aim of this research was to find out the ability of bile and acid tolerance of the three isolates namely Lactobacillus plantarum CM 25, Lactobacillus. casei subsp. rhamnosus CM 33 and Lactobacillus. casei subsp. casei CM 34. Bile tolerance of the isolates was tested against three concentrations 0.1%, 0.2% and 0.3% of sodium glycocholate and sodium taurocholate both. With increase in the concentration of bile salts the growth of all the isolates was decreased. Among all the three isolates tested Lactobacillus plantarum CM 25 and Lactobacillus casei subsp. casei CM 34 showed highest survival at 0.3% concentration of sodium glycocholate and sodium taurocholate respectively. Among the two bile salts used, more tolerance of the isolates was found against sodium taurocholate. Acid tolerance of the isolates was tested at various acidic pH values ranging from pH 2.0 to 6.0. Survival percentage of all the three isolates decreased along with the decrease in pH. Lactobacillus plantarum CM 25 showed the highest survival at pH 2.0. These findings suggest that all the three Lactobacillus isolates are capable to grow in the presence of bile salts and acid.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"8 1","pages":"17-25"},"PeriodicalIF":0.0,"publicationDate":"2010-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85757603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A REVIEW OF THE METABOLISM ENHANCING PHYTOECDYSTEROIDS WITH OPTIMIZATION OF ITS EXTRACTION AND PURIFICATION PROCESS 促代谢植物甾体及其提取纯化工艺的研究进展

Journal of Global Pharma Technology Pub Date : 2010-12-31 DOI: 10.1234/JGPT.V2I12.322

M. A. Mansury, N. Manocha, V. Deshmukh

{"title":"A REVIEW OF THE METABOLISM ENHANCING PHYTOECDYSTEROIDS WITH OPTIMIZATION OF ITS EXTRACTION AND PURIFICATION PROCESS","authors":"M. A. Mansury, N. Manocha, V. Deshmukh","doi":"10.1234/JGPT.V2I12.322","DOIUrl":"https://doi.org/10.1234/JGPT.V2I12.322","url":null,"abstract":"Phytoecdysteroids are plant derived ecdysteroids.Chemically they are classed as triterpenoids, the group of compounds that includes triterpene saponins, phytosterols, and phytoecdysteroids. Only Plants, synthesize phytoecdysteroids from mevalonic acid in the mevalonate pathway of the plant cell. 20-hydroxyecdysone is basic moeity possessing the cholesterol nucleus, is present in Ajuga turkestanica (Labiatae), Vitex glabrata (Verbenaceae), etc. Ecdysteroids attribute their desired effects by influencing signal transduction pathways, like the anabolic steroids; possibly via membrane bound receptors (Do not bind to the cytosolic steroid receptors). Experimental findings on ecdysteroids have indicated their anabolic and cholesterol level reducing effects and antiglycaemic activity. Ecdysteroid- containing preparations are recommended for hypotension, hepatoprotective, immunoprotective, antioxidant and hypoglycemic agents. It also can be used as a novel drug molecule with potent biological activity as it possess basic steroidal moiety but have higher margin of safety as compared to the chemical steroid derivatives (with low margin of safety). Further research is envisaged towards the search of new phytoecdysteroid molecules and also optimization of techniques involved in extraction and isolation of potent phytochemicals so as to preserve its pharmacological properties.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"16 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2010-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85815856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

3D QSAR STUDIES ON A SERIES OF POTENT AND HIGH SELECTIVE INVERSE AGONISTS OF HUMAN CANNABINOID RECEPTOR 1 一系列强效、高选择性的人大麻素受体1逆激动剂的3d qsar研究

Journal of Global Pharma Technology Pub Date : 2010-12-31 DOI: 10.1234/JGPT.V2I12.320

R. Sharma, S. G. Reddy, S. Mehmood

{"title":"3D QSAR STUDIES ON A SERIES OF POTENT AND HIGH SELECTIVE INVERSE AGONISTS OF HUMAN CANNABINOID RECEPTOR 1","authors":"R. Sharma, S. G. Reddy, S. Mehmood","doi":"10.1234/JGPT.V2I12.320","DOIUrl":"https://doi.org/10.1234/JGPT.V2I12.320","url":null,"abstract":"In the present study, a series of 49 5,6-diarylpyridineheterocyclic analogues exhibiting inhibitory activity against cannabinoid receptor 1 were investigated using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices (CoMSIA) methods. Both the models exhibited good correlation between the calculated 3D-QSAR fields and the observed biological activity for the respective training set compounds. The most optimal CoMFA and CoMSIA models yielded significant leave-one-out cross-validation coefficient, q 2 of 0.762, 0.767 and conventional cross-validation coefficient, r 2 of 0.954, 0.985 respectively. These validation tests not only revealed the robustness of the models but also demonstrated that for our models r 2 pred based on the mean activity of test set compounds can accurately estimate external predictivity. The factors affecting activity were analyzed carefully according to standard coefficient contour maps of steric, electrostatic, hydrophobic, acceptor and donor fields derived from the CoMFA and CoMSIA. These contour plots identified several key features which explain the wide range of activities. The results obtained from models offer important structural insight into designing novel Cb1 inverse agonists prior to their synthesis.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"30 1","pages":"32-51"},"PeriodicalIF":0.0,"publicationDate":"2010-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81003970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXTRACTION OF MUCILAGE FROM OCIMUM AMERICANUM LINN & ITS ROLE AS DISINTEGRANT IN TABLETS FORMULATION 美洲胡麻粘液的提取及其崩解剂在片剂中的作用

Journal of Global Pharma Technology Pub Date : 2010-12-31 DOI: 10.1234/JGPT.V2I12.321

N. Sheth, N. V. Shah, N. Shah

引用次数: 15

INSULIN DELIVERY: PRESENT & FUTURE PROSPECTIVES 胰岛素输送:现在和未来的前景

Journal of Global Pharma Technology Pub Date : 2010-11-10 DOI: 10.1234/JGPT.V2I9.282

pravin dhmaliya

引用次数: 0

SYNTHESIS AND BIOLOGICAL EVALUATION OF OXAZOLONE DERIVATIVES 恶唑酮类衍生物的合成及生物学评价

Journal of Global Pharma Technology Pub Date : 2010-09-11 DOI: 10.1234/JGPT.V2I10.257

G. Mariappan, D. Sarkar, R. Karki, L. Pandey, Deepak Kumar

引用次数: 5

ANTIBACTERIAL EVALUATION OF QUASSIA INDICA (GAERTN.) NOOTEB. IN STEENIS TOWARDS BACTERIA INVOLVED IN SKIN DISEASES 番槐的抑菌性能评价NOOTEB。在steenis中，细菌与皮肤病有关

Journal of Global Pharma Technology Pub Date : 2010-09-11 DOI: 10.1234/JGPT.V2I10.286

Toji Thomas

引用次数: 1

CALENDULA OFFICINALIS: AN IMPORTANT HERB WITH VALUABLE THERAPUTIC DIMENSIONS -AN OVERVIEW 金盏菊:具有重要治疗价值的草药综述

Journal of Global Pharma Technology Pub Date : 2010-09-11 DOI: 10.1234/JGPT.V2I10.288

A. Mishra, A. Mishra, P. Chattopadhyay

引用次数: 12

FORMULATION AND EVALUATION OF THERMOREVERSIBLE MUCOADHESIVE MICROEMULSION BASED IN-SITU GEL (TMMIG) OF AN ANTI-OSTEOPOROTIC AGENT 抗骨质疏松剂热可逆黏附微乳液原位凝胶(tmmig)的研制与评价

Journal of Global Pharma Technology Pub Date : 2010-09-11 DOI: 10.1234/JGPT.V2I10.301

S. Chaudhari, P. Bhise, A. Lahane, M. Misra, U. Mandal

引用次数: 6

EFFECT OF PUMPKIN CONCENTRATE ON ALLOXAN INDUCED DIABETIC RATS 南瓜浓缩液对四氧嘧啶诱导的糖尿病大鼠的影响

Journal of Global Pharma Technology Pub Date : 2010-09-11 DOI: 10.1234/JGPT.V2I10.300

Ashish Baldi, N. Chaudhary, J. Maru, R. Joshi

引用次数: 11