EFFECT OF PUMPKIN CONCENTRATE ON ALLOXAN INDUCED DIABETIC RATS

Abstract

In the present study, pumpkin concentrate was investigated for antidiabetic activity in alloxan induced diabetic albino rats, at two different doses (200 mg/kg and 300 mg/kg b.w., p.o.). Gilbenclamide was used as standard antidiabetic drug at a concentration of 5 mg/kg. Blood samples were collect and analyzed for plasma glucose till 14 th day. The low molecular weight fraction in pumpkin juice at the dose of 300 mg/kg produced significant reductions in plasma glucose at the end of treatments period of fourteen days. Our results clearly indicated that the pumpkin concentrate exhibited potential hypoglycemic activity in alloxan induced diabetic rats.