FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE MOUTH DISSOLVING TABLET

Tramadol is an Opioid pain-killer. It is bitter in taste. In the present study an attempt has been made to prepare bitterless mouth dissolving tablets of Tramadol hydrochloride using ion exchange resin Indion 294 as a taste masking agent. Ion exchange resinates and tasteless granules were prepared with Indion 294 in weight ratio of 1:2. Prepared complex was further examined through U.V. Visible Spectroscopy. The mouth dissolving tablets of both resinates and granules were prepared with different superdisintegrants e.g. cross carmallose sodium, crosspovidone & Indion 234 in different concentration. The blend was examined for their flow properties. The tablets were evaluated for physiochemical properties. The tasteless blends having good flow properties. The prepared zero defect mouth dissolving tablets were passed all the official and non-official parameters. The disintegration time was also tested and was found to be less than one minute. A tablet having resinates shows less time for onset of action of drug due to enhanced and fast release of Tramadol hydrochloride.  It was concluded that tablets prepared by addition of superdisintegrant Indion 234 has less disintegration time, fast and more dug release than those prepared by crosspovidone.