Journal of Global Pharma Technology最新文献_第7页

IN-VITRO ANTHELMINTIC ACTIVITY OF METHANOLIC EXTRACT OF AERIAL PARTS OF TRIBULUS TERRESTRIS LINN 刺蒺藜地上部分甲醇提取物体外驱虫活性研究

Journal of Global Pharma Technology Pub Date : 2011-07-30 DOI: 10.1234/JGPT.V3I6.393

R. Devi, A. Balasubramaniam, B. Jayalakshmi, M. Mohanraj, N. Senthilkumar

引用次数: 2

PROTECTIVE EFFECTS OF SOME NATURAL AND SYNTHETIC ANTIDEPRESSANTS AGAINST CHRONIC FATIGUE INDUCED ALTERATIONS 一些天然和合成抗抑郁药对慢性疲劳引起的改变的保护作用

Journal of Global Pharma Technology Pub Date : 2011-07-03 DOI: 10.1234/JGPT.V3I2.349

Y. Sahu, J. Vaghela

引用次数: 7

FORMULATION DESIGN, DEVELOPMENT AND EVALUATION OF VANCOMYCIN HYDROCHLORIDE TABLETS FOR PSEUDOMEMBRANOUS COLITIS BY DIRECT COMPRESSION METHOD 直接压缩法治疗假膜性结肠炎的盐酸万古霉素片处方设计、研制及评价

Journal of Global Pharma Technology Pub Date : 2011-07-03 DOI: 10.1234/JGPT.V3I2.345

M. M. Gupta, Madhulika Kedawat, B. Srivastava, T. Saini

引用次数: 0

ANTI-ULCER ACTIVITY OF ADHATODA VASICA LEAVES AGAINST GASTRIC ULCER IN RATS 荷叶对大鼠胃溃疡的抗溃疡作用

Journal of Global Pharma Technology Pub Date : 2011-07-03 DOI: 10.1234/JGPT.V3I2.346

G. Vinothapooshan, K. Sundar

引用次数: 13

ANTIMICROBIAL AND ANALGESIC ACTIVITIES OF VARIOUS EXTRACTS OF MUSSAENDA FRONDOSA L. BARK 灰树皮不同提取物的抗菌和镇痛活性

Journal of Global Pharma Technology Pub Date : 2011-07-03 DOI: 10.1234/JGPT.V3I2.347

B. Basavaraja, H. Vagdevi, L. P. Srikrishna, B. C. Hanumanthapa, S. Joshi, V. P. Vaidya

引用次数: 7

PREPARATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE MICROSPHERES BY COACERVATION PHASE SEPARATION TECHNIQUE USING VARIOUS SOLVENTS AND NON-SOLVENTS 不同溶剂和非溶剂凝聚相分离法制备盐酸曲马多微球及评价

Journal of Global Pharma Technology Pub Date : 2011-05-21 DOI: 10.1234/JGPT.V3I4.377

P. Amareshwar, M. S. Kumar, P. Chakravarti

引用次数: 4

IN-VITRO OCCLUSION STUDIES OF SOLID LIPID NANOPARTICLES LOADED HYDROGEL BY WATER VAPOUR PERMEABILITY ANALYSIS 通过水蒸气渗透性分析负载水凝胶的固体脂质纳米颗粒的体外闭塞研究

Journal of Global Pharma Technology Pub Date : 2011-05-21 DOI: 10.1234/JGPT.V3I4.373

G. Tripathi, B. Dubey

{"title":"IN-VITRO OCCLUSION STUDIES OF SOLID LIPID NANOPARTICLES LOADED HYDROGEL BY WATER VAPOUR PERMEABILITY ANALYSIS","authors":"G. Tripathi, B. Dubey","doi":"10.1234/JGPT.V3I4.373","DOIUrl":"https://doi.org/10.1234/JGPT.V3I4.373","url":null,"abstract":"Solid lipid nanoparticles (SLN) offer sustained release of drug into skin and work as drug depot within epidermal space. This inherent property is greatly employed for topical application of several drugs. Skin penetration of various drugs as well as cosmetic products depends upon skin hydration. Trans-epidermal water loss causes drying of skin thereby making stratum corneum more impermeable to most topical drugs. Solid lipid nanoparticles being smaller in size offer less inter-particles space for water evaporation. It is therefore necessary to evaluate its occlusive effect by some parameters. In the present study we prepared dithranol loaded solid lipid nanoparticles by using tristearin as lipid matrix. In-vitro occlusive studies were performed using water-vapour permeability evaluation. Method is simple and economic. Studies revealed that SLN reduced 14.89 % trans-epidermal water loss when compared to normal formulations. Scanning electron microscopy and particle size distribution studies were also performed. Our method produced SLN having 332 nm sizes with very less polydispersity and good spherical shapes. It can therefore be concluded that SLN carrier can be an advantageous choice for topical drug application as well as cosmetics.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"29 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2011-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85533221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

ANTIDIABETIC EFFECT OF BARK OF ALANGIUM SALVIFOLIUM IN 丹参皮的降糖作用

Journal of Global Pharma Technology Pub Date : 2011-05-21 DOI: 10.1234/JGPT.V3I4.376

A. Sharma, S. Sharma, B. Chauhan, A. Sharma, R. Punia

{"title":"ANTIDIABETIC EFFECT OF BARK OF ALANGIUM SALVIFOLIUM IN","authors":"A. Sharma, S. Sharma, B. Chauhan, A. Sharma, R. Punia","doi":"10.1234/JGPT.V3I4.376","DOIUrl":"https://doi.org/10.1234/JGPT.V3I4.376","url":null,"abstract":"The objective of this study was to verify the traditional claims and evaluate the bark of Alangium salvifolium in organic solvents to screen the antidiabetic activity. The ethanol, and water extracts of Alangium salvifolium bark were obtained and subjected for phytochemical screening and evaluated for their antidiabetic activity in alloxan induced diabetic rats. From the acute toxicity study it was observed that ethanol, and aqueous extracts of Alangium salvifolium bark are non-toxic at a fixed dose of 2000 mg/kg. Ethanol and aqueous extracts had exhibited significant (P<0.01) protection and lowered the blood glucose levels in oral glucose tolerance test as well as in alloxan induced diabetic rats with respect to standard metformin (P<0.01). Ethanol extract significantly (P<0.01) restored body weight in alloxan induced diabetic rats. The results of biochemical estimation showed that the ethanol extract was most active in normalizing the blood serum parameters pertaining to liver function test, an attempt was also made to see that is there any correlation between the active extract and metformin significantly (P<0.01). The study results suggested that Alangium salvifolium bark possess potential anti-diabetic activity.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"125 1","pages":"26-32"},"PeriodicalIF":0.0,"publicationDate":"2011-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78456417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

PHYTOCHEMICAL SCREENING OF MALLOTUS PHILIPINESIS FOR ITS ANTIBACTERIAL ACTIVITY 马来花抗菌活性的植物化学筛选

Journal of Global Pharma Technology Pub Date : 2011-05-21 DOI: 10.1234/JGPT.V3I4.375

J. Jain, B. Marya, K. Sarwa, A. Nair

引用次数: 1

A COMPARATIVE 2D QSAR ANALYSIS OF LEVETIRACETAM& ITS ANALOGS:-THE INHIBITOR OF GLIOBLASTOMA, BY DIFFERENT STATISTICAL TECHNIQUES: MLR, PLS, SVM, ANN 利用不同的统计技术:mlr, pls, svm, Ann对胶质母细胞瘤抑制剂左乙拉西坦及其类似物的二维qsar比较分析

Journal of Global Pharma Technology Pub Date : 2011-05-21 DOI: 10.1234/JGPT.V3I4.372

R. Guru, R. Behera, S. Ghosh, A. Bajpayee, J. Panigrahi, A. K. Patel

{"title":"A COMPARATIVE 2D QSAR ANALYSIS OF LEVETIRACETAM& ITS ANALOGS:-THE INHIBITOR OF GLIOBLASTOMA, BY DIFFERENT STATISTICAL TECHNIQUES: MLR, PLS, SVM, ANN","authors":"R. Guru, R. Behera, S. Ghosh, A. Bajpayee, J. Panigrahi, A. K. Patel","doi":"10.1234/JGPT.V3I4.372","DOIUrl":"https://doi.org/10.1234/JGPT.V3I4.372","url":null,"abstract":"Levetiracetam is a Antiepileptic drugs (AEDs) that act as an inhibitor of Glioblastoma. AEDs may have an impact in modulating O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that has an important role in tumour cell resistance to alkylating agents. Levetiracetam (LEV) is the most potent MGMT inhibitor among several AEDs with diverse MGMT regulatory actions. A QSAR study has been performed by taking 64 analogs of Levetiracetam. Various 2D Constitutional, Geometrical and Chemical Feature Distance Matrix (CFDM) descriptors were generated by using Molegro Data Modeller V2.5.0 tool. The consequence was calculated for each type of descriptors by taking the Andrews coefficient as dependent variable. Multiple regression analysis was performed by Minitab 16 tool. Good correlation R-sq value 0.93 was obtained from the CFDM descriptors in comparison to 2D Constitutional, Geometrical descriptor calculation. The results were also further verified by using PLS (Partial Least Square), SVM (Support vector machines) and ANN (artificial neural networks) based calculation. The results obtained were consistent with ANN statistics and the ANN based method show R-sq value as 0.93 in case of CFDM descriptor which was observed to be the highest among above three methods of analysis. The results obtained with these models suggest, for this particular drug CFDM descriptors modulates strongly the activity rather than 2D Constitutional & Geometrical Descriptor.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"13 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2011-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89342930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0