Journal of Feline Medicine and Surgery最新文献

{"title":"EXPRESS: Prevalence and clinical relevance of hypocobalaminaemia and hypercobalaminaemia in cats.","authors":"Clara Casas, Charlotte Dye","doi":"10.1177/1098612X261478796","DOIUrl":"https://doi.org/10.1177/1098612X261478796","url":null,"abstract":"<p><p>ObjectivesTo investigate the prevalence of hypo- and hypercobalaminemia in a cohort of cats with diverse disease pathologies and to assess associations with signalment and disease characteristics.MethodsResidual blood from cats presented to a large veterinary referral hospital during a 24-month period was used for serum B12 quantification. All cats requiring blood collection as part of diagnostic investigations were eligible for inclusion regardless of clinical presentation. Serum B12 concentration was assessed according to signalment, body weight, body condition score, primary affected body system and type of disease pathology as derived from the clinical notes.ResultsA total of 229 cats were enrolled: 128 male (119 neutered, 9 entire) and 101 female (88 neutered, 13 entire). Of these, 176 were domestic shorthair or longhair, and 53 were purebred. The median age was 9.9 years and median body weight 4.1 kg. Of the 229 cats, 80 (34.9%) had high, 86 (37.6%) normal, 18 (7.9%) borderline, and 45 (19.7%) low serum B12. Median serum B12 concentration was higher in cats aged <8.0 years than ≥8.0 years, and there was a weak but significant negative correlation between age and serum B12. Median serum B12 concentration was lower in cats weighing <3.0 kg than in those ≥3.0 kg, and a weak but significant positive correlation was found between body weight and serum B12 concentration. No associations were found between serum B12 and sex, breed, body condition score, affected body system, or pathology type.Conclusions and relevanceVitamin B12 aberrations were common in this cohort of cats, approximately a third and a fifth having abnormally high and low serum concentrations respectively. Serum vitamin B12 concentration declined with advancing age, and hypocobalaminemia was more prevalent in cats with body weights <3.0kg. Hypo- and hypercobalaminemia were documented in cats with a wide variety of clinical presentations, and no specific disease associations were elucidated.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261478796"},"PeriodicalIF":2.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats.","authors":"Lorna Hardy, Angie Hibbert, Séverine Tasker, Natalie C Finch","doi":"10.1177/1098612X261466163","DOIUrl":"10.1177/1098612X261466163","url":null,"abstract":"<p><p>ObjectivesThe aim of the present study was to determine the frequency and clinical significance of discordant serum symmetric dimethylarginine (SDMA) and creatinine concentrations relative to glomerular filtration rate (GFR) in mature and senior hyperthyroid cats treated with radioactive iodine (RAI). Secondary aims of the study were to compare the sensitivity and specificity of two SDMA upper reference intervals (RIs; >14 and ⩾18 µg/dl) and creatinine (⩾175 µmol/l) for detecting decreased GFR and to evaluate the intra-individual variability of both biomarkers.MethodsA prospective longitudinal study of 27 client-owned hyperthyroid cats receiving low-dose RAI therapy was conducted. At baseline, 1, 6 and 12 months after RAI, cats were evaluated for thyroid status, GFR, SDMA and creatinine concentrations. Discordance was defined as one renal biomarker exceeding its RI with the other within/below the RI, using laboratory and age-specific SDMA RIs. In euthyroid cats, sensitivity, specificity and predictive values of SDMA/creatinine for decreased GFR and intra-individual variability were determined.ResultsDiscordance between SDMA and creatinine was in the range of 10-75% and was highest with the SDMA limit >14 µg/dl. SDMA-GFR discordance exceeded creatinine-GFR discordance at all time points and was highest at baseline, when all cats were hyperthyroid. In cats with euthyroid status at 12 months, SDMA >14 µg/dl was more sensitive (83%) but less specific (50%) for decreased GFR than SDMA ≥18 µg/dl (sensitivity 50%, specificity 71%) and creatinine (sensitivity 50%, specificity 85%). Intra-individual variability was similar for both biomarkers (~15%).Conclusions and relevanceDiscordant SDMA and creatinine concentrations are frequent in older hyperthyroid cats and are influenced by thyroid status and SDMA RIs, complicating interpretation. The SDMA limit ≥18 µg/dl improves specificity for decreased GFR and is more appropriate for senior cats. SDMA concentrations in the range of 15-18 µg/dl are less likely to reflect true GFR reduction when creatinine is normal; therefore, non-renal influences such as hyperthyroidism should be considered and ongoing monitoring of renal parameters is recommended.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261466163"},"PeriodicalIF":2.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ala vestibuloplasty for treatment of feline brachycephalic syndrome: a description of the procedure and long-term outcomes in 27 cats.","authors":"Daniel Shinsako, Annette M McCoy, Jonathan P Samuelson, Audrey C Billhymer, Heidi Phillips","doi":"10.1177/1098612X261465216","DOIUrl":"10.1177/1098612X261465216","url":null,"abstract":"<p><p>ObjectivesThe aims of the study were to describe a technique for feline ala vestibuloplasty and report long-term postoperative outcomes in 27 brachycephalic (BC) cats.MethodsThe study was a retrospective, questionnaire-based study of owned, clinically affected BC cats (n = 27). Owners completed a single, two-part questionnaire regarding presence or absence, frequency or severity of clinical signs before and more than 6 months after ala vestibuloplasty. The questionnaire consisted of questions regarding respiratory and gastrointestinal signs, sleep and activity-related behaviors, and ocular, aural and dental health before and after surgery. Response options were scored and individual scores summed to give a total clinical severity score for each cat (range 0-129). Relationships between clinical variables and outcome were evaluated by regression analysis. A total of 13 cats in the cohort were also enrolled in a previous questionnaire-based study reporting real-time preoperative clinical signs. Owner responses regarding preoperative clinical signs gathered at that time and in the present study were compared to assess for recall bias.ResultsOf the 27 cats, 25 (92.5%) sustained long-term clinical improvement for a mean of 1190 days (range 354-1802 days) after ala vestibuloplasty. Median clinical severity score improved from 48 preoperatively to 17 postoperatively (<i>P</i> <0.0001). Owners reported reduced frequencies of sneezing (<i>P</i> <0.0001), coughing (<i>P</i> = 0.001), nasal discharge (<i>P</i> = 0.0002), snoring (<i>P</i> <0.0001), open-mouth breathing (<i>P</i> = 0.001), dyspnea (<i>P</i> = 0.0001), difficulty eating (<i>P</i> = 0.04), messy eating (<i>P</i> = 0.01), dyspnea while eating (<i>P</i> = 0.003), regurgitation (<i>P</i> = 0.03), vomiting (<i>P</i> = 0.03) and dyspnea during activity (<i>P</i> = 0.007). Owners also reported increased frequency (<i>P</i> = 0.0002) and duration (<i>P</i> = 0.0004) of activity. Owners of cats enrolled in both studies recalled their cats' preoperative clinical signs as slightly more severe than originally reported.Conclusions and relevanceAla vestibuloplasty yields long-term clinical improvements in cats' respiratory, gastrointestinal, sleep, activity, aural and ocular signs. Ala vestibuloplasty should be considered for effective treatment of the described clinical signs of feline BC syndrome.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261465216"},"PeriodicalIF":2.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of four cats with congenital intrahepatic portosystemic shunts treated by a modified percutaneous transvenous coil embolization technique.","authors":"Kornelia Tiffinger, Erin Gibson, Justin Ganjei, Dana Clarke","doi":"10.1177/1098612X261456677","DOIUrl":"10.1177/1098612X261456677","url":null,"abstract":"<p><p>Case series summarySimultaneous portogram/cavogram and continuous portal pressure monitoring during coil deployment are standard practices during percutaneous transvenous coil embolization (PTCE) for the interventional treatment of congenital intrahepatic portosystemic shunts (IHPSSs). In cats, vascular access is more challenging because of their smaller size. The minimum vascular sheath size required to accommodate standard instrumentation for dual-catheter PTCE is 9 Fr, which can be challenging to place in the feline jugular vein. The objective of this case series was to retrospectively describe a single-catheter modification of the PTCE technique in cats to avoid complications associated with large vascular sheaths and the outcomes of these cats. Four cats from two different institutions underwent single-catheter PTCE for left divisional IHPSSs between January 2024 and May 2025. Data collected from medical records included patient demographic data and peri- and post-procedural data. Single-catheter PTCE was performed in all cats through a 6 Fr vascular sheath percutaneously placed in the jugular vein. Isolated portogram and cavogram were performed to localize the shunt, measure caval diameter and determine caval stent positioning using a 4 Fr Berenstein catheter. A laser-cut stent was selected based on CT and cavogram measurements and positioned to span the shunt ostium. The same Berenstein catheter was used for portal pressure measurement and coil deployment by alternating between the shunt and portal vein locations. No complications associated with venous trauma or portal hypertension were reported.Relevance and novel informationThe case series results suggest the modified PTCE technique is a viable alternative that was associated with reasonable procedural duration and avoided vascular complications that may be associated with large vascular sheaths in cats.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261456677"},"PeriodicalIF":2.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13477513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial measurement of serum pancreatic lipase immunoreactivity and trypsin-like immunoreactivity concentrations in cats with chronic enteropathy.","authors":"Dimitra A Karra, Katerina T Moraiti, Jonathan A Lidbury, Joerg M Steiner, Shelley J Newman, Paula R Giaretta, João Pedro Cavasin, Panagiotis G Xenoulis","doi":"10.1177/1098612X261472195","DOIUrl":"10.1177/1098612X261472195","url":null,"abstract":"<p><p>ObjectivesSerial measurement of serum feline pancreatic lipase immunoreactivity (fPLI) and trypsin-like immunoreactivity (fTLI) concentrations in cats with chronic enteropathy (CE) has not been previously reported. The aim of the current observational study was to serially evaluate serum fPLI and fTLI concentrations in cats with different forms of CE.MethodsA total of 60 cats with CE were included, diagnosed either with immunosuppressive-responsive enteropathy (IRE; n = 22), food-responsive enteropathy (FRE; n = 7) or low-grade intestinal T-cell lymphoma (LGITL; n = 32, one diagnosed previously as FRE progressed to lymphoma). Serum fPLI and fTLI concentrations were measured in 252 and 245 serum samples, respectively, from 60 cats with CE at initial presentation and during re-examination.ResultsSerum fPLI concentrations indicative of pancreatitis were found in 3/60 cats (one with IRE and two with LGITL) at initial presentation and in an additional 8/60 cats (four with IRE and four with LGITL) during treatment (24/252 serum samples). Serum fTLI concentrations indicative of exocrine pancreatic insufficiency were found in 2/60 cats (both with IRE) at initial presentation and during re-examination (n = 3/245). None of the cats with FRE had fPLI concentrations above or fTLI concentrations below the respective reference intervals (RIs).Conclusions and relevanceSerum fPLI concentrations may fluctuate during treatment in a subset of cats with IRE or LGITL and, in some cats, are indicative of pancreatitis. Serum fTLI concentrations may vary within and outside the RI in a relatively small proportion of cats with IRE. The long-term clinical importance of these findings requires further study.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261472195"},"PeriodicalIF":2.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative opioid-sparing effect of a quadratus lumborum block using low-concentration bupivacaine and dexmedetomidine in cats undergoing ovariohysterectomy.","authors":"Fumihiko Takusagawa, Yoshimi Takusagawa, Taro Kimura","doi":"10.1177/1098612X261473455","DOIUrl":"10.1177/1098612X261473455","url":null,"abstract":"<p><p>ObjectivesThis study aimed to evaluate the intraoperative opioid-sparing effect of quadratus lumborum block (QLB) using low-concentration bupivacaine combined with dexmedetomidine in cats undergoing ovariohysterectomy.MethodsA total of 28 cats scheduled for ovariohysterectomy and classified as American Society of Anaesthesiologists status I were enrolled and randomly allocated to either a bupivacaine (0.125%) and saline (BS) or bupivacaine (0.125%) and dexmedetomidine (1 µg/kg) (BD) group. The cats underwent ultrasound-guided QLB in sternal recumbency using the allocated solution. If heart rate or mean arterial pressure increased by 20% or more from baseline during surgery, fentanyl (2 µg/kg IV) was administered as rescue analgesia. Postoperative pain was assessed 1, 2, 3, 6 and 12 h after extubation using the Short-Form UNESP-Botucatu Multidimensional Composite Pain Scale. Buprenorphine (0.02 mg/kg IM) was administered if the pain score was 4/12 or higher.ResultsThe cumulative intraoperative dose of fentanyl was significantly lower in the BD group (1 µg/kg [range 0-6]) than in the BS group (2 µg/kg [range 0-8]; <i>P</i> = 0.030). No significant difference was observed between the groups in terms of the proportion of cats requiring intraoperative or postoperative rescue analgesia, postoperative pain scores at any time point, intraoperative physiological parameters or time-related variables.Conclusions and relevanceQLB performed in sternal recumbency using low-concentration bupivacaine with dexmedetomidine was associated with a modest reduction in intraoperative opioid requirements during ovariohysterectomy in cats. However, as this study design could not differentiate between the local and systemic effects of dexmedetomidine, further research is needed to clarify their relative contributions and determine the optimal adjunctive dose.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261473455"},"PeriodicalIF":2.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical repair of steroidal and non-steroidal anti-inflammatory drug-associated full-thickness gastrointestinal ulcers in 10 cats.","authors":"Juan Carlos Jimeno Sandoval, Constança Ribeiro da Cunha, Matteo Rossanese, Mariette Aurelie Pilot, Timothy Menghini, Erika Jennifer Amandine Villedieu, Robert James Quinn","doi":"10.1177/1098612X261467165","DOIUrl":"10.1177/1098612X261467165","url":null,"abstract":"<p><p>ObjectivesThis study aimed to describe the clinical presentation, surgical management, complications and outcomes of cats with gastrointestinal (GI) ulcer perforation associated with recent administration of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids or both.MethodsA retrospective review of medical records from five UK referral hospitals was conducted between 2009 and 2024. Cats were included if they underwent surgical correction of GI ulceration within 14 days of NSAID and/or corticosteroid administration.ResultsA total of 10 cats met the inclusion criteria. The proximal duodenum was the most common site of perforation (n = 6/10), followed by the gastric body (n = 2/10). Surgical techniques varied and included primary repair (n = 5/10), Y-U pyloroplasty (n = 2/10), enterectomy (n = 2/10) and partial gastrectomy (n = 1/10). All cats survived the immediate postoperative period; however, one cat did not survive to discharge (median hospitalisation time 6 days [range 3-15]). Short-term complications were noted in three cats: one death (sepsis 9 days postoperatively) and three mild complications, with two of these complications occurring in the same cat. Long-term complications were noted in one cat (severe ulcerative duodenopathy and euthanased 16 days postoperatively). Long-term follow-up (median 928 days [range 9-1215]) revealed that 5/10 cats remained alive at study completion. Two deaths (n = 2/10) were attributed to GI ulcer-related complications.Conclusions and relevanceGI perforation secondary to recent NSAID or corticosteroid administration in cats carries a favourable prognosis after surgical correction. Despite the high-risk nature of GI perforation, the majority of cats survived to discharge.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261467165"},"PeriodicalIF":2.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and virological effects of the integrase inhibitor raltegravir in cats with naturally progressive feline leukaemia virus infection.","authors":"Pedro Morais de Almeida, Adriana Belas, João Martins, Rita Picado, André Meneses, Joana Tavares de Oliveira, Carlos Viegas","doi":"10.1177/1098612X261452556","DOIUrl":"10.1177/1098612X261452556","url":null,"abstract":"<p><p>ObjectivesFeline leukaemia virus (FeLV) infection - particularly the progressive course - continues to cause substantial morbidity and reduced survival in cats. Therapeutic options with proven antiviral effectiveness remain limited. This study aimed to evaluate the clinical and virological effects of the integrase inhibitor raltegravir in naturally infected, FeLV-progressive cats with FeLV-related conditions, clinical outcome, viraemia, proviral burden and survival.MethodsIn total, 14 client-owned cats with confirmed progressive FeLV infection and at least one FeLV-related condition were enrolled. Raltegravir was administered for 90 days, followed by a 90-day treatment-free observation period. Clinical evaluation and quantification of viral RNA and proviral DNA loads were performed at treatment initiation, day 45, day 90 and day 180. Cats continued to receive standard of care as clinically indicated. Survival data were recorded until study closure.ResultsAfter 45 days of treatment, plasma viral RNA load showed a non-significant mean reduction of 1.34 log₁₀ (<i>P</i> = 0.204). At day 90, mean viral load continued to decrease, with reductions of 1.10 log₁₀ at 40 mg (<i>P</i> = 0.208) and 1.39 log₁₀ at 80 mg (<i>P</i> = 0.195), none of which reached statistical significance. Raltegravir did not exert a consistent effect on proviral DNA load. Most FeLV-related conditions remained clinically stable or improved during the 180-day monitoring period. Leukaemia and lymphoma were the main causes of death. Median survival time was 48 months from FeLV diagnosis and 10.8 months from treatment initiation.Conclusions and relevanceTo the authors' knowledge, this is the first prospective longitudinal study in naturally infected, FeLV-progressive cats with FeLV-related conditions assessing the effects of raltegravir on viraemia, proviral load and clinical outcomes. These real-world data suggest that raltegravir may be associated with numerical reductions in viraemia and clinical stabilisation in some cats. A definitive virological or survival benefit, however, could not be demonstrated. Longer term controlled studies - potentially within multimodal antiviral strategies - are warranted to further define its therapeutic role.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261452556"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13369549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low incidence of feline infectious peritonitis in rehomed shelter cats with known feline coronavirus status: a cohort study of 767 cats.","authors":"Caroline Carlton, Jacqueline M Norris, Nerida Atkin, Luisa Monteiro de Miranda, Mark E Westman, Evelyn Hall, Kate A Worthing","doi":"10.1177/1098612X261447040","DOIUrl":"10.1177/1098612X261447040","url":null,"abstract":"<p><p>ObjectivesThis study aimed to investigate long-term (up to 6 years) post-adoption outcomes in rehomed shelter cats with confirmed feline coronavirus (FCoV) infection, including the development of feline infectious peritonitis (FIP) and gastrointestinal diseases.MethodsA cohort study was performed with a population of adopted cats from a shelter in Sydney, Australia. FCoV infection status was determined within 48 h of shelter admission by faecal viral nucleic acid detection. Long-term health outcomes were determined via an online survey distributed by the shelter to 2641 cat owners 2-6 years after adoption. The relationship between FCoV infection and health outcomes was analysed using logistic regression analysis, including calculation of odds ratios for the occurrence and frequency of health outcomes based on the cat's infection status.ResultsA total of 882 cat owners responded to the survey (response rate = 34%). FCoV faecal test results were available for 767/882 (87%) cats, with corresponding completed survey responses. The prevalence of FCoV infection in this response group was 20% (n = 156/767). Of 767 adopted cats, two (0.3%) were ultimately diagnosed with FIP after rehoming. Of the two adopted cats diagnosed with FIP, 1/611 (0.2%) had a negative FCoV result on shelter entry and 1/156 (0.6%) had a positive result. Vomiting (n = 486/719, 68%) and diarrhoea (n = 262/680, 39%) were commonly observed in the adopted cats during the study period.Conclusions and relevanceThere was no association between FCoV infection upon initial testing and subsequent long-term development of FIP or other post-adoption health conditions. The estimated incidence of FIP 2-6 years after confirmed FCoV infection (0.6%) was lower than previously reported.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261447040"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal comparison of serum pancreatic lipase activity and pancreatic lipase immunoreactivity with clinical signs in cats with suspicion of pancreatitis.","authors":"Peter Hendrik Kook","doi":"10.1177/1098612X261451449","DOIUrl":"10.1177/1098612X261451449","url":null,"abstract":"<p><p>ObjectivesIt remains unclear whether pancreatic lipase immunoreactivity (PLI) and lipase activity similarly reflect clinical status and disease severity in cats with suspected pancreatitis. This retrospective cohort study aimed to directly compare their association with clinical disease severity over time.MethodsA total of 21 client-owned cats with a suspicion of pancreatitis were followed up over a median of 6 weeks (range 1-130). The median number of rechecks was two (range 1-9). Lipase activity (LIPC, Roche Diagnostics; reference interval [RI] 8-26 U/l) and PLI (Spec fPL; RI 0-4.4 µg/l) were measured at each examination and compared with the clinical status of cats expressed as a clinical disease activity score (CDAS).ResultsNo significant correlation between CDAS and either lipase assay was detected at the initial evaluation. During 50 follow-up visits, both lipase assays showed moderate correlations of similar magnitude with CDAS (lipase activity: <i>r</i>_<i>s</i> = 0.486, <i>P</i> = 0.0003; PLI: <i>r</i>_<i>s</i> = 0.432, <i>P</i> = 0.0017). Median lipase activity (76 U/l, range 20-421), PLI (23 µg/l, range 1.3-50) and CDAS (5, range 1-9) were significantly higher at initial presentation compared with follow-up visits (lipase activity 33 U/l, range 9-357; PLI 7 µg/l, range 0.7-50; CDAS 2, range 0-10). In total, 17 cats had concurrent chronic enteropathy. Immunomodulatory therapy was administered during 31/50 (62%) follow-up visits compared with four (19%) cats at initial presentation. Discordant results relative to respective RIs were rare (n = 3/72 visits, 4%), with normal lipase activity and mildly increased PLI; CDAS was 0 (n = 2) or 1 (n = 1) because of minimal weight loss in these three cats.Conclusions and relevanceBoth lipase assays provide clinically equivalent information; however, a moderate correlation with clinical status was only seen during follow-up visits. The lack of correlation with clinical status in sicker cats may reflect the limited spectrum of clinical signs in feline pancreatitis.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261451449"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}