Journal of Feline Medicine and Surgery最新文献

{"title":"Refreshed brands for <i>JFMS</i>'s publishing organisations.","authors":"Nicola Martin, Heather O'Steen","doi":"10.1177/1098612X241307819","DOIUrl":"10.1177/1098612X241307819","url":null,"abstract":"","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241307819"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triage body temperature predicts outcome in cats at emergency department admission: a retrospective study of 1440 cases (January 2018 to December 2021).","authors":"Alessandra Pontiero, Cecilia Bulgarelli, Elena Ciuffoli, Francesca Buzzurra, Agnese Villani, Roberta Troìa, Massimo Giunti","doi":"10.1177/1098612X241291295","DOIUrl":"10.1177/1098612X241291295","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to evaluate the association between triage body temperature (BT) and outcome in cats presenting to the emergency department (ED).</p><p><strong>Methods: </strong>A retrospective observational study was conducted on cats presented to the ED. BT, clinical diagnosis and outcome were recorded. BT was categorised as follows: normothermia (37.8-39.7°C); hyperthermia (⩾39.8°C); mild hypothermia (36.8-37.7°C); moderate hypothermia (35.6-36.7°C); severe hypothermia (33.1-35.5°C); and critical hypothermia (⩽33°C). Outcome in the ED was categorised as death, euthanasia, hospital admission and discharge. Outcome at hospital discharge was evaluated in patients admitted to the intensive care unit (ICU). Systemic inflammatory response syndrome (SIRS) was identified in patients. No-SIRS cats were divided into three disease categories (urinary system, cardiovascular and miscellanea) and SIRS cats into four categories (urinary system, cardiovascular, trauma and miscellanea). The presence of sepsis was evaluated. Non-parametric statistics were used.</p><p><strong>Results: </strong>A total of 1440 cats were included. The hospital mortality rate was 21.9%. Hypothermia in the ED was reported in 510 (35.4%) cats, normothermia in 849 (59%) cats and hyperthermia in 81 (5.6%) cats. In the ED, the median temperature in non-survivors (35.4°C, 95% confidence interval [CI] 34.6-36.3) was significantly lower than in survivors (38.2°C, 95% CI 38.1-38.3; <i>P</i> <0.0001). The risk of non-survival in the ED was significantly higher in cats with a decreased BT, progressively increasing with the severity of hypothermia (<i>P</i> <0.0001). Furthermore, BT was significantly associated with a higher risk of mortality in the ICU (<i>P</i> <0.0001). A diagnosis of sepsis was associated with a high prevalence of hypothermia (79/124 cats, 63.7%) and a higher risk of non-survival (odds ratio [OR] 2.62, 95% CI 1.52-4.54; <i>P</i> = 0.0006). The mortality risk significantly increased in SIRS cats with a cardiovascular disease (OR 8.27, 95% CI 4.09-16.68; <i>P</i> <0.0001).</p><p><strong>Conclusions and relevance: </strong>Hypothermia is common in cats at ED admission and is significantly associated with outcome. Triage hypothermia might identify patients with sepsis or SIRS complicated by comorbidities, such as cardiovascular and urinary diseases.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241291295"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular changes in Persian cats with polycystic kidney disease: a study of cardiac troponin I, echocardiography and blood pressure.","authors":"Niloufar Saberi, Ehsan Khaksar, Mohammad Molazem, Seeyamak Mashhady Rafiee","doi":"10.1177/1098612X241303311","DOIUrl":"10.1177/1098612X241303311","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiovascular complications are well known in humans with autosomal dominant polycystic kidney disease (PKD), but limited data exist for cats. This study aimed to assess echocardiographic changes, cardiac troponin I (cTnI) levels and systolic blood pressure (SBP) in Persian cats with PKD to detect early cardiac abnormalities.</p><p><strong>Methods: </strong>In total, 52 Persian and mixed-Persian cats were enrolled, with 26 cats in the control group and 26 diagnosed with PKD via ultrasound due to the unavailability of genetic testing. Although genetic testing is the gold standard for definitive diagnosis, this study utilised high-sensitivity ultrasound as an alternative diagnostic tool. This method aligns with existing literature supporting its effectiveness in detecting PKD, particularly in regions where genetic testing is not accessible. Echocardiographic examinations employed M-mode and two-dimensional echocardiography to measure the diastolic thickness of the interventricular septum and the left ventricular free wall. Doppler ultrasonography was used to measure SBP and cTnI serum levels were determined using a Monobind-ELISA kit.</p><p><strong>Results: </strong>Median SBP and cTnI levels in PKD cats were 155 mmHg and 85.80 ng/l, respectively, which was significantly higher than the control group (<i>P</i> ⩽0.001). Interventricular septum in systole, as well as diastolic thickness of the interventricular septum and the left ventricular free wall, was significantly elevated in PKD cats compared with controls (<i>P</i> ⩽0.001). No significant differences were observed in other echocardiographic parameters.</p><p><strong>Conclusions and relevance: </strong>Asymptomatic PKD-affected Persian cats exhibited elevated SBP and cardiac structural changes; however, the clinical significance of these findings remains uncertain due to a lack of long-term follow-up. While early cardiac changes may be present, further research is necessary to establish their clinical relevance and guide appropriate management strategies. Monitoring PKD cats is advised, but a direct clinical impact is not confirmed at this stage.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241303311"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of the feline herpesvirus-1 modified live vaccine strain F2 from one of four cats with dendritic ulcers.","authors":"Yasuharu Suga, Rikio Kirisawa","doi":"10.1177/1098612X241306954","DOIUrl":"10.1177/1098612X241306954","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the pathogenicity of feline herpesvirus-1 (FHV-1) to the cornea, FHV-1 strains isolated from feline eyes with dendritic ulcers were subjected to genomic analysis to determine whether FHV-1 vaccine strains are involved in the formation of dendritic ulcers.</p><p><strong>Methods: </strong>All open reading frame (ORF) sequences of the three F2 strains (Virbac, Intervet and Merial) and the FHV-1 clinical isolates from cats registered in GenBank were compared to detect nucleotide variants unique to the F2 strains, with those nucleotides then being used for simple genotyping of the F2 strains. In all isolates from feline eyes with dendritic ulcers, the regions including nucleotide variants of the F2 strain were amplified with PCR and sequenced. Isolates with nucleotide variants of the F2 strain were then subjected to next-generation sequencing to determine their full genome sequences, which were compared with all ORF sequences of the three F2 strains.</p><p><strong>Results: </strong>Analysis of ORF sequences for simplified genotyping of F2 strains detected a single nucleotide variant in ORF28 and in ORF44. These were considered to be nucleotide variants unique to the F2 strain. Among the four FHV-1 isolates from eyes of four cats with dendritic ulcers, nucleotide variants of the F2 strain were detected in 1/4 strains (the NS strain). Next-generation sequencing of the NS strain was performed, and all ORF sequences of the NS strain were compared with the those of the three F2 strains. All ORF sequences of the NS strain were completely identical to those of two F2 strains (Virbac and Intervet) and some clones of the Merial vaccine strain.</p><p><strong>Conclusions and relevance: </strong>The F2 strain was isolated from an eye with a dendritic ulcer, indicating that the strain has the potential to replicate in the corneal epithelium and form lesions.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241306954"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acetate- and lactate-containing intravenous fluid on acid-base status, electrolytes and plasma lactate concentration in dehydrated cats.","authors":"Isabel Banzhaf, Ute Klein-Richers, Annika Heitland, Katrin Hartmann, René Dörfelt","doi":"10.1177/1098612X241297878","DOIUrl":"10.1177/1098612X241297878","url":null,"abstract":"<p><strong>Objectives: </strong>Acetate (ACE) and lactate (LAC)-containing balanced resuscitation fluids are commonly used for fluid therapy in cats. These fluids can influence acid-base and electrolyte status. This prospective randomised study compared two balanced crystalloid solutions regarding their effect on acid-base status, electrolytes and LAC concentrations in dehydrated cats after intravenous fluid therapy.</p><p><strong>Methods: </strong>A total of 100 client-owned cats presenting to the emergency service with dehydration ⩾5% due to diarrhoea, vomiting or anorexia were included in this study. They were randomised to receive either ACE- (Sterofundin ISO; B Braun Vet Care) or LAC-containing (Ringer-Laktat nach Hartmann; B. Braun Vet Care) fluids for rehydration. Exclusion criteria were age <6 months, severe electrolyte abnormalities, severely increased creatinine or bolus therapy, and decompensated heart disease and liver diseases. Vital parameters were assessed and venous blood gas analysis was performed before and after fluid therapy. Data were analysed using the Mann-Whitney U-test and the Wilcoxon matched-pairs signed-rank test. The significance level was set at <i>P</i> ⩽0.05.</p><p><strong>Results: </strong>Post-rehydration pH normalised, and bicarbonate and base excess increased in both groups. Anion gap and LAC and potassium concentrations decreased in both groups. No difference in electrolyte, acid-base status and LAC was observed between cats receiving ACE and cats receiving LAC.</p><p><strong>Conclusions and relevance: </strong>Both fluids have similar effects on dehydrated cats' acid-base status and electrolyte and LAC concentrations. No significant differences in values were found between ACE- and LAC-containing resuscitation fluids. Blood LAC concentration decreased in both groups.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241297878"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma glucagon-like peptide-2 in cats with chronic enteropathies.","authors":"Maria C Jugan, Brandon L Plattner, Alexandra K Ford, Leah Freilich, Zackery Bieberly, Thomas Schermerhorn","doi":"10.1177/1098612X241305923","DOIUrl":"10.1177/1098612X241305923","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to compare plasma glucagon-like peptide-2 (GLP-2) concentrations in cats with chronic enteropathies (CE) with those of healthy cats.</p><p><strong>Methods: </strong>Nineteen client-owned cats with a histopathologic diagnosis of either idiopathic chronic enteropathy (CIE) or low-grade lymphoma and six healthy client-owned cats were enrolled in a prospective study between 2 December 2021 and 9 June 2023. Fasted and postprandial plasma GLP-2 concentrations were measured via ELISA in CE cats at the time gastrointestinal biopsies were obtained and before CE treatment. In cats with a histopathologic diagnosis of CIE, plasma GLP-2 concentrations were re-evaluated after 1 month of CE treatment.</p><p><strong>Results: </strong>There was no significant difference in plasma GLP-2 concentrations between healthy cats (0.53 ng/ml) and cats with CE (0.52 ng/ml). GLP-2 concentrations in cats with CIE were not significantly different following 1 month of treatment (0.43 ng/ml) from those at initial presentation (0.44 ng/ml).</p><p><strong>Conclusions and relevance: </strong>GLP-2 can be successfully detected in the plasma of cats with CE. Based on the lack of differences observed between this population of CE cats and healthy cats, GLP-2 cannot be recommended as a biomarker of feline CE using this ELISA method. Further investigation of larger CE cat populations and analytic methods would be needed to determine the overall utility of GLP-2 evaluation in feline CE.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241305923"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a point-of-care test for quantitative determination of total thyroxine in feline serum.","authors":"Eva Spada, Roberta Perego, Luciana Baggiani, Daniela Proverbio","doi":"10.1177/1098612X241303324","DOIUrl":"10.1177/1098612X241303324","url":null,"abstract":"<p><strong>Objectives: </strong>Total thyroxine (TT4) evaluation is the most commonly used first-line test for the diagnosis and monitoring of cats with hyperthyroidism. Vcheck T4 is a point-of-care immunoassay that measures TT4 using a Vcheck V200 analyser. This study aimed to evaluate the analytic performance of the Vcheck T4 assay in feline sera and the agreement in the classification of normal, high and low TT4 concentrations of Vcheck T4 with those measured by an enzyme immunoassay (EIA).</p><p><strong>Methods: </strong>Assay precision, reproducibility and linearity were evaluated for the Vcheck T4. For method comparison, TT4 concentrations in 73 serum samples were analysed by both methods.</p><p><strong>Results: </strong>Vcheck T4 demonstrated good precision, reproducibility (intra- and inter-assay coefficients of variation between 3% and 13.5%) and linearity in the diagnostic range of <0.5 and >8 μg/dl. The correlation coefficient was 0.87, Passing-Bablok regression showed a proportional, but not constant bias, Bland-Altman plots revealed a mean difference of +0.5 μg/dl. The overall inter-rater agreement (<i>K</i>) between TT4 EIA and Vcheck results was substantial (<i>K</i> = 0.69), with 82.2% of concordant results. As a diagnostic test for hyperthyroidism, Vcheck T4 showed a sensitivity and specificity of 88.9% and 84.4%, and a positive predictive value (PPV) and negative predictive value (NPV) of 44.5% and 98.2%, respectively.</p><p><strong>Conclusions and relevance: </strong>Vcheck T4 assay provided precise and reproducible results in substantial agreement with the EIA. Given the high NPV, Vcheck T4 is useful in ruling out hyperthyroidism when screening cats, but, based on low PPV, samples with results with high TT4 need to be analysed by another reference method. Further analysis with haemolytic, icteric and lipaemic samples is needed to assess the test performance. Finally, the reference intervals provided by the manufacturer require verification, and TT4 intervals specific to this method must be established in future studies.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241303324"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of age, sex, breed and venipuncture site on platelet count and clumping in feline blood samples.","authors":"Sarah M Larkin, Matthew R Kornya","doi":"10.1177/1098612X241305919","DOIUrl":"10.1177/1098612X241305919","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the associations between sex, age, breed and collection site on platelet count and platelet clumping in feline blood samples.</p><p><strong>Methods: </strong>Cats presenting to a primary care feline hospital from January 2016 to January 2017 were recruited. Any cat undergoing blood collection for a complete blood count was eligible. Cats were excluded if they were receiving clopidogrel or aspirin, had a disease known to affect platelet function, or if they required sedation for phlebotomy. All cats had their sex, age, site of venipuncture, platelet count, degree of platelet clumping and platelet morphology recorded.</p><p><strong>Results: </strong>In total, 649 cats were prospectively recruited. Of these, 579 (89%) cats had no clumping observed on blood smears. A significant association (<i>P</i> = 0.025) was found between sex and platelet count, with females having lower platelet counts. No significant association was found between sex and degree of platelet clumping (<i>P</i> = 0.323). Age did not have a statistically significant association with platelet clumping <i>(P</i> = 0.959); however, it did have a small significant (<i>P</i> = 0.003) positive correlation with platelet count. There was no significant effect of purebred status on platelet count (<i>P</i> = 0.457); however, the domestic group had a higher rate of platelet clumping (<i>P</i> = 0.009). No association was found between platelet count (<i>P</i> = 0.322) or degree of platelet clumping (<i>P</i> = 0.793) and collection site. When considering platelet clumping as a binary outcome, no association was found with sex (<i>P</i> = 0.292), age (<i>P</i> = 0.681), site of collection (<i>P</i> = 0.809) or breed (<i>P</i> = 0.264).</p><p><strong>Conclusions and relevance: </strong>The lack of effect of collection site/technique suggests that multiple sites of collection are valid when accurate platelet counts are important. The finding of lower platelet counts in younger and female cats may highlight the need to recognize age and sex when considering the management and monitoring of platelet counts and platelet disorders. Additional studies are needed to understand breed variation.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241305919"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signalment, clinicopathological findings, management practices and comorbidities in cats with diabetes mellitus in Germany: cross-sectional study of 144 cases.","authors":"Bente Guse, Judith Langenstein, Natali Bauer, Katarina Hazuchova","doi":"10.1177/1098612X241303303","DOIUrl":"https://doi.org/10.1177/1098612X241303303","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to describe signalment, clinicopathological findings, management practices and the occurrence of comorbidities in feline diabetes mellitus (DM) in Germany.</p><p><strong>Methods: </strong>This was a cross-sectional study using questionnaires and laboratory submissions to a commercial laboratory, Antech Lab Germany, between May 2021 and July 2022. Inclusion criteria were diagnosis of DM by the attending veterinarian and submission of a completed questionnaire besides blood samples. Laboratory testing included haematology, serum biochemistry, concentration of total thyroxine (TT4), insulin-like growth factor 1 (IGF-1), cobalamin (COB), fructosamine, b-hydroxybutyrate and DGGR (1,2-<i>O</i>-dilauryl-<i>rac</i>-glycero-3-glutaric acid-[6'-methylresorufin] ester) lipase activity. Data are presented as the median (range) and analysed by non-parametric tests. <i>P</i> <0.05 was considered statistically significant.</p><p><strong>Results: </strong>The median (range) age of the 144 diabetic cats at diagnosis was 11 years (0.9-18.7), 66.4% were male, 84.6% were domestic shorthair, 50.4% were currently overweight and 61.5% were previously overweight (body condition score >5/9). Most cats were treated with insulin (84%), most commonly protamine zinc insulin (57.5%). Blood glucose curves or continuous glucose monitoring alone or in combination with other methods were performed to adjust insulin therapy in 70.6% of cats. Based on questionnaires, 78.6% were poorly controlled and 21.4% were well controlled. Increased TT4 occurred in 3/139 and hyperthyroidism was known in 5/139 cats (frequency of known/suspected hyperthyroidism: 5.8% [n = 8/139]); 17.5% (n = 17/97) had increased IGF-1 (IGF-1 >746 ng/ml, cut-off for hypersomatotropism with the chemiluminescence assay used in this study); 24.5% (n = 34/139) had COB <295.2 pmol/l and 54.2% (n = 78/144) had increased DGGR. Cats with IGF-1 >746 ng/ml were receiving a higher insulin dose than cats with IGF-1 ≤746 ng/ml (median 1.63 vs 0.86 U/kg/day, <i>P</i> = 0.018).</p><p><strong>Conclusion and relevance: </strong>Increased DGGR and increased IGF-1 indicating hypersomatotropism are common in diabetic cats and should be tested for. Almost one-quarter of diabetic cats might require COB supplementation.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241303303"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum galectin-3 concentrations in healthy cats and in cats with ureteral obstruction.","authors":"Dennis J Woerde, Carrie A Palm, Krystle L Reagan, William Tn Culp","doi":"10.1177/1098612X241288191","DOIUrl":"https://doi.org/10.1177/1098612X241288191","url":null,"abstract":"<p><strong>Objectives: </strong>Serum galectin-3 (sGal-3) is a protein present in renal tubules and increases in experimental rodent models of acute kidney injury. The aim of this study was to compare sGal-3 concentrations in healthy cats and cats with ureteral obstruction (UO).</p><p><strong>Methods: </strong>This was a retrospective study. Banked serum was used for sGal-3 evaluations in 15 healthy control cats and 22 cats with UO. For the control cats, creatinine and symmetric dimethylarginine were within reference intervals and ultrasound showed minimal to no kidney changes. A feline-specific sGal-3 ELISA was used to determine sGal-3 concentrations. Samples were analyzed in duplicate, and results were included if the coefficient of variation between samples was <20%. Shapiro-Wilk testing was used to evaluate for normality and parametric statistics were performed. <i>P</i> <0.05 was considered significant.</p><p><strong>Results: </strong>Mean (±SD) sGal-3 was lower in healthy cats (274.3 ± 146.5 pg/ml) than in cats with UO (707.7 ± 223.3 pg/ml; <i>P</i> <0.0001). There was no difference in sGal-3 concentrations between cats with unilateral or bilateral UO (<i>P</i> = 0.24) and no correlation between sGal-3 and creatinine, body weight or age. With a cutoff of 500 pg/ml, sGal-3 had a sensitivity of 86% (95% confidence interval [CI] 0.67-0.95) and specificity of 100% (95% CI 0.79-1.00) for differentiating cats with UO from healthy cats.</p><p><strong>Conclusions and relevance: </strong>An early diagnosis of UO is critical, given its associated morbidity and mortality. Given the differences in sGal-3 concentrations in healthy cats and those with UO in this study, sGal-3 shows potential for an early UO diagnosis; however, further research is needed.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 1","pages":"1098612X241288191"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}