Journal of Feline Medicine and Surgery最新文献

{"title":"Fundoscopy in cats: a practical guide and common findings.","authors":"Natalia Giannakopoulou, Ben Blacklock","doi":"10.1177/1098612X251338463","DOIUrl":"https://doi.org/10.1177/1098612X251338463","url":null,"abstract":"<p><strong>Practical relevance: </strong>Comprehensive examination of the feline fundus should be in every clinician's arsenal. It is an integral part of both the physical and ophthalmic examination, especially in senior cats and in the presence of intraocular inflammation and visual impairment. Fundoscopy provides critical insight into a wide range of systemic diseases, often leading to quicker diagnoses and better treatment outcomes.</p><p><strong>Clinical challenges: </strong>Practice is needed to become proficient and take high-quality photos of the retina. Distinguishing between normal variants and pathological findings can be challenging initially.</p><p><strong>Evidence base: </strong>This review includes information from published references of common retinal pathologies in cats, as well as the authors' extensive experience on performing fundoscopy.</p><p><strong>Equipment: </strong>The essential tools for fundoscopy include a direct and indirect ophthalmoscope, condensing lens and a focal light source. High-quality images of the fundus can be achieved with any smartphone.</p><p><strong>Audience: </strong>This review is aimed at veterinary clinicians and outlines all the steps and equipment needed to confidently perform fundoscopy. It also provides tips on how to capture photos of the fundus using a smartphone. Common findings are discussed in relation to different retinal pathologies.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 5","pages":"1098612X251338463"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feline immune-mediated skin disorders: Part 2.","authors":"Frane Banovic, Paulo Gomes, Karen Trainor","doi":"10.1177/1098612X251323424","DOIUrl":"https://doi.org/10.1177/1098612X251323424","url":null,"abstract":"<p><p>Practical relevanceCutaneous immune-mediated diseases in cats can present with clinical signs of erythema, hair loss, scaling/crusting, and erosions with or without pruritus, mimicking many differential diagnoses such as hypersensitivity dermatitis and infections (eg, parasitic and fungal dermatitis). Veterinarians are encouraged to become familiar with the characteristic clinical features of various immune-driven skin disorders to permit early diagnosis and appropriate treatment.Clinical challengesDiagnosis and therapeutic management of feline immune-mediated skin diseases can be challenging. Although immune-mediated skin diseases in cats are rare, these can be associated with severe systemic clinical signs, which can lead to poor quality of life and owners electing euthanasia.AimsIn the second of a two-part article series, the clinical presentations of the feline immune-mediated skin diseases erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum, plasma cell pododermatitis, proliferative and necrotizing otitis externa, pseudopelade, alopecia areata and auricular chondritis are reviewed and differential diagnoses, diagnosis and therapeutic approach are discussed. In Part 1, the equivalent is discussed for feline immune-mediated skin diseases related to the pemphigus complex, cutaneous lupus erythematosus, and thymoma- and non-thyoma-associated exfoliative dermatitis.Evidence baseThe information in this article is based on a review of the existing veterinary literature.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251323424"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality and life table analysis in a young cohort of pet cats in the UK.","authors":"Aimee R Taylor, Jennifer McDonald, Rae Foreman-Worsley, Angie Hibbert, Emily J Blackwell","doi":"10.1177/1098612X251314689","DOIUrl":"https://doi.org/10.1177/1098612X251314689","url":null,"abstract":"<p><p>ObjectivesMortality data represent an important resource for understanding population health that previously have mostly been extrapolated from veterinary records. The aims of this study were to explore mortality for a cohort of pet cats in the UK using data from owner-completed questionnaires, thus potentially representing a more comprehensive population, and to determine the all-cause mortality and survival probabilities.MethodsData were collated from the 'Bristol Cats' study questionnaires, owner communications and medical records for the cohort's first 8 years of life. Mortality was classified by organ system, disease or event, and analysed by age and life stage. Age-specific mortality and cumulative survival probability curves were constructed using life table analysis.ResultsOf 2444 cats recruited into the 'Bristol Cats' study, at least 362 died before reaching the age of 9 years. The most common cause of death in cats up to the age of 8 years was road traffic accident (RTA; 45.6%). For kittens (aged <1 year), the most common causes were RTA (61.2%), feline infectious peritonitis (11.9%) and other trauma (7.5%). The most common causes of mortality in young adult cats (aged 1-6 years) were RTA (49.6%), non-specified (14.4%), renal disease (6.5%) and cardiovascular disease (6.5%). Cats aged up to 2 years had an annual probability of dying in the range of 2.8-3.1%, which decreased between 2 and 3 years of age to 1.7%. Thereafter, the probability of dying gradually increased with age, with the oldest age group (aged 7-8 years) having a 3.6% probability of dying.Conclusions and relevanceThis study identified important differences in causes of mortality for the first two life stages in a population of cats that may not be fully accounted for in medical records. Life table analysis documented an increasing probability of death with age after year interval 2-3 with a higher mortality risk for cats aged up to 2 years.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251314689"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of urinary kidney injury molecule-1 in cats with chronic kidney disease.","authors":"Matthew Kornya, Alice Defarges, Dorothee Bienzle","doi":"10.1177/1098612X251314778","DOIUrl":"https://doi.org/10.1177/1098612X251314778","url":null,"abstract":"<p><p>ObjectivesKidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein on proximal renal tubular epithelial cells that is increased in the urine of cats with acute kidney injury. The utility of measuring urine KIM-1 in cats with chronic kidney disease (CKD) and the relationship with International Renal Interest Society (IRIS) stage are unknown. The objectives of this study were to determine the distribution of KIM-1 concentrations in cats with different stages of CKD and investigate the relationship between urine KIM-1 and urine specific gravity (USG), urine protein and serum urea, creatinine, phosphorus, potassium and symmetric dimethylarginine concentrations.MethodsA total of 74 cats with CKD were recruited prospectively from a first-opinion feline-only practice. Blood and urine samples were collected from all cats. The stage of CKD was determined as per IRIS guidelines. Urine KIM-1 concentration was determined with a previously validated lateral flow assay. KIM-1 was reported as a test:control ratio. The distribution of KIM-1 values in cats with CKD was determined, and the correlation between KIM-1 and other determinants of renal function was calculated. Urine KIM-1 was normalized to a USG of 1.035 and the analysis was repeated.ResultsCats with CKD had a median urine KIM-1 value of 0.1544 (range 0.038-0.540). The median KIM-1 values in cats with IRIS stage 1, 2, 3 and 4 CKD were 0.152 (range 0.113-0.512), 0.165 (range 0.038-0.540), 0.150 (range 0.037-0.448) and 0.140 (range 0.067-0.448), respectively. There were no differences in urine KIM-1 values relative to IRIS stage. Urine KIM-1 values were correlated with USG (<i>r</i>² = 0.482; <i>P</i> = 0.005). An analysis of KIM-1 values normalized to USG resulted in similar findings.Conclusions and relevanceUrine KIM-1 values in cats with CKD were similar to those previously described in healthy cats. There was a moderately strong correlation between urine KIM-1 concentration and USG. Sequential measurement of KIM-1 in cats with progressive CKD may be informative.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251314778"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro-induced Heinz bodies showed no impact on feline reticulocyte haemoglobin content measurement using the Advia 2120i analyser.","authors":"Asger Lundorff Jensen, Julie Dreyer Vestergaard, Lise Nikolic Nielsen, Anne Kh Krogh, Rebecca Langhorn","doi":"10.1177/1098612X251314709","DOIUrl":"10.1177/1098612X251314709","url":null,"abstract":"<p><p>ObjectivesReticulocyte haemoglobin content (CHr) is a promising tool for evaluating iron status in dogs; however, its usefulness in cats varies. Heinz bodies interfere with haematological analyses on the Advia 120/2120i analyser (Siemens Healthineers), but the effect of Heinz bodies on CHr measurement in feline blood samples is unknown.MethodsIn an analytical intervention study, CHr concentration was measured pairwise in 30 feline blood samples with and without Heinz bodies chemically induced in vitro using 1-acetyl-2-phenylhydrazine (APH).ResultsThe percentage of Heinz bodies and the amount of Heinz body material were assessed by microscopy after staining with New Methylene Blue, and both increased significantly after in vitro APH incubation. After incubation, CHr levels decreased significantly in both samples without APH and in APH-treated samples, but no significant difference was detected between the samples with and without APH.Conclusions and relevanceIn vitro<i>-</i>induced Heinz bodies did not impact CHr levels. Explaining the lesser diagnostic utility of CHr measurements in cats compared with dogs as an effect of Heinz bodies is therefore not substantiated by this in vitro study. Accordingly, variations in feline patient populations and varying definitions of iron deficiency in previous studies are likely the main explanations for the lesser diagnostic utility of CHr measurements in cats.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251314709"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture of the greater trochanter of the femur in 17 cats: imaging, clinical features and concurrent injuries.","authors":"Genziana Nurra, Mariette Pilot, Beatrice Grek-Fritzner, Mario Coppola, James Michael Grierson, Sorrel Langley-Hobbs","doi":"10.1177/1098612X241305918","DOIUrl":"10.1177/1098612X241305918","url":null,"abstract":"<p><p>ObjectivesThe objectives of this study were to evaluate the population, concurrent injuries, best diagnostic radiographic projection, management and short-term outcome of cats presenting with a fracture of the greater trochanter.MethodsMedical records, imaging studies, methods of repair, complications and short-term outcome of cats that presented with a fracture of the greater trochanter were retrospectively reviewed at two referral institutions. Radiographs were evaluated using a quantitative scoring system. Short-term outcome (>3-6 months) and complications were determined at the follow-up appointment.ResultsSeventeen cats were included. The mean age was 10.5 months (range 3-16). All 17 cats exhibited concurrent orthopaedic injuries, with 5/17 (29%) presenting with multiple orthopaedic injuries. Coxofemoral luxation was the most common, representing more than half (58.8%) of the concurrent orthopaedic injuries identified, followed by pelvic/sacral fractures (52.9%). Further orthopaedic injuries such as sacroiliac luxation and femoral neck fractures were the least common and were present in 11.7% of the studied population. Greater trochanteric fractures were most easily identified on the ventrodorsal radiographic projection of the pelvis, with increased accuracy in the frog-leg ventrodorsal view. Most cats (94.4%) were managed surgically using two or three Kirschner (K)-wires and a tension band wire. Short-term follow-up was available for all 17 cats at a mean of 6.3 months (range 3-8). Major complications were seen in 4/17 (23.5%) patients. These included mild lameness and persistent discomfort due to periosteal reaction, which resolved following surgical or medical intervention. Short-term mobility was considered good in 58.8% of cats, acceptable in 29.5% and poor in the remaining 11.7%.Conclusions and relevanceCoxofemoral luxation was the most prevalent concurrent orthopaedic injury (58.8%). The majority of the greater trochanteric fractures (94.4%) were managed surgically with K-wires and a tension band wire. Ventrodorsal and specifically frog-leg radiographic projections of the pelvis enhance the diagnosis of greater trochanteric fractures. Specific outcomes of greater trochanteric fractures are uncertain because of the high occurrence of concurrent orthopaedic injuries.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X241305918"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of longitudinal systolic function using tissue motion annular displacement in cats with hypertrophic cardiomyopathy: a prospective case-control study.","authors":"Nadthagarn Glaewketgarn, Sirilak Disatian Surachetpong","doi":"10.1177/1098612X251320240","DOIUrl":"https://doi.org/10.1177/1098612X251320240","url":null,"abstract":"<p><p>ObjectivesThe aim of this study was to investigate left ventricular (LV) longitudinal systolic function in cats with hypertrophic cardiomyopathy (HCM) and healthy control cats using tissue motion annular displacement (TMAD).MethodsThe study included 26 control cats and 21 HCM cats. All cats underwent assessment using two-dimensional echocardiography, M-mode echocardiography, pulsed-wave Doppler, tissue Doppler imaging techniques, longitudinal strain and TMAD.ResultsGlobal TMAD and percentage (%) global TMAD were not influenced by breed, sex, age or heart rate. Mean global TMAD and % global TMAD significantly decreased in the HCM group (2.86 ± 0.86 mm and 11.46% ± 3.37%, respectively) compared with the control group (3.95 ± 0.89 mm and 16.12% ± 2.94%, respectively) (<i>P</i> <0.001 for both), suggesting LV longitudinal systolic dysfunction in HCM cats. LV fractional shortening showed no difference between the control (52.76% ± 11.63%) and the HCM groups (59.80% ± 13.51%) (<i>P</i> = 0.061). Global TMAD and % global TMAD were significantly correlated with global longitudinal strain (<i>P</i> <0.001). The intraclass correlation coefficient of global TMAD and % global TMAD was considered moderate.Conclusions and relevanceGlobal TMAD and % global TMAD were significantly decreased in cats with HCM compared with the control group, and were sensitive and repeatable techniques for evaluating LV longitudinal systolic dysfunction in cats with HCM.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251320240"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Owners' experiences of caring for cats with chronic kidney disease in the UK.","authors":"Jenna Elliott, Holly Reyes-Hughes, Angie Hibbert, Emily Blackwell, Natalie C Finch","doi":"10.1177/1098612X251314769","DOIUrl":"https://doi.org/10.1177/1098612X251314769","url":null,"abstract":"<p><p>ObjectivesThe aim of the present study was to describe current practices in the management of feline chronic kidney disease (CKD), and the experiences and emotions of caring for a cat with CKD, reported by UK cat owners.MethodsA survey study was conducted of UK owners of cats with CKD that included multiple-choice, Likert scale and open questions reported using descriptive statistics.ResultsResponses from 100 UK owners of cats with CKD were included in the study. Of the owners, 73% had knowledge of their cat's International Renal Interest Society stage and 76% were feeding their cat a renal diet, with 70% reporting that veterinary recommendation had influenced this decision. Of the owners, 35% were administering phosphate binders, 26% natural supplements and 25% antiproteinuric therapies to their cat. Of concern was the high number of owners reporting feelings of anxiety (99%) as well as other negative emotions associated with caring for their cat with CKD. Extreme worry, anxiety or concern were high at both the time of CKD diagnosis and survey completion, related to disease prognosis (72% and 50%, respectively) and cats' quality of life (63% and 46%, respectively). Many owners agreed that their daily routine had changed a lot since their cat was diagnosed with CKD (66%) and that caring for their cat negatively impacted or restricted their own life (37%).Conclusions and relevanceAlthough owners' knowledge and understanding of their cat's CKD and appropriate management was generally in line with expert guidelines, the finding that many owners reported experiencing feelings of anxiety associated with caring for their cat, suggesting caregiver burden, was concerning. This highlights the impact that veterinary professionals, including veterinary nurses, may have in providing greater education and support to enhance the relationship and communication with owners of cats with CKD, thus helping to alleviate anxiety and ensure ongoing successful CKD management.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251314769"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of haemorrhage and lactated Ringer's solution or tetrastarch 130/0.4 resuscitation on colloidal osmotic pressure and osmolality in cats.","authors":"Anthea Michaletos, Marinell Breytenbach, Gareth E Zeiler","doi":"10.1177/1098612X251320299","DOIUrl":"10.1177/1098612X251320299","url":null,"abstract":"<p><p>ObjectivesTo determine the effects of haemorrhage and fluid over-resuscitation on colloidal osmotic pressure of albumin (COP albumin), plasma (Posm) and effective (Eosm) osmolality in anaesthetised cats.MethodsA total of six cats were given three treatments once, at 2-month intervals, in a randomised, crossover haemorrhage-resuscitation study. The treatments were divided into two phases, a controlled haemorrhage phase and a fluid resuscitation phase, as follows: (1) NoHR = no controlled haemorrhage and no resuscitation; (2) LRS = controlled haemorrhage followed by lactated Ringer's solution infusion (60 ml/kg/h); and (3) TS = controlled haemorrhage followed by 6% tetrastarch 130/0.4 suspended in 0.9% saline infusion (20 ml/kg/h). The resuscitation fluids were administered for 120 mins. Data were collected before haemorrhage, before resuscitation and at 30 min intervals until 120 mins. Variables were calculated at each time point as follows: COP albumin = albumin concentration (g/l) × 0.57; Posm = (2 × sodium) + glucose + blood urea nitrogen; and Eosm = (2 × sodium) + glucose. All Posm and Eosm concentrations were measured as mmol/l. Data were compared using a general linear mixed model (significance: <i>P</i> <0.05).ResultsMean ± SD total haemorrhage volumes for NoHR, LRS and TS were 10.2 ± 2.3, 29.3 ± 9.0 and 29.1 ± 6.3 ml/kg, respectively. The COP albumin decreased over time in all treatments regardless of volumes of blood lost and fluid administered. The decrease in COP albumin was profound and clinically relevant in LRS and TS (both <i>P</i> <0.001). There were no statistical differences in Posm and Eosm over time except in LRS at 90 (<i>P</i> = 0.004) and 120 ml/kg (<i>P</i> <0.001).Conclusions and relevanceThe COP albumin decreased in all treatments but to low and clinically relevant concentrations in LRS and TS, putting the cats at risk of fluid overload. There were no clinically relevant derangements in Posm and Eosm.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251320299"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of feline oral squamous cell carcinoma with accelerated radiation and carboplatin with and without follow-up toceranib phosphate.","authors":"Andrew Schlueter, Camille Hanot, Rance Sellon, Janean Fidel","doi":"10.1177/1098612X251314343","DOIUrl":"10.1177/1098612X251314343","url":null,"abstract":"<p><p>ObjectivesOral squamous cell carcinoma (SCC) is the most common oral tumor in cats but treatment options that provide long-term tumor control are limited. Radiation therapy is a reported treatment option, but local tumor control is still difficult to obtain and additional treatment options are needed. Toceranib phosphate recently emerged as having biologic activity against feline oral SCC. This study is a preliminary evaluation of radiation therapy and toceranib phosphate in cats with oral SCC.MethodsThis non-blinded, retrospective, single-institutional study included all patients between 2011 and 2023 that underwent the same treatment with accelerated radiation therapy and concurrent carboplatin as previously described, with the exception of one additional fraction of radiation. Once the early side effects abated, toceranib phosphate was offered as follow-up maintenance therapy. The median survival time (MST) and progression-free interval (PFI) were assessed for the cats that received toceranib after radiation therapy and carboplatin, and were compared with the cats that received the same radiation and carboplatin protocol within the same time period but did not receive follow-up toceranib.ResultsOverall, 47 cats met the criteria for evaluation; of them, 15 received follow-up toceranib. The MST of all cats was 164 days; there was no significant difference in MST or PFI between the cats that did and did not receive adjuvant toceranib (MST 208 days vs 162 days, respectively; <i>P</i> = 0.35). When comparing cats with lingual tumors, the PFI was significantly longer in the cats that received toceranib than those that did not (142 days vs 104 days, respectively; <i>P</i> = 0.045); however, there was no difference in MST (197 days vs 147 days; <i>P</i> = 0.15).Conclusions and relevanceThis study suggests that most cats with oral SCC do not benefit from toceranib after radiation therapy. There may be clinical benefit to administering adjuvant toceranib after radiation in cats with lingual SCCs, but the mechanism remains unclear and additional studies are warranted.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"27 4","pages":"1098612X251314343"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}