Journal of Feline Medicine and Surgery最新文献

{"title":"Owner personality traits associated with non-conventional feeding practices in domestic cats.","authors":"Sara Hoummady, Nancy Rebout, Guillaume Prorel, Morgane Robles","doi":"10.1177/1098612X261462429","DOIUrl":"10.1177/1098612X261462429","url":null,"abstract":"<p><p>ObjectivesThe objectives of the present study were to assess the association between owner personality traits and the owner-reported use of non-conventional diets in domestic cats (starch-free, meat-only, grain-free, raw or vegetarian), and to compare personality traits between owners reporting the incorporation of fresh meat-based foods and those relying exclusively on commercial diets.MethodAn anonymous nationwide online survey of French cat owners was conducted (n = 1566). The owner's personality was assessed using the French version of the Big Five Inventory. Two outcomes were defined: (1) use of a non-conventional diet (yes: n = 439) and (2) inclusion of fresh meat-based foods in the diet (ie, not exclusively commercial with fresh meat; yes: n = 61). Two multivariable logistic regression models were built, with owner personality traits as explanatory variables. Model 1 evaluated the likelihood of using a non-conventional diet, while model 2 assessed the likelihood of incorporating fresh meat in the diet.ResultsHigher Conscientiousness was associated with lower odds of feeding a non-conventional diet (OR 0.80, 95% CI 0.67-0.95), whereas higher Openness was associated with higher odds (OR 1.19, 95% CI 1.01-1.41). Daily cooking (OR 1.49, 95% CI 1.17-1.91) and access to autonomous enrichment devices (OR 1.74, 95% CI 1.11-2.84) were also positively associated with non-conventional feeding. Lower Agreeableness was associated with higher odds of including fresh meat in the diet (OR 0.55, 95% CI 0.35-0.87). Training activities with the cat (OR 2.40, 95% CI 1.32-4.18) and owning a purebred cat (OR 2.10, 95% CI 1.10-3.82) were also positively associated with fresh meat feeding.Conclusions and relevanceThese results suggest that owners who choose non-conventional diets may present different personality traits. Recognising these differences may help veterinarians adapt their communication and facilitate dialogue regarding feeding decisions in the interest of feline health.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261462429"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148225979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the efficacy of transmucosal and subcutaneous glucagon administration in response to insulin-induced hypoglycemia in healthy cats.","authors":"Jessica Pui Man Lam, Olivia Justus-Heale, Elisabeth Snead","doi":"10.1177/1098612X261471152","DOIUrl":"10.1177/1098612X261471152","url":null,"abstract":"<p><p>ObjectivesThe aim of the present study was to evaluate the efficacy of two different formulations of glucagon given by three different routes (subcutaneous [SC], rectal [RCT] and intranasal [IN]) for correcting insulin-induced hypoglycemia in cats and to describe any adverse effects and compare the time required for administration by each route.MethodsA randomized, non-blinded, sham-controlled crossover study was conducted in six healthy cats, with a 7-day washout period between treatments. Hypoglycemia was induced using a constant rate infusion (CRI) of rapid-acting insulin lispro. Glucagon nasal powder (single-dose, ready-to-use) was given intranasally and rectally and compared with SC glucagon injection and IN sham control. Blood glucose (BG) concentration was measured from samples collected at baseline (T-15), after induction of hypoglycemia (T0) and at 5-min intervals for 30 mins, and then at 15-min intervals for 1 h after glucagon administration. Plasma glucagon and potassium (K⁺) concentrations were measured at T-15, T0, T15 and T30 after glucagon administration. The time taken to prepare and administer each treatment was recorded.ResultsMedian BG was 2.6 mmol/l at T0 and increased significantly after glucagon administration by all routes, reaching peak median concentrations of 11.2 mmol/l (IN), 9.7 mmol/l (RCT) and 10.15 mmol/l (SC). Plasma glucagon concentrations increased markedly by T15, with the highest concentrations observed after IN administration (1562 pmol/l), followed by SC (191.7 pmol/l) and RCT (158.5 pmol/l) routes of administration. Plasma K^⁺ decreased after insulin administration and increased modestly by T30 after glucagon administration by all routes. No serious adverse effects occurred after glucagon administration.Conclusions and relevanceTransmucosal glucagon effectively restores BG towards baseline after insulin-induced hypoglycemia with minimal side effects. The IN route resulted in the highest plasma glucagon and BG concentrations compared with the RCT and SC routes of administration. Further studies are needed to quantify the efficacy and safety of transmucosal glucagon in diabetic cats in response to spontaneous insulin-induced hypoglycemia.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261471152"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats.","authors":"Samantha Taylor, Natalie Finch, Sarah Caney, Jonathan Elliott, Rebecca Geddes, Femke Mortier, Valerie Parker, Jessica Quimby, Gilad Segev, Joanna White","doi":"10.1177/1098612X261466553","DOIUrl":"10.1177/1098612X261466553","url":null,"abstract":"<p><strong>Practical relevance: </strong>Chronic kidney disease (CKD) is common in senior cats. Early diagnosis can facilitate interventions to slow progression and minimise clinical signs. Management according to the International Renal Interest Society (IRIS) staging system for CKD can lead to prolonged survival and an excellent quality of life for affected cats.</p><p><strong>Aim: </strong>The '2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats' provide information on the pathogenesis of CKD, guidance on making a diagnosis and staging of disease, and practical content on medical and nutritional treatment. They also discuss optimising the home and veterinary clinic environment to positively influence mental wellbeing and, in turn, physical health, as well as working with the whole veterinary team and caregivers to slow disease progression and maximise quality of life.</p><p><strong>Clinical challenges: </strong>Affected cats may show minimal or no clinical signs in the early stages of CKD, which can result in a delay in diagnosis. The condition is generally progressive and management requires consideration of multiple factors in order to address clinical signs. Complications such as hypercalcaemia, hypertension, proteinuria and anaemia may develop, requiring treatment. Moreover, as advancing age is a risk factor for CKD, cats may have important comorbidities that need to be balanced, with impacts on the kidney. Caring for a cat with CKD can result in caregiver burden. Hence, supporting caregivers, contextualising monitoring to the individual cat, and involving both the veterinary and nursing teams is important.</p><p><strong>Evidence base: </strong>These Guidelines have been created by a panel of experts brought together by International Cat Care (iCatCare) Veterinary Society. Information is based on the available literature, expert opinion and the panel members' experience.Specific abbreviations:ACE = angiotensin-converting enzyme; ACKD = acute-on-chronic kidney disease; AKI = acute kidney injury; ARB = angiotensin receptor blocker; CKD = chronic kidney disease; CKD-MBD = CKD-mineral and bone disorder; FGF23 = fibroblast growth factor 23; GFR = glomerular filtration rate; iCa = ionised calcium; ICGN = immune-complex glomerulonephritis; IRIS = International Renal Interest Society; PTH = parathyroid hormone; SDMA = symmetric dimethylarginine.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"28 9","pages":"1098612X261466553"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an ultrasound-guided pericapsular knee desensitization technique in cats: An anatomical cadaveric study.","authors":"Dominique Lemaitre, Pamela Mejías, María Belén Vásquez, Diego Arredondo, Marta Garbin, Diego A Portela, Pablo E Otero","doi":"10.1177/1098612X261478799","DOIUrl":"10.1177/1098612X261478799","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to develop an ultrasound-guided pericapsular knee desensitization (PKD) technique targeting the medial (MAN), lateral (LAN), and posterior (PAN) articular branches of the saphenous, common fibular, and tibial nerves, respectively, and to evaluate its accuracy in domestic feline cadavers.</p><p><strong>Methods: </strong>In phase I, six pelvic limbs from three cadavers underwent ultrasonographic evaluation and gross dissection to describe the course of the MAN, LAN, and PAN, and identify anatomical and sonographic landmarks for PKD. In phase II, bilateral PKD was performed in eight cadavers (16 limbs) using 0.1 ml (low volume (LV)) or 0.2 ml (high volume (HV)) of dye per nerve, randomly assigned between limbs. MAN and PAN injections were performed under ultrasound guidance through a single medial percutaneous approach, whereas LAN injections were landmark-guided. Dissection was used to assess dye distribution around target nerves, the joint capsule, and parent nerves.</p><p><strong>Results: </strong>The MAN was consistently located within the distal subsartorial canal alongside the descending genicular vessels, the PAN coursed adjacent to the popliteal vessels, and the LAN ran superficially near the fibular head and lateral head of the gastrocnemius muscle. Overall success was 23/24 (95.8%) injections (95% confidence interval (CI) 78.9-99.9) in the LV group and 21/24 (87.5%) injections (95% CI 67.6-97.3) in the HV group. Both volumes stained the MAN, LAN, and PAN trajectories and the medial, caudal, and lateral surfaces of the knee joint capsule without intracapsular injection.</p><p><strong>Conclusions and relevance: </strong>Ultrasound-guided PKD is feasible in domestic feline cadavers, and small injection volumes (0.1-0.2 ml per nerve) reliably reach pericapsular compartments containing the principal articular branches, while largely sparing major motor nerves. These findings provide an anatomical and technical basis for future clinical evaluation of PKD for perioperative and chronic knee pain management in cats.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261478799"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positional impact on ocular lens and thyroid radiation doses during feline cranial CT: A thermoluminescent dosimetry study of 70 cases.","authors":"Kurtuluş Parlak, Osman Vefa Gül, Hilmican Ergin, Nuriza Zamirbekova Erdoğan","doi":"10.1177/1098612X261478797","DOIUrl":"10.1177/1098612X261478797","url":null,"abstract":"<p><strong>Objectives: </strong>The increasing use of CT in feline medicine necessitates the optimization of radiation protocols to adhere to the ALARA (as low as reasonably achievable) principle. This prospective study aimed to evaluate the impact of patient positioning (dorsoventral (DV) vs ventrodorsal (VD)) on radiation doses absorbed by the ocular lenses and thyroid gland during feline cranial CT.</p><p><strong>Methods: </strong>A total of 70 cats were divided into two equal groups (DV: n = 35, VD: n = 35). Radiation doses were measured using thermoluminescent dosimeters (TLD-100) placed at the anatomical projections of the target organs.</p><p><strong>Results: </strong>Although no statistically significant difference was observed in ocular lens doses between the groups (<i>P</i> >0.05), VD positioning resulted in a 24.4% reduction in mean radiation dose absorbed by the thyroid gland compared with the DV position (1.33 ± 0.17 mGy vs 1.76 ± 0.35 mGy, respectively; <i>P</i> = 4.97 ×10^-9). This reduction is attributed to the \"natural shielding\" effect provided by the dorsal axial skeleton and epaxial muscles in the VD position.</p><p><strong>Conclusions and relevance: </strong>VD positioning offers a significant dosimetric advantage for protecting the thyroid gland without requiring additional equipment or compromising diagnostic quality. Adopting the VD position as a routine standard in feline cranial CT is recommended to minimize radiation exposure to the thyroid gland.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261478797"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consuming treats with amino acids, osmolytes and sodium increased total water intake and decreased urine specific gravity of healthy cats.","authors":"Pauline Al Kosmal, Anna K Shoveller, Sydney Banton, Kira Cheer, Nicolas Farentino, Lawrence E Armstrong","doi":"10.1177/1098612X261477044","DOIUrl":"10.1177/1098612X261477044","url":null,"abstract":"<p><p>ObjectivesIt is estimated that cats do not drink enough water, particularly those maintained on a dry diet. As such, the objective of this study was to determine the effects of providing two different high-moisture lickable treats containing glycine, alanine, taurine and betaine, and two sodium levels, on water intake and hydration indices in cats fed dry diets.MethodsA total of 12 adult cats were provided treatments in a 3 × 3 replicated Latin square design for 5 days per leg: dry diet (CON), CON + one treat with 0.99% sodium (TRT A) and CON + one treat with 1.55% sodium (TRT B). Daily free water intake (FWI) was measured using fountains, and total water intake (TWI) was calculated as FWI + moisture from food and treats. Urine specific gravity (USG) and pH were measured daily; urine protein (UP), urine creatinine (CR) and the protein:creatinine (UP:CR) ratio were assessed on the final day of each leg. Fasted blood samples were collected for serum biochemistry.ResultsDaily TWI was lower on CON than on TRT B (<i>P</i> = 0.001) and TRT A (<i>P</i> = 0.009). Average USG was higher on CON than on TRT B (<i>P</i> <0.001) and TRT A (<i>P</i> = 0.005). UP and CR were also higher on CON (<i>P</i> <0.001; <i>P</i> = 0.003). Daily TWI, average USG, UP and CR were similar on TRT A and TRT B. Urine pH varied by day (<i>P</i> <0.001), but treatments did not differ. Magnesium was greater in CON than TRT B (<i>P</i> = 0.006). Average FWI, UP:CR ratio and all other biochemistry values did not differ.Conclusions and relevanceThese data support that feeding either TRT A or TRT B increased the TWI of domestic cats fed a dry diet, and additional benefits accrued in lower USG, UP and CR.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261477044"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESS: Colonization of Helicobacter Species and Associated Gastritis in Cats with Gastrointestinal disease: a Cross-Sectional Study on 154 Cases.","authors":"Teija Kaarina Immonen, Jenni Me Pettersson, Hanna Vauhkonen, Sara Palen, Ilya Weinstein, Tarja Sironen, Ravi Kant, Antti Kalle Kalervo Sukura, Niina Airas","doi":"10.1177/1098612X261485559","DOIUrl":"https://doi.org/10.1177/1098612X261485559","url":null,"abstract":"<p><p>ObjectivesThis study aimed to determine the occurrence of gastric Helicobacter species colonization in cats with confirmed gastrointestinal disease and to investigate possible associations between Helicobacter species colonization and gastric histopathological changes. It also aimed to identify the Helicobacter species present in cats in countryX.MethodsPrivately owned cats were prospectively enrolled between May 2018 and December 2022. Regardless of the reason for presentation, the owners of all cats presented to the cat clinic during that time period were systematically interviewed regarding chronic gastrointestinal signs. Cats with suspected chronic gastrointestinal disease underwent non-invasive diagnostic evaluation, and those with persistent suspicion proceeded to gastrointestinal biopsies. Full-thickness gastric and small intestinal biopsies were collected from each cat to evaluate histopathological lesions and to determine the presence and localization of Helicobacter species in the stomach. A total of 154 cats that underwent biopsies were included in the study. A subset of Helicobacter-positive samples was further analyzed to the species level using the nanopore sequencing technique.ResultsAll cats had chronic small intestinal disease. Of these, 79% had inflammatory enteropathy and 21% had lymphoma. Helicobacter species were detected in 75% of cats. Colonization with multiple Helicobacter species was common, with Helicobacter heilmannii being the most prevalent species. Gastritis was present in 58% of cats and occurred with similar frequency in both small intestinal diseases. The presence of Helicobacter species was significantly associated with lymphoplasmacytic gastritis. However, the density of bacterial colonization was not associated with gastritis severity.Conclusions and relevanceOur findings indicate that colonization by Helicobacter species is common in cats with gastrointestinal clinical signs and is associated with chronic lymphoplasmacytic gastritis. Nevertheless, the causal relationship between Helicobacter species and gastritis cannot be established with this study design due to the lack of a control group. Most cats were colonized with mixed Helicobacter species.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261485559"},"PeriodicalIF":2.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESS: Agreement between point-of-care and external reference laboratory RT-qPCR testing for feline coronavirus in cats with suspected feline infectious peritonitis.","authors":"Marieke Knies, Nikki Hofman, Johanna Jackson-Onis, Els M Broens, Erik Teske","doi":"10.1177/1098612X261483596","DOIUrl":"https://doi.org/10.1177/1098612X261483596","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the agreement of a commercially available point-of-care FCoV RT-qPCR assay and external laboratories RT-qPCR testing in cats with effusive and non-effusive FIP, and in cats with other diseases presenting with similar clinical signs.</p><p><strong>Methods: </strong>Client-owned cats suspected of FIP were enrolled with owner consent. Effusions and ultrasound-guided fine-needle aspirates (FNAs) from liver, spleen, or mesenteric lymph nodes were collected, split, and analysed using both a point-of-care RT-qPCR and an external laboratory RT-qPCR. FIP was diagnosed based on AAFP/EveryCat guidelines. Sensitivity and negative predictive values were calculated, agreement assessed with Cohen's kappa, paired differences tested with McNemar's test, and correlation of crossing point (Cp) values analysed using Pearson's coefficient and paired t-tests.</p><p><strong>Results: </strong>One hundred cats were included (effusions n = 62, FNAs n = 38). Overall agreement between assays was substantial (κ = 0.73), with near-perfect concordance for effusions (κ = 0.81) and lower agreement for FNAs (κ = 0.61). Relative sensitivity was highest in effusions (98.1% point-of-care, 92.3% external) and lower in FNAs (63.3-64.5%), with negative predictive values showing similar trends. Cp values were moderately correlated between assays, with minor mean differences (~1 cycle).</p><p><strong>Conclusion and relevance: </strong>The point-of-care FCoV RT-qPCR assay is a practical and reliable tool and shows very good agreement with external reference laboratory RT-qPCR testing. FNAs remain useful when effusions are unavailable but carry higher risk of false negatives likely due to low viral loads and heterogeneous distribution. Point-of-care testing offers rapid turnaround, supporting timely clinical decision-making, but results must be interpreted alongside clinical presentation and other diagnostics.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261483596"},"PeriodicalIF":2.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESS: MYOCARDIAL INJURY IN CATS WITH ACUTE BLUNT TRAUMA: PREVALENCE AND PROGNOSTIC IMPLICATIONS.","authors":"Greta Dossi, Marta Mismetti, Liliana Carnevale, Vitaliano Borromeo, Paola Pocar, Chiara Locatelli","doi":"10.1177/1098612X261480992","DOIUrl":"https://doi.org/10.1177/1098612X261480992","url":null,"abstract":"<p><p>ObjectivesTo determine the prevalence of increased serum high-sensitivity cardiac troponin I (hs-cTnI) concentrations in cats with acute blunt trauma and assess associations with trauma severity, clinicopathological variables, echocardiographic findings, and short-term outcome.MethodsThirty-nine cats presenting within 48 hours of blunt trauma were prospectively enrolled. All cats underwent physical examination, Animal Trauma Triage scoring, thoracic radiography, electrocardiography, echocardiography, complete blood count, serum biochemistry, NTproBNP testing, and hs-cTnI measurement. Associations between hs-cTnI concentrations and clinical, laboratory, echocardiographic, and outcome variables were assessed. Receiver operating characteristic (ROC) analysis was performed as an exploratory assessment of prognostic performance.ResultsIncreased hs-cTnI concentrations were detected in 34/39 cats (87%; 95% CI 72-96%). A significant ordinal association was identified between trauma severity and hs-cTnI class (linear-by-linear association, p=0.036), although the overall Fisher-Freeman-Halton test was not significant (p=0.088). Hs-cTnI concentrations correlated positively with urea, creatinine, neutrophil count, ALT, NLR, blood glucose, IVSd, and LVPWd, and negatively with LVIDd. Increased left ventricular wall thickness was identified in 10/39 cats and was associated with higher hs-cTnI concentrations (p=0.033). No traumatic cardiac rupture, pericardial effusion, or pleural effusion were observed. Electrocardiographic abnormalities were detected in 6/39 cats and were not associated with hs-cTnI concentrations. Seven cats (18%) died during hospitalization. Increased urea concentration , white blood cell count, and neutrophil count were associated with non-survival. ROC analyses were considered exploratory because of the limited number of outcome events.Conclusions and relevanceIncreased hs-cTnI concentrations were common in cats with acute blunt trauma and were associated with leukocyte variables, renal function markers, and subtle echocardiographic abnormalities. These findings suggest that hs-cTnI may reflect a multifactorial biological response involving myocardial stress or injury, systemic disease severity, altered renal handling, and possible underlying subclinical cardiac disease. Further studies are needed to clarify the relative contribution and clinical significance of these mechanisms.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261480992"},"PeriodicalIF":2.6,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESS: Renal Health in Cats with Feline Infectious Peritonitis treated with GS-441524: Baseline Findings and Longitudinal Effects.","authors":"Celia C de Witt Curtius, Marina L Meli, Aline Crespo Bouzon, Jennifer Wenk, Julia Maria Stachowski, Ilaria Cerchiaro, Benita Pineroli, Stefan Unterer, Sandra Felten, Andrea Major, Solène M Meunier, Judith Howard, Katharina Zwicklbauer, Roswitha Dorsch, Katrin Hartmann, Regina Hofmann-Lehmann, Andrea Monika M Spiri","doi":"10.1177/1098612X261480355","DOIUrl":"10.1177/1098612X261480355","url":null,"abstract":"<p><p>ObjectivesGS-441524 is effective against feline infectious peritonitis (FIP), but potential renal toxicity remains debated. Renal health was assessed in cats with FIP undergoing antiviral treatment.MethodsCats with confirmed FIP (n = 80) receiving oral GS-441524 for 42 days were assessed before (day 1; D1), during (D7, D42), and after treatment (D84, D183). Assessments included urine specific gravity (USG), urine protein:creatinine ratio (UPC), urinary cystatin B (uCysB), urine protein electrophoresis, serum creatinine, urea and symmetric dimethylarginine (SDMA).The term potential renal dysfunction was used for cats fulfilling the following criteria: creatinine >140 µmol/l or SDMA ≥ 18 µg/dl and USG <1.035. Serum amyloid A (SAA) and alpha-1-acid glycoprotein (AGP) were assessed in serum, feline coronavirus (FCoV) RNA in blood and urine (D1-D42).ResultsAt baseline, 97.5% of cats had creatinine concentrations <140 µmol/l; by D183, 23.8% exceeded this threshold (D1-D183: PD <0.0001). Potential renal dysfunction criteria were met in 2.5% of cats at baseline and 8.8% at D183. In contrast, uCysB was increased in 83.8% of cats at D1 and declined during treatment (D1-D183: PD <0.0001). Cats with uCysB >100 ng/ml had higher UPC values (PMWU <0.0001). Most cats had elevated AGP and SAA at baseline, which normalised during treatment (D1-D42: PD <0.0001). Proteinuria (UPC >0.2) was present in 91.3% on D1 and 3.8% on D183; urine protein electrophoresis at D1 revealed predominantly tubular and mixed patterns. Urine was more frequently FCoV RNA-positive than blood on D1 (68.8%/61.3%), but not on D7 (16.3%/45.0%).Conclusions and relevanceTreatment reversed FIP-associated renal abnormalities and inflammation observed at baseline. A small subset of cats met criteria compatible with potential renal dysfunction during the study. Whether these findings reflect delayed FIP-related renal insults or adverse antiviral effects remains unknown but indicate that treatment should not be extended unnecessarily.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261480355"},"PeriodicalIF":2.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}