Journal of Evolutionary Biochemistry and Physiology最新文献

{"title":"EEG Sensorimotor Rhythms Dynamics in Children with Cerebral Palsy during the Course of Neurorehabilitation, Depending in the Success of Their Imagination of Movements","authors":"V. B. Pavlenko, S. V. Vlasenko, E. N. Chuyan, A. I. Kaida, L. S. Orekhova, E. A. Birukova, D. V. Pavlenko, S. E. Tataris","doi":"10.1134/s0022093024040288","DOIUrl":"https://doi.org/10.1134/s0022093024040288","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>An analysis of changes in sensorimotor rhythms of the electroencephalogram\u0000(EEG) and features of the restoration of motor functions during\u0000a course of neurorehabilitation using a non-invasive brain-computer-hand\u0000exoskeleton interface was carried out in 50 children aged 7–15 years\u0000of both sexes suffering from cerebral palsy (CP). EEG was recorded\u0000in 32 leads under conditions of rest and kinesthetic imagination\u0000of hand extension movements. Depending on the success of the classifier program\u0000in determining imaginary states based on the EEG pattern, the children\u0000were divided into two groups—with high and low success when imagining\u0000movements. In children of the studied groups, when undergoing a\u0000course of neurorehabilitation, differences were revealed in the\u0000nature of changes in EEG amplitude in the sensorimotor mu (8–13\u0000Hz) and beta (15–25 Hz) rhythms frequency ranges. When imagining\u0000movements of the right hand, intergroup differences for the mu rhythm\u0000reached the level of statistical significance in the medial electrodes\u0000of the fronto-central and parietal areas of the neocortex, for the\u0000beta rhythm—in the medial lead of the parietal region. Children\u0000in the group with high success showed a decrease or slight increase\u0000in the amplitude of the mu- and beta rhythm in these brain areas\u0000at the last session of the course compared to the first. We hypothesize\u0000that children in this group are not only better able to kinesthetically\u0000imagine movements throughout the course of neurorehabilitation,\u0000but also, based on feedback signals, learn to effectively adjust\u0000their strategies for movement imagination. Children in the group\u0000with low success showed an increase in the amplitude of sensorimotor\u0000rhythms in these brain areas, indicating the development of inhibition\u0000in the frontoparietal motor network. Patients, whose conditions\u0000were determined more accurately by the classifier, achieved higher\u0000rates of motor rehabilitation. The results of the study are important\u0000for clarifying the brain mechanisms of motor functions restoration\u0000in patients with cerebral palsy under the influence of a course\u0000of neurorehabilitation.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"9 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of the Temperature Coefficient Q10 in Hibernating Ground Squirrels Urocitellus undulatus and Cooled Rats of Different Ages","authors":"N. M. Zakharova, Yu. S. Tarahovsky, M. O. Khrenov","doi":"10.1134/s0022093024040148","DOIUrl":"https://doi.org/10.1134/s0022093024040148","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The temperature coefficients of heart rate (<i>Q10</i>\u0000_HR) or\u0000oxygen consumption (<i>Q10</i>\u0000_Ox)\u0000were analyzed upon arousal from natural hibernation in long-tailed\u0000ground squirrels <i>Urocitellus undulatus</i> and\u0000during the rewarming of artificially precooled adult rats and rat\u0000pups. The <i>Q10</i>\u0000_Ox value\u0000was calculated using a standard equation, whereas for calculating <i>Q10</i>\u0000_HR, the\u0000equation was empirically modified to track changes in this parameter\u0000over a wide range of body temperatures (<i>T</i>\u0000_b).\u0000It was found that during the initial period of arousal from torpor,\u0000at <i>T</i>\u0000_h ≤\u000010°C, ground squirrels demonstrated a sharp increase in the temperature\u0000coefficients up to <i>Q10</i>\u0000_HR =\u000040–50 and <i>Q10</i>\u0000_Ox =\u00006–7. Even higher values of <i>Q10</i>\u0000_HR (&gt;100) were\u0000recorded at the onset of rewarming of rat pups, although they had\u0000a low level of <i>Q10</i>\u0000_Ox (1.2).\u0000Adult rats could not tolerate cooling below 16°C and demonstrated\u0000a moderate variability of both <i>Q10</i>\u0000_HR = 2.0–4.0\u0000and <i>Q10</i>\u0000_Ox =\u00002.0–2.2. During the recovery of normal <i>T</i>\u0000_b,\u0000the <i>Q10</i>\u0000_HR values\u0000in all animals approximated to ~2.0, as predicted by the van’t Hoff–Arrhenius\u0000rule for chemical reactions in both living and inanimate nature.\u0000We assume that high values of <i>Q10</i>\u0000_HR and <i>Q10</i>\u0000_Ox, detected\u0000in the early period of ground squirrel’s arousal from hibernation,\u0000may indicate the functioning of adaptive processes aimed at accelerating\u0000body warming. Resistance to cooling and a high <i>Q10</i>\u0000_HR in\u0000rat pups may suggest the rudimentary adaptability to hibernation\u0000in the juvenile period of rats as representatives of the order Rodentia,\u0000which also includes such natural hibernators as ground squirrels.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"51 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Size Influence on Respiration Rate and Mitochondrial Metrics in Mytilus edulis L. Gill Tissue","authors":"A. Sukhotin, N. Alekseeva, M. Gerasimova, A. Kovalev","doi":"10.1134/s0022093024040112","DOIUrl":"https://doi.org/10.1134/s0022093024040112","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Metabolic rate is a crucial trait shaping organismal physiology,\u0000adaptability, and ecological roles, with extensive studies on its\u0000allometric relationship with body size. Larger organisms have lower\u0000mass-specific metabolic rates, a pattern observed across taxa and\u0000ontogeny. Despite numerous hypotheses, no universally accepted theory\u0000exists on the biological mechanisms of metabolic allometry, particularly\u0000for suborganism-level. We investigated the relationship between\u0000body size and metabolic rate as well as mitochondrial characteristics\u0000in isolated gill tissue of the marine mussel <i>Mytilus edulis</i>. Results indicated that metabolic allometry patterns\u0000observed at the organismal level did not manifest at the tissue level.\u0000Our study also revealed that while the density of mitochondria in\u0000gill tissue did not differ significantly between large and small\u0000individuals, area and perimeter of mitochondrial cross-sections increased\u0000significantly with body mass. This finding contrasts with mammalian\u0000data, suggesting potential phylogenetic differences. Larger mussels\u0000exhibited higher mitochondrial activity, supporting a link between\u0000mitochondrial morphology, activity, and growth rates. Our results\u0000highlight the importance of mitochondria in mollusk metabolism and\u0000growth, warranting further exploration into the mechanisms translating\u0000mitochondrial characteristics into growth rates.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"15 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Dynamics and Metabolic Remodeling in a Xenograft of Human iPSC-Derived Neural Precursors","authors":"D. N. Voronkov, A. V. Egorova, E. N. Fedorova, A. V. Stavrovskaya, O. S. Lebedeva, A. S. Olshanskiy, V. V. Podoprigora, V. S. Sukhorukov","doi":"10.1134/s0022093024030062","DOIUrl":"https://doi.org/10.1134/s0022093024030062","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Regulation of mitochondrial functions impacts on neuronal\u0000differentiation and maturation. Studying these processes is of both\u0000fundamental and practical importance for regenerative neurobiology.\u0000This work was aimed to characterize the changes in mitochondrial\u0000fission and their link with the activation of oxidative phosphorylation\u0000(metabolic switch) during the maturation of human induced pluripotent\u0000stem cell (iPSC)-derived neural progenitors xenografted in the rat\u0000striatum. Wistar rats (<i>n</i> =\u000015) were unilaterally injected into the caudate nucleus with neural\u0000precursors derived from the human iPSCs. Changes in the localization\u0000and expression of neuronal differentiation markers, such as nestin,\u0000NeuN, neuron-specific enolase, mitochondrial outer membrane protein,\u0000ATP synthase, and mitochondrial fission protein Drp1, were assessed\u0000by immunostaining. Measurements of grafted cells were performed\u00002 weeks, 3 and 6 months after surgery. The maturation of grafted\u0000neurons was associated with fluctuations in morphometric parameters\u0000of the mitochondrial fraction and Drp1 levels. An increase in mitochondrial\u0000fission was detected 3 months after grafting, preceded by an increase\u0000in ATP synthase level by month 6 and switching grafted neurons to\u0000oxidative phosphorylation. The experiment revealed a link between\u0000mitochondrial dynamics and changes in the metabolic profile and\u0000maturation of grafted neurons. The regulation of mitochondrial dynamics\u0000may have future implications for developing methods to improve the\u0000integration of grafted neurons into recipient brain structures.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"51 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoglin Regulates Intercellular Interactions between Trophoblast and Natural Killer Cells","authors":"E. Tyshchuk, P. Grebenkina, I. Krutetskaya, I. Smirnov, A. Stolbovaya, O. Shashkova, M. Samoilovich, D. Bazhenov, O. Stepanova, S. Selkov, D. Sokolov","doi":"10.1134/s0022093024030074","DOIUrl":"https://doi.org/10.1134/s0022093024030074","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The interaction of natural killer and trophoblast cells underlies\u0000maternal-fetal immune tolerance. The data on the participation of\u0000endoglin (ENG, CD105), or its soluble form, in the regulation of\u0000the communication of these cells are currently insufficient. In\u0000this study, we have investigated the role of endoglin in the intercellular\u0000interactions between natural killer cells and trophoblasts. Here,\u0000we show that NK-92 cells and JEG-3 cells constitutively express\u0000MICA/B, and CD105. In the presence of JEG-3 cells, the expression\u0000of NKG2D, CD94, MICA/B, and CD105 by NK-92 cells was increased,\u0000and the number of NK-92 cells expressing NKG2A, CD94, and MICA was\u0000reduced. Antibodies against ENG and recombinant endoglin (rENG),\u0000attenuated the trophoblasts’ influence and returned the phenotype of\u0000the NK-92 cells to that of cells found in monoculture conditions.\u0000The antibodies and rENG also increased the expression of pSMAD2/3\u0000by NK cells in both monoculture and co-culture conditions. The antibodies\u0000increased the trophoblasts’ sensitivity to the cytotoxic effect\u0000of NK cells. In general, our findings indicate a significant role\u0000of endoglin in the intercellular communication between NK cells\u0000and trophoblasts. We also speculate that endoglin forms a complex\u0000with TGFβ, which aids in TGFβ trafficking between these cells.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"75 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of GABA-A Receptors and Cation-Chloride Cotransporters in the Hippocampus of Krushinsky–Molodkina Audiogenic Rats during the Postnatal Development","authors":"A. P. Ivlev, A. A. Naumova","doi":"10.1134/s0022093024030025","DOIUrl":"https://doi.org/10.1134/s0022093024030025","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Epilepsy development can be caused by impaired postsynaptic\u0000action of GABA that is mediated by altered expression of GABA-A\u0000receptors and cation-chloride cotransporters, KCC2 (K⁺/Cl^– cotransporter\u00002) and NKCC1 (Na⁺/K⁺/Cl^– cotransporter\u00001). In the present study, we analyzed the expression of GABA-A receptors,\u0000KCC2, and NKCC1 in the hippocampus of Krushinsky–Molodkina (KM)\u0000rats, genetically prone to audiogenic seizures (AGS), during the\u0000first few months of the postnatal development (at P15, P60, and\u0000P120). Wistar rats of the corresponding ages were used as the control groups.\u0000In the hippocampus of KM pups, we observed downregulation of both\u0000KCC2 and NKCC1; however, the expression of GABA-A receptor α1-subunit\u0000(GABAAR(α1)) was increased. Moreover, KCC2 was not detected in an\u0000abnormally broad region of the granular layer, indicating the Cl^– imbalance\u0000and impaired GABA-mediated inhibition in postsynaptic targets of\u0000GABA. These results suggested a delayed maturation of the hippocampal\u0000GABAergic system in KM rats in comparison with Wistar rats. In adult\u0000KM rats (P120) with fully developed susceptibility to AGS, normalization\u0000of both KCC2 and NKCC1 expression and KCC2 phosphorylation in the\u0000hippocampus was revealed. In contrast, GABAAR(α1) expression was\u0000decreased. We supposed that lower expression of GABA-A receptors\u0000in the hippocampus of adult KM rats might contribute either to the\u0000establishment of increased convulsive readiness or to hyperexcitation\u0000of the hippocampus during audiogenic kindling.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"27 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Flow Changes in the Rabbit Cranial and Caudal Venae Cavae during Postural Loads after Propranolol, Bisoprolol and Methyldopa Pretreatment","authors":"V. I. Evlakhov, T. P. Berezina, T. V. Sergeev, M. V. Kuropatenko, I. Z. Poyassov","doi":"10.1134/s0022093024030050","DOIUrl":"https://doi.org/10.1134/s0022093024030050","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The β_1,2-adrenergic receptor blocker\u0000propranolol, β₁-blocker bisoprolol, and central\u0000presynaptic α₂-adrenergic receptor agonist\u0000methyldopa are used in clinical practice to treat the hyperadrenergic\u0000type of postural orthostatic tachycardia syndrome. There are no\u0000literature data on the effects of these drugs on vena cava flows\u0000during postural tests. In acute experiments on anesthetized rabbits,\u0000we studied blood flow changes in the cranial vena cava (CrVC) and\u0000caudal vena cava (CdVC) during orthostatic (head-up tilt by 25°)\u0000and antiorthostatic (head-down tilt by –25°) tests for 20 s after\u0000propranolol, bisoprolol and methyldopa intravenous preadministration.\u0000Before drug pretreatment, both CrVC and CdVC flows decreased in\u0000response to orthostasis at the 4th and 20th s. During antiorthostasis,\u0000CdVC flow increased at the 4th s and decreased to the baseline value\u0000by the 20th s, while CrVC flow decreased by the 4th s and exceeded\u0000the baseline level by the 20th s. After propranolol pretreatment,\u0000CdVC flow decreased to a greater extent than in response to bisoprolol\u0000and methyldopa pretreatment. After methyldopa pretreatment during\u0000orthostasis, by the 20th s, CrVC flow decreased more notably than\u0000CdVC flow, while after propranolol and bisoprolol pretreatment under\u0000conditions of orthostasis, both CrVC and CdVC flows decreased about\u0000equally. During antiorthostasis, 20 s after propranolol pretreatment,\u0000CdVC flow increased more considerably compared to CrVC flow. After\u0000bisoprolol and methyldopa pretreatment, CrVC flow increased in response\u0000to antiorthostasis not only to a greater extent than CdVC flow but\u0000even more pronouncedly compared to its initial increment. Thus,\u0000postural tests after the pretreatment with the above drugs reveal\u0000differences in the mechanisms of blood flow redistribution in CrVC\u0000and CdVC basins.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"355 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of DNA Methylation in Zebrafish Models of CNS Diseases","authors":"L. V. Yushko, A. D. Shevlyakov, M. A. Romazeva, K. V. Apukhtin, A. D. Volgin, D. A. Abramov, M. M. Kotova, A. V. Kalueff","doi":"10.1134/s0022093024030104","DOIUrl":"https://doi.org/10.1134/s0022093024030104","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>DNA methylation plays an important role in the regulation\u0000of gene expression. Its deficits in the brain cause various neurological\u0000diseases, including autism, schizophrenia and mood disorders. The\u0000zebrafish (<i>Danio rerio</i>) is\u0000a promising model organism in biomedicine. Given its high genetic\u0000and physiological homology with humans, studying genome methylation\u0000deficits in zebrafish can help elucidate the molecular processes\u0000underlying the etiology and pathogenesis of various neurological\u0000diseases, as well as develop novel therapies. Here, we discuss the\u0000mechanisms of DNA methylation in the brain and the diseases associated\u0000with its dysregulation in humans, as well as their genetic and pharmacological\u0000models in zebrafish. We also evaluate the limitations of zebrafish\u0000models and possible directions for further research in this field.\u0000Mounting evidence summarized here supports zebrafish as an effective\u0000model for elucidating the molecular mechanisms of brain pathologies\u0000associated with compromised DNA methylation.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"75 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Na+/K+-ATPase and Components of the Ca2+-Transporting System in Myocardium under Experimental Prediabetes and Type 1 Diabetes in Rats","authors":"I. B. Sukhov, O. V. Chistyakova, M. G. Dobretsov","doi":"10.1134/s0022093024030232","DOIUrl":"https://doi.org/10.1134/s0022093024030232","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>One of the complications of diabetes mellitus (DM) is diabetic\u0000cardiomyopathy (DCM), whose molecular mechanisms of pathogenesis\u0000have not been fully studied. Previously, the involvement of Na⁺/K⁺-ATPase\u0000and components of the Ca²⁺ transport\u0000system in cardiomyocytes in the development of DCM was shown. The\u0000aim of the work was to study the expression and activity of Na⁺/K⁺-ATPase\u0000and Ca²⁺-ATPase (SERCA2) in the myocardium\u0000of male Wistar rats in a model of streptozotocin (STZ)-induced prediabetes\u0000and overt type 1 diabetes (T1DM). STZ was administered at once i.p.\u0000in doses of 30–35 mg/kg. Rats with glucose levels above 11 mM were\u0000considered diabetic (STZ-D1 group), and those with moderate hyperglycemia\u0000were considered prediabetic (STZ-preD1 group). The activity of Na⁺/K⁺-ATPase\u0000and Ca²⁺-ATPase was determined (by the\u0000rate of release of inorganic phosphate, P_i), and\u0000the expression of the genes α1- and α2-isoforms of Na⁺/K⁺-ATPase,\u0000SERCA2, and Kir6.1, Kv7.1, and Kv2.1 potassium channels was also\u0000determined. In the control (C) group, the activity of ouabain (1 mM)\u0000-sensitive Mg²⁺-dependent ATPase was\u00006.03 ± 0.6 mmol Pi/g/h. In the STZ-D1 and STZ-preD1 groups, Na⁺/K⁺-ATPase\u0000activity did not differ from group C. The level of gene expression\u0000of α1- and α2- subunits of Na⁺/K⁺-ATPase\u0000in the STZ-D1 group decreased by more than 45%, then both in the\u0000STZ-preD1 group increased by 64 and 81%, which may indicate a high\u0000sensitivity of expression to insulinopenia. The activity of Ca²⁺-ATPase\u0000and the expression of the SERCA2 gene did not differ between the\u0000groups, which might be because the 4-week period after STZ administration\u0000is not sufficient for the development of Ca²⁺-ATPase\u0000deficiency in the rat heart. The level of expression of the genes\u0000of the potassium channel subtypes Kv2.1, Kir6.1, and Kv7.1 increased\u0000in the STZ-preD1 group, which may indicate a potential contribution\u0000of the studied potassium channel subtypes to the adaptation mechanism to\u0000moderate hyperglycemia.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barbering in Laboratory Rodents: Problems and Prospects","authors":"M. M. Kotova, V. D. Riga, A. V. Kalueff","doi":"10.1134/s0022093024030207","DOIUrl":"https://doi.org/10.1134/s0022093024030207","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Barbering is a behavior which involves the plucking or nibbling\u0000of fur, hair, or whiskers (vibrissae), leading to focal hair loss,\u0000and is often seen in laboratory mice and rats. The role of this\u0000behavior, including its relationship with stress, aggression, grooming,\u0000and aberrant stereotypic behavior, is actively discussed. Insights\u0000into the nature of barbering and its impact on laboratory rodents\u0000should be considered when planning experimental studies. Here, we\u0000discuss recent data on the neurobiology and genetics of barbering,\u0000as well as its role in the behavior and central nervous system of\u0000laboratory rodents.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"17 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}