{"title":"Measuring antiaging effects through changes in telomere length after mesenchymal stem cells therapy.","authors":"Suyeon Kim","doi":"10.12965/jer.2652394.197","DOIUrl":"10.12965/jer.2652394.197","url":null,"abstract":"<p><p>Telomere length is a well-known biomarker indicating cellular aging and biological age. Shortening of telomere length is associated with an increased risk of age-related diseases, cellular aging, and reduced re-generative capacity. This study measured changes in peripheral blood telomere length following intravenous mesenchymal stem cells (MSCs) administration. Changes in telomere length (kb/cell) before and after intravenous MSCs treatment were evaluated, and the consistency and extent of telomere elongation were assessed among subjects of various ages, sexes, and treatment durations. Peripheral blood deoxyribo-nucleic acid was extracted and telomere lengths were measured in kb/cell units for a retrospective analysis of 19 cases (18 subjects). Treatment durations ranged from 25 days to 14 months, and the ages of the subjects ranged from 34 to 78 years. Intravenous MSCs treatment was associated with a consistent and measurable increase in peripheral blood telomere length. These results support the hypothesis that telomere length can be used as an outcome biomarker and patient selection criterion for MSCs-based antiaging therapy.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 3","pages":"102-108"},"PeriodicalIF":1.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13328783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A literature review of multimodal interventions for improving health behaviors in obese upper elementary school students.","authors":"Yun-Jeong Boo, Yeong-Mi Jo, Da-Jung Kim","doi":"10.12965/jer.2652274.137","DOIUrl":"10.12965/jer.2652274.137","url":null,"abstract":"<p><p>Recent studies emphasize that behavioral change is a key strategy in managing childhood obesity, stressing the importance of improving healthy behaviors rather than focusing solely on weight loss. This study aimed to analyze research trends in multimodal interventions targeting the improvement of health behaviors in obese upper elementary school children. A systematic literature review was conducted on studies published in Korean academic journals from 2005 to 2025. The analysis focused on intervention components, delivery methods, and outcome variables. The results showed that multimodal interventions generally integrate nutrition education, physical activity, and behavioral strategies, which leads to improvements in self-efficacy and health behaviors, particularly dietary habits and physical activity. These interventions have been proven effective in improving health behaviors. Future research needs to develop more systematic intervention designs and comprehensive evaluation frameworks to enhance long-term effectiveness.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 3","pages":"73-77"},"PeriodicalIF":1.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13328780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multidimensional factors associated with cognitive impairment: the roles of depression, sarcopenia, frailty, and chronic diseases in community-dwelling older women.","authors":"Namsu Kim, Sam-Jun Lee, Jinseok Lee","doi":"10.12965/jer.2652422.211","DOIUrl":"10.12965/jer.2652422.211","url":null,"abstract":"<p><p>As population aging accelerates globally, cognitive impairment has emerged as a major public health concern, particularly among older women. This study aimed to examine the independent and combined associations of depression, sarcopenia, frailty, and chronic diseases with cognitive impairment in community-dwelling older women in South Korea. A total of 1,065 women aged ≥65 years were recruited from 13 cities. Cognitive function was assessed using the Mini-Mental State Examination for Dementia Screening. Depression, sarcopenia, and frailty were evaluated using the Geriatric Depression Scale-Short Form, Strength, Assistance in walking, Rising from a chair, Climbing stairs and Falls questionnaire, and Fried frailty criteria. Information on physician-diagnosed chronic diseases (diabetes, arthritis, and hypertension) was also collected. Continuous variables were analyzed using independent <i>t</i>-tests, and categorical variables were analyzed using chi-square tests. Multivariable logistic regression analyses were performed to identify factors associated with cognitive impairment, adjusting for age group, depression, diabetes, hypertension, arthritis, sarcopenia, and frailty. Participants with cognitive impairment exhibited significantly higher levels of depression, sarcopenia, frailty, and a greater prevalence of chronic diseases compared to those with normal cognition. In multivariable analyses, depression, diabetes, arthritis, sarcopenia, and frailty remained significantly associated with cognitive impairment. These findings indicate that cognitive impairment in older women is associated with a complex interplay of psychological, physical, and metabolic factors. Addressing modifiable conditions, particularly depression, sarcopenia, and frailty, may be important for reducing the burden of cognitive impairment.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 3","pages":"95-101"},"PeriodicalIF":1.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13328788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stem cell therapy alleviates hair loss caused by COVID-19 vaccination.","authors":"Suyeon Kim","doi":"10.12965/jer.2652242.121","DOIUrl":"10.12965/jer.2652242.121","url":null,"abstract":"<p><p>A case of a female patient with hair loss induced by coronavirus disease 2019 (COVID-19) vaccination who was treated with autologous CD34+ enriched hematopoietic progenitor cell fraction (CD34+ HPCF) and umbilical cord blood-derived mesenchymal stem cells (UC-MSCs) was reported. The patient presented with generalized pain and hair loss after COVID-19 vaccination. The patient received subcutaneous injections of autologous CD34+ HPCF at 1-cm intervals into the scalp. These injections were administered once a week for a total of 10 times, except in weeks 5 and 10. During this period, UC-MSCs were administered intravenously at dose of 7×10<sup>7</sup> cells in 20 mL and subcutaneously at a dose of 1×10<sup>7</sup> cells in 5 mL into the scalp twice each in weeks 5 and 10. After 12 weeks of treatment, the patient's hair loss improved without significant adverse effects. Autologous CD34+ HPCF and UC-MSC injections showed significant effects on hair loss induced by COVID-19 vaccination.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 2","pages":"66-70"},"PeriodicalIF":1.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Play, physical activity, and exercise interventions for behavioral and social outcomes in autism spectrum disorder: a narrative review.","authors":"Tae-Hyun Yoon","doi":"10.12965/jer.2652112.056","DOIUrl":"10.12965/jer.2652112.056","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is characterized by persistent difficulties in social communication and interaction, alongside restricted and repetitive patterns of behavior. Growing evidence suggests that play, physical activity (PA), and exercise may contribute to improvements in behavioral regulation and social functioning in individuals with ASD. However, findings across studies remain heterogeneous with respect to intervention type, intensity, and targeted outcomes, making it challenging to draw unified conclusions. This narrative review aimed to synthesize and discuss existing literatures on play-based, PA, and exercise interventions targeting behavioral and social outcomes in individuals with ASD. Overall, the literature indicated that PA and exercise programs-particularly those incorporating social interaction, task-oriented play, or group-based formats-were associated with meaningful improvements in both sociobehavioral domains. Potential mechanisms underlying these effects included enhanced executive functioning, improved self-regulation, neurobiological adaptations, and increased opportunities for social learning. Nevertheless, variability in study design, outcome measures, and methodological quality limits the generalizability of findings. Future research should prioritize well-designed trials with standardized outcome measures and clearly defined intervention parameters to strengthen the evidence base and inform clinical and educational practice.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 2","pages":"40-50"},"PeriodicalIF":1.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effects of an 8-week Pilates program on physical fitness and spinal posture in adult women.","authors":"Jun-Su Kim","doi":"10.12965/jer.2652170.085","DOIUrl":"10.12965/jer.2652170.085","url":null,"abstract":"<p><p>This study analyzed the effects of an 8-week Pilates exercise program on health-related physical fitness and spinal morphology in female college students. As a result of performing 8 weeks of Pilates exercise program, there was a significant difference in flexibility and muscular endurance in the experimental group. In addition, there was a significant difference in lateral deviation after performing 8 weeks of Pilates exercise program. Therefore, it is expected that consistent participation in Pilates exercise will lead to improvements in flexibility, endurance, and lateral deviation. Pilates requires professional and systematic theoretical establishment, and therefore, future research requires more specific qualitative studies on Pilates exercise.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 2","pages":"62-65"},"PeriodicalIF":1.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differential hemodynamic adaptations to identical body conditioning program across blood pressure categories: a quasi-experimental study.","authors":"Sang-Geun Jo, Yong-Seok Jee","doi":"10.12965/jer.2652192.096","DOIUrl":"10.12965/jer.2652192.096","url":null,"abstract":"<p><p>This study examined whether identical body conditioning program would differentially affect hemodynamic, body composition, and physical fitness parameters across blood pressure (BP) categories, and explored the potential role of autonomic modulation in mediating exercise-induced adaptations. In this quasi-experimental study, 85 participants completed a structured 15-week exercise program. All participants were categorized into four groups as follows: normal BP (n=21), elevated BP (n=20), stage 1 hypertension (n=22), and stage 2 hypertension (n=22). Because muscle mass and basal metabolic rate (BMR) differed among the groups at baseline, a repeated-measures analysis of covariance was conducted using these variables as covariates to assess the effects of time and group. Significant interactions were observed for systolic BP with pronounced reductions in the stage 1 hypertension and stage 2 hypertension groups, particularly in stage 2 hypertension. Diastolic BP and heart rate also demonstrated significant differential responses across groups. Cardiorespiratory fitness showed group-dependent responses, with significant group and time × group effects observed for maximal oxygen uptake. In contrast, no significant interactions were found for body weight, fat mass, body circumferences and grip strength. Importantly, the hemodynamic improvements occurred independently of changes in body composition and were robust after adjustment for baseline muscle mass and BMR. These findings are consistent with the possibility that exercise-induced autonomic modulation may contribute to early BP improvements; however, direct autonomic indices were not measured.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 2","pages":"51-61"},"PeriodicalIF":1.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Manuscript publication process of the <i>Journal of Exercise Rehabilitation</i>.","authors":"Chang-Ju Kim","doi":"10.12965/jer.2652160.080","DOIUrl":"https://doi.org/10.12965/jer.2652160.080","url":null,"abstract":"","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 2","pages":"39"},"PeriodicalIF":1.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physical activity and academic performance in adolescents: a systematic review of intensity, frequency, and mediating factors.","authors":"Haemi Jee","doi":"10.12965/jer.2550854.427","DOIUrl":"10.12965/jer.2550854.427","url":null,"abstract":"<p><p>Adolescence is a critical period during which physical activity (PA) may influence cognitive processes and academic performance (AP). Although PA has been linked to favorable academic outcomes, evidence remains mixed with respect to activity intensity, frequency, and developmental stage. This systematic review narratively synthesized recent empirical studies (2024-2025) examining the relationship between PA and AP in healthy adolescents, with attention to activity characteristics, developmental moderators, and cognitive and psychosocial mediators. Searches in PubMed, ScienceDirect, and Google Scholar identified 9 original research from 825 articles. Overall, moderate-to-vigorous PA and vigorous PA were generally associated with better AP, however, effect sizes were modest and associations were not uniform. Several studies indicated curvilinear relationships, whereby moderate PA was associated with optimal AP, while higher frequency or intensity was linked to weaker outcomes or inconsistent associations. Positive relationships were more consistently observed in middle school than high school students. Evidence from selected studies suggested that PA may influence AP indirectly through attention, inhibitory control, self-concept, and physical and mental health. These findings support promoting regular, moderate-intensity PA within adolescents' daily routines, particularly in school-based programs, while emphasizing balanced approaches that account for developmental stage and mediating mechanisms.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 1","pages":"3-8"},"PeriodicalIF":1.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12960045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Linkages between functional independence, depressive symptoms, and social networks in aging populations: a systematic review.","authors":"Tae-Hyun Yoon, Yong-Seok Jee","doi":"10.12965/jer.2550886.443","DOIUrl":"10.12965/jer.2550886.443","url":null,"abstract":"<p><p>Activities of daily living (ADL) and instrumental ADL (IADL), main indicators of functional independence in older adults, are closely associated with depression and social networks and represent a critical determinant of well-being. Despite the growing body of research, both original and review articles to date have been limited in their ability to provide a comprehensive and coherent explanation of the interrelationships among these three domains, largely due to methodological constraints. Accordingly, this study systematically reviewed a wide range of publications addressing functional ability, depression, and social networks in older adults, with the aim of providing evidence-based insights to inform strategies for maintaining well-being and preparing for functional decline in aging populations. The synthesized findings indicate that declines in functional ability, as reflected by impairments in IADL/ADL, are associated with reduced instrumental ADL, increased depressive symptoms, and decreased social participation, collectively contributing to a self-reinforcing cycle of functional and psychological deterioration. Notably, this review demonstrates that while functional disability increases the risk of depression, robust social networks serve as protective factors that mitigate both functional and psychological decline.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"22 1","pages":"9-21"},"PeriodicalIF":1.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12960044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}