Minsook Ye, Sung Ja Rhie, Woojin Jeong, Hyo-Jeong Yu, Youngsuk Kim, Jiyoun Kim, Insop Shim
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引用次数: 0
摘要
接地,即与地球表面直接接触的做法,因其具有减轻炎症和神经毒性的潜力而备受关注。三甲基锡(TMT)是一种强效神经毒性化合物,可诱发严重的中枢神经系统损伤,尤其是海马体的神经元死亡和神经炎症,由于其能够诱发氧化应激、炎症反应和神经退行性疾病,因此经常被用作研究阿尔茨海默病等神经退行性疾病的动物模型。本研究调查了接地垫对 TMT 诱导的神经毒性大鼠的认知功能、神经炎症和神经保护的影响。大鼠被分为五组:无接地垫生理盐水组(Nor)、无接地垫TMT组(Con)、电热垫21天TMT组(EM)、接地垫7天TMT组(A-7D)和接地垫21天TMT组(A-21D)。认知功能通过 Y 型迷宫试验进行评估,血液中的白细胞介素 (IL)-1β、IL-4、前列腺素 E2 (PGE2) 和海马乙酰胆碱酯酶 (AChE) 水平则通过酶联免疫吸附试验进行测定。与 Nor 组相比,Con 组记忆力受损,IL-1β 和 PGE2 水平升高,IL-4 水平降低。A-7D 组的记忆力有所改善,A-21D 组的 IL-1β 和 P PGE2 水平降低,IL-4 水平升高。与 Con 组相比,A-7D 组和 A-21D 组的 AChE 水平都有所提高。这些研究结果表明,在神经毒性模型中,接地可通过减少炎症和促进神经保护来增强认知功能。
Anti-inflammatory effect of grounding mat on trimethyltin-induced neurotoxicity rats.
Grounding, the practice of direct contact with the Earth's surface, has been explored for its potential to alleviate inflammation and neurotoxicity. Trimethyltin (TMT) is a potent neurotoxic compound known for inducing severe central nervous system damage, particularly neuronal death and neuroinflammation in the hippocampus, which is frequently used as an animal model to study neurodegenerative disorders, such as Alzheimer disease, due to its ability to induce oxidative stress, inflammatory responses, and neurodegeneration. This study investigated the effect of a grounding mat on cognitive function, neuroinflammation, and neuroprotection in a TMT-induced neurotoxicity rats. Rats were divided into five groups: no grounding mat with saline (Nor), no grounding mat with TMT (Con), electric mat for 21 days with TMT (EM), grounding mat for 7 days with TMT (A-7D), and grounding mat for 21 days with TMT (A-21D). Cognitive function was assessed via the Y-maze test, while blood levels of interleukin (IL)-1β, IL-4, prostaglandin E2 (PGE2), and hippocampal acetylcholinesterase (AChE) were measured by enzyme-linked immunosorbent assay. The Con group showed impaired memory and elevated IL-1β and PGE2 levels, alongside reduced IL-4, compared to the Nor group. The A-7D group improved memory performance, and the A-21D group showed reductions in IL-1β and P PGE2, with increased IL-4 levels. Both A-7D and A-21D groups had elevated AChE levels compared to the Con group. These findings suggest that grounding may enhance cognitive function by reducing inflammation and promoting neuroprotection in a neurotoxicity model.
期刊介绍:
The Journal of Exercise Rehabilitation is the official journal of the Korean Society of Exercise Rehabilitation, and is published six times a year. Supplementary issues may be published. Its official abbreviation is "J Exerc Rehabil". It was launched in 2005. The title of the first volume was Journal of the Korean Society of Exercise Rehabilitation (pISSN 1976-6319). The journal title was changed to Journal of Exercise Rehabilitation from Volume 9 Number 2, 2013. The effects of exercise rehabilitation are very broad and in some cases exercise rehabilitation has different treatment areas than traditional rehabilitation. Exercise rehabilitation can be presented as a solution to new diseases in modern society and it can replace traditional medicine in economically disadvantaged areas. Exercise rehabilitation is very effective in overcoming metabolic diseases and also has no side effects. Furthermore, exercise rehabilitation shows new possibility for neuropsychiatric diseases, such as depression, autism, attention deficit hyperactivity disorder, schizophrenia, etc. The purpose of the Journal of Exercise Rehabilitation is to identify the effects of exercise rehabilitation on a variety of diseases and to identify mechanisms for exercise rehabilitation treatment. The Journal of Exercise Rehabilitation aims to serve as an intermediary for objective and scientific validation on the effects of exercise rehabilitation worldwide. The types of manuscripts include research articles, review articles, and articles invited by the Editorial Board. The Journal of Exercise Rehabilitation contains 6 sections: Basic research on exercise rehabilitation, Clinical research on exercise rehabilitation, Exercise rehabilitation pedagogy, Exercise rehabilitation education, Exercise rehabilitation psychology, and Exercise rehabilitation welfare.