{"title":"Physical activity, sedentary behavior, and metabolic syndrome in adults with arthritis: cross-sectional and Mendelian randomization analysis.","authors":"Dehua Gong, Seung-Soo Baek","doi":"10.12965/jer.2550080.040","DOIUrl":null,"url":null,"abstract":"<p><p>This study examined the relationship between moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and metabolic syndrome, employing both cross-sectional and Mendelian randomization methods to enhance causal inference. The cross-sectional analysis included adults aged 20 years and older with arthritis (n=4,227) from the National Health and Nutrition Examination Survey and assessed the associations between MVPA, SB, and metabolic syndrome. Mendelian randomization analysis used genome-wide association studies to validate causal relationships, employing instrumental variables selected from single nucleotide polymorphisms linked to accelerometer-based physical activity (fraction of time with accelerations >425 milli-gravities) and SB. The primary Mendelian randomization methods included inverse variance weighting and Bayesian Weighted Mendelian Randomization. Sensitivity analyses, including Mendelian Randomization-Egger intercept test, the weighted median method, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier, were conducted to ensure result robustness. Cross-sectional analysis revealed a significant association between higher levels of MVPA and reduced SB with a lower prevalence of metabolic syndrome. Participants in the high MVPA/low SB group demonstrated lower odds of metabolic syndrome (odds ratio [OR], 0.40; 95% confidence interval [CI], 0.29-0.56), hypertension (OR, 0.55; 95% CI, 0.40-0.75), fasting glucose (OR, 0.52; 95% CI, 0.35-0.77), and waist circumference (OR, 0.34; 95% CI, 0.22-0.54). Mendelian randomization analysis confirmed a causal relationship, showing that physical activity decreases risk factors for metabolic syndrome, while SB exacerbates them. This study emphasizes the critical roles of regular physical activity and reduced SB in mitigating the risk of metabolic syndrome, especially among older adults with arthritis.</p>","PeriodicalId":15771,"journal":{"name":"Journal of Exercise Rehabilitation","volume":"21 2","pages":"102-111"},"PeriodicalIF":1.2000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061776/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Exercise Rehabilitation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12965/jer.2550080.040","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"REHABILITATION","Score":null,"Total":0}
引用次数: 0
Abstract
This study examined the relationship between moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and metabolic syndrome, employing both cross-sectional and Mendelian randomization methods to enhance causal inference. The cross-sectional analysis included adults aged 20 years and older with arthritis (n=4,227) from the National Health and Nutrition Examination Survey and assessed the associations between MVPA, SB, and metabolic syndrome. Mendelian randomization analysis used genome-wide association studies to validate causal relationships, employing instrumental variables selected from single nucleotide polymorphisms linked to accelerometer-based physical activity (fraction of time with accelerations >425 milli-gravities) and SB. The primary Mendelian randomization methods included inverse variance weighting and Bayesian Weighted Mendelian Randomization. Sensitivity analyses, including Mendelian Randomization-Egger intercept test, the weighted median method, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier, were conducted to ensure result robustness. Cross-sectional analysis revealed a significant association between higher levels of MVPA and reduced SB with a lower prevalence of metabolic syndrome. Participants in the high MVPA/low SB group demonstrated lower odds of metabolic syndrome (odds ratio [OR], 0.40; 95% confidence interval [CI], 0.29-0.56), hypertension (OR, 0.55; 95% CI, 0.40-0.75), fasting glucose (OR, 0.52; 95% CI, 0.35-0.77), and waist circumference (OR, 0.34; 95% CI, 0.22-0.54). Mendelian randomization analysis confirmed a causal relationship, showing that physical activity decreases risk factors for metabolic syndrome, while SB exacerbates them. This study emphasizes the critical roles of regular physical activity and reduced SB in mitigating the risk of metabolic syndrome, especially among older adults with arthritis.
期刊介绍:
The Journal of Exercise Rehabilitation is the official journal of the Korean Society of Exercise Rehabilitation, and is published six times a year. Supplementary issues may be published. Its official abbreviation is "J Exerc Rehabil". It was launched in 2005. The title of the first volume was Journal of the Korean Society of Exercise Rehabilitation (pISSN 1976-6319). The journal title was changed to Journal of Exercise Rehabilitation from Volume 9 Number 2, 2013. The effects of exercise rehabilitation are very broad and in some cases exercise rehabilitation has different treatment areas than traditional rehabilitation. Exercise rehabilitation can be presented as a solution to new diseases in modern society and it can replace traditional medicine in economically disadvantaged areas. Exercise rehabilitation is very effective in overcoming metabolic diseases and also has no side effects. Furthermore, exercise rehabilitation shows new possibility for neuropsychiatric diseases, such as depression, autism, attention deficit hyperactivity disorder, schizophrenia, etc. The purpose of the Journal of Exercise Rehabilitation is to identify the effects of exercise rehabilitation on a variety of diseases and to identify mechanisms for exercise rehabilitation treatment. The Journal of Exercise Rehabilitation aims to serve as an intermediary for objective and scientific validation on the effects of exercise rehabilitation worldwide. The types of manuscripts include research articles, review articles, and articles invited by the Editorial Board. The Journal of Exercise Rehabilitation contains 6 sections: Basic research on exercise rehabilitation, Clinical research on exercise rehabilitation, Exercise rehabilitation pedagogy, Exercise rehabilitation education, Exercise rehabilitation psychology, and Exercise rehabilitation welfare.