Physical activity, sedentary behavior, and metabolic syndrome in adults with arthritis: cross-sectional and Mendelian randomization analysis.

IF 1.2 Q3 REHABILITATION
Journal of Exercise Rehabilitation Pub Date : 2025-04-30 eCollection Date: 2025-04-01 DOI:10.12965/jer.2550080.040
Dehua Gong, Seung-Soo Baek
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引用次数: 0

Abstract

This study examined the relationship between moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and metabolic syndrome, employing both cross-sectional and Mendelian randomization methods to enhance causal inference. The cross-sectional analysis included adults aged 20 years and older with arthritis (n=4,227) from the National Health and Nutrition Examination Survey and assessed the associations between MVPA, SB, and metabolic syndrome. Mendelian randomization analysis used genome-wide association studies to validate causal relationships, employing instrumental variables selected from single nucleotide polymorphisms linked to accelerometer-based physical activity (fraction of time with accelerations >425 milli-gravities) and SB. The primary Mendelian randomization methods included inverse variance weighting and Bayesian Weighted Mendelian Randomization. Sensitivity analyses, including Mendelian Randomization-Egger intercept test, the weighted median method, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier, were conducted to ensure result robustness. Cross-sectional analysis revealed a significant association between higher levels of MVPA and reduced SB with a lower prevalence of metabolic syndrome. Participants in the high MVPA/low SB group demonstrated lower odds of metabolic syndrome (odds ratio [OR], 0.40; 95% confidence interval [CI], 0.29-0.56), hypertension (OR, 0.55; 95% CI, 0.40-0.75), fasting glucose (OR, 0.52; 95% CI, 0.35-0.77), and waist circumference (OR, 0.34; 95% CI, 0.22-0.54). Mendelian randomization analysis confirmed a causal relationship, showing that physical activity decreases risk factors for metabolic syndrome, while SB exacerbates them. This study emphasizes the critical roles of regular physical activity and reduced SB in mitigating the risk of metabolic syndrome, especially among older adults with arthritis.

成人关节炎患者的身体活动、久坐行为和代谢综合征:横断面和孟德尔随机化分析。
本研究采用横断面和孟德尔随机化方法,探讨了中高强度体力活动(MVPA)、久坐行为(SB)和代谢综合征之间的关系,以加强因果推理。横断面分析纳入了来自全国健康与营养调查的年龄在20岁及以上的关节炎患者(n=4,227),评估了MVPA、SB和代谢综合征之间的关系。孟德尔随机化分析使用全基因组关联研究来验证因果关系,使用从单核苷酸多态性中选择的工具变量,与基于加速度计的身体活动(加速度bb0 - 425毫重力的时间比例)和SB相关。孟德尔随机化的主要方法包括逆方差加权和贝叶斯加权孟德尔随机化。敏感度分析包括孟德尔随机化-艾格截距检验、加权中位数法、孟德尔随机化多效残差和和异常值,以确保结果稳健性。横断面分析显示,较高水平的MVPA和降低的SB与较低的代谢综合征患病率之间存在显著关联。高MVPA/低SB组的参与者出现代谢综合征的几率较低(比值比[OR], 0.40;95%可信区间[CI], 0.29-0.56),高血压(OR, 0.55;95% CI, 0.40-0.75),空腹血糖(OR, 0.52;95% CI, 0.35-0.77)和腰围(OR, 0.34;95% ci, 0.22-0.54)。孟德尔随机化分析证实了两者之间的因果关系,表明体育活动降低了代谢综合征的危险因素,而SB则加剧了这些危险因素。这项研究强调了规律的身体活动和降低SB在减轻代谢综合征风险方面的关键作用,特别是在患有关节炎的老年人中。
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来源期刊
CiteScore
3.50
自引率
5.30%
发文量
45
审稿时长
10 weeks
期刊介绍: The Journal of Exercise Rehabilitation is the official journal of the Korean Society of Exercise Rehabilitation, and is published six times a year. Supplementary issues may be published. Its official abbreviation is "J Exerc Rehabil". It was launched in 2005. The title of the first volume was Journal of the Korean Society of Exercise Rehabilitation (pISSN 1976-6319). The journal title was changed to Journal of Exercise Rehabilitation from Volume 9 Number 2, 2013. The effects of exercise rehabilitation are very broad and in some cases exercise rehabilitation has different treatment areas than traditional rehabilitation. Exercise rehabilitation can be presented as a solution to new diseases in modern society and it can replace traditional medicine in economically disadvantaged areas. Exercise rehabilitation is very effective in overcoming metabolic diseases and also has no side effects. Furthermore, exercise rehabilitation shows new possibility for neuropsychiatric diseases, such as depression, autism, attention deficit hyperactivity disorder, schizophrenia, etc. The purpose of the Journal of Exercise Rehabilitation is to identify the effects of exercise rehabilitation on a variety of diseases and to identify mechanisms for exercise rehabilitation treatment. The Journal of Exercise Rehabilitation aims to serve as an intermediary for objective and scientific validation on the effects of exercise rehabilitation worldwide. The types of manuscripts include research articles, review articles, and articles invited by the Editorial Board. The Journal of Exercise Rehabilitation contains 6 sections: Basic research on exercise rehabilitation, Clinical research on exercise rehabilitation, Exercise rehabilitation pedagogy, Exercise rehabilitation education, Exercise rehabilitation psychology, and Exercise rehabilitation welfare.
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