Journal of Functional Biomaterials最新文献

{"title":"Role of Endophytic Fungi in the Biosynthesis of Metal Nanoparticles and Their Potential as Nanomedicines.","authors":"Hanadi Sawalha, Simon E Moulton, Andreas Winkel, Meike Stiesch, Bita Zaferanloo","doi":"10.3390/jfb16040129","DOIUrl":"https://doi.org/10.3390/jfb16040129","url":null,"abstract":"<p><p>Metal nanoparticles (MNPs) produced through biosynthesis approaches have shown favourable physical, chemical, and antimicrobial characteristics. The significance of biological agents in the synthesis of MNPs has been acknowledged as a promising alternative to conventional approaches such as physical and chemical methods, which are confronted with certain challenges. To meet these challenges, the use of endophytic fungi as nano-factories for the synthesis of MNPs has become increasingly popular worldwide in recent times. This review provides an overview of the synthesis of MNPs using endophytic fungi, the mechanisms involved, and their important biomedical applications. A special focus on different biomedical applications of MNPs mediated endophytic fungi involved their antibacterial, antifungal, antiviral, and anticancer applications and their potential as drug delivery agents. Furthermore, this review highlights the significance of the use of endophytic fungi for the green synthesis of MNPs and discusses the benefits, challenges, and prospects in this field.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physico-Chemical Properties and Push-Out Bond Strength to Root Dentine of Calcium Silicate-Based Sealers.","authors":"Ivana Milanovic, Vesna Miletic, Bojan Dzeletovic, Djordje Antonijevic, Tatjana Savic Stankovic, Danilo Pavlovic, Ana Despotovic, Violeta Petrovic","doi":"10.3390/jfb16040131","DOIUrl":"https://doi.org/10.3390/jfb16040131","url":null,"abstract":"<p><p>The calcium silicate-based sealers currently available on the market have different compositions and formulations, which is why their physical and chemical properties may vary. (1) The aim of the study was to measure the physico-chemical properties of calcium silicate-based sealers and their push-out bond strength to root dentine, comparing two push-out testing protocols. (2) Standardized specimens of EndoSequence BC, BioRoot RCS, MTA Fillapex, and AH Plus (control) were subjected to pH measurements over 28 days. Radiopacity was measured using a CCD sensor, and flexural strength was assessed using a three-point bending setup. Push-out bond strength was measured in coronal, middle, and apical sections of 40 single-root teeth (conventional method), and cylindrical cavities were prepared for all sealers on the same root dentine disks in 11 third molars (disk method). (3) EndoSequence BC exhibited a higher pH than MTA Fillapex and the highest radiopacity (<i>p</i> < 0.05). The highest flexural and push-out bond strengths were found for AH Plus. The push-out bond strength of EndoSequence BC and BioRoot RCS was higher than MTA Fillapex (<i>p</i> < 0.05). The conventional and disk methods exhibited similar push-out bond strength results, but the data were more homogeneously distributed in the disk method. (4) All calcium silicate-based sealers exhibited a higher pH than AH Plus. MTA Fillapex did not meet the ISO standard. Calcium silicate-based sealers showed weaker performance in terms of physical properties compared to AH Plus.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commercial Biomaterial-Based Products for Tendon Surgical Augmentation: A Scoping Review on Currently Available Medical Devices.","authors":"Marta Pluchino, Leonardo Vivarelli, Gianluca Giavaresi, Dante Dallari, Marco Govoni","doi":"10.3390/jfb16040130","DOIUrl":"https://doi.org/10.3390/jfb16040130","url":null,"abstract":"<p><p>Tendon defect is one of the common clinical diseases related to the growing population mean age and the number of athletes. Due to an increasing demand for tendon repair surgical interventions, several tendon augmentation products, capable of guaranteeing the necessary biological and visco-elasticity properties and mechanical support, have been developed. In this regard, commercially available products may be grouped into three main categories: (i) natural, (ii) synthetic, and (iii) hybrid biomaterial-based products. Firstly, to better define the research area of this work, common search engines were employed to acquire information from reports or website portfolios of important competitors in the global tendon repair market. Secondly, public registries and bibliographic databases were also employed to analyse data from registered clinical trials and published clinical studies performed to evaluate the safety and efficacy of each product. Ten new products have been launched on the market in the last fifteen years: advantages, disadvantages, and future perspectives regarding their use for tendon augmentation treatment are discussed. Although hybrid biomaterial-based products may be considered as more oriented to the new frontiers of tendon augmentation technology, future improvements, especially focused on both mechanical properties and biocompatibility, are needed. However, scientific innovations must navigate convoluted clinical regulatory paths, which, due to high costs for investors, long development timelines, and funding shortages, hinder the translation of many scientific discoveries into routine clinical practice.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Cytotoxicity Evaluation of Nanosized Hydroxyapatite and Fluorapatite on Cell Lines and Their Relevance to the Alveolar Augmentation Process.","authors":"Wojciech Zakrzewski, Maria Szymonowicz, Anna Nikodem, Agnieszka Rusak, Zbigniew Rybak, Katarzyna Szyszka, Dorota Diakowska, Benita Wiatrak, Rafal J Wiglusz, Maciej Dobrzyński","doi":"10.3390/jfb16040125","DOIUrl":"https://doi.org/10.3390/jfb16040125","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Materials with an apatite structure were investigated in vitro in dental bone augmentation procedures. This scientific study aimed to compare nanosized hydroxyapatite (nHAp) and fluorapatite (nFAp) materials in the form of tablets in in vitro studies, including cytotoxicity assessment and fluoride release. <b>Methods:</b> The nHAp and nFAp nanosized materials were obtained using the microwave hydrothermal method. Subsequently, the tablets were prepared from these nanosized powders as further studied materials. Cytotoxicity tests were conducted on Balb/3T3 fibroblast cells and L929 cells. Fluoride ion release was tested at 3, 24, 48, 72, and 168 h periods. <b>Results:</b> Both materials presented viability levels above 70%, indicating a lack of cytotoxic potential. The amount of fluoride (F^-) ions released and accumulated from nFAp was greatly higher than from nHAp. The release of F^- ions in both samples was the highest in the first 3 h of exposition. The accumulation of F^- ions reached the highest values in the deionized water. The most significant differences in the released or cumulated fluoride ions were observed between deionized water and lower 4.5 pH AS (artificial saliva) samples. <b>Conclusions:</b> Both nanosized hydroxyapatite and fluorapatite materials are biocompatible, and their in vitro examination showed promising results for their future in vivo application.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Hydroxyapatite Composites in Bone Tissue Engineering: A Review.","authors":"Weijie Liu, Nalini Cheong, Zhuling He, Tonghan Zhang","doi":"10.3390/jfb16040127","DOIUrl":"https://doi.org/10.3390/jfb16040127","url":null,"abstract":"<p><p>The treatment of bone defects is complicated by clinical conditions, such as trauma, tumor resection, and infection, which result in defects and impair the bone's regenerative capacity. Hydroxyapatite (HAp), the primary inorganic component of bone, possesses good biocompatibility and osteoconductivity. However, it has poor mechanical properties, a slow degradation rate, and limited functionality, necessitating combination with other materials to broaden its application scope. This paper summarizes the importance and properties of HAp composites and provides a categorized review of current research on HAp composites in bone tissue engineering. These composite scaffolds not only offer excellent mechanical support for cell growth and tissue regeneration but also facilitate new bone formation and vascularization. Additionally, the challenges faced by HAp composites, such as material property optimization and improvement of preparation techniques, are discussed. The paper also summarizes the applications of HAp composites in bone defect repair, dental implants, spinal fusion, and other fields.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the Structure and Mechanical Properties of Ti-38Zr-11Nb Alloy.","authors":"Konstantin V Sergienko, Sergei V Konushkin, Yaroslava A Morozova, Mikhail A Kaplan, Artem D Gorbenko, Boris A Rumyantsev, Mikhail E Prutskov, Evgeny E Baranov, Elena O Nasakina, Tatiana M Sevostyanova, Sofia A Mikhlik, Andrey P Chizhikov, Lyudmila A Shatova, Aleksandr V Simakin, Ilya V Baimler, Maria A Sudarchikova, Mikhail L Kheifetz, Alexey G Kolmakov, Mikhail A Sevostyanov","doi":"10.3390/jfb16040126","DOIUrl":"https://doi.org/10.3390/jfb16040126","url":null,"abstract":"<p><p>Hip joint implants are among the most prevalent types of medical implants utilized for the replacement of damaged joints. The utilization of modern implant materials, such as cobalt-chromium alloys, stainless steel, titanium, and other titanium alloys, is accompanied by challenges, including the toxicity of certain elements (e.g., aluminum, vanadium, nickel) and excessive Young's modulus, which adversely impact biomechanical compatibility. A mismatch between the stiffness of the implant material and the bone tissue, known as stress shielding, can lead to adverse outcomes such as bone resorption and implant loosening. Recent studies have shifted the focus to β-titanium alloys due to their exceptional biocompatibility, corrosion resistance, and low Young's modulus, which is close to the Young's modulus of bone tissue (10-30 GPa). In this study, the microstructure, mechanical properties, and phase stability of the Ti-38Zr-11Nb alloy were investigated. Energy dispersion spectrometry was employed to confirm the homogeneous distribution of Ti, Zr, and Nb in the alloy. A subsequent microstructural analysis revealed the presence of elongated β-grains subsequent to rolling and quenching. Furthermore, grinding contributed to the process of recrystallization and the formation of subgrains. X-ray diffraction analysis confirmed the presence of a stable β-phase under any heat treatment conditions, which can be explained by the use of Nb as a β-stabilizer and Zr as a neutral element with a weak β-stabilizing effect in the presence of other β-stabilizers. Furthermore, the modulus of elasticity, as determined by tensile testing, exhibited a decline from 85 GPa to 81 GPa after annealing. Mechanical tests demonstrated a substantial enhancement in tensile strength (from 529 MPa to 628 MPa) concurrent with a 32% reduction in elongation to fracture of the samples. These alterations are attributed to microstructural transformations, including the formation of subgrains and the rearrangement of dislocations. This study's findings suggest that the Ti-38Zr-11Nb alloy has potential as a material of choice due to its lower Young's modulus compared to traditional materials and its stable β-phase, which enhances the implant's durability and reduces the risk of brittle phases forming over time. This study demonstrates that the corrosion resistance of titanium grade 2 and Ti-38Zr-11Nb is comparable. The material in question exhibited no evidence of cytotoxic activity in the context of mammalian cells.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tea Polyphenol-Infused Sprayable Thermosensitive Liposomal Hydrogel for Enhanced Anti-Inflammatory and Antibacterial Psoriasis Treatment.","authors":"Wei Shen, Qilian Ye, Hongbo Zhang, Shenghong Xie, Shiqi Xie, Cailian Chen, Jinying Liu, Zhengwei Huang, Hai-Bin Luo, Ling Guo","doi":"10.3390/jfb16040124","DOIUrl":"https://doi.org/10.3390/jfb16040124","url":null,"abstract":"<p><p>Psoriasis is a chronic and recurrent inflammatory disease driven not only by intrinsic factors such as immune system dysregulation but also by external factors, including bacterial infections. In contrast to the control of a single pathogenic pathway, combination therapies addressing both the immune and infectious components of psoriasis pathogenesis may offer a more effective strategy for controlling its progression. In this study, we developed a sprayable hydrogel incorporating tea polyphenol-loaded lauric acid liposomes (TP@LA-Lipo gel) to investigate its anti-inflammatory and antibacterial role in psoriasis. Our results demonstrated that TP@LA-Lipo modulated macrophage activity, reduced the expression of iNOS and TNF-α, and remodeled the immune microenvironment. Meanwhile, TP@LA-Lipo effectively eliminated <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> through membrane disruption, mitigating the provoked inflammatory response. More importantly, TP@LA-Lipo gel, when sprayed onto the psoriasis lesions, provided sustained drug release over three days, enabling deeper penetration through the thickened stratum corneum to reach the inflamed layers beneath. Furthermore, in an imiquimod-induced psoriasis mouse model, TP@LA-Lipo gel effectively restored the damaged skin, alleviated histopathological changes, and reduced the systemic immune response. In summary, these findings indicate that TP@LA-Lipo gel offers a comprehensive strategy for effective disease management and improving the quality of life for psoriasis patients.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydopamine-Coated Copper-Doped Mesoporous Silica/Gelatin-Waterborne Polyurethane Composite: A Multifunctional GBR Membrane Bone Defect Repair.","authors":"Mengmeng Jin, Yi Hou, Feiwu Kang","doi":"10.3390/jfb16040122","DOIUrl":"https://doi.org/10.3390/jfb16040122","url":null,"abstract":"<p><p>Guided bone regeneration (GBR) membrane has proven to be a fundamental tool in the realm of bone defect repair. In this study, we develop a mussel-inspired composite biomaterial through polydopamine-assisted, combining gelatin-WPU matrix with the ion-release behavior of Cu-MSNs for augmented bone regeneration. The optimized composite membrane exhibits enhanced mechanical stability, demonstrating a tensile strength of 11.23 MPa (representing a 2.3-fold increase compared to Bio-Gide^®), coupled with significantly slower degradation kinetics that retained 73.3% structural integrity after 35-day immersion in physiological solution. Copper ions act as angiogenic agents to promote blood vessel growth and as antimicrobial agents to prevent potential infections. The combined effect of these components creates a biomimetic environment that is ideal for cell adhesion, growth, and differentiation. This research significantly contributes to the development of advanced biomaterials that combine regeneration and infection-prevention functions. It provides a versatile and effective solution for treating bone injuries and defects, offering new hope for patients in need.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic Ceramic Bracket Removal Using Lasers: A Systematic Review.","authors":"Mateusz Michalak, Sylwia Kiryk, Agnieszka Kotela, Kamila Wiśniewska, Jan Kiryk, Jacek Zbigniew Zborowski, Jacek Matys, Maciej Dobrzyński","doi":"10.3390/jfb16040123","DOIUrl":"https://doi.org/10.3390/jfb16040123","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this systematic review was to evaluate the effectiveness and safety of various laser systems for debonding ceramic orthodontic brackets compared to conventional mechanical removal methods. The primary outcomes assessed included enamel damage, pulp temperature changes, adhesive remnant index (ARI), and shear bond strength (SBS).</p><p><strong>Materials and methods: </strong>A systematic search was conducted in November 2024 across the PubMed, Scopus, and Web of Science (WoS) databases following PRISMA guidelines. The initial search yielded 453 records, of which 41 studies met the inclusion criteria for qualitative and quantitative analysis. The risk of bias was assessed using a standardized scoring system, and only studies with accessible full texts were included.</p><p><strong>Results: </strong>The review highlighted significant heterogeneity in laser parameters, measurement protocols, and study methodologies. Among the evaluated lasers, CO₂ and Er:YAG were the most frequently studied and demonstrated high efficacy in debonding ceramic brackets while maintaining enamel integrity. Sixteen studies assessing SBS reported a reduction from baseline values of 13-23 MPa to clinically acceptable ranges of 7-12 MPa following laser application. ARI was analyzed in 25 studies, with laser-treated groups exhibiting higher scores (2-3), indicating safer debonding with more adhesive remaining on the tooth surface, thereby reducing enamel damage. Pulpal temperature increases were examined in 23 studies, revealing that most laser types, when used within optimal parameters, did not exceed the 5.5 °C threshold considered safe for pulpal health. However, diode and Tm:YAP lasers showed potential risks of overheating in some studies.</p><p><strong>Conclusions: </strong>Laser-assisted debonding of ceramic orthodontic brackets is an effective and safe technique when applied with appropriate laser parameters. CO₂ and Er:YAG lasers were the most effective in reducing SBS while preserving enamel integrity. However, variations in laser settings, study methodologies, and the predominance of in vitro studies limit the ability to establish standardized clinical guidelines. Further randomized controlled trials (RCTs) are necessary to develop evidence-based protocols for safe and efficient laser-assisted bracket removal in orthodontic practice.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass Density Characterization of Hydrogel-Based Systems Inoculated with Bacterial Strains and Dose-Response Performance of <i>Escherichia coli</i> Inoculation.","authors":"Carolina Salinas Domján, Mauro Valente, Marcelo R Romero","doi":"10.3390/jfb16040121","DOIUrl":"https://doi.org/10.3390/jfb16040121","url":null,"abstract":"<p><p>This study aims to determine the density of two hydrogel-based media, medium with agar-agar and medium with agar-agar and glucose, which are suitable for both irradiation and bacterial growth, considering the presence or absence of <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> strains. The viability of Escherichia coli cell-inoculated systems was also evaluated to explore potential applications in radiation dosimetry within the 0-10 Gy range, using spectrophotometric and bacterial culture methods. Mass density measurements were performed at varying temperatures using two approaches: the first one, based on direct measurements of mass and volume, yielded densities comparable to liquid water, with uncertainties ranging from 9 to 16%, while the second approach, employing Archimedes' principle (mass in air vs. mass in a liquid of known density), produced more accurate results, with uncertainties between 0.04 and 0.08%, thus proving more reliable for density determinations. Furthermore, the feasibility study of Escherichia coli-inoculated systems for ionizing radiation dosimetry demonstrated a linear spectrophotometric response to radiation doses across the investigated range, particularly for samples stored at 25 °C. The studied systems were characterized in terms of the corresponding growth curve and post-irradiation bacterial survival, supporting their potentiality as reliable ionizing radiation dosimeters.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}