Journal of Functional Biomaterials最新文献

{"title":"Photothermally Responsive Biomimetic Composite Scaffolds Based on Polydopamine-Functionalized Nanoparticles/Polyurethane for Bone Repair.","authors":"Ruqing Bai, Jiaqi Chen, Ting Zhang, Tao Chen, Xiaoying Liu, Weihu Yang, Tuck-Whye Wong, Jianwei Zhang, Li Wang","doi":"10.3390/jfb16080294","DOIUrl":"10.3390/jfb16080294","url":null,"abstract":"<p><p>In this study, a shape-changeable 3D scaffold with photothermal effects was developed to address the clinical challenges of complex bone defects. The multifunctional construct was fabricated via in situ polymerization combined with a gas foaming technique, creating hierarchical porous architectures that mimic the native bone extracellular matrix. By incorporating polydopamine (PDA)-modified amorphous calcium phosphate (CA) into poly(propylene glycol) (PPG)- and poly(ԑ-caprolactone) (PCL)-based polyurethane (PU). The obtained scaffolds achieved osteoinductive potential for bone tissue engineering. The surface PDA modification of CA enabled efficient photothermal shape conversion under near-infrared (NIR) irradiation, facilitating non-invasive remote control of localized hyperthermia. The optimized scaffolds exhibited interconnected porosity (approximately 70%) with osteoconductive pore channels (200-500 μm), resulting in good osteoinduction in cell culture, and precise shape-memory recovery at physiological temperatures (~40 °C) under NIR for minimally invasive delivery. The synergistic effect of osteogenesis promotion and photothermal transition demonstrated this programmable scaffold as a promising solution for integrated minimally invasive bone repair and defect reconstruction.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIL-53 MOF on Sustainable Biomaterial for Antimicrobial Evaluation Against <i>E. coli</i> and <i>S. aureus</i> Bacteria by Efficient Release of Penicillin G.","authors":"Delia Monserrat Ávila-Márquez, Alien Blanco Flores, Helen Paola Toledo Jaldin, Mateo Burke Irazoque, Maribel González Torres, Alfredo Rafael Vilchis-Nestor, Carla Calderon Toledo, Sergio Gutiérrez-Cortez, Juan Pablo Díaz Rodríguez, Alejandro Dorazco-González","doi":"10.3390/jfb16080295","DOIUrl":"10.3390/jfb16080295","url":null,"abstract":"<p><p>The development of efficient antibiotic-releasing materials derived from sustainable and recyclable compounds represents a key area within biomedical materials science, particularly in the treatment of antibacterial infections. Herein, a Fe³⁺/terephthalate-based metal-organic framework (<b>MIL-53</b>) and a novel advanced material made of <b>MIL-53</b> with biogenic hydroxyapatite (<b>1</b>) were prepared by solvothermal reactions, and these were studied in detail as a Penicillin-G-releasing material. After loading Penicillin G on <b>1</b> and <b>MIL-53</b>, the antibiotic percentage release was studied, and the antimicrobial effectiveness of each material was evaluated against two bacterial ATCC strains (<i>E. coli</i> and <i>S. aureus</i>) and various Penicillin-G-resistant uropathogenic strains such as <i>E. coli</i> isolates (HHM 25, ERV 6, and FGI 4). Functional, structural, and morphological characteristics of these materials were thoroughly studied by analytical tools (FTIR, XRD, BET, SEM-EDS, and XPS). The Penicillin G load did not exceed 50% in both materials. The Penicillin G adsorption mechanism involves several types of interactions with the materials. The release of the antibiotic was more efficient from <b>MIL-53</b>, where the load did not exceed 20%. The release was analyzed using mathematical models. They indicated that when Penicillin G is released from <b>MIL-53</b>, the process follows diffusion through a uniform matrix; however, <b>1</b> is more porous, which helps with the release by diffusion of Penicillin G, and <b>1</b> exhibits more than a 90% inhibition of the growth of bacteria and strains like <b>MIL-53</b>. This suggests a valuable approach to antibiotic activity against resistant pathogens. The use of composite materials derived from the Fe-MOF with a sustainable matrix of hydroxyapatite as antibiotic-releasing materials has been unexplored until now.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Endodontic Files in Root Canal Retreatment: A Systematic Review of In Vitro Studies.","authors":"Anna Soler-Doria, José Luis Sanz, Marcello Maddalone, Leopoldo Forner","doi":"10.3390/jfb16080293","DOIUrl":"10.3390/jfb16080293","url":null,"abstract":"<p><p>The success rate of root canal treatment is high, but it can fail. In these cases, orthograde root canal retreatment is often the treatment of choice, for which numerous biomaterials are available on the market, including endodontic files. This systematic review aimed to study the endodontic files available on the market and establish their efficacy in root canal retreatment. An electronic search of six different databases was performed, and in vitro experimental studies that studied root canal cleaning, debris extrusion, retreatment time, or dentinal damage produced with any of the comparison methods were selected. The quality of the studies was assessed with the QUIN scale. In total, 78 studies were included for the analysis, of which 9 had a high risk of bias, 53 had a moderate risk, and 16 had a low risk. The methods used to evaluate the efficacy of endodontic files in root canal retreatment are heterogeneous. Manual files produce more apical extrusion than rotary files. PTUR files are the most studied endodontic files. It is the file system that leaves the least residual filling material in the canal, takes the least time during retreatment, and removes the greatest amount of dentine. However, no file system achieved the complete removal of the root canal filling material. No consistent pattern emerged across studies when comparing rotary files with continuous and reciprocating rotation in terms of the removal of the filling material, the time required for de-obturation, dentine damage produced, or apical extrusion.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable Thermosensitive Hydrogel Containing Bakuchiol Reduces Periodontal Inflammation and Alveolar Bone Loss in a Rat Model.","authors":"Seong-Jin Shin, Gyu-Yeon Shim, Seong-Hee Moon, Yu-Jin Kim, Hyun-Jin Kim, Seunghan Oh, Jung-Hwan Lee, Ji-Myung Bae","doi":"10.3390/jfb16080292","DOIUrl":"10.3390/jfb16080292","url":null,"abstract":"<p><p>This study aimed to develop and evaluate a bakuchiol-loaded thermosensitive hydrogel (BTH) as a novel local drug delivery system for the management of periodontitis. Bakuchiol, a natural phenolic compound extracted from <i>Psoralea corylifolia</i>, was incorporated into a hydrogel composed of poloxamers and carboxymethylcellulose. The gelation behavior, physicochemical properties, and drug release profile were analyzed. Additionally, antibacterial activity against <i>Porphyromonas gingivalis</i> was assessed. Cytotoxicity was evaluated in human gingival fibroblasts and RAW 264.7 cells. Anti-inflammatory effects were determined by measuring proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. Furthermore, alveolar bone loss, cytokine expression, and histological findings were assessed in a rat model of ligature-induced periodontitis. BTH demonstrated sol-gel transition at body temperature, with sustained drug release over 15 days. Moreover, it exhibited significant antibacterial activity against <i>P. gingivalis</i> and was non-cytotoxic at an extract concentration of 6.25%. In vitro, it significantly downregulated inflammatory cytokines in activated macrophages. In vivo, BTH application reduced alveolar bone loss and interleukin-1β expression in gingival tissues. Histological analysis confirmed decreased inflammatory cell infiltration and alveolar bone destruction. Thus, BTH demonstrated both antibacterial and anti-inflammatory activities, exhibiting potential as a promising therapeutic strategy for localized periodontal treatment.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Insertion Torque of Orthodontic Mini-Implants Depending on the System and the Morphological Substrate.","authors":"Tamara Rahela Ioana, Filip George Boeru, Ioana Mitruț, Anne-Marie Rauten, Mahmoud Elsaafin, Mihaela Ionescu, Ionela Elisabeta Staicu, Horia Octavian Manolea","doi":"10.3390/jfb16080291","DOIUrl":"10.3390/jfb16080291","url":null,"abstract":"<p><p>Orthodontic mini-implants are well-known anchorage devices and stand out as a particularly effective tool for ensuring maximum anchorage without relying on patient compliance. Therefore, it is necessary to understand what levels of torque strains remain in the physiological limits and can guarantee the stability of these mini-implants. The aim of this study was to investigate and measure the initial and final torque values of orthodontic mini-implants when placed perpendicular to the maxillary and mandibular bone surfaces. In our study, orthodontic mini-implants from different companies were inserted perpendicularly using different insertion torques on the plate of both maxillary and mandibular bones from pig specimens. The torque values were then analyzed. The results of this study highlight the need for continued research to analyze the ideal insertion torque of different types of mini-implants depending on the insertion area, in order to achieve clinical success of mini-implants.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Fracture Toughness and Fracture Mirror in Modern Polymer-Based Dental Composites.","authors":"Nicoleta Ilie","doi":"10.3390/jfb16080290","DOIUrl":"10.3390/jfb16080290","url":null,"abstract":"<p><p>The mechanical behavior of dental composites depends on the sample size and stress configuration. This makes it difficult to extrapolate laboratory data to clinical restorations with significant variations in size and geometry. Intrinsic parameters, such as fracture toughness, are therefore of great importance, even if they are less common and more difficult to measure. The aim of this study was to apply principles of fractography and fracture mechanics to exploit the results obtained from a three-point bending test. The objectives include calculating a material-specific constant, validating the experimental findings, and establishing a correlation with fracture toughness. Forty representative composites with wide variation in filler quantity (65-83% by weight and 46.4-64% by volume), type (compact glasses and pre-polymerized), and composition were examined. Fracture toughness/K_Ic was evaluated in a notchless triangular prism test. Fracture type, origin, and mirror size were determined on 280 flexural fracture specimens (<i>n</i> = 20). The amount of filler strongly influences all measured parameters, with the effect strength varying in the sequence: mechanical work (η_P² = 0.995), modulus of elasticity (η_P² = 0.991), flexural strength (η_P² = 0.988), fracture toughness (η_P² = 0.979), and mirror constant (η_P² = 0.965). Fracture surfaces allowed the delineation of the fracture mirror and the application of fracture mechanics approaches. The mirror constant was derived from the radius of the fracture mirror, measured in the direction of constant stress, using Orr's equation, and correlates well with K_Ic (0.81). Larger confidence intervals were observed for the mirror constant data, while for 5 of 14 materials, the mirror constant was overestimated compared to K_Ic. The overestimation was attributed to the lower refractive index of the urethane methacrylate composition.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear Bond Strength of Self-Adhesive and Self-Etching Resin Cements to Dentin for Indirect Restorations.","authors":"Janet Kirilova, Georgi Veselinov Iliev, Sevda Yantcheva, Elitsa Deliverska, Viktoria Petrova","doi":"10.3390/jfb16080289","DOIUrl":"10.3390/jfb16080289","url":null,"abstract":"<p><p>This study assessed and compared the shear bond strength of self-adhesive and self-etching resin cements for indirect aesthetic restorations to dentin. Four different materials, lithium disilicate ceramics, zirconia ceramics, polymethyl methacrylate (PMMA) composites, and hybrid materials, were used for indirect restorations cemented to dentin. The null hypothesis was that there would be no differences in shear bond strength between the investigated materials. Eighty extracted human molars were used. Eighty dentin specimens with a flat surface were prepared and randomly distributed in groups of 10 (n = 10). From each material (Cerasmart 270, Initial LiSi Blok, Katana ZR Noritake, and Crowntec Next Dent), 20 blocks were made and cemented to the dentin samples. Half of the blocks from each material were cemented to dentin using self-etching resin cement (Panavia V5), and the other half using self-adhesive resin cement (i-CEM). After the specimens were prepared, a laboratory test was conducted to evaluate the shear bond strength. The fracture type was determined using a light microscope, and SEM confirmed the results. The results were statistically analysed. All materials cemented with self-etching cements (Panavia V5) showed statistically higher shear strength values than those cemented with self-adhesive resin cement (i-CEM). In the specimen groups where self-adhesive cement (i-CEM) was used, Cerasmart 270 bonded statistically better. A statistical difference was found between all groups of materials cemented with self-etching cement. The Initial LiSi Block showed the strongest bond, followed by Katana Zr Noritake, Crowntec NextDent, and Cerasmart 270. Adhesion fracture to dentin was observed for all groups cemented with i-CEM. This study highlights the superior performance of self-etching cements in terms of shear bond strength. 10-Methacryloyloxydecyl dihydrogen phosphate (10-MDP), a functional monomer, was found to enhance adhesion strength significantly. However, using self-adhesive cements was associated with a weaker bond to dentin, highlighting the importance of the right cementing agent in restorative dentistry.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting Surface Energy and Osteoblast Viability on Zirconia Implant Abutments Through Glass-Ceramic Spray Deposition Technology.","authors":"Wen-Chieh Hsu, Tao-Yu Cha, Yu-Chin Yao, Chien-Ming Kang, Sheng-Han Wu, Yuichi Mine, Chien-Fu Tseng, I-Ta Lee, Dan-Jae Lin, Tzu-Yu Peng","doi":"10.3390/jfb16080288","DOIUrl":"10.3390/jfb16080288","url":null,"abstract":"<p><p>Zirconia is used widely for high-precision custom abutments; however, stress concentration can compromise osseointegration. Although glass-ceramic spray deposition (GCSD) can enhance the surface properties of zirconia, its biological effects remain unclear. In this study, the biological responses of human osteoblast-like (MG-63) cells to GCSD-modified zirconia surfaces were evaluated to assess the potential application in zirconia abutments. Disk-shaped zirconia and titanium alloy samples were prepared; titanium served as the control (Ti). Zirconia was subjected to polishing (NT), airborne-particle abrasion (AB), or GCSD with (GE) or without (GC) hydrofluoric acid (HF) etching. Surface characteristics, including wettability, surface energy (SE), and surface potential (SP), were analyzed. Cytotoxicity and MG-63 cell adhesion were assessed using the PrestoBlue assay, scanning electron microscopy (SEM), viability staining, and confocal laser scanning microscopy (CLSM). Statistical analysis was performed with a significance level of 0.05. GCSD produced a dense glass-ceramic coating on the zirconia surface, which significantly enhanced hydrophilicity as indicated by reduced water contact angles and increased SE in the GC and GE groups (<i>p</i> < 0.05). HF etching increased SP (<i>p</i> < 0.05). No cytotoxicity was observed in any group. SEM, viability staining, and CLSM revealed enhanced MG-63 cell attachment on Ti and GE surfaces and the highest viability ratio in the GE group. The NT group exhibited the lowest cell attachment and viability at all time points. GCSD effectively improved zirconia abutment surface properties by enhancing hydrophilicity and promoting MG-63 cell adhesion, with biocompatibility comparable to or better than that of titanium.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Compression Fabrics with Dual Scar-Suppressing and Antimicrobial Properties: Microencapsulation Design and Performance Evaluation.","authors":"Lihuan Zhao, Changjing Li, Mingzhu Yuan, Rong Zhang, Xinrui Liu, Xiuwen Nie, Bowen Yan","doi":"10.3390/jfb16080287","DOIUrl":"10.3390/jfb16080287","url":null,"abstract":"<p><p>Pressure therapy combined with silicone has a significant effect on scar hyperplasia, but limitations such as long-term wearing of compression garments (CGs) can easily cause bacterial infection, cleanliness, and lifespan problems of CGs caused by the tedious operation of applying silicone. In this study, a compression garment fabric (CGF) with both inhibition of scar hyperplasia and antibacterial function was prepared. A polydimethylsiloxane (PDMS)-loaded microcapsule (PDMS-M) was prepared with chitosan quaternary ammonium salt (HACC) and sodium alginate (SA) as wall materials and PDMS as core materials by the complex coagulation method. The PDMS-Ms were finished on CGF and modified with (3-aminopropyl)triethoxysilane (APTES) to obtain PDMS-M CGF, which was further treated with HACC to produce PDMS-M-HACC CGF. X-ray Photoelectron Spectroscopy(XPS) and Fourier transform infrared spectroscopy (FTIR) analysis confirmed the formation of covalent bonding between PDMS-M and CGF. The PDMS-M CGF exhibited antibacterial rates of 94.2% against Gram-negative bacteria <i>Escherichia coli</i> (<i>E. coli</i>, AATCC 6538) and of 83.1% against Gram-positive bacteria <i>Staphylococcus aureus</i> (<i>S. aureus</i>, AATCC 25922). The antibacterial rate of PDMS-M-HACC CGF against both <i>E. coli</i> and <i>S. aureus</i> reached 99.9%, with wash durability reaching grade AA for <i>E. coli</i> and approaching grade A for <i>S. aureus</i>. The finished CGF maintained good biocompatibility and showed minimal reduction in moisture permeability compared to unfinished CGF, though with decreased elastic recovery, air permeability and softness. The finished CGF of this study is expected to improve the therapeutic effect of hypertrophic scars and improve the quality of life of patients with hypertrophic scars.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Hydroxyapatite-β-Tricalcium Phosphate Collagen Composites for Socket Preservation in a Canine Model.","authors":"Dong Woo Kim, Donghyun Lee, Jaeyoung Ryu, Min-Suk Kook, Hong-Ju Park, Seunggon Jung","doi":"10.3390/jfb16080286","DOIUrl":"10.3390/jfb16080286","url":null,"abstract":"<p><p>This study aimed to compare the performance of three hydroxyapatite-β-tricalcium phosphate (HA-β-TCP) collagen composite grafts in a canine model for extraction socket preservation. Eight mongrel dogs underwent atraumatic bilateral mandibular premolar extraction, and sockets were randomly grafted with HBC28 (20% high-crystalline HA, 80% β-TCP bovine collagen), HBC37 (30% HA, 70% β-TCP, bovine collagen), or HPC64 (60% HA, 40% β-TCP, porcine collagen). Grafts differed in their HA-β-TCP ratio and collagen origin and content. Animals were sacrificed at 4 and 12 weeks, and the healing sites were evaluated using micro-computed tomography (micro-CT) and histological analysis. At 12 weeks, all groups showed good socket maintenance with comparable new bone formation. However, histological analysis revealed that HBC28 had significantly higher residual graft volume, while HPC64 demonstrated more extensive graft resorption. Histomorphometric analysis confirmed these findings, with statistically significant differences in residual graft area and bone volume fraction. No inflammatory response or adverse tissue reactions were observed in any group. These results suggest that all three HA-β-TCP collagen composites are biocompatible and suitable for socket preservation, with varying resorption kinetics influenced by graft composition. Selection of graft material may thus be guided by the desired rate of replacement by new bone.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 8","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}