Journal of Functional Biomaterials最新文献

{"title":"Multi-Scale Mechanics of Cryopreserved Human Arterial Allografts Across a Six-Month Period.","authors":"Gergely Imre Kovács, László Hidi, Evelin Forró, Dóra Haluszka, Dániel Sándor Veres, Gergő Péter Gyurok, Andrea Kőszegi, Attila Fintha, Miklós Kellermayer, Péter Sótonyi","doi":"10.3390/jfb16060198","DOIUrl":"10.3390/jfb16060198","url":null,"abstract":"<p><p>Operating under septic conditions poses significant challenges in vascular surgery. Infection is a serious risk when handling synthetic vessel prostheses and is one of the most dreaded complications. In the event of graft infection, an infection-resistant alternative is necessary. Cryopreserved vascular allografts offer a suitable alternative to replace an infected vessel or a section of a synthetic graft. However, there are no international guidelines for the preparation, storage, and thawing of such vessel grafts. Here, we aimed to investigate the mechanical properties of human cryopreserved arteries across multiple scales, ranging from nanonewton to newton forces and identify the optimal cryogenic storage duration. Human arterial allograft samples were frozen in a slow, controlled process and stored at -80 °C. One native and four cryopreserved samples were examined during a six-month-long period. Dimethyl-sulphoxide was used as a cryoprotectant. The mechanical properties of fresh and stored samples were explored in uniaxial ring tests and nanoindentation. We found no significant changes in the multi-scale mechanical properties during the examination period. Our results indicate that the cryopreserved vascular allografts are mechanically stable for up to six months under cryogenic conditions; hence, they represent ideal samples in vascular surgery.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Novel Pretreatment on Bond Strength of Universal Adhesive to Conventional and CAD/CAM Resin Composites: In Vitro Study.","authors":"Ali A Elkaffas, Abdullah Alshehri, Feras Alhalabi, Rania Bayoumi, Abdullah Ali Alqahtani, Abdulellah Almudahi, Abdulaziz Fahd Alsubaie, Abdulaziz Fahd Alharbi","doi":"10.3390/jfb16060197","DOIUrl":"10.3390/jfb16060197","url":null,"abstract":"<p><p>Novel dentin bonding pretreatment using copper sulfate (CuSO₄) and dipotassium hydrogen phosphate (K₂HPO₄) may create a more hydrophobic environment for dentin bonding. Thus, this study aims to investigate the impact of a CuSO₄ + K₂HPO₄ pretreatment on dentin μTBS when bonded with a universal adhesive to conventional and CAD/CAM resin composites. Eighty recently extracted human molars (n = 80) were chosen and placed in transparent acrylic blocks to expose the crowns entirely. Nano-filled resin composite and CAD/CAM resin blocks were selected. Based on the dentin pretreatment, type of resin composite, and adhesion strategy, the teeth were randomly allocated into eight equal groups (n = 10). The microtensile bond strength (μTBS) and fracture mode were determined. A three-way analysis of variance (ANOVA) was used to analyze the μTBS data, followed by Tukey's post hoc test. The μTBS values were not significantly affected by either the resin composite type (<i>p</i> > 0.05) or the adhesive strategy (<i>p</i> > 0.05) according to the three-way ANOVA results. Conversely, significant differences were detected between no dentin pretreatment (24.20 ± 4.54 MPa) and CuSO₄ + K₂HPO₄ pretreatment (33.66 ± 5.22 MPa) using an etch-and-rinse adhesive strategy for nano-filled composites (<i>p</i> < 0.001). Additionally, significant differences were detected between no dentin pretreatment (24.71 ± 4.33 MPa) and CuSO₄ + K₂HPO₄ pretreatment (32.49 ± 4.92 MPa) using an etch-and-rinse adhesive strategy for CAD/CAM resin blocks (<i>p</i> < 0.001). Moreover, significant differences were detected between no dentin pretreatment (21.20 ± 3.40 MPa) and CuSO₄ + K₂HPO₄ pretreatment (30.31 ± 3.87 MPa) using a self-etching adhesive strategy for nano-filled composites (<i>p</i> < 0.001). Also, significant differences were detected between no dentin pretreatment (23.89 ± 3.89 MPa) and CuSO₄ + K₂HPO₄ pretreatment (31.22 ± 4.71 MPa) using a self-etching adhesive strategy for CAD/CAM resin blocks (<i>p</i> < 0.001). In conclusion, dentin μTBS was enhanced by a copper-based treatment when used with nano-filled and CAD/CAM resin blocks.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Adhesive Hydrogel Patch Containing Genipin-Crosslinked Gelatin-Hyaluronic Acid for Future Use in Atopic Dermatitis.","authors":"Nurul Ain Zawawi, Manira Maarof, Nur Izzah Md Fadilah, Daniel Looi Qi Hao, Yasuhiko Tabata, Mh Busra Fauzi","doi":"10.3390/jfb16060195","DOIUrl":"10.3390/jfb16060195","url":null,"abstract":"<p><p>Hydrogel patches have gained significant attention in wound healing applications as they are similar to hydrogel dressings due to their moisture-retentive properties, biocompatibility, and ability to promote tissue regeneration. In this study, gelatin-based hydrogels crosslinked with genipin and incorporated with hyaluronic acid (HA) were developed to enhance mechanical stability, swelling behavior, and structural integrity. Fourier transform infrared (FTIR), thermogravimetric (TGA), and energy-dispersive X-ray (EDX) analyses were conducted and confirmed successful crosslinking and good thermal stability, ensuring hydrogel durability under physiological conditions. The optimized hydrogel (GE_HA_GNP) exhibited a sufficient water vapor transmission rate (WVTR), swelling ratio, and contact angle, allowing for effective wound exudate absorption and hydration maintenance, which is essential for accelerated healing. The findings demonstrate that the crosslinked hydrogels were able to maintain a WVTR of 500 to 1500 gm^-2 day^-1, a contact angle of >40°, and a swelling ratio of 700-1000%. The combination of genipin as a crosslinker and the addition of HA significantly improved the mechanical properties and biocompatibility of the hydrogels, making them promising candidates for an alternative treatment for atopic dermatitis and a potential wound dress-ing. Furthermore, the hydrogel patches show potential for future drug delivery appli-cations, with further studies required to evaluate their antimicrobial properties and long-term clinical performance.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Superparamagnetic Iron Oxide Nanoparticles as a Tracer for Sentinel Lymph Node Mapping in Early-Stage Cervical Cancer: The Preliminary Clinical Experience.","authors":"Marcin A Jedryka, Andrzej Czekanski, Marcin Kryszpin, Tymoteusz Poprawski, Krzysztof Grobelak, Piotr Lepka, Rafał Matkowski","doi":"10.3390/jfb16060196","DOIUrl":"10.3390/jfb16060196","url":null,"abstract":"<p><p>Sentinel lymph node (SLN) mapping has been investigated as part of surgical staging in women with early-stage cervical cancer (CC); however, pelvic lymphadenectomy (PLND) remains the standard of care. This study aimed to assess feasibility and safety of SLN detection using superparamagnetic iron oxide (SPIO) nanoparticles as a tracer in CC. Thirty CC patients presumed to be stage I were included in this study with SPIO administered intracervically as a tracer for SLN mapping using a magnetometer and followed by PLND. The endpoints of the study included the proportion of successful SLN detection, the average number of SLNs per patient, and the proportion of pathologically positive results per patient and per node. The diagnostic accuracy of SPIO nanoparticles for detection of metastatic SLNs was evaluated by Receiver Operating Characteristic (ROC) curve analysis, with the area under the ROC curve (AUC) used to demonstrate the studied method's sensitivity. Safety endpoints were a summary of all reported adverse events. SLNs were detected in all cases, bilaterally in 27 patients (90%). The median number of SLNs per patient was 3.5. Four cases had metastatic SLNs. The general malignancy rate per patient was 13.3%, and per node, it was 0.8%. The malignancy detection rate of SLNs was 100% per patient and 80% per node. The AUC of 1.0 (<i>p</i> < 0.001) confirmed the diagnostic value of the SPIO technique for the detection of metastatic SLNs, with a sensitivity of 100%. No adverse events related to the SPIO administration were reported. SPIO nanoparticles, as a tracer for SLN mapping in early-stage CC patients, demonstrated satisfactory accuracy parameters and safety; however, these data need to be evaluated by further research.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Bioavailability and Stability of Plant Secondary Metabolites: Formulation and Characterization of Nanophytosomes Encapsulating Red Bryony and Horned Poppy Extracts.","authors":"Atoosa Olfati, Naser Karimi, Elham Arkan, Mohsen Zhaleh, M R Mozafari","doi":"10.3390/jfb16060194","DOIUrl":"10.3390/jfb16060194","url":null,"abstract":"<p><p>Biocompatible nanocarriers were formulated by encapsulating medicinal extracts from <i>Bryonia dioica</i> (Red Bryony) and <i>Glaucium leiocarpum</i> (Horned Poppy) using a nanophytosome approach. The nanophytosomes were prepared by employing a thin-film hydration technique. The SEM results showed a broad size distribution for both nanophytosomes, and the encapsulation efficiency was about 75-80% for both Red Bryony and Horned Poppy nanophytosomes, as confirmed through scanning electron microscopy (SEM) and dynamic light scattering (DLS). Zeta potential analysis indicated sufficient surface charges to maintain colloidal stability. Encapsulation improved the release characteristics of the extracts, exhibiting an initial burst release followed by sustained release, which is advantageous for enhancing bioavailability within a liquid environment. Fourier-transform infrared (FTIR) spectroscopy identified key functional groups, confirming the successful encapsulation of bioactive ingredients within the nanophytosomes. Cytotoxicity tests on fibroblast cell lines (HSF-PI 16) demonstrated the safety of these nanocarriers, indicating biocompatibility at concentrations up to 200 μg/mL. Stability tests over 30 days revealed minimal size fluctuations, further supporting the structural integrity of the formulations. Results suggest that the synthesized nanophytosomes could serve as effective and novel nanocarriers for herbal delivery, addressing the bioavailability limitations of herbal extracts and offering a promising approach for therapeutic applications in both traditional and alternative medicine. This is the first study to report nanophytosome-based delivery of Red Bryony and Horned Poppy extracts.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12193903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Bleaching Intensity and Laser Activation on the Durability of Selected Aesthetic Composites-An In Vitro Study.","authors":"Żaneta Anna Mierzejewska, Kamila Łukaszuk, Bartłomiej Rusztyn, Kacper Maliszewski","doi":"10.3390/jfb16060193","DOIUrl":"10.3390/jfb16060193","url":null,"abstract":"<p><p>The aim of this study was to evaluate the effect of different bleaching protocols, including laser-assisted techniques, on the microhardness, surface roughness, and tribological resistance of selected light-cured composites. Three Estelite Universal Flow composites with different flow properties and G-aenial Universal Flo composites were tested. Each group underwent bleaching procedures using Opalescence agents at 10%, 16%, and 40% concentrations, with and without laser activation. Surface microhardness was assessed using the Vickers method, roughness was measured with 3D confocal laser microscopy, and friction coefficients and wear patterns were evaluated using tribological testing. All bleaching protocols resulted in reduced microhardness and increased surface roughness. The most significant changes were observed after treatment with 40% hydrogen peroxide. Laser application, particularly at 16% concentration of carbamide peroxide, helped to partially mitigate these effects in some materials. Bleaching procedures, especially those involving high peroxide concentrations, significantly deteriorated the surface properties of dental composites, which may have clinical implications for the patients.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effectiveness of the Socket Preservation Technique Using Allogeneic and Xenogeneic Materials-A Preliminary Study.","authors":"Piotr Wróbel, Adam Piecuch, Michał Bąk, Paweł Krynicki, Jakub Adamczyk, Piotr Mojżesz, Agnieszka Kiełboń, Sylwia Wójcik, Martin Starosta, Won-Pyo Lee, Tadeusz Morawiec","doi":"10.3390/jfb16060192","DOIUrl":"10.3390/jfb16060192","url":null,"abstract":"<p><strong>Background: </strong>The socket preservation technique involves filling the bone defect created after tooth extraction with a bone substitute material. This helps to reduce bone resorption of the post-extraction alveolar ridge. Various types of bone substitute biomaterials are used as augmentation materials, including autogeneic, allogeneic, and xenogeneic materials. The purpose of this study was to evaluate changes in alveolar ridge dimensions and alterations of optical bone density in sockets grafted with two different biomaterials. Additionally, bone biopsies taken from the grafted sites underwent histological evaluation.</p><p><strong>Methods: </strong>This study enrolled 10 generally healthy patients, who were divided into two equal groups. Patients in the first group were treated with an allogeneic material (BIOBank^®, Biobank, Paris, France), while patients in the second group were treated with an xenogeneic material (Geistlich Bio-Oss^®, Geistlich Pharma AG, Wolhusen, Switzerland). Tooth extraction was performed, following which the appropriate material was placed into the debrided socket. The material was secured with a collagen membrane (Geistlich Bio-Gide^®, Geistlich Pharma AG, Wolhusen, Switzerland) and sutures, which were removed 7 to 10 days after the procedure. Micro-CBCT examinations were performed, for the evaluation of alveolar ridge dimensions and bone optical density, at 7-10 days and six months after the procedure. Bone trepanbiopsy was performed simultaneously to the implant placement, six months after socket preservation. The retrieved biopsy was subjected to histological examination via hematoxylin and eosin (H&E) staining and Masson's trichrome staining.</p><p><strong>Results: </strong>The results showed that the allogeneic material was more effective in preserving alveolar buccal height and was probably more rapidly transformed into the patient's own bone. Sockets grafted with the xenogeneic material presented higher optical bone density after six months. Both materials presented similar effectiveness in alveolar width preservation.</p><p><strong>Conclusions: </strong>Based on the outcomes of this study, it can be concluded that both materials are suitable for the socket preservation technique. However, the dimensional changes in the alveolar ridge and the quality of the newly formed bone may vary depending on the type of biomaterial used.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards Enhanced Osteointegration: A Comparative and In-Depth Study of the Biocompatibility of an Innovative Calcium-Doped Zirconia Coating for Biomedical Implants.","authors":"Tchinda Alex, Olivier Joubert, Richard Kouitat-Njiwa, Pierre Bravetti","doi":"10.3390/jfb16060191","DOIUrl":"10.3390/jfb16060191","url":null,"abstract":"<p><p>Innovation in oral implantology is constantly on the move, with a constant search for new biomaterials to overcome many of the limitations of the biomaterials used in current implantable medical devices. This study explores the biocompatibility of an innovative 5% calcium-to-zirconia (Ca-SZ) coating deposited by PVD on TA6V substrates for use in oral implantology. In order to determine the contribution of the Ca-SZ coating, an in vitro biocompatibility study was carried out to assess the potential influence of the Ca-SZ coating (1) on the viability and proliferation of saos-2 and HaCaT cells over a short-term exposure period of 96 h, (2) on the synthesis of pro-inflammatory cytokines, and (3) on the synthesis of osteogenic differentiation markers over a long-term exposure period of 21 days, in comparison with reference biomaterials. The sampling consisted of <i>n</i> = 3 biological replicates, and a <i>p</i>-value of <0.05 was used as the threshold for statistical significance. Viability and proliferation kinetics to WST-1 and CyQUANT NF, respectively, showed improved viability/proliferation of Ca-SZ exposed to both cell lines independently. The TNF-alpha and IL-6 assays revealed reduced levels of cytokines compared with the reference biomaterials, including the control groups. In parallel, in Saos-2 cells exposed to Ca-SZ for 21 days under osteogenic conditions increased expression of osteogenic markers, such as the synthesis of soluble collagens, alkaline phosphatase (ALP), osteopontin, and osteocalcin, reflecting dynamic and facilitated osteoblastic differentiation, which was supported by the formation of hydroxyapatite (HA) crystals observed by SEM micrograph and confirmed by EDS mapping. In conclusion, Ca-SZ demonstrates an overall better biocompatibility compared with reference biomaterials, linked to a bioactive interaction of calcium, promoting cell proliferation and differentiation for optimal osteointegration, underlining its potential as a relevant innovation for next-generation implants.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 6","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterial-Based and Surgical Approaches to Local Hemostasis in Contemporary Oral Surgery: A Narrative Review.","authors":"Atanaska Dinkova, Petko Petrov, Dobromira Shopova, Hristo Daskalov, Stanislava Harizanova","doi":"10.3390/jfb16050190","DOIUrl":"10.3390/jfb16050190","url":null,"abstract":"<p><p>Effective local hemostasis is essential in oral surgery to prevent complications such as delayed healing, infection, and the need for re-intervention. Postoperative bleeding occurs in 4-6% of cases, increasing to 9-12% in patients receiving anticoagulant or antiplatelet therapy. This review evaluates the efficacy, safety, and clinical utility of local hemostatic agents based on 51 studies published between 1990 and 2023. Traditional agents, such as oxidized cellulose and gelatin sponges, control bleeding in over 85% of standard cases but offer limited regenerative benefits. Autologous platelet concentrates (APCs), including platelet-rich plasma (PRP) and leukocyte- and platelet-rich fibrin (L-PRF), reduce bleeding time by 30-50% and enhance soft tissue healing. Studies show the PRP may reduce postoperative bleeding in dental surgery by 30-50%, and in orthopedic and cardiac surgery by 10-30%, particularly in patients on anticoagulants. Tranexamic Acid mouthwash can reduce postoperative bleeding by up to 50-60%. Fibrin sealants achieve a 70-90% reduction in bleeding among high-risk patients, while topical tranexamic acid decreases hemorrhagic events by up to 80% in anticoagulated individuals without increasing thromboembolic risk. However, comparative studies remain limited, particularly in medically compromised populations. Additional gaps persist regarding long-term outcomes, cost-effectiveness, and the standardized use of emerging agents such as nanomaterials. Future research should prioritize high-quality trials across diverse patient groups and develop clinical guidelines that integrate both safety and regenerative outcomes.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in Medical Biomaterials for Bone Infections.","authors":"Tianxu Lian, Yiwei Wang, Pengfei Zheng","doi":"10.3390/jfb16050189","DOIUrl":"10.3390/jfb16050189","url":null,"abstract":"<p><p>Bone infection is a debilitating condition characterized by inflammation of the bone and its marrow. It poses significant challenges in clinical practice due to its recalcitrant nature and difficulty in eradicating the infecting microorganisms. Recent advancements in the field of medical biomaterials have shown hope in the treatment of bone infections. This article reviews the research progress of medical biomaterials for anti-osteomyelitis in recent years, focusing on the mechanism of action, unique advantages, and application backgrounds of various materials. At the same time, we pay attention to the need for materials used in the treatment of osteomyelitis to promote bone healing.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12111946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}