Synthesis of ε-Fe_2-3N Particles for Magnetic Hyperthermia.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of Functional Biomaterials Pub Date : 2025-06-01 DOI:10.3390/jfb16060203

Soichiro Usuki, Tomoyuki Ogawa, Masaya Shimabukuro, Taishi Yokoi, Masakazu Kawashita

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Abstract

Little research has focused on using iron nitride as thermoseed particles in magnetic hyperthermia, although magnetite (Fe₃O₄) is commonly used for this purpose. In the present study, we focus on iron nitride, especially ε-Fe_2-3N. ε-Fe_2-3N particles were synthesized from hematite (α-Fe₂O₃) and sodium amide (NaNH₂) under various synthesis conditions, and the heat-generation properties of the particles were investigated to reveal the synthesis conditions that lead to particles with notable heat-generation performance. The particles synthesized at 250 °C for 12 h increased the temperature of an agar phantom by approximately 20 °C under an alternating magnetic field (100 kHz, 125 Oe, 600 s), suggesting that ε-Fe_2-3N particles can be used for magnetic hyperthermia. The analysis results for the particles synthesized under different conditions suggest that the heat-generation properties of ε-Fe_2-3N were affected by several factors, including the nitrogen content, particle size, crystallite size, saturation magnetization, and coercive force.

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磁热疗用ε-Fe2-3N粒子的合成

很少有研究集中在使用氮化铁作为热籽颗粒在磁热疗中，尽管磁铁矿（Fe3O4）通常用于此目的。本文主要研究氮化铁，特别是ε-Fe2-3N。以赤铁矿（α-Fe2O3）和酰胺钠（NaNH2）为原料，在不同的合成条件下合成了ε-Fe2-3N颗粒，并对颗粒的生热性能进行了研究，揭示了使颗粒具有显著生热性能的合成条件。在交变磁场（100 kHz, 125 Oe, 600 s）下，在250°C条件下合成的ε-Fe2-3N粒子使琼脂体体温度提高了约20°C，表明ε-Fe2-3N粒子可用于磁热疗。对不同条件下合成的颗粒的分析结果表明，ε-Fe2-3N的产热性能受氮含量、颗粒尺寸、晶粒尺寸、饱和磁化强度和矫顽力等因素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.