Journal of endodontics最新文献_第8页

The Effect of Different Chelating Agents in Different Application Times on the Release of Growth Factors from Dentin. 不同螯合剂在不同使用时间对牙本质生长因子释放的影响。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.006

Deniz Erdogan, Ali Erdemir, Ercan Tekin

{"title":"The Effect of Different Chelating Agents in Different Application Times on the Release of Growth Factors from Dentin.","authors":"Deniz Erdogan, Ali Erdemir, Ercan Tekin","doi":"10.1016/j.joen.2025.05.006","DOIUrl":"10.1016/j.joen.2025.05.006","url":null,"abstract":"Introduction: The purpose of this study was to evaluate the effect of ethylene diamine tetra acetic acid (EDTA), etidronic acid (HEBP), boric acid (BA), or saline at different application times on transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor-A, and insulin-like factor-1 (IGF-1) release levels from inner root dentin.Methods: Seventy-five root segments, obtained from extracted fully developed premolar human teeth, were standardized to 8 mm long and prepared with Gates Glidden burs number 1-4 for simulating an open apex. The samples were irrigated with 1.5% sodium hypochlorite and then divided into 4 main groups according to chelation agents (17% EDTA, 9% HEBP, 6% BA, or saline) and 3 subgroups according to application times. TGF-β1, vascular endothelial growth factor-A, and IGF-1 release levels were measured on the 1st and 7th days by enzyme-linked immunosorbent assay. The final concentrations were calculated based on the root canal volume measured by cone-beam computed tomography. Data were compared using a one-way analysis of variance, the Tukey test, Kruskal Wallis, and Wilcoxon test.Results: In all growth factors (GFs), the EDTA group had a statistically significantly higher release than the saline group (P < .001). Increasing EDTA application time did not affect statistically significant GFs release (P >.05). All GFs were released more on the 7th than the 1st day.Conclusions: The release levels of GFs vary according to the type of chelating agent and application time. BA in the release of IGF-1 and HEBP in the release of TGF-β1 were as effective as EDTA at all application times.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinician Perspective of Regenerative Endodontic Procedures for Immature Anterior Teeth: An Observational Web-based Study. 临床医生对未成熟前牙再生牙髓治疗的看法——一项基于网络的观察性研究。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.005

Alexander Brett, Federico Foschi, Shanon Patel

{"title":"Clinician Perspective of Regenerative Endodontic Procedures for Immature Anterior Teeth: An Observational Web-based Study.","authors":"Alexander Brett, Federico Foschi, Shanon Patel","doi":"10.1016/j.joen.2025.05.005","DOIUrl":"10.1016/j.joen.2025.05.005","url":null,"abstract":"Introduction: Regenerative endodontic procedures (REPs) are beneficial in preserving infected immature permanent teeth. The aim of this observational study was to assess treatment planning of REPs, geographical differences in their provision, clinical hesitancy and provision rate.Methods: Digitally manipulated radiographs showing varying degrees of root development in a maxillary central incisor with apical pathosis were used in an anonymized online questionnaire to assess clinical predisposition. The data were analyzed using descriptive statistics.Results: Among 160 participants (59.4% specialist endodontists), 73.1% favored REPs for the most immature apices, decreasing with root maturity. Specialist experience did not impact REP provision. UK endodontists performed REPs less frequently than international counterparts. Key perceived REP benefits included fracture resistance and root lengthening. Hesitancy stemmed from unfamiliarity (32.9%) and healing concerns (25.9%). Confidence varied and 25% had never performed a REP.Conclusion: REPs are generally appropriately treatment planned, although more education with regards to clinical suitability and case selection is suggested. Geographical variance in provision of REPs is apparent between the UK and non-UK endodontists. Hesitancy exists in the provision of REPs, and prevalence of provision is low.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of In Vivo Vertical Root Fracture in Endodontically Treated Teeth Using Machine Learning Techniques. 应用机器学习技术诊断根管治疗牙齿体内垂直根断裂。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.004

Shujun Ran, Qiang Wang, Jia Wang, Jing Huang, Wei Zhou, Pengfei Zhang, Keyong Yuan, Yushan Cheng, Shensheng Gu, Jingjing Zhu, Zhengwei Huang

{"title":"Diagnosis of In Vivo Vertical Root Fracture in Endodontically Treated Teeth Using Machine Learning Techniques.","authors":"Shujun Ran, Qiang Wang, Jia Wang, Jing Huang, Wei Zhou, Pengfei Zhang, Keyong Yuan, Yushan Cheng, Shensheng Gu, Jingjing Zhu, Zhengwei Huang","doi":"10.1016/j.joen.2025.05.004","DOIUrl":"10.1016/j.joen.2025.05.004","url":null,"abstract":"Introduction: This study aimed to diagnose vertical root fracture (VRF) of endodontically treated teeth using clinical features and bone loss information from cone beam computed tomography with machine learning models.Methods: A total of 887 patients with 941 teeth undergoing endodontic surgery were included in this retrospective study. The clinical factors and bone defects detected via cone beam computed tomography were measured and recorded. Linear machine learning models, logistic regression model and nonlinear models, including XGBoost, LightGBM, and CatBoost were used to diagnose VRF. Model performance was evaluated using 5-fold cross-validation and based on various performance parameters, including the area under the curve, sensitivity, specificity, precision, and F score. Model interpretations were visualized by Shapley Additive Explanations.Results: Of the 941 teeth, 112 VRF teeth (11.9%) were identified during endodontic surgery or after tooth extraction. XGBoost and LightGBM showed excellent performance with area under the curves of 0.98 [0.96, 0.99], specificity of 0.978 and 0.983, sensitivity of 0.883 and 0.803, and precision of 0.846 and 0.865, respectively. Shapley Additive Explanations values showed that lingual/buccal bone defect, the ratio of bone defect height above the root apex to the defect total height, width of bone defect and age were the top 5 contributors.Conclusions: Machine learning models for the diagnosis of VRF using age, sex, tooth type, the quality of root canal filling and bone loss position, height, width, and depth are valuable for clinical decision making after root canal treatment.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Systemic and Local Anti-tumor Necrosis Factor-α Receptor-1 Administration on Periapical Bone Loss in Mice. 全身和局部给药抗肿瘤坏死因子-α受体-1对小鼠根尖周骨丢失的影响。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.007

Luciano Aparecido de Almeida-Junior, Juliana de Lima Gonçalves, Maya Fernanda Manfrin Arnez, Nallery Steysi Rostrán Jimenez, Guido Artemio Marañón-Vasquez, Francisco Wanderley Garcia de Paula-Silva

{"title":"Effects of Systemic and Local Anti-tumor Necrosis Factor-α Receptor-1 Administration on Periapical Bone Loss in Mice.","authors":"Luciano Aparecido de Almeida-Junior, Juliana de Lima Gonçalves, Maya Fernanda Manfrin Arnez, Nallery Steysi Rostrán Jimenez, Guido Artemio Marañón-Vasquez, Francisco Wanderley Garcia de Paula-Silva","doi":"10.1016/j.joen.2025.05.007","DOIUrl":"10.1016/j.joen.2025.05.007","url":null,"abstract":"Introduction: The aim of this study was to evaluate whether systemic or topical administration of a monoclonal antibody against tumor necrosis factor-α receptor-1 (TNFR1) could control periapical bone loss in mice.Methods: Thirty C57Bl6 mice were used for induction of periapical lesion through the exposure of the root canals to the oral environment. The root canals remained open to microbial contamination from the oral cavity for 28 days. Then, the animals were randomly assigned to 3 different experimental groups: G1: animals received no medication and periapical lesion followed its natural course up to 42 days; G2: systemic administration of the TNFR1 antibody; G3: intracanal topical administration of the TNFR1 antibody. Healthy teeth were used as controls. At 42 days following periapical lesion induction, the animals were anesthetized then euthanized, and tissues containing bone and teeth were collected for microtomographic, histomorphometry, and quantitative reverse transcriptase polymerase chain reaction analysis. Then groups were compared using one-way analysis of variance followed by Turkey tests (α = 5%).Results: Systemic and topical anti-TNFR1 administered in groups G2 and G3 did not have an impact on the area and volume of periapical lesions when compared to the untreated control group G1 (P > .05). Lower expression of RANKL mRNA was observed in G3 compared to G1 (P < .05) but no change on OPG, MMP-9 or CTSK was detected (P > .05).Conclusions: Under the experimental conditions of this study, systemic or local administration of a TNFR1 antibody was not effective in limiting the expansion of periapical lesions.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomous Robot-Assisted Endodontic Microsurgery on First Molar in Complex Anatomical Scenarios: A Case Series. 在复杂解剖情况下自主机器人辅助第一磨牙根管显微手术：一个案例系列。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-09 DOI: 10.1016/j.joen.2025.04.017

Lishan Huang, Minting Wan, Xiaoxing Li, Siyu Li, Qingsong Wu, Chengji Gong, Yufei Li, Xuechao Yang

{"title":"Autonomous Robot-Assisted Endodontic Microsurgery on First Molar in Complex Anatomical Scenarios: A Case Series.","authors":"Lishan Huang, Minting Wan, Xiaoxing Li, Siyu Li, Qingsong Wu, Chengji Gong, Yufei Li, Xuechao Yang","doi":"10.1016/j.joen.2025.04.017","DOIUrl":"10.1016/j.joen.2025.04.017","url":null,"abstract":"Endodontic microsurgery (EMS) is an important approach for preserving teeth with failed root canal treatment. However, implementing minimally invasive osteotomies and accurate apicoectomies can be challenging in anatomically complex areas, especially posterior teeth close to critical structures. The introduction of autonomous robotic system into EMS represents a pioneering advancement aimed at enhancing digital endodontic surgery. Robot-assisted EMS (RA-EMS) integrates cone-beam computed tomography and intraoral optical scanning data to plan three-dimensional surgical paths, adopting infrared optical motion-tracking technology and robot autonomous drive, enabling precise apicoectomy. This report presents the successful application of RA-EMS in 4 complex molar cases, during which adjacent vital anatomical structures were preserved. Immediate radiographic examination revealed accurate root-end resections. All patients demonstrated satisfactory healing during the follow-up visits at 1-6 months, with periapical radiolucent area decreased in radiographic examination. RA-EMS is a safe and feasible clinical procedure that minimizes the risk of human error and mitigates technique sensitivity. Meanwhile, it provides a valuable alternative for assisting anatomically challenging EMS.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Type 2 Diabetes Mellitus on Apical Periodontitis Size, Endotoxin Levels, and Bacterial Load in Root Canals with Necrotic Pulp. 2型糖尿病对坏死牙髓根管内牙周炎大小、内毒素水平及细菌负荷的影响。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-09 DOI: 10.1016/j.joen.2025.05.003

Mirela Cesar Barros, Evelyn Giuliana Velasquez-Espedilla, Luciane Dias de Oliveira, Brenda Paula F A Gomes, Marco Antônio Hungaro Duarte, Carlos Antônio Negrato, Flaviana Bombarda Andrade

{"title":"Impact of Type 2 Diabetes Mellitus on Apical Periodontitis Size, Endotoxin Levels, and Bacterial Load in Root Canals with Necrotic Pulp.","authors":"Mirela Cesar Barros, Evelyn Giuliana Velasquez-Espedilla, Luciane Dias de Oliveira, Brenda Paula F A Gomes, Marco Antônio Hungaro Duarte, Carlos Antônio Negrato, Flaviana Bombarda Andrade","doi":"10.1016/j.joen.2025.05.003","DOIUrl":"10.1016/j.joen.2025.05.003","url":null,"abstract":"Introduction: This clinical study was conducted to describe the endodontic microbiological profile of teeth with apical periodontitis in patients with type 2 diabetes mellitus (T2DM), focusing on bacterial count and endotoxin levels found in primary infection, as well as the size of periapical lesions, determined by cone-beam computed tomography (CBCT) analysis.Methods: Thirty-four patients were selected and divided into 2 groups: 17 with T2DM and 17 nondiabetic controls. Anamnesis, clinical examinations, and radiographic evaluations were performed. Root canal samples were collected using sterile/pyrogen-free paper tips. Endotoxins were quantified using limulus amoebocyte lysate assay, and bacterial counts (colony forming units/mL) were determined using anaerobic culture techniques. The periapical status of the teeth was assessed using the CBCT periapical index. Data were analyzed using Pearson correlation, simple linear regression, t-tests, and Chi-square tests (P < .05).Results: A larger size of periapical lesions (CBCT periapical index ≥4) was observed in patients with T2DM (64.8%) compared to controls (17.7%) (P < .05). There was a significant increase in the number of bacteria by culture and endotoxin levels in diabetic patients. A positive correlation was found between elevated endotoxin levels and the diameter of periapical lesions (P < .05).Conclusions: This study supports the hypothesis that T2DM is associated with a greater microbial load and higher endotoxin levels, contributing to more severe periapical bone destruction, which may negatively affect endodontic treatment outcomes in these patients.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of Epstein-Barr Virus in Periapical Pathoses: A Systematic Review and Meta-Analysis. 爱泼斯坦-巴尔病毒在根尖周围疾病中的存在——一项系统综述和荟萃分析。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-09 DOI: 10.1016/j.joen.2025.05.002

Jagveer Yadav, Mala Kamboj, Gopikrishnan Vijayakumar, Anjali Narwal, Anju Devi, Adarsh Kumar, R Keerthika

{"title":"Presence of Epstein-Barr Virus in Periapical Pathoses: A Systematic Review and Meta-Analysis.","authors":"Jagveer Yadav, Mala Kamboj, Gopikrishnan Vijayakumar, Anjali Narwal, Anju Devi, Adarsh Kumar, R Keerthika","doi":"10.1016/j.joen.2025.05.002","DOIUrl":"10.1016/j.joen.2025.05.002","url":null,"abstract":"Background: Periapical lesions, often arising from polymicrobial infections, exhibit varied clinical manifestations. The role of herpes viruses, particularly Epstein-Barr virus (EBV), in the etiopathogenesis of these conditions remains underexplored despite evidence that suggests its involvement in inflammatory processes.Objective: This systematic review and meta-analysis aimed to evaluate the presence of EBV in periapical diseases and to assess its probable role in their etiopathogenesis.Material and methods: Literature searches were conducted across PubMed, Scopus, Web of Science, and Google Scholar until July 2024. Original research that examined the association of EBV in periapical diseases was included for review. The risk of bias for each study was assessed using the modified Newcastle-Ottawa scale and Review Manager 5.4 was used to generate the results.Results: A total of 31 studies were included for qualitative synthesis, with 15 contributing to quantitative analysis. Findings revealed higher EBV detection rates in periapical lesions, particularly in symptomatic cases and lesions with larger sizes. Meta-analysis using random effects models also affirmed that EBV-positive transcripts significantly enhanced the risk of periapical lesions and symptomatic cases.Conclusion: This review highlights a significant association between EBV and periapical lesions, particularly in symptomatic cases and larger lesions. The findings warrant further investigation into the mechanisms by which EBV contributes to the pathogenesis of periapical diseases and the implications for clinical management, including potential antiviral therapies.Prospero registration number: CRD4202344796.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An In Vitro Tube Model for Cell Biocompatibility Study of Capping Materials for Regenerative Endodontics. 再生牙髓学盖层材料细胞生物相容性的体外试管模型研究。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-09 DOI: 10.1016/j.joen.2025.04.018

Nela Pilbauerova, Divyamaanasa Dasi, Isaac J de Souza Araujo, George T-J Huang

{"title":"An In Vitro Tube Model for Cell Biocompatibility Study of Capping Materials for Regenerative Endodontics.","authors":"Nela Pilbauerova, Divyamaanasa Dasi, Isaac J de Souza Araujo, George T-J Huang","doi":"10.1016/j.joen.2025.04.018","DOIUrl":"10.1016/j.joen.2025.04.018","url":null,"abstract":"Introduction: Cell-based pulp regeneration utilizes capping materials underneath a final restoration to seal the tooth after delivering cells into the canal system. Studying the immediate biocompatibility of materials with injected cells has been challenging. This study aimed to utilize a tube model to observe cell response directly and conveniently to the capping materials in a cell culture in vitro system.Methods: A tapered plastic tube (14 mm in length, 2 mm diameter of the apex opening) to simulate root canal space was filled with fluorescence-labeled dental pulp cells mixed in fibrin gel and the larger end sealed with various capping materials including Mineral Trioxide Aggregate (MTA), Biodentine, hydroxyapatite-tricalcium phosphate (HA-TCP), composite, and glass ionomer. The tube was placed in wells of culture plates and incubated for various times in vitro and observed under the microscope for cell morphological changes. pH changes within the tube were monitored over time.Results: Both fresh MTA and Biodentine caused adverse response to the cells in the tube. Only a few normally growing cells were observed at the apical end. Composite or glass ionomer appeared better tolerated by cells. HA-TCP mixed in fibrin gel demonstrated the highest compatibility with cells; however, using HA-TCP to separate cells from fresh MTA or Biodentine did not reduce the negative effect of these 2 calcium silicate cements. The pH increased within the tube may explain the observed toxicity.Conclusions: Using HA-TCP mixed in fibrin gel as a capping material appears highly biocompatible to cells while fresh MTA and Biodentine are not.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Soffit Preservation on Root Stress Distribution in Mandibular Molars: A Finite Element Study. 柔度保存对下颌磨牙牙根应力分布影响的有限元研究

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-08 DOI: 10.1016/j.joen.2025.04.016

Marco A Versiani, Sungwook Kang, Hyeon-Cheol Kim, Mingoo Cho, Emmanuel J N L Silva, Felipe G Belladonna, Marco Simões-Carvalho, Maristela G H Carestiato, Gustavo De-Deus

{"title":"Influence of Soffit Preservation on Root Stress Distribution in Mandibular Molars: A Finite Element Study.","authors":"Marco A Versiani, Sungwook Kang, Hyeon-Cheol Kim, Mingoo Cho, Emmanuel J N L Silva, Felipe G Belladonna, Marco Simões-Carvalho, Maristela G H Carestiato, Gustavo De-Deus","doi":"10.1016/j.joen.2025.04.016","DOIUrl":"10.1016/j.joen.2025.04.016","url":null,"abstract":"Introduction: This study evaluated the influence of soffit preservation on stress distribution in roots of mandibular molars using finite element analysis.Methods: An extracted two-rooted mandibular molar was scanned by micro-computed tomography to create 3 models: an intact tooth, a contracted access cavity with partial soffit preservation, and a contracted access cavity without soffit. The models were integrated into a three-dimensional mandibular bone block including cortical and trabecular bone, periodontal ligament, and lamina dura. All regions were initially assumed to be fully tied together. Static loads were applied simulating normal vertical loading (250 N), maximum vertical loading (600 N and 800 N), and lateral loading (225 N). In the prepared models, root canals were digitally filled with gutta-percha and access cavities restored with composite resin. Stress distribution and von Mises stress were evaluated at the pericervical area, furcation region, middle third, and apical third of the roots.Results: Access cavity preparation altered stress distribution compared to the intact model, with peak von Mises stresses consistently located at the pericervical and furcation regions. Lateral loading produced lower stress values than vertical loading. No significant differences in stress magnitude or distribution were observed between models with and without soffit preservation. Under higher vertical loads, peak stresses occurred on the distal aspect of the distal root (pericervical level) and the distal aspect of the mesial root (middle third).Conclusions: Soffit preservation did not significantly influence stress distribution in mandibular molar roots under the conditions tested, suggesting that it may offer limited biomechanical benefit in reducing fracture risk following access cavity preparation.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Large Language Models in Addressing Patient Questions on Endodontic Pain: A Comparative Analysis of Accessible Chatbots. 评估大型语言模型在解决牙髓疼痛患者问题：可访问聊天机器人的比较分析。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-05 DOI: 10.1016/j.joen.2025.04.015

Sanaa Aljamani, Yazan Hassona, Hoda A Fansa, Hiba M Saadeh, Kifah Dafi Jamani

{"title":"Evaluating Large Language Models in Addressing Patient Questions on Endodontic Pain: A Comparative Analysis of Accessible Chatbots.","authors":"Sanaa Aljamani, Yazan Hassona, Hoda A Fansa, Hiba M Saadeh, Kifah Dafi Jamani","doi":"10.1016/j.joen.2025.04.015","DOIUrl":"10.1016/j.joen.2025.04.015","url":null,"abstract":"Introduction: Patients increasingly use large language models for health-related information, but their reliability and usefulness remain controversial. Continuous assessment is essential to evaluate their role in patient education. This study evaluates the performance of ChatGPT-3.5 and Gemini in answering patient inquiries about endodontic pain.Methods: A total of 62 frequently asked questions on endodontic pain were categorized into etiology, symptoms, management, and incidence. Responses from ChatGPT 3.5 and Gemini were assessed using standardized tools, including the Global Quality Score (GQS), Completeness, Lack of false information, Evidence supported, Appropriateness and Relevance reliability tool, and readability indices (Flesch-Kincaid and Simple Measure of Gobbledygook).Results: Compared to Gemini, ChatGPT 3.5 responses scored significantly higher in terms of overall quality (GQS: 4.67-4.9 vs 2.5-4, P < .001) and reliability (Completeness, Lack of false information, Evidence supported, Appropriateness and Relevance: 23.5-23.6 vs 19.35-22.7, P < .05). However, it required a higher reading level (Simple Measure of Gobbledygook: 14-17.6) compared to Gemini (8.7-11.3, P < .001). Gemini's responses were more readable (6th-7th grade level) but lacked depth and completeness.Conclusion: While ChatGPT 3.5 outperformed Gemini in quality and reliability, its complex language reduced accessibility. In contrast, Gemini's simpler language enhanced readability but sacrificed comprehensiveness. These findings highlight the need for professional oversight in integrating artificial intelligence-driven tools into healthcare communication to ensure accurate, accessible, and empathetic patient education.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0