Journal of endodontics最新文献

{"title":"Associate Registry","authors":"","doi":"10.1016/S0099-2399(25)00047-0","DOIUrl":"10.1016/S0099-2399(25)00047-0","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 222-253"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143327940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Markers in the Gingival Crevicular Fluid Associated with External Invasive Resorption: A Split-Mouth Cross-Sectional Study","authors":"Matthew Malek DDS,&nbsp;Laura Steff DDS,&nbsp;Nikita Vakil DDS,&nbsp;Rathimala Jothilingam DDS,&nbsp;Sunna Huh DDS,&nbsp;Tiffany Chien DDS,&nbsp;Rachel Halpern DDS,&nbsp;Nihan Gencerliler MPH ,&nbsp;Ozge Erdoğan DDS, DMSc ,&nbsp;Kamolthip Songtrakul DDS, MS","doi":"10.1016/j.joen.2024.11.013","DOIUrl":"10.1016/j.joen.2024.11.013","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to investigate the levels of interleukin-1 receptor antagonist (IL-1RA), receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG), interleukin-1β, osteopontin, and tissue necrotizing factor-α in teeth with external invasive resorption (EIR) in comparison to the contralateral healthy tooth of the same patient.</div></div><div><h3>Methods</h3><div>Twenty-nine patients with at least one tooth with EIR and a healthy tooth on the contralateral side (33 paired teeth) were included. Data on patient demographics and medical and dental history were collected. Gingival crevicular fluid was collected from the subject and control teeth. Clinical, radiographical, and cone-beam computed tomography examinations were performed. Wilcoxon signed-rank test was used to compare biomarker concentrations, RANKL/OPG, and IL-1RA/interleukin-1β ratios in the diseased and healthy teeth. Teeth pairs were grouped based on Heithersay and Patel's classification, and the differences in biomarker concentrations between diseased and healthy teeth were compared using a Kruskal–Wallis test.</div></div><div><h3>Results</h3><div>Teeth with EIR had significantly lower concentrations of IL-1RA and OPG compared to their respective healthy control teeth (<em>P</em> &lt; .05). The RANKL/OPG ratio in teeth with EIR was significantly higher than in their paired healthy teeth (<em>P</em> &lt; .05). A history of herpes zoster infection was associated with a higher IL-1RA concentration and RANKL/OPG ratio (<em>P</em> &lt; .05). Orthodontic treatment was significantly associated with lower OPG concentration (<em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>There is a significant association between EIR and specific biological markers. A history of orthodontic treatment and herpes zoster infection are significantly associated with altered levels of biomarkers in the gingival crevicular fluid.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 150-156.e1"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for Authors","authors":"","doi":"10.1016/S0099-2399(25)00021-4","DOIUrl":"10.1016/S0099-2399(25)00021-4","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages A9-A11, A14-A16"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143327801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of pH on the Piezoelectric Properties of Dentin in Root Canal Treated Teeth: Implications for Dental Materials and Oral Health","authors":"Mohammad Ali Saghiri BS, MS, DEng, PhD ,&nbsp;Mina Shekarian DDS ,&nbsp;Fatereh Samadi DDS ,&nbsp;David S. Briss DMD, FRCD(C) ,&nbsp;Salvatore Napoli DDS, MD, FACS ,&nbsp;Michael Conte DMD, MPH","doi":"10.1016/j.joen.2024.11.001","DOIUrl":"10.1016/j.joen.2024.11.001","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to evaluate the impact of pH on the dentin piezoelectric response in root canal treated teeth.</div></div><div><h3>Materials and Methods</h3><div>Thirty extracted mandibular canines were selected by simple random sampling and based on specific inclusion criteria. The middle third of each root was cut into cubic specimens of approximately 2 mm × 2 mm x 4 mm. The prepared samples were soaked in 17% EDTA and 1% sodium hypochlorite for 1 minute. The sections were rinsed in distilled water, dried immediately, and then randomly allocated into 3 groups of 10 each. Samples in each group were soaked in one of 3 solutions with pH 4.4, 7.4, or 10.4 for 5 min. A compression load was applied by a universal mechanical testing machine. The 8000-8-SM scanner detected the potential generated.</div></div><div><h3>Results</h3><div>No significant differences were observed among the groups when the force was applied vertical to the dentinal tubules (<em>P</em> &gt; .05). However, all subgroups indicated significant differences when the force was applied along the dentinal tubules (<em>P</em> &lt; .05). When the force was applied along to the tubules, the mean dentin piezoelectricity was higher in the alkaline, neutral, and acidic groups, respectively.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that the piezoelectric properties of dentin in root canal treated teeth can be influenced by variations in pH, depending on the direction of force applied to the dentinal tubules.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 195-199"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Relationships Between Circulating Interleukins and Pulp and Periapical Diseases: A Bidirectional Mendelian Randomization Study","authors":"Yuqiang Wang DDS, MSc,&nbsp;Jiakang Zhu DDS, MSc, PhD,&nbsp;Yueli Zhou DDS, MSc, PhD,&nbsp;Ying Tang DDS, MSc, PhD,&nbsp;Cui Huang DDS, MSc, PhD","doi":"10.1016/j.joen.2024.11.010","DOIUrl":"10.1016/j.joen.2024.11.010","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to comprehensively evaluate the links of genetic predisposition among 13 common circulating interleukins (ILs) and endodontic diseases by using a 2-sample Mendelian randomization method.</div></div><div><h3>Methods</h3><div>Single nucleotide polymorphisms were chosen as instrumental variables from summary data of genome-wide association studies (GWASs), using the inverse-variance–weighted method as the primary analysis. In addition, a variety of sensitivity analyses was conducted to evaluate the resilience of the primary outcomes and identify any inherent pleiotropic effects.</div></div><div><h3>Results</h3><div>After multiple comparison corrections, 4 circulating ILs were genetically predicted to significantly play a role in endodontic diseases. Among these, circulating IL-17 (odds ratio [OR]_IVW, 1.33; 95% confidence interval [CI], 1.15–1.54; <em>P</em> &lt; 3.85 × 10⁻³) were significantly identified as potential risk-increasing factors toward pulp and periapical diseases, and circulating IL-16 (OR_IVW, 0.89; 95% CI, 0.83 to 0.94; <em>P</em> &lt; 3.85 × 10⁻³) may exert protective effects on the development of periapical abscess. In the reverse analyses, null significantly association was found between genetic liability to endodontics disorders and the corresponding circulating inflammatory biomarkers. Overall, sensitivity analyses were consistent with the estimates direction of primary analyses results, supporting the reliability of findings.</div></div><div><h3>Conclusions</h3><div>Given the unavoidable limitations presented in this study, our findings provided significant evidence to support the identification of elevated IL-16 levels as a potential risk-mitigating factor, whereas elevated IL-17 levels exhibit potentially deleterious effects on endodontic disorders. Future validation is warranted to examine the conclusions of our study and to evaluate the potential application of these circulating ILs as lifestyle or pharmacological targets for oral health care.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 132-139"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Links between Nosocomial Endodontic Infections and Bacteremia Associated with Apical Periodontitis and Endodontic Treatment","authors":"Abdulaziz Bakhsh BDS, MclinDent, MEndo RCSEd, PhD ,&nbsp;David Moyes BSc, MSc, PhD ,&nbsp;Francesco Mannocci MD, DDS, PhD ,&nbsp;Gordon Proctor BSc, PhD ,&nbsp;Sadia Niazi BDS, MSc, PhD, MEndo (RCSEd, RCS End)","doi":"10.1016/j.joen.2024.11.009","DOIUrl":"10.1016/j.joen.2024.11.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Nosocomial endodontic infections can cause treatment failure and are potential risk of bacteremia. This study is aimed to investigate bacteremia associated with apical periodontitis and immediate postendodontic treatment using next-generation sequencing. The study will also elucidate if the endodontic nosocomial pathogens are present in the blood microbiome.</div></div><div><h3>Methods</h3><div>Saliva, blood, and intracanal samples were collected from patients undergoing endodontic treatment (<em>n</em> = 65), while gloves samples were collected from the operator. Bacterial DNA was extracted and the targeted 16S ribosomal ribonucleic acid gene was sequenced using the Illumina Miseq 300 platform for the V1-V2 hypervariable region. The alpha and beta diversities were carried out using the <em>phyloseq</em> package (version-1.36.0) in R (version-4.1). Differences in abundance and diversity were calculated using Mann-Whitney test. Linear discriminant analysis Effect Size was used to compare the biological relevance between different sample sources.</div></div><div><h3>Results</h3><div>The phyla <em>firmicutes, actinobacteria, proteobacteria,</em> and <em>bacteroidetes</em> were identified from all sample sources. In blood and glove samples, <em>Cutibacterium</em> genus was highly abundant (14.6%, 17.7%, respectively), while in intracanal samples, <em>Enterococcus</em> took precedence (18.2%). Saliva samples exhibited <em>Prevotella</em> as the most abundant genera (17.9%). Common genera were present between intracanal and postoperative blood samples. Circos graph showed that all the phyla identified from a patient were consistently present in all the samples investigated from the same patient.</div></div><div><h3>Conclusions</h3><div>Nosocomial endodontic pathogens being predominant in both; gloves and blood samples, along with common genera present in all sample sources, suggests a potential pathway of transfer of pathogens from saliva to gloves, intracanal, and blood, thus providing evidence of nosocomial endodontic bacteremia.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 140-149"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locating a Calcified Root Canal with Robotic Assistance: A Case Report.","authors":"Xiaoxiang Huang, Lisha Mao, Benxiang Hou","doi":"10.1016/j.joen.2025.01.019","DOIUrl":"https://doi.org/10.1016/j.joen.2025.01.019","url":null,"abstract":"<p><strong>Introduction: </strong>Precise, minimally invasive, and efficient endodontic treatment of calcified root canals is challenging. Robot-assisted treatment has been applied in the field of implantology and has demonstrated excellent accuracy. This case report presents the methods and steps for locating a calcified root canal using robotic assistance.</p><p><strong>Methods: </strong>A 49-year-old female patient was diagnosed with symptomatic apical periodontitis and pulp necrosis with pulp canal obliteration in the left maxillary central incisor. Using patient data, we entered a digital model into the preoperative planning software to acquire an operation path design. The robotic system utilized spatial alignment techniques for registration, guiding the robotic arm to autonomously and precisely obtain access to the calcified root canal, based on the path design. After rigorous infection control and root canal filling, the patient's symptoms disappeared.</p><p><strong>Results: </strong>With the robotic assistance, the calcified root canal was accurately and efficiently located in a minimally invasive manner, and the patient experienced symptom relief and functional recovery.</p><p><strong>Conclusions: </strong>The findings reported from this case support robotic assistance as a promising technique for locating calcified root canals.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Endodontic Treatment Feasibility for Cracked Teeth Using Quantitative Light-Induced Fluorescence: A Retrospective Clinical Study.","authors":"Soyeon Yang, Mi-Jeong Jeon, Baek-Il Kim, Su-Jung Shin, Jeong-Won Park","doi":"10.1016/j.joen.2025.01.013","DOIUrl":"10.1016/j.joen.2025.01.013","url":null,"abstract":"<p><strong>Introduction: </strong>Cracked teeth present diagnostic and treatment challenges due to their complex etiology and uncertain prognoses. This study evaluated the potential of quantitative light-induced fluorescence (QLF) technology for diagnosing cracked teeth and its utility in predicting the need for root canal treatment (RCT).</p><p><strong>Methods: </strong>A total of 207 cracked teeth from 149 patients diagnosed between April 2019 and April 2023 were analyzed. QLF parameters (ΔF, ΔFmax, ΔR, ΔRmax) were measured using a Qraypen C device and analyzed with specialized software. Clinical characteristics, including age, sex, symptoms, tooth number, restoration type, pulp vitality, and crack direction, were recorded. The patients were monitored until August 2023, with an average follow-up of 19.1 months. Statistical analyses included t tests, analysis of variance, correlation analysis, and logistic regression analyses.</p><p><strong>Results: </strong>Of the 207 cracked teeth, 44 (21.3%) underwent RCT and 4 (1.9%) were extracted during the follow-up period. The QLF parameters differed significantly between teeth receiving restorative treatment and those requiring RCT (P < .0001). Cracked teeth with ΔF <-10, ΔFmax <-30, ΔR >15, or ΔRmax >30 had approximately 60% probability of undergoing RCT (P < .05). Logistic regression analysis confirmed that all QLF parameters correlated with RCT probability (P < .0001).</p><p><strong>Conclusions: </strong>This study demonstrated the utility of QLF technology in diagnosing cracked teeth and aiding treatment decision-making. The results suggest that careful monitoring, based on clinical evidence, is necessary before definitive restoration, particularly for cracked teeth with QLF parameters that exceed certain thresholds. Further studies with standardized protocols are required to validate the clinical application of QLF.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Intra-canal Medicaments on Infrared Light Energy Transmission Through Enamel and Dentin During Photobiomodulation: An In Vitro Study.","authors":"Sachin Kulkarni, Laurence J Walsh, Yash Bhurani, Roy George","doi":"10.1016/j.joen.2025.01.014","DOIUrl":"10.1016/j.joen.2025.01.014","url":null,"abstract":"<p><strong>Introduction: </strong>This in vitro study assessed how shade changes induced by endodontic medicaments affect the transmission of single and multiples wavelengths of infrared light through enamel and dentin.</p><p><strong>Methods: </strong>Eighteen extracted single-rooted permanent teeth were prepared, removing all extrinsic staining, and cementum. Tooth slices were treated for 4 weeks with UltraCal XS, Ledermix, or were untreated controls. Light transmission through enamel-dentin and dentin regions was assessed using diode lasers (660, 808, 904 nm) and a multi-wavelength light-emitting diode (LED) light source (700-1100 nm). Absorption studies were performed to evaluate light absorption by components of medicaments.</p><p><strong>Results: </strong>Samples treated with Ledermix showed the greatest shade change, with a corresponding reduction in visible and near infrared light transmission (P < .001) in dentin, whereas UltraCal XS had a milder effect (P < .01). Across different substrates, the greatest light transmission was seen for the multi-wavelength LED light source, followed by 904 nm, 808 nm, and finally 660 nm. Spectrophotometric studies revealed light absorption by turbid and saturated calcium hydroxide solutions.</p><p><strong>Conclusions: </strong>This study shows that medicaments may influence transmission of visible red and near infrared light. Photobiomodulation protocols used in regenerative endodontics should take this effect into account, by incorporating longer near infrared wavelengths (up to 1100 nm) and using multi-wavelength light sources to account for this absorption.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Persistent Post-Endodontic Pain With a Standardized Gabapentin Pyramid Protocol: A Case Series and Clinical Guidelines.","authors":"Zakery James, Biraj Patel, Jianing He, Kenneth M Hargreaves, Nikita B Ruparel","doi":"10.1016/j.joen.2025.01.007","DOIUrl":"10.1016/j.joen.2025.01.007","url":null,"abstract":"<p><strong>Introduction: </strong>Persistent postendodontic pain following endodontic therapy is a rare but substantial clinical challenge. Mechanisms that mediate peripheral neuropathy and/or central sensitization likely play a pivotal role in its development and chronification. The objective of this case series is to describe a management plan for persistent postendodontic pain and provide prescription guidelines using a standardized \"Gabapentin Pyramid Protocol\" for clinical practice.</p><p><strong>Methods: </strong>Four cases of persistent postendodontic pain are presented. A peripheral etiology for pain was eliminated in all 4 cases. All patients were also refractory to conventional analgesics. Patients received the \"Gabapentin Pyramid Protocol.\"</p><p><strong>Results: </strong>Three of the 4 cases experienced complete resolution of symptoms within the prescribed treatment period. In 1 case, symptoms were greatly reduced but recurred upon discontinuation of the drug.</p><p><strong>Conclusions: </strong>The \"Gabapentin Pyramid Protocol\" represents an effective treatment option for persistent postendodontic pain, demonstrating significant symptom relief and potential for complete resolution.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}