Journal of endodontics最新文献

{"title":"Adherence to Registration and Selective Outcome Reporting in Randomized Clinical Trials Published in Endodontic Journals Over the Past 5 Years: A Meta-Research Study.","authors":"Filipe Colombo Vitali, Pablo Silveira Santos, Aurélio de Oliveira Rocha, Lucianne Cople Maia, Lucas da Fonseca Roberti Garcia, Cleonice da Silveira Teixeira","doi":"10.1016/j.joen.2024.12.001","DOIUrl":"10.1016/j.joen.2024.12.001","url":null,"abstract":"<p><strong>Introduction: </strong>Prospective registration of randomized clinical trials (RCTs) is highly recommended to ensure research transparency and prevent selective outcome reporting (SOR). This study aimed to evaluate the adherence to registration and the presence of SOR in RCTs published in endodontic journals over the past 5 years.</p><p><strong>Methods: </strong>Electronic searches were conducted in PubMed and the libraries of the Journal of Endodontics, International Endodontic Journal, European Endodontic Journal, and Australian Endodontic Journal. Two reviewers were involved in the study selection and evaluation. Publications were assessed for key methodological aspects, including the presence and timing of trial registration. RCT registries were examined to identify discrepancies between publication and registered protocols and the presence of SOR. Logistic regression was used to explore the effect of study variables on registration practices and SOR.</p><p><strong>Results: </strong>Of the 144 RCTs included, 104 (72.2%) were registered. Among those registered, only 19 (18.3%) adhered to prospective registration. Registration practice increased by 53% per year (OR 1.53; 95% CI: 1.34-2.08; P < .01). Discrepancies between publication and protocol were identified in 55.8% of studies, primarily related to sample size (33.7%). SOR was identified in 41 trials (39.4%), mainly due to discrepancies in the outcome time frame (18.3%). Studies evaluating multiple outcomes had 4.95 times higher odds of exhibiting SOR (OR 4.95; 95% CI: 1.63-12.95; P < .01). Furthermore, studies that were registered retrospectively or exhibited discrepancies between publication and protocol accounted for 6.10 times (OR 6.10; 95% CI: 1.81-18.96; P = .03) and 5.61 times (OR 5.61; 95% CI: 2.93-16.58; P < .01) higher odds of exhibiting SOR, respectively.</p><p><strong>Conclusions: </strong>RCTs published in endodontic journals over the past 5 years presented low adherence to prospective trial registration and a high prevalence of SOR.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Pulpal Mineralization in Mandibular Anteriors: A Micro-computed Tomography Analysis","authors":"Georgina Marshall BDS, BScD(Hons) ,&nbsp;Konstantinos Verdelis DDS, PhD ,&nbsp;Ove A. Peters DMD, MS, PhD","doi":"10.1016/j.joen.2024.09.010","DOIUrl":"10.1016/j.joen.2024.09.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Current understanding of the morphology of pulpal mineralizations is limited. Understanding the specific location and type of such mineralizations will aid clinicians in diagnosis, case complexity assessment, and treatment planning. Therefore, this study correlated the appearance of a reduced canal volume (CV) in conventional radiographs with the presence of pulp mineralizations (PMs) utilizing micro-computed tomography (CT) analysis. The morphology of PMs utilizing micro-CT technology was also analyzed.</div></div><div><h3>Methods</h3><div>One hundred and twenty-one extracted permanent mandibular incisors were collected. Periapical radiographs were taken of the teeth to determine if a reduced canal space was present, in which case the sample was included for micro-CT assessment. Various descriptors for PM were then determined and these labels were then applied to the entire sample to demonstrate PM. Numerical analysis was undertaken for all teeth scanned; the following data was extracted: the presence or absence of PMs, types of PM, and their morphological structures; CVs were determined. Cohen's kappa test was used to assess intraexaminer agreement.</div></div><div><h3>Results</h3><div>Based on radiographic appearance, forty-two teeth were included for micro-CT analysis. PMs were demonstrable in 57% and absent 43% of teeth. When PMs were absent, the CV was significantly smaller compared to when they were present (<em>P</em> &lt; .05). Discrete mineralizations were more frequently located in the coronal and middle thirds compared to diffuse mineralization (<em>P</em> &lt; .01). No differences in the prevalence of the individual features of discrete or diffuse mineralizations were detected (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>Two detectable forms of PMs were found in micro-CT analysis at all levels of the canal: discrete and diffuse mineralizations. A reduced CV on a PA was reflective of mineralized changes within the pulp but the type of PM could not be determined. PMs occurred at any level of the root canal; clinicians need to be aware of this when performing root canal treatment.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1734-1742"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of Variable Taper Files and Corresponding Gutta-Percha Cones Amongst Manufacturers","authors":"Aaron M. Keith DDS, MS ,&nbsp;Susan E. Hinman DDS, MS ,&nbsp;Noel E. Dickens DMD, PhD, MPhil, MPH ,&nbsp;Jeffrey J. Kim DDS, PhD ,&nbsp;Rodney V. Scott DDS, MS ,&nbsp;Nancy H. Osborne DDS, MS","doi":"10.1016/j.joen.2024.10.002","DOIUrl":"10.1016/j.joen.2024.10.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Currently there is no standardization of variable taper endodontic files and corresponding gutta-percha (GP) cones. The aim of this study was to evaluate intramanufacturer and intermanufacturer variability of diameter and taper in the apical third of GP master cones and finishing files from 3 commercially available variable taper endodontic systems.</div></div><div><h3>Methods</h3><div>Diameter measurements were recorded using digital microscopy at 1-mm increments (D1-D4) for F2 files and corresponding GP cones (<em>n</em> = 20 per system) from ProTaper Gold (Dentsply Tulsa Dental Specialties, Johnson City, TN), EdgeTaper Platinum (EdgeEndo, Albuquerque, NM), and ExactTaper H (SS White, Lakewood, NJ). Taper was defined as the rate of change in diameter per 1-mm increment. Mean differences in diameter were assessed using repeated measures of analysis of variance for D1 to D4 and the Wilks test for differences in taper.</div></div><div><h3>Results</h3><div>In the apical third, ProTaper and EdgeEndo mean file diameters were significantly smaller than corresponding GP cone diameters (<em>P</em> &lt; .01, <em>P</em> &lt; .01, respectively). Contrastingly, SS White file diameters were significantly larger than their corresponding GP cones (<em>P</em> = .02). Files from all manufacturers had significantly smaller diameters than advertised (nominal) values (<em>P</em> &lt; .01). ProTaper GP cones had similar diameters to nominal values (<em>P</em> = .30), while EdgeEndo and SS White GP cones were significantly smaller (<em>P</em> &lt; .01). Amongst files and corresponding GP cones from all systems, taper was nonstandardized.</div></div><div><h3>Conclusions</h3><div>Size discrepancies between finishing files and corresponding GP cones can be expected amongst variable taper endodontic systems. Therefore, clinicians should be prepared to make intraoperative adjustments when obturating.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1766-1771"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Implants on the Periapical Health of Natural Adjacent Teeth: A Systematic Review and Meta-Analysis","authors":"Mohammad A. Sabeti DDS, MA,&nbsp;Heather Kim DDS","doi":"10.1016/j.joen.2024.06.015","DOIUrl":"10.1016/j.joen.2024.06.015","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this systematic review was to evaluate the pooled estimate and relative risk of periapical lesions in natural teeth adjacent to implants.</div></div><div><h3>Methods</h3><div>MEDLINE (PubMed), Embase, Cochrane Library, and gray literature were searched (inception-November 2023) to identify studies. Eligible studies were selected and data extracted. Studies were critically assessed for risk of bias and quality of evidence. Quantitative analysis was performed to determine the pooled estimate of periapical radiolucent lesions (PARLs) in teeth adjacent to implants and to assess the relative risk of developing such lesions in these teeth compared to teeth adjacent to nonimplants.</div></div><div><h3>Results</h3><div>A total of 6 studies were included. The pooled estimate of PARL in implant adjacent teeth was 2.55%. The risk ratio for PARL in a tooth adjacent to an implant in comparison to a tooth adjacent to a nonimplant was 2.12. Analyses presented low certainty of evidence.</div></div><div><h3>Conclusions</h3><div>A natural tooth adjacent to an implant has 2.12 times higher probability of developing a PARL compared to a tooth adjacent to a nonimplant. The overall quality of evidence was low.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1705-1713"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Silk Fibroin Methacrylated Scaffolds for Regenerative Endodontics","authors":"Ramyasaketha Narayanam BDS ,&nbsp;Lais M. Cardoso DDS, MS, PhD ,&nbsp;Alexandre H. dos Reis-Prado DDS, MS ,&nbsp;Ana Beatriz G. de Carvalho DDS, MS, PhD ,&nbsp;Caroline Anselmi DDS, MS ,&nbsp;Abdel H. Mahmoud BDS, MS ,&nbsp;J. Christopher Fenno PhD ,&nbsp;Renan Dal-Fabbro DDS, MS, PhD ,&nbsp;Marco C. Bottino DDS, MSc, PhD","doi":"10.1016/j.joen.2024.08.004","DOIUrl":"10.1016/j.joen.2024.08.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Recognizing the necessity of novel disinfection strategies for improved bacterial control to ultimately favor tissue regeneration, this study developed and characterized antibiotics-laden silk fibroin methacrylated (SilkMA) scaffolds for regenerative endodontics.</div></div><div><h3>Methods</h3><div>SilkMA-based solutions (10% w/v) containing Clindamycin (CLI) or Tinidazole (TIN) (0 – control; 5, 10, or 15% w/w) or the combination of both drugs (BiMix CLI/TIN 10%) were electrospun and photocrosslinked. Morphology and composition were assessed using scanning electron microscopy and Fourier-transform infrared spectroscopy. Additionally, swelling and degradation profiles were also determined. Cytotoxicity was evaluated in stem cells from apical papilla. Antibacterial efficacy was tested using direct and indirect contact assays against <em>Aggregatibacter actinomycetemcomitans</em>/<em>Aa</em>, <em>Actinomyces naeslundii</em>/<em>An</em>, <em>Enterococcus faecalis</em>/<em>Ef,</em> and <em>Fusobacterium nucleatum</em>/<em>Fn</em>. <em>E. faecalis</em> biofilm inhibition on dentin discs was specifically evaluated for BiMix-laden scaffolds. Data were statistically analyzed with a significance level of 5%.</div></div><div><h3>Results</h3><div>Scanning electron microscopy revealed that all scaffolds had similar characteristics, including fiber morphology and bead absence. Fourier-transform infrared spectroscopy showed the incorporation of CLI and TIN into the fibers and in BiMix scaffolds. Antibiotic-laden scaffolds exhibited lower swelling capacity than the control and were degraded entirely after 45 days. Scaffolds laden with CLI, TIN, or BiMix throughout all time points did not reduce stem cells from apical papilla's viability. CLI-laden scaffolds inhibited the growth of <em>Aa</em>, <em>An</em>, and <em>Ef</em>, while TIN-laden scaffolds inhibited <em>Fn</em> growth. BiMix-laden scaffolds significantly inhibited <em>Aa</em>, <em>An</em>, <em>Ef</em>, and <em>Fn</em> in direct contact, and their aliquots inhibited <em>An</em> and <em>Fn</em> through indirect contact, with additional biofilm inhibition against <em>Ef</em>.</div></div><div><h3>Conclusions</h3><div>BiMix-laden SilkMA scaffolds are cytocompatible and exhibit antimicrobial effects against endodontic pathogens, indicating their therapeutic potential as a drug delivery system for regenerative endodontics.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1752-1760.e2"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associate Registry","authors":"","doi":"10.1016/S0099-2399(24)00644-7","DOIUrl":"10.1016/S0099-2399(24)00644-7","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1784-1793"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PAINe: An Artificial Intelligence–based Virtual Assistant to Aid in the Differentiation of Pain of Odontogenic versus Temporomandibular Origin","authors":"Bianca Marques de Mattos de Araujo MDS, PhD ,&nbsp;Pedro Felipe de Jesus Freitas DDS ,&nbsp;Angela Graciela Deliga Schroder MDS, PhD ,&nbsp;Erika Calvano Küchler MDS, PhD ,&nbsp;Flares Baratto-Filho MDS, PhD ,&nbsp;Vania Portela Ditzel Westphalen MDS, PhD ,&nbsp;Everdan Carneiro MDS, PhD ,&nbsp;Ulisses Xavier da Silva-Neto MDS, PhD ,&nbsp;Cristiano Miranda de Araujo MDS, PhD","doi":"10.1016/j.joen.2024.09.008","DOIUrl":"10.1016/j.joen.2024.09.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Pain associated with temporomandibular dysfunction (TMD) is often confused with odontogenic pain, which is a challenge in endodontic diagnosis. Validated screening questionnaires can aid in the identification and differentiation of the source of pain. Therefore, this study aimed to develop a virtual assistant based on artificial intelligence using natural language processing techniques to automate the initial screening of patients with tooth pain.</div></div><div><h3>Methods</h3><div>The PAINe chatbot was developed in Python (Python Software Foundation, Beaverton, OR) language using the PyCharm (JetBrains, Prague, Czech Republic) environment and the openai library to integrate the ChatGPT 4 API (OpenAI, San Francisco, CA) and the Streamlit library (Snowflake Inc, San Francisco, CA) for interface construction. The validated TMD Pain Screener questionnaire and 1 question regarding the current pain intensity were integrated into the chatbot to perform the differential diagnosis of TMD in patients with tooth pain. The accuracy of the responses was evaluated in 50 random scenarios to compare the chatbot with the validated questionnaire. The kappa coefficient was calculated to assess the agreement level between the chatbot responses and the validated questionnaire.</div></div><div><h3>Results</h3><div>The chatbot achieved an accuracy rate of 86% and a substantial level of agreement (κ = 0.70). Most responses were clear and provided adequate information about the diagnosis.</div></div><div><h3>Conclusions</h3><div>The implementation of a virtual assistant using natural language processing based on large language models for initial differential diagnosis screening of patients with tooth pain demonstrated substantial agreement between validated questionnaires and the chatbot. This approach emerges as a practical and efficient option for screening these patients.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1761-1765.e2"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into the December 2024 Issue of the Journal of Endodontics","authors":"Anita Aminoshariae DDS, MS,&nbsp;Amir Azarpazhooh DDS, MSc, PhD, FRCD(C),&nbsp;Ashraf F. Fouad DDS, MS,&nbsp;Gerald N. Glickman DDS, MS, MBA, JD,&nbsp;Jianing He DMD, PhD,&nbsp;Sahng G. Kim DDS, MS,&nbsp;Anil Kishen BDS, MDS, PhD,&nbsp;Ariadne M. Letra DDS, MS, PhD,&nbsp;Linda Levin DDS, PhD,&nbsp;Frank C. Setzer DMD, PhD, MS,&nbsp;Franklin R. Tay BDSc(Hons), PhD,&nbsp;Kenneth M. Hargreaves DDS, PhD","doi":"10.1016/j.joen.2024.12.004","DOIUrl":"10.1016/j.joen.2024.12.004","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1695-1697"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Calcium Hydroxide as an Intracanal Medication on Dentine Fracture Resistance: A Systematic Review and Network Meta-Analysis","authors":"Chayanit Sunlakawit DDS ,&nbsp;Chitpol Chaimanakarn DDS, MSc ,&nbsp;Natchalee Srimaneekarn DDS, MSc, PhD ,&nbsp;Sittichoke Osiri DDS, MSc","doi":"10.1016/j.joen.2024.08.005","DOIUrl":"10.1016/j.joen.2024.08.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Bacterial infections necessitate effective root canal disinfection during endodontic therapy. Calcium hydroxide (CH), a widely used intracanal medication, shows conflicting effects on dentine fracture resistance in different studies. This study aimed to perform a comprehensive systematic review and network meta-analysis to evaluate the effects of CH on the fracture resistance of dentine in human teeth across different periods.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, MEDLINE (EBSCO), Cochrane Library, Scopus, Google Scholar, and ProQuest databases were exhaustively searched to identify studies published until February 29, 2024, with no language restrictions. Laboratory studies that investigated dentine fracture resistance in human permanent teeth following intracanal CH exposure were included. The risk of bias was evaluated using modified criteria derived from previous studies. Network meta-analysis was performed using the frequentist method. Prespecified subgroup analyses focused on simulating immature teeth.</div></div><div><h3>Results</h3><div>The search yielded 2,265 studies from all databases, and 27 met the inclusion criteria, involving 3,879 teeth or roots. The overall results from network meta-analysis indicated that CH affected the fracture resistance of human dentine. Subgroup analysis revealed that the duration influencing fracture resistance was ≥4 weeks for mature teeth, but no specific time limitation for immature teeth. The overall quality of the evidence showed a moderate to high risk of bias.</div></div><div><h3>Conclusions</h3><div>Short-term use of CH does not compromise human root dentine strength, supporting its routine application in clinical practice. CH remains a viable treatment strategy for over 4 weeks of medication needs but requires carefully considering the associated risks and benefits emphasizing on preservation and disease resolution.</div></div><div><h3><strong>Registration</strong></h3><div>PROSPERO database (CRD 42024513199).</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1714-1724.e6"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinician/Patient-Reported Outcomes and Their Association After Root Canal Treatment","authors":"Jasmine Wong MDS ,&nbsp;Angeline Hui Cheng Lee MDS ,&nbsp;Gary Shun Pan Cheung MDS, PhD ,&nbsp;Colman McGrath BDentSci, PhD ,&nbsp;Prasanna Neelakantan MDS, PhD","doi":"10.1016/j.joen.2024.09.009","DOIUrl":"10.1016/j.joen.2024.09.009","url":null,"abstract":"<div><h3>Introduction</h3><div>The relationship between clinician-reported outcome measures (CROM) and patient-reported outcome measures (PROM) after root canal treatment is poorly understood. Oral health–related quality of life (OHRQOL) is a crucial PROM. Determination of the minimal important difference (MID) is critical for determining patients’ perspective of treatment effectiveness, but the MID required to perceive any meaningful change in the OHRQOL after root canal treatment remains unclear. The aim of this prospective study was to investigate the relationship between the clinical outcome and OHRQOL after root canal treatment and to determine the corresponding MID values.</div></div><div><h3>Methods</h3><div>Patients (<em>N</em> = 64) requiring primary nonsurgical root canal treatment were recruited. Clinical and radiographic (cone-beam computed tomography) assessment of treatment outcomes was performed at the 12-month follow-up. OHRQOL and pain were evaluated preoperatively and at the 12-month follow-up using the Oral Health Impact Profile-14 and visual analog scale, respectively. <em>P</em> &lt; .05 was considered statistically significant. MID was assessed using distribution- and anchor-based approaches.</div></div><div><h3>Results</h3><div>The final analysis included 47 patients. The clinical outcome was favorable for 92.6% of teeth. OHRQOL and pain showed significant improvement after treatment (<em>P</em> &lt; .001). No significant association was found between clinical outcome and OHRQOL (<em>P</em> &gt; .05). The mean Oral Health Impact Profile-14 score change (ie, 13.6) was greater than the range of MID values determined.</div></div><div><h3>Conclusions</h3><div>Root canal treatment significantly improves OHRQOL. Improvement in the OHRQOL score was greater than the MID values determined, implying a clinically significant change. However, PROM (OHRQOL) does not appear to be correlated with CROM.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1725-1733"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}