Journal of endodontics最新文献

{"title":"Apical Extrusion of Bacteria during Canal Preparation: A Systematic Review of Laboratory Studies.","authors":"Thamyres M Monteiro, Warley O Silva, Jeferson O Marques, Ana Carolina S P Guerra, Flávio R F Alves","doi":"10.1016/j.joen.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.joen.2025.04.009","url":null,"abstract":"<p><strong>Introduction: </strong>Apical extrusion of bacteria is an unintended event that occurs during the chemical-mechanical preparation of infected root canals. Flare-ups and the spread of infection to periradicular tissues are possible consequences. This systematic review aimed to determine which type of engine-driven nickel-titanium systems, reciprocating or rotary, promote greater bacterial extrusion. Studies that compared manual and engine-driven systems or different brands of rotary instruments were also analyzed as a secondary objective.</p><p><strong>Methods: </strong>Searches were performed in PubMed, Embase, Web of Science, Scopus, and ProQuest up to April 2024. Ex vivo studies that quantified the apical extrusion of bacteria comparing different instrumentation systems were included. The studies were critically assessed using a customized checklist.</p><p><strong>Results: </strong>Of the 4938 articles initially retrieved, 38 were selected for full-text reading and 35 were included in this review. Thirteen studies compared rotary and reciprocating instruments, 11 compared manual and engine-driven systems, and 11 compared different rotary instruments. Among the 13 studies comparing rotary and reciprocating systems, 5 reported greater bacterial extrusion with the rotary systems, 5 found no significant differences, and 3 reported mixed results. The available evidence indicates a similar or greater apical extrusion of bacteria with rotary systems compared to reciprocating instruments. Additionally, manual preparation is associated with significantly greater bacterial extrusion than the 2 engine-driven methods. The results varied across studies primarily due to methodological differences, particularly the instrumentation systems employed.</p><p><strong>Conclusion: </strong>Rotary systems extrude similar or greater quantities of bacteria than reciprocating systems. Conversely, manual instrumentation promotes greater bacterial extrusion than the 2 engine-driven methods.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly(amidoamine) Dendrimers as Potential Therapeutic Agents for Conservative Treatment of Irreversible Pulpitis.","authors":"Lintong Yu, Feng Yang, Chenxi Li, Jing Ruan, Jun Wang","doi":"10.1016/j.joen.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.joen.2025.04.007","url":null,"abstract":"<p><strong>Introduction: </strong>Although cell-free DNA (cfDNA) is involved in several inflammation-related diseases, its role in pulp inflammation remains unclear. The aims of this study were to explore the role of cfDNA in the development of irreversible pulpitis and to identify a potential therapeutic strategy.</p><p><strong>Methods: </strong>Pulpitis plasma samples were collected from patients diagnosed with irreversible pulpitis, and the cfDNA concentration associated with pulpitis was measured using a Quant-iT PicoGreen dsDNA kit. Dental pulp stem cells and Tohoku Hospital Pediatrics -1 macrophages were stimulated with pulpitis plasma, and the expression of inflammatory factors was investigated via real-time reverse transcription PCR and ELISA. Toll-like receptor 9 expression in pulpitis blood-derived cells was analyzed by flow cytometry. Finally, the effects of cationic poly(amidoamine) (PAMAM) on the treatment of inflammation in vitro and in a rat pulpitis model were evaluated.</p><p><strong>Results: </strong>We first revealed that pulpitis-derived plasma had elevated cfDNA levels, which caused M1-like macrophage polarization through the toll-like receptor 9 signaling pathway and then induced an inflammatory response in dental pulp stem cells. M1-like macrophage polarization affected the pulp inflammatory microenvironment and could be reversed via a synergistic effect of irrigation and cationic PAMAM for cfDNA scavenging. PAMAM has shown potential for inhibiting inflammatory M1-like macrophage polarization and alleviating pulpitis at the cellular and organism levels.</p><p><strong>Conclusions: </strong>This study elucidated the importance of cfDNA in pulpitis and provides a potential therapeutic strategy. cfDNA scavenging could alleviate the inflammatory response in pulpitis and potentially preserve more vital pulp for teeth with irreversible pulpitis.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Repeated Use on Cyclic and Torsional Fatigue of 3 Rotary Files: Implications for Clinical Safety.","authors":"Raimundo Sales de Oliveira Neto, Rafael da Rocha Tavares Duarte, Marco Antonio Hungaro Duarte, Guilherme Ferreira da Silva, Murilo Priori Alcalde, Leonardo Rigoldi Bonjardim","doi":"10.1016/j.joen.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.joen.2025.04.008","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare the cyclic and torsional fatigue of S2, Logic, and Flat File NiTi files, new and after repeated use by an undergraduate student.</p><p><strong>Methods: </strong>Ninety (n = 90) artificial mandibular molars were prepared using S2, Logic, and Flat File systems. For each system, 10 new instruments were tested mechanically, and the other 10 were tested after preparing three prototyped molars with curved mesial roots (60°). Cyclic fatigue tests were conducted in a custom device simulating a curved canal (60° curvature angle, 5 mm radius), while torsional strength tests followed ISO 3630-1 (1992) standards. Data were analyzed by analysis of variance and Tukey's tests (P = .05).</p><p><strong>Results: </strong>Among the new #25-diameter instruments, Logic exhibited the highest number of cycles to fracture, while Flat File had the lowest (P < .05). For the used #25-diameter instruments, Logic and S2 demonstrated superior performance than Flat File regarding cycles to fracture (P < .05). The used Flat File #25-diameter instruments demonstrated a significant decrease in cycles to fracture after repeated use, and the lowest maximum torque until fracture (P < .05). All #25-diameter instruments showed a significant increase in angular deflection after repeated use (P < .05). For the #35-diameter instruments, S2 and Logic outperformed Flat File (P < .05).</p><p><strong>Conclusions: </strong>The Logic #35-diameter instruments displayed higher maximum torque and angular deflection than the new instruments, with only Logic showing significant reductions in angular deflection after use (P < .05). The repeated use negatively affected the mechanical properties of the endodontic instruments with #25 and #35 diameters, particularly the Flat File and Logic instruments.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dentinal Surface Roughness after Apicoectomy Improves Cell Attachment.","authors":"Luiza Salles Alves Berti Pereira, Leandro Augusto Pinto Pereira, Gabriela Fernanda Bombarda, Ana Cristina Padilha Janini, May Anny Alves Fraga, Américo Bortolazzo Correr, Flávia Medeiros Saavedra, Lauter Eston Pelepenko, Marina Angélica Marciano","doi":"10.1016/j.joen.2025.04.005","DOIUrl":"10.1016/j.joen.2025.04.005","url":null,"abstract":"<p><strong>Introduction: </strong>Apicoectomy is an endodontic surgery useful to treat persistent apical periodontitis in case of nonsurgical treatment failure. The aim of this study was to compare dentinal roughness following apicoectomies using different instruments, and cellular attachment viability over these surfaces.</p><p><strong>Methods: </strong>Sixty-four single-rooted human extracted teeth were selected, endodontically treated, and apicectomies performed. High-speed carbide burs: Zekrya (Dentsply), ultrasonic tips Blade Sonic (Helse) or OT12 (Mectron) were used. Time required for resection, the root-end surface roughness and viability of the attached cells (ATCC PCS-201-018) were analyzed. As control, high speed burs cut samples were obtained and polished using a multiblade burs sequence. Results were analyzed statistically using ANOVA or Kruskal-Wallis tests at the significance level of 5%.</p><p><strong>Results: </strong>OT12 was the fastest and Blade Sonic the slowest to perform the apicoectomies (P < .05). Regardless of the cut time, both ultrasonic instruments resulted in higher surface roughness. Cell attachment was observed on all specimens and the human primary gingival fibroblasts attachment demonstrated a time-dependent increase where the best results were obtained by the ultrasonic instruments.</p><p><strong>Conclusions: </strong>A rougher dentinal surface improved the cell attachment. OT12 tips showed a favorable cell attachment with the fastest apicoectomy. Although the cutting time has presented statistical differences between conditions, none could negatively impact the total time of a microsurgery. Future clinical studies can investigate dentinal surfaces correlating it with repair, following apicoectomy.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reinforcing Effect of Intraradicular Filling Materials in Simulated Immature Mandibular Premolars with Mineral Trioxide Aggregate Apical Barrier: A Weibull Analysis.","authors":"Ploy Opacharoensuk, Danuchit Banomyong, Kanet Chotvorrarak, Pimchanok Suphanarongpun, Sittichoke Osiri","doi":"10.1016/j.joen.2025.04.003","DOIUrl":"10.1016/j.joen.2025.04.003","url":null,"abstract":"<p><strong>Introduction: </strong>Incomplete root formation following pulp necrosis requires mineral trioxide aggregate (MTA) apexification. Although effective, this treatment does not increase the root thickness, necessitating additional reinforcement. This study aimed to evaluate the fracture resistance of simulated immature mandibular premolars apexified with MTA and reinforced with various materials using Weibull analysis.</p><p><strong>Methods: </strong>Ninety human mandibular first premolars were prepared to simulate immature teeth. After MTA apexification, teeth were divided into six groups: negative control (intact teeth), positive control (untreated apexified teeth), gutta-percha (GP) with AH Plus, GP with Bioceramic sealer, core, and fiber post/core. The teeth underwent thermocycling, periodontal ligament simulation, and fracture testing.</p><p><strong>Results: </strong>Negative and positive controls exhibited the highest and lowest fracture resistance, respectively. Core and fiber post/core had hazard ratios of 4.79 and 6.23, respectively, outperforming GP with AH Plus and GP with Bioceramic sealer (hazard ratios: 14.23 and 17.22, respectively). Most fractures occurred in the coronal third.</p><p><strong>Conclusions: </strong>Intraradicular reinforcement materials (fiber post/core and core) provided greater support to MTA-apexified roots than conventional root filling materials (GP/AH Plus and GP/Bioceramic sealer).</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asiaticoside-Loaded Nanosponges Hydrogel Has an Anti-inflammatory Effect and Promotes Human Dental Pulp Regeneration.","authors":"Zar Chi Soe, Daneeya Na Nan, Rahman Wahyudi, Vorasit Vongsutilers, Paksinee Kamolratanakul, Vincent Everts, Thanaphum Osathanon, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus","doi":"10.1016/j.joen.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.joen.2025.04.004","url":null,"abstract":"<p><strong>Introduction: </strong>Asiaticoside (AS) demonstrated potential in wound healing and anti-inflammation. However, its therapeutic applications are limited due to poor solubility and low bioavailability, which make it difficult to use as dental pulp capping agent. The nanosponges (Ns) are nanosized carriers capable of carrying small drug molecules. We proposed a method to encapsulate AS in Ns (asiaticoside-loaded nanosponges) and incorporate it into hydrogel (asiaticoside-loaded nanosponges hydrogel [AS/Ns-gel]).</p><p><strong>Methods: </strong>Using different concentrations of polymer and carbopol four different fractions of asiaticoside-loaded nanosponges (N1-N4) and AS/Ns-gel (G1-G4) were prepared. The optimal fraction was determined by characterizing physiochemical properties and in vitro release kinetics. An in vitro model of inflammatory human dental pulp cells (hDPCs) was induced using a cytokine cocktail and/or lipopolysaccharide prior to application of AS/Ns-gel. Messenger ribonucleic acid (mRNA) and protein expression of inflammatory cytokines were measured. To assess the wound healing potential of AS/Ns-gel, an in vitro scratch test was performed.</p><p><strong>Results: </strong>N1/G3 AS/Ns-gel exhibited the most optimized and uniform particle size distribution, with good solubility, sustained AS release, and effective encapsulation. In an in vitro study of hDPCs pretreated with lipopolysaccharide or cytokine cocktail, the AS/Ns-gel downregulated interleukin 6 and interleukin 8 mRNA expression while upregulating interleukin 10 expression. Reverse transcription quantitative polymerase chain reaction and western blot analysis revealed a time-dependent increase in transforming growth factor β1, collagen type 1 and matrix metalloproteinase 9 mRNA/protein levels. Additionally, AS/Ns-gel accelerated hDPCs migration.</p><p><strong>Conclusions: </strong>We successfully developed an AS/Ns-gel that reduced the expression of inflammatory cytokines in an inflamed pulp model in vitro. AS-loaded hydrogels have sustained release properties, promote cell proliferation and cell migration, thus suggesting its potential to be used in regenerative endodontic therapy.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mystifying Role of Mast Cells in the Pathogenesis of Periapical Pathologies - a Systematic Review.","authors":"Mala Kamboj, Shashibala Malik, R Keerthika, Anjali Narwal, Anju Devi, Gopikrishnan Vijayakumar, Adarsh Kumar","doi":"10.1016/j.joen.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.joen.2025.04.001","url":null,"abstract":"<p><strong>Introduction: </strong>Oral periapical lesions present a significant global health burden, with their pathogenesis shrouded in complexity due to multifaceted mechanisms. Despite extensive research, the precise role of mast cells in their pathogenesis remains elusive. The present systematic review aimed to elucidate the mechanism of mast cells in the immunopathology of periapical lesions.</p><p><strong>Methods: </strong>An extensive literature search conducted across databases (MEDLINE via PubMed, Scopus, Cochrane Library, and EMBASE and gray literature) of original research articles that examined the role of mast cells in periapical lesions were investigated and selected for review. The risk of bias for each study was meticulously assessed using the QUADAS-2, and Review Manager 5.4 (RevMan v5.4, The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) was utilized to generate the results.</p><p><strong>Results: </strong>A total of 41 published articles were included for data synthesis. The findings revealed significant variations in mast cell number within the fibrous capsule of periapical granuloma and periapical cyst, with notably elevated counts in the latter. Periapical granuloma manifested a predominance of granulated mast cells in the subepithelial region. In contrast, the periapical cyst exhibited a preponderance of degranulated mast cells in the deeper areas of the capsule.</p><p><strong>Conclusions: </strong>The current evidence substantiates that mast cells play a crucial role in the pathogenesis, progression, fibrosis, and chronicity of periapical lesions.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Pain and Periapical Healing after Endodontic Treatment Using Pachymic Acid-Modified Epoxy Resin Root Canal Sealer: A Double-Blind Randomized Controlled Trial.","authors":"Shiza Yezdani, Monisha Khatri, Sampath Vidhya, Sekar Mahalaxmi, Srinivasan Narasimhan","doi":"10.1016/j.joen.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.joen.2025.04.002","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the effect of adding pachymic acid (PAC) to an epoxy resin root canal sealer (AH Plus) on the postoperative pain and periapical (PA) healing in teeth with necrotic pulp and apical periodontitis.</p><p><strong>Methods: </strong>Fifty single-rooted teeth with necrotic pulp and apical periodontitis were randomly assigned to two groups according to the sealer (n = 25), AH Plus (AHP) and AHP modified with PAC (AHP/PAC). Endodontic treatment was conducted in 2 visits, with calcium hydroxide as an intracanal medicament. Pain scores were recorded using visual analog scale at baseline, 24 hours and 7 days postoperatively. PA healing was evaluated by measuring lesion size at baseline and postoperatively at 3, 6, 9, and 12 months using digital radiograph. Cone-beam computed tomography (CBCT) was used to assess PA lesion volume and PA volume index score at baseline and 1-year follow-up. Statistical analysis was done using Mann-Whitney U test.</p><p><strong>Results: </strong>Postoperative pain in AHP/PAC was significantly lower than AHP at 24 hours (P = .03), with no pain in either group at day 7. PA lesion size at 3-month follow-up showed no significant difference (P = .10) between the groups, but a significant reduction was seen in AHP/PAC at 6-, 9-, and 12-months (P < .001). A significant reduction in lesion volume and PA volume index score score were also seen in AHP/PAC at 1-year follow-up (P < .001).</p><p><strong>Conclusions: </strong>The addition of PAC to AHP decreased the immediate postoperative pain and improved the long-term healing of PA lesions, with a marked reduction in lesion size from 6-month onward.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical and Biological Properties of Biodentine XP, Endosequence RRM, and Bio-C Repair Cements.","authors":"Danilo Cassiano Ferraz, Juliana Garuba Rahhal, Maria Eduarda Paz Dotto, Lais Alberti Ferreira, Carla Renata Sipert, Ariadne Letra, Renato Menezes Silva, Letícia Chaves de Souza","doi":"10.1016/j.joen.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.joen.2025.03.009","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the physicochemical and biological properties of calcium silicate-based cements used in vital pulp therapy (VPT).</p><p><strong>Methods: </strong>Setting time, solubility, and pH of Biodentine XP (BD-XP), Bio-C Repair (BC), and Endosequence RRM Fast Set Putty (ES) were evaluated following ISO guidelines. Human dental pulp stem cells were challenged with lipoteichoic acid and then exposed to the cement's eluates. Cell viability was evaluated with XTT assay and messenger RNA (mRNA) expression analysis of relevant genes using quantitative reverse-transcript polymerase chain reaction. Statistical significance levels were set at 5%.</p><p><strong>Results: </strong>The initial and final setting time of BD-XP was shorter than BC (P ≤ .0005), and ES and BC (P ≤ .0001), respectively. BD-XP and ES showed significantly lower solubility levels in comparison to BC (P ≤ .05). All materials were alkaline for up to 7 days and exhibited significantly higher cell viability than the positive control (P ≤ .0001). RANKL mRNA expression was higher at 6 hours in the ES and BD-XP groups when compared to BC, however it decreased to low levels at 24h. ES and BD-XP groups exhibited a significant upregulation of COL1A1 mRNA expression. ALP expression was significantly higher in all tested groups, with the BD-XP group exhibiting the highest levels. BC and BD-XP groups had significantly increased RUNX2 expression after 24 hours.</p><p><strong>Conclusion: </strong>BD-XP, ES, and BC appear suitable materials for VPT, despite higher solubility. The gene expression pattern may suggest a potential pathway for pulp healing.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Core Outcome Set in Endodontics (COS-ENDO): Part 2 – COS-ENDO for Studies of Nonsurgical Root Canal Treatment and Retreatment in Permanent Teeth","authors":"Maryam Zanjir DDS, MSc ,&nbsp;Elaine Cardoso DDS, MSc, MBA ,&nbsp;Nicola L. Harman BSc, MSc, PhD ,&nbsp;Ava Khansari BScH ,&nbsp;Hamid Jafarzadeh DDS, MSc ,&nbsp;Gevik Malkhassian DDS, MSc, FRCP(C) ,&nbsp;Mike Sabeti DDS, MA ,&nbsp;Anita Aminoshariae DDS, MA ,&nbsp;Anil Kishen BDS, MDS, PhD ,&nbsp;Joanna E.M. Sale MSc, PhD ,&nbsp;Prakesh S. Shah MSc, MBBS, MD, DCH, MRCP, FRCP(C) ,&nbsp;Amir Azarpazhooh DDS, MSc, PhD, FRCP(C)","doi":"10.1016/j.joen.2025.01.010","DOIUrl":"10.1016/j.joen.2025.01.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Methodological heterogeneity and reporting bias complicate interpreting endodontic outcomes. Supported by the American Association of Endodontists and its Foundation, this study developed the Core Outcome Set in Endodontics (COS-ENDO) to standardize reporting for studies of Nonsurgical Root Canal Treatment/Retreatment, Surgical Endodontics, Vital Pulp Therapy, Apexification, and Regenerative Endodontics. This article, Part 2 of a 5-part series, focuses on COS-ENDO for Nonsurgical Root Canal Treatment/Retreatment, while other parts address the remaining treatments.</div></div><div><h3>Methods</h3><div>Outcomes were identified through scoping reviews, a qualitative study with patients, and a web-based survey of American Association of Endodontists practicing members. In a 2-round Delphi survey, clinicians, patients, and researchers rated outcomes on a 9-point scale. Ratings were assessed against consensus criteria, and a virtual meeting finalized COS-ENDO.</div></div><div><h3>Results</h3><div>Of the 97 invited participants to Round 1, 77 registered, and 73 (24 Academicians/Researchers, 26 Clinicians, and 23 Patients (or their parents/caregivers)) assessed 39 outcomes, with 18 excluded. The remaining outcomes—7 achieving consensus for inclusion and 14 lacking consensus—advanced to Round 2 for re-rating by 70 participants. This resulted in 9 outcomes achieving consensus for inclusion, and 12 lacking consensus. In the final meeting, 16 participants finalized the COS-ENDO for Nonsurgical Root Canal Treatment/Retreatment, including Tooth survival, Pain, Signs of infection, Radiographic evidence of periradicular healing, Success, Functional tooth, Need for further intervention, and Adverse events/Complications.</div></div><div><h3>Conclusions</h3><div>COS-ENDO is an important step in standardizing outcome reporting in endodontics, ensuring consistent reporting and enhancing research utility. Further efforts are needed to establish optimal measurement methods.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 4","pages":"Pages 412-426"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}