Journal of endodontics最新文献

{"title":"Anatomical Configuration of the MB2 Canal Using High-Resolution Cone-Beam Computed Tomography.","authors":"Luciana Magrin Blank-Gonçalves, Emmanuel João Nogueira Leal da Silva, Monikelly do Carmo Chagas Nascimento, Ana Grasiela Limoeiro, Luiz Roberto Coutinho Manhães-Jr","doi":"10.1016/j.joen.2025.01.006","DOIUrl":"10.1016/j.joen.2025.01.006","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the anatomical configuration of the mesiobuccal (MB) root of the maxillary first molar and to assess the prevalence of the second mesiobuccal canal (MB2).</p><p><strong>Methods: </strong>A total of 307 high-resolution cone-beam computed tomography images of maxillary molars were analyzed. These images were classified based on the anatomical configuration and prevalence of the MB2 canal. An experienced evaluator examined the images by dynamically navigating through the entire tomographic volume, making necessary adjustments to the MB root in the axial, sagittal, and coronal planes along the canal trajectory. The anatomical configurations were classified according to Vertucci's classification.</p><p><strong>Results: </strong>Overall, the prevalence of the MB2 canal within the sample was 90%. The most common anatomical configuration of the MB root was type IV (35%), followed by type VI (25%). MB roots with a single foramen were observed in 24% of the specimens, while 77% exhibited 2 foramina. No statistically significant differences were found between genders regarding prevalence and anatomical classifications (P < .05).</p><p><strong>Conclusions: </strong>The MB2 canal is highly prevalent, with the most common anatomical configuration being Vertucci's type IV, followed by type VI.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping Ability of XP-Endo Shaper Files With Extended Use Time and R40 Blue in Oval Canals: A Microcomputed Tomography Study in Contralateral Premolars.","authors":"Leonardo Pinto Fontes, Flávia Galvão Cândido, Marília Fagury Videira Marceliano-Alves, Evaldo de Aguiar Braga, Raissa Faria Andrade, Morgana Figueiredo Gonçalves, Élida Boaventura Mendes, Marcos Roberto Dos Santos Frozoni","doi":"10.1016/j.joen.2025.01.003","DOIUrl":"10.1016/j.joen.2025.01.003","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the shaping ability of the single-file XP-endo Shaper (XP-S) system, employing an extended working time, and the Reciproc Blue number 40/.06 (REC) instrument during the preparation of oval-shaped canals.</p><p><strong>Methods: </strong>Eleven pairs of contralateral premolars with a single canal were divided into two groups (n = 11) according to the canal preparation protocol: XP-S (with an additional 45 seconds of instrumentation) and REC. Microcomputed tomography images captured before and after preparation were analyzed to assess morphometric measurements (prepared volume/area and unprepared canal walls at 10 mm and 4 mm from the foramen), centroid deviation (at 10 mm), dentin thickness with mesial or distal deviation, and canal-to-root ratio (at 1, 5, and 10 mm from the foramen).</p><p><strong>Results: </strong>In both groups, root canal preparation significantly altered all tested parameters across all evaluated cross-sections (P_Intra ≤ 0.003). No significant differences were observed between the groups in canal centralization, volume or surface area increase at 10 mm or 4 mm, nor in the number of unprepared canal walls at 10 mm. However, the REC system showed a greater reduction in unprepared walls in the critical apical zone (P_Inter = 0.047). The XP-S group exhibited greater reductions in mesial (P_Inter = 0.007) and distal (P_Inter = 0.028) dentin thickness at 1 mm from the foramen.</p><p><strong>Conclusions: </strong>The REC instrument prepared more root canal walls than the XP-S system and promoted greater dentin preservation in the apical zone.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Endodontic Treatment through the Labial/Buccal Cervical Approach - Protocol and Case Series.","authors":"Xinfeng Wang, Jin Zhang, Jiaying Wang, Jing Zhang, Ping Luo, Bingchang Xin","doi":"10.1016/j.joen.2025.01.005","DOIUrl":"10.1016/j.joen.2025.01.005","url":null,"abstract":"<p><strong>Introduction: </strong>Traditional access cavity preparation involves removing the roof of the pulp chamber and smoothing the dentin bulges at the root canal orifice, thereby creating straight-line access. However, this may damage more healthy dental tissue and reduce the tooth's fracture resistance. This case series presents a novel minimally invasive endodontic protocol for 1 maxillary canine and 4 mandibular premolars, which required root canal therapy, due to labial/buccal cervical decay that caused pulpitis or periapical periodontitis.</p><p><strong>Methods: </strong>Our treatment protocol includes the following steps: preoperative assessment, removing decay in the labial/buccal cervical region, preparing an endodontic access cavity utilizing the affected region, establishing a working-length reference line using resin, cleansing the pulp horn with ultrasonic retro-preparation tip, root canal preparation, disinfection, obturation through the labial/buccal cervical access, and final resin restoration.</p><p><strong>Results: </strong>Ideal root canal obturation outcomes were achieved in all cases, while avoiding the abrasion of tooth tissue at the pulp chamber roof, caused by traditional endodontic access cavity methods.</p><p><strong>Conclusions: </strong>Minimally invasive endodontic treatment through the labial/buccal cervical approach offers clinicians new insights and options for endodontic access design.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of 4 Artificial Intelligence Chatbots in Answering Endodontic Questions.","authors":"Saleem Abdulrab, Hisham Abada, Mohammed Mashyakhy, Nawras Mostafa, Hatem Alhadainy, Esam Halboub","doi":"10.1016/j.joen.2025.01.002","DOIUrl":"10.1016/j.joen.2025.01.002","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence models have shown potential as educational tools in healthcare, such as answering exam questions. This study aimed to assess the performance of 4 prominent chatbots: ChatGPT-4o, MedGebra GPT-4o, Meta LIama 3, and Gemini Advanced in answering multiple-choice questions (MCQs) in endodontics.</p><p><strong>Methods: </strong>The study utilized 100 MCQs, each with 4 potential answers. These MCQs were obtained from 2 well-known endodontic textbooks. The performance of the above chatbots regarding choosing the correct answers was assessed twice with a 1-week interval.</p><p><strong>Results: </strong>The stability of the performance in the 2 rounds was highest for ChatGPT-4o, followed by Gemini Advanced and Meta Llama 3. MedGebra GPT-4o provided the highest percentage of true answers in the first round (93%) followed by ChatGPT-4o in the second round (90%). Meta Llama 3 provided the lowest percentages in the first (73%) and second rounds (75%). Although the performance of MedGebra GPT-4o was the best in the first round, it was less stable upon the second round (McNemar P > .05; Kappa = 0.725, P < .001).</p><p><strong>Conclusions: </strong>ChatGPT-4o and MedGebra GPT-4o answered a high fraction of endodontic MCQs, while Meta LIama 3 and Gemini Advanced showed lower performance. Further training and development are required to improve their accuracy and reliability in endodontics.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cold and Electric Pulp Tests for Assessing the Success of Inferior Alveolar Nerve Block for Mandibular First Molars Diagnosed with Symptomatic Irreversible Pulpitis","authors":"Farzaneh Afkhami DDS, MSc ,&nbsp;Sholeh Ghabraei DDS, MSc ,&nbsp;Nasim Hashemi DDS, MSc ,&nbsp;Ove A. Peters DMD, MS, PhD","doi":"10.1016/j.joen.2024.10.013","DOIUrl":"10.1016/j.joen.2024.10.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Fear of dentistry, often due to past painful experiences, is a significant barrier preventing patients from visiting dentists. Achieving effective pain control, especially during root canal treatments, is crucial. However, inferior alveolar nerve blocks (IANBs) have a low success rate, influenced by factors such as anxiety, anatomical variations, and technique limitations, leading to anesthesia failure. Although numerous studies have examined the cold test and electric pulp test (EPT) in assessing the success of local anesthesia, no standardized method has been established. This study evaluated the effectiveness of EPT and cold tests in assessing the depth of anesthesia in patients with symptomatic irreversible pulpitis in the mandibular first molar teeth.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted on 50 patients with symptomatic irreversible pulpitis who met the inclusion criteria and exhibited lip numbness. Following the administration of the IANBs and confirmation of lip numbness, cold tests and EPT were performed on all patients. Subsequently, the preparation of the access cavity (gold standard test) was initiated, and patients' responses during cavity preparation were recorded as either “presence of pain or discomfort” or “absence of pain or discomfort,” indicating IANB failure and success, respectively. Sensitivity (SN), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), positive and negative likelihood ratios, and accuracy (AC) with 95% confidence intervals were calculated for each test separately as well as for sequential testing.</div></div><div><h3>Results</h3><div>IANB failure was determined in 56% of the patients. A comparative analysis of diagnostic tests (cold test and EPT) showed no significant difference in SN, NPV, and AC; however, the cold test had higher SP, PPV, and positive likelihood ratio. Combining cold test and EPT evaluations improved SN, NPV, PPV, and negative likelihood ratio, but SP and AC were similar to EPT alone. No correlation was found between IANB success and patient age, sex, or initial pain.</div></div><div><h3>Conclusions</h3><div>Despite evidence of lip numbness, a significant number of IANBs failed in cases of painful pulpitis. A positive result from the cold test strongly indicated anesthesia failure. The findings of the current study suggested that when the cold test yielded a negative result, further evaluation with EPT was necessary to confirm anesthetic success and ensure complete pain control.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 28-34"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone-Beam Computed Tomographic Scan–based Assessment of the Correlation between the Location of Caries and Pulp Canal Obliteration: An Aid to Treatment Planning","authors":"Ganesh R. Jadhav MDS ,&nbsp;Priya Mittal MDS","doi":"10.1016/j.joen.2024.10.005","DOIUrl":"10.1016/j.joen.2024.10.005","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to determine the correlation between proximal caries and the extent and site of pulp canal obliteration (PCO) in cone-beam computed tomographic (CBCT) scans of mandibular molar teeth.</div></div><div><h3>Methods</h3><div>A total of 1491 CBCT scans of patients 18–49 years of age were selected from the database (2002–2022). From them, 328 teeth with proximal caries and satisfying inclusion criteria were evaluated by 2 calibrated evaluators. PCO was observed in the sagittal and coronal planes. PCO and proximal caries were compared concerning different age groups, sexes, and sites using an independent sample <em>t</em> test.</div></div><div><h3>Results</h3><div>The prevalence of PCO among patients with proximal caries is 47%. In mesial proximal caries, the extent of PCO is significantly greater in the distal root canal (73.4%), whereas in distal proximal caries, PCO is more often found in the mesial canal (77.3%). The mean extent of intraradicular calcification was higher in the distal canal (<em>P</em> &lt; .001). Moreover, mesial proximal caries showed a greater extent of intraradicular obliteration (<em>P</em> &lt; .001). The probability of developing PCO was significantly higher in females (<em>P</em> = .003).</div></div><div><h3>Conclusions</h3><div>Within the limitations of this study, it can be concluded that the extent of calcification is more common on the opposite side of the location of the proximal caries. Moreover, such intraradicular calcification is greater in a distal canal compared to a mesial canal. Sex plays a significant role in the calcification process, showing higher predilection in females compared to males.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 15-20"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Temperature Changes with Preheated and Intracanal Heated Solutions and Ultrasonic Activation in Immature Teeth","authors":"Öznur Sariyilmaz DDS, MSc ,&nbsp;Evren Sariyilmaz DDS, PhD ,&nbsp;Cangül Keskin DDS, PhD","doi":"10.1016/j.joen.2024.10.009","DOIUrl":"10.1016/j.joen.2024.10.009","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to examine the temperature changes on root canal and root surface in immature teeth with thin dentinal walls when irrigation solutions are preheated or intracanal heated, as well as the additional effects of passive ultrasonic irrigation (PUI) on these temperature changes.</div></div><div><h3>Methods</h3><div>Sixteen maxillary canine teeth were trimmed to a length of 20 mm and prepared to mimic immature teeth with an apical width of 1.3 mm by enlarging those using Gates Glidden burs. To measure temperatures inside the canal and on the root surface, one thermocouple was placed from the apex into the root canal, while the other thermocouple was positioned outside the root. Irrigation was performed by heating the irrigation solution with different methods (room temperature, preheated to 60°C, 5 sec intracanal heated, 20 sec intracanal heated), and PUI was applied after each method. Temperature changes occurring inside the root canal and on the root surface were recorded and subjected to statistical analysis.</div></div><div><h3>Results</h3><div>Using the irrigation solution preheated and intracanal heated resulted in a significant increase in both intracanal and root surface temperatures compared to using at room temperature (<em>P</em> &lt; .05). The application of PUI significantly increased the temperature of the irrigation solution only at room temperature group (<em>P</em> &lt; .05). None of the applications caused an increase in temperature on the root surface exceeding 10°C.</div></div><div><h3>Conclusions</h3><div>Applying PUI to heated solutions does not significantly increase the temperature in heating methods, but it does prolong heat retention in the canal by slowing down the cooling process. Although using preheated solution for 20 seconds results in higher intracanal temperatures, it should be noted that the solution cools rapidly within the canal. Short-term heating applications, such as 5 seconds, repeated frequently, can help maintain the high temperature during activation.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 71-77"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endodontic Treatment in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study","authors":"Maria Emília Mota DDS ,&nbsp;José F. Siqueira Jr DDS, MSc, PhD ,&nbsp;Isabela N. Rôças DDS, MSc, PhD ,&nbsp;Fábio Abreu Alves DDS, MSc, PhD ,&nbsp;Graziella Chagas Jaguar DDS, PhD ,&nbsp;Juliana Bertoldi Franco DDS, PhD ,&nbsp;Jayr Schmidt Filho MD ,&nbsp;Maria Stella Moreira DDS, MSc, PhD","doi":"10.1016/j.joen.2024.10.014","DOIUrl":"10.1016/j.joen.2024.10.014","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigated the implications of root canal treatment (RCT) of infected teeth with apical periodontitis (AP) in patients undergoing hematopoietic stem cell transplantation (HSCT).</div></div><div><h3>Methods</h3><div>One hundred patients were selected. Clinical data, oncologic and endodontic diagnosis and treatment, and type of HSCT were recorded. Data on the exacerbation of AP were investigated. Leukocyte/neutrophil and C-reactive protein levels were evaluated before and after RCT.</div></div><div><h3>Results</h3><div>One hundred patients underwent HSCT (55% autologous). The need for RCT was identified in 41% of the participants. AP was diagnosed in 75.6% of these patients and large lesions (≥5 mm) occurred in 45.2%. A higher prevalence of AP was observed in males (<em>P</em> = .012). RCT was performed in 54.8% of the individuals and no AP exacerbation, pain, swelling, bacteremia, and need for additional medications was observed. Blood cultures were negative for bacteria and fungi. C-reactive protein levels were ≥1 mg/dL in 54.9% of the individuals 1 month before RCT and &lt;1 mg/dL in 64.6% 6 months after treatment (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>RCT was effective in controlling infection with no complications in patients undergoing HSCT. Given the potential for exacerbation of endodontic infections, RCT and patient monitoring are essential and highly recommended.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 35-42"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Outcomes of Cell-based Regenerative Endodontic Therapy in Postautogenous Transplantation of a Mature Tooth: A Case Report","authors":"Noriaki Yoshihashi DDS","doi":"10.1016/j.joen.2024.11.003","DOIUrl":"10.1016/j.joen.2024.11.003","url":null,"abstract":"<div><div>Autogenous tooth transplantation (ATT) offers advantages; however, success rates depend on factors like socket formation, donor tooth manipulation, and endodontic treatment. Root canal treatment in a mature post-ATT tooth remains challenging. Cell-based regenerative endodontic therapy (RET) shows promise for regenerating the pulp-dentin complex in mature teeth. However, its application in a post-ATT tooth is unexplored. This case report demonstrates the feasibility and outcomes of cell-based RET in a post-ATT tooth. A 37-year-old male underwent ATT for a missing maxillary left first molar. The maxillary right third molar served as the donor tooth and transplanted with surgical guides. Root canal treatment began two weeks after ATT, confirming no detectable residual bacteria and fungi after 11 weeks. Dental pulp stem cells isolated from the maxillary left third molar were transplanted into the root canal 17 weeks after ATT. The ATT tooth responded positively to the electric pulp test after 1 week. Most of the periodontal ligament of the donor tooth was absent, and the ATT tooth initially showed ankylosis-like signs but regained normal mobility after 28 weeks after RET. Cone-beam computed tomography imaging showed successful outcomes with the presence of the periodontal ligament space and lamina dura, and without root resorption and ankylosis after 52 weeks. Magnetic resonance imaging revealed signal intensity of the regenerated tissue comparable to normal pulp after 60 weeks. This case report suggests the effectiveness of dental pulp stem cells in regenerating dental pulp and periodontal ligament, potentially preventing root resorption and ankylosis in the post-ATT tooth.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 85-93"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for Authors","authors":"","doi":"10.1016/S0099-2399(24)00653-8","DOIUrl":"10.1016/S0099-2399(24)00653-8","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages A8-A13"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143353820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}