Journal of endodontics最新文献

Effect of precooling the anesthetic agent in comparison to increasing the dosage on the success rate of inferior alveolar nerve block using articaine in mandibular first molars with symptomatic irreversible pulpitis: Double-blind, randomized controlled clinical trial. 双盲、随机对照临床试验：麻醉药物预冷却与增加剂量对下颌第一磨牙下牙槽神经阻滞治疗症状不可逆性牙髓炎成功率的影响

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-28 DOI: 10.1016/j.joen.2025.05.011

Bafrin Fattahi, Negin Ghasemi, Sahar Shakouei, Mahsa Ladan Moghaddam

{"title":"Effect of precooling the anesthetic agent in comparison to increasing the dosage on the success rate of inferior alveolar nerve block using articaine in mandibular first molars with symptomatic irreversible pulpitis: Double-blind, randomized controlled clinical trial.","authors":"Bafrin Fattahi, Negin Ghasemi, Sahar Shakouei, Mahsa Ladan Moghaddam","doi":"10.1016/j.joen.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.joen.2025.05.011","url":null,"abstract":"Introduction: Achieving anesthesia in mandibular molar teeth with irreversible pulpitis has been challenging. This study aimed to compare the efficacy of precooling articaine and increasing its dosage for inferior alveolar nerve block (IANB) in the mandibular first molars with symptomatic irreversible pulpitis.Methods: In this randomized double-blind clinical trial, 90 first mandibular molar teeth with symptomatic irreversible pulpitis (VAS > 54) were randomly divided into three groups and received conventional IANB injection with 1.8 mL (one cartridge )1C Group() or 3.6 mL (two cartridges )2C Group() of 4% articaine with 1:200,000 epinephrine with room temperature or 1.8 ml of the same agent with 4°C temperature (cold cartridge )CC Group(). The patients recorded their pain during the injection and access cavity preparation, pulp chamber and root canal entrance using a visual analog scale. Data were analyzed by repeated measure of ANOVA and Bonferroni tests (P < 0.05).Results: In all three groups, the pain levels at different injection times were significantly different (P < 0.05). The pain level did not differ significantly between the 2C Group and the CC Group (P > 0.05), but the difference was significant between the 1C Group and 2C Groups (P < 0.05) and also between the 1C Group and CC Group (P < 0.05).Conclusions: Administration of cold articaine provides a significantly higher success rate of IANBs in mandibular first molar teeth with symptomatic irreversible pulpitis compared to IANB with articaine kept at room temperature, however, increasing the dosage of articaine led to a significantly higher success rate.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the neurocompatibility of 3 different classes of endodontic materials, resin based (AH-Plus), calcium silicate (BC-Sealer) and hydrogel based (OdneTMFill). 树脂基（AH-Plus）、硅酸钙（BC-Sealer）和水凝胶基（OdneTMFill） 3种不同类型根管材料的神经相容性比较。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-27 DOI: 10.1016/j.joen.2025.05.010

Benoit Michot, Gozde Yildirim, Lina Alzahrani, Jennifer L Gibbs

{"title":"Comparison of the neurocompatibility of 3 different classes of endodontic materials, resin based (AH-Plus), calcium silicate (BC-Sealer) and hydrogel based (OdneTMFill).","authors":"Benoit Michot, Gozde Yildirim, Lina Alzahrani, Jennifer L Gibbs","doi":"10.1016/j.joen.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.joen.2025.05.010","url":null,"abstract":"Introduction: Endodontic therapy is generally effective at relieving pain in patients experiencing acute odontogenic pain, but a small percentage of patients can experience long lasting post-operative pain. Post-operative pain could result from a variety of factors including toxicity of the chemical factors and the amount and type of tissue damage. Since dental sealers can come into contact with periapical tissue including nerve endings and potentially induce nerve injury and inflammatory pain, this study aims to compare the neurocompatibility of three distinct classes of endodontic material, resin-based sealer (AH-Plus), calcium silicate-based sealer (BC-Sealer) and a new class endodontic root canal filling material that is hydrogel-based (OdneFill in both solid and liquid forms) METHODS: In-vitro models of human and mouse sensory neurons. Cell viability was determined using a live/dead cell assay and MTT assay. Neurite growth was measured to study neuronal health and function, and neurotoxicity gene marker expression was measured by qPCR.Results: We show that each material induces a different level of neuronal toxicity, with AH+ sealer being the least compatible, BC-sealer and liquid OdneFill having intermediate compatibility and the solid OdneFill being the most compatible.Conclusion: This study provides new insight into the relationship between endodontic materials and neuronal injury, adding to clinicians' understanding of the neurotoxic effects of sealers. This might assist in their material selection to minimize nerve injury following root canal therapy. Within the limitations of this study we found that OdneFill and BC-sealer exhibited the most neurocompatibility, while AH+ had the least neurocompatibility.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time Guided Endodontics with a Miniaturized Dynamic Navigation System in Calcified Posterior Teeth: Performance in Regard to the Operator's Level of Experience. 用微型动态导航系统实时引导牙髓治疗钙化后牙：与操作者经验水平相关的表现。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-16 DOI: 10.1016/j.joen.2025.05.009

Lukas Hirt, Hauke Hildebrand, Roland Weiger, Florian M Thieringer, Thomas Connert, Wadim Leontiev

{"title":"Real-time Guided Endodontics with a Miniaturized Dynamic Navigation System in Calcified Posterior Teeth: Performance in Regard to the Operator's Level of Experience.","authors":"Lukas Hirt, Hauke Hildebrand, Roland Weiger, Florian M Thieringer, Thomas Connert, Wadim Leontiev","doi":"10.1016/j.joen.2025.05.009","DOIUrl":"10.1016/j.joen.2025.05.009","url":null,"abstract":"Introduction: This study aimed to evaluate the use of a dynamic navigation system for endodontic access cavity preparation (EACP) in posterior teeth.Methods: Partially calcified posterior teeth replicas were 3D printed to generate 24 maxillary and mandibular models. Preoperative cone-beam computed tomographic (CBCT) scans were performed for all models. After digital planning of access cavities for dynamic navigation, 2 operators (operator 1 with 7 years of experience and limited to endodontics vs operator 2 with 3 years of experience working as a general dentist) received 12 models with a total of 96 teeth each and performed EACP under simulated clinical conditions. Four weeks after performing EACP using a dynamic navigation system (DNS), EACP was performed using a conventional freehand approach. Postoperative CBCT scans were performed for all models, and substance loss determination was conducted by registering pre- and postoperative CBCT scans.Results: The overall substance loss was significantly lower using the DNS compared to conventional freehand approach in molars (29.6 mm3 vs 82.6 mm3; P < .001) and premolars (11.8 mm3 vs 25.3 mm3; P < .001). No significant differences in substance loss between operators 1 and 2 were observed when using a DNS. Operator 1 significantly reduced substance loss only in molars, but not in premolars, when using a DNS.Conclusions: Dynamic navigation for EACP is a reliable method in posterior teeth and results in tooth substance preservation. When used by a less experienced general dentist, dynamic navigation can raise the level of performance to that of an experienced endodontist.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Association between Apical Periodontitis and Inflammatory Bowel Disease Through Mendelian Randomization. 通过孟德尔随机化揭示根尖牙周炎和炎症性肠病之间的关系。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-14 DOI: 10.1016/j.joen.2025.05.008

Yuqiang Wang, Yueli Zhou, Fangfang Song, Ying Tang, Cui Huang

{"title":"Unraveling the Association between Apical Periodontitis and Inflammatory Bowel Disease Through Mendelian Randomization.","authors":"Yuqiang Wang, Yueli Zhou, Fangfang Song, Ying Tang, Cui Huang","doi":"10.1016/j.joen.2025.05.008","DOIUrl":"10.1016/j.joen.2025.05.008","url":null,"abstract":"Introduction: The objective of this investigation was to assess the genetic predispositions linking apical periodontitis to inflammatory bowel disease (encompassing ulcerative colitis [UC] and Crohn's disease [CD]).Methods: Single nucleotide polymorphisms were used as instrumental variables, and the radial inverse-variance weighted method was utilized as the primary analytical approach. Steiger filtering and additional sensitivity analyses were conducted to assess the robustness of the primary results, while also accounting for various common confounders to minimize inherent pleiotropic effects.Results: Upon the evaluation of specific confounding variables, findings combined by mete-analysis indicated that genetically predicted apical periodontitis had no significant correlation with inflammatory bowel disease (OR = 0.99, 95% CI: 0.89-1.10, P > .05), UC (OR = 1.08, 95% CI: 0.97-1.20, P > .05), and CD (OR = 1.05, 95% CI: 0.94-1.18, P > .05). Conversely, in the inverse analyses, CD was genetically predicted to exert a weak influence on apical periodontitis (OR = 1.07, 95% CI: 1.02-1.12, P < .05), whereas the impact of inflammatory bowel disease on apical periodontitis risk was deemed nonsignificant (OR = 1.03, 95% CI: 1.00-1.07, P > .05). There was no discernible association between genetically influenced UC and apical periodontitis (OR = 0.98, 95% CI: 0.93-1.04, P > .05). Sensitivity analyses corroborated the primary outcomes, aligning with the direction of the estimates and thereby bolstering the robustness of the findings.Conclusions: Despite the limitations acknowledged within this study, our results provided evidence suggesting a potential role of CD in the risk of apical periodontitis.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Different Chelating Agents in Different Application Times on the Release of Growth Factors from Dentin. 不同螯合剂在不同使用时间对牙本质生长因子释放的影响。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.006

Deniz Erdogan, Ali Erdemir, Ercan Tekin

{"title":"The Effect of Different Chelating Agents in Different Application Times on the Release of Growth Factors from Dentin.","authors":"Deniz Erdogan, Ali Erdemir, Ercan Tekin","doi":"10.1016/j.joen.2025.05.006","DOIUrl":"10.1016/j.joen.2025.05.006","url":null,"abstract":"Introduction: The purpose of this study was to evaluate the effect of ethylene diamine tetra acetic acid (EDTA), etidronic acid (HEBP), boric acid (BA), or saline at different application times on transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor-A, and insulin-like factor-1 (IGF-1) release levels from inner root dentin.Methods: Seventy-five root segments, obtained from extracted fully developed premolar human teeth, were standardized to 8 mm long and prepared with Gates Glidden burs number 1-4 for simulating an open apex. The samples were irrigated with 1.5% sodium hypochlorite and then divided into 4 main groups according to chelation agents (17% EDTA, 9% HEBP, 6% BA, or saline) and 3 subgroups according to application times. TGF-β1, vascular endothelial growth factor-A, and IGF-1 release levels were measured on the 1st and 7th days by enzyme-linked immunosorbent assay. The final concentrations were calculated based on the root canal volume measured by cone-beam computed tomography. Data were compared using a one-way analysis of variance, the Tukey test, Kruskal Wallis, and Wilcoxon test.Results: In all growth factors (GFs), the EDTA group had a statistically significantly higher release than the saline group (P < .001). Increasing EDTA application time did not affect statistically significant GFs release (P >.05). All GFs were released more on the 7th than the 1st day.Conclusions: The release levels of GFs vary according to the type of chelating agent and application time. BA in the release of IGF-1 and HEBP in the release of TGF-β1 were as effective as EDTA at all application times.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinician Perspective of Regenerative Endodontic Procedures for Immature Anterior Teeth: An Observational Web-based Study. 临床医生对未成熟前牙再生牙髓治疗的看法——一项基于网络的观察性研究。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.005

Alexander Brett, Federico Foschi, Shanon Patel

{"title":"Clinician Perspective of Regenerative Endodontic Procedures for Immature Anterior Teeth: An Observational Web-based Study.","authors":"Alexander Brett, Federico Foschi, Shanon Patel","doi":"10.1016/j.joen.2025.05.005","DOIUrl":"10.1016/j.joen.2025.05.005","url":null,"abstract":"Introduction: Regenerative endodontic procedures (REPs) are beneficial in preserving infected immature permanent teeth. The aim of this observational study was to assess treatment planning of REPs, geographical differences in their provision, clinical hesitancy and provision rate.Methods: Digitally manipulated radiographs showing varying degrees of root development in a maxillary central incisor with apical pathosis were used in an anonymized online questionnaire to assess clinical predisposition. The data were analyzed using descriptive statistics.Results: Among 160 participants (59.4% specialist endodontists), 73.1% favored REPs for the most immature apices, decreasing with root maturity. Specialist experience did not impact REP provision. UK endodontists performed REPs less frequently than international counterparts. Key perceived REP benefits included fracture resistance and root lengthening. Hesitancy stemmed from unfamiliarity (32.9%) and healing concerns (25.9%). Confidence varied and 25% had never performed a REP.Conclusion: REPs are generally appropriately treatment planned, although more education with regards to clinical suitability and case selection is suggested. Geographical variance in provision of REPs is apparent between the UK and non-UK endodontists. Hesitancy exists in the provision of REPs, and prevalence of provision is low.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of In Vivo Vertical Root Fracture in Endodontically Treated Teeth Using Machine Learning Techniques. 应用机器学习技术诊断根管治疗牙齿体内垂直根断裂。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.004

Shujun Ran, Qiang Wang, Jia Wang, Jing Huang, Wei Zhou, Pengfei Zhang, Keyong Yuan, Yushan Cheng, Shensheng Gu, Jingjing Zhu, Zhengwei Huang

{"title":"Diagnosis of In Vivo Vertical Root Fracture in Endodontically Treated Teeth Using Machine Learning Techniques.","authors":"Shujun Ran, Qiang Wang, Jia Wang, Jing Huang, Wei Zhou, Pengfei Zhang, Keyong Yuan, Yushan Cheng, Shensheng Gu, Jingjing Zhu, Zhengwei Huang","doi":"10.1016/j.joen.2025.05.004","DOIUrl":"10.1016/j.joen.2025.05.004","url":null,"abstract":"Introduction: This study aimed to diagnose vertical root fracture (VRF) of endodontically treated teeth using clinical features and bone loss information from cone beam computed tomography with machine learning models.Methods: A total of 887 patients with 941 teeth undergoing endodontic surgery were included in this retrospective study. The clinical factors and bone defects detected via cone beam computed tomography were measured and recorded. Linear machine learning models, logistic regression model and nonlinear models, including XGBoost, LightGBM, and CatBoost were used to diagnose VRF. Model performance was evaluated using 5-fold cross-validation and based on various performance parameters, including the area under the curve, sensitivity, specificity, precision, and F score. Model interpretations were visualized by Shapley Additive Explanations.Results: Of the 941 teeth, 112 VRF teeth (11.9%) were identified during endodontic surgery or after tooth extraction. XGBoost and LightGBM showed excellent performance with area under the curves of 0.98 [0.96, 0.99], specificity of 0.978 and 0.983, sensitivity of 0.883 and 0.803, and precision of 0.846 and 0.865, respectively. Shapley Additive Explanations values showed that lingual/buccal bone defect, the ratio of bone defect height above the root apex to the defect total height, width of bone defect and age were the top 5 contributors.Conclusions: Machine learning models for the diagnosis of VRF using age, sex, tooth type, the quality of root canal filling and bone loss position, height, width, and depth are valuable for clinical decision making after root canal treatment.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Systemic and Local Anti-tumor Necrosis Factor-α Receptor-1 Administration on Periapical Bone Loss in Mice. 全身和局部给药抗肿瘤坏死因子-α受体-1对小鼠根尖周骨丢失的影响。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-13 DOI: 10.1016/j.joen.2025.05.007

Luciano Aparecido de Almeida-Junior, Juliana de Lima Gonçalves, Maya Fernanda Manfrin Arnez, Nallery Steysi Rostrán Jimenez, Guido Artemio Marañón-Vasquez, Francisco Wanderley Garcia de Paula-Silva

{"title":"Effects of Systemic and Local Anti-tumor Necrosis Factor-α Receptor-1 Administration on Periapical Bone Loss in Mice.","authors":"Luciano Aparecido de Almeida-Junior, Juliana de Lima Gonçalves, Maya Fernanda Manfrin Arnez, Nallery Steysi Rostrán Jimenez, Guido Artemio Marañón-Vasquez, Francisco Wanderley Garcia de Paula-Silva","doi":"10.1016/j.joen.2025.05.007","DOIUrl":"10.1016/j.joen.2025.05.007","url":null,"abstract":"Introduction: The aim of this study was to evaluate whether systemic or topical administration of a monoclonal antibody against tumor necrosis factor-α receptor-1 (TNFR1) could control periapical bone loss in mice.Methods: Thirty C57Bl6 mice were used for induction of periapical lesion through the exposure of the root canals to the oral environment. The root canals remained open to microbial contamination from the oral cavity for 28 days. Then, the animals were randomly assigned to 3 different experimental groups: G1: animals received no medication and periapical lesion followed its natural course up to 42 days; G2: systemic administration of the TNFR1 antibody; G3: intracanal topical administration of the TNFR1 antibody. Healthy teeth were used as controls. At 42 days following periapical lesion induction, the animals were anesthetized then euthanized, and tissues containing bone and teeth were collected for microtomographic, histomorphometry, and quantitative reverse transcriptase polymerase chain reaction analysis. Then groups were compared using one-way analysis of variance followed by Turkey tests (α = 5%).Results: Systemic and topical anti-TNFR1 administered in groups G2 and G3 did not have an impact on the area and volume of periapical lesions when compared to the untreated control group G1 (P > .05). Lower expression of RANKL mRNA was observed in G3 compared to G1 (P < .05) but no change on OPG, MMP-9 or CTSK was detected (P > .05).Conclusions: Under the experimental conditions of this study, systemic or local administration of a TNFR1 antibody was not effective in limiting the expansion of periapical lesions.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomous Robot-Assisted Endodontic Microsurgery on First Molar in Complex Anatomical Scenarios: A Case Series. 在复杂解剖情况下自主机器人辅助第一磨牙根管显微手术：一个案例系列。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-09 DOI: 10.1016/j.joen.2025.04.017

Lishan Huang, Minting Wan, Xiaoxing Li, Siyu Li, Qingsong Wu, Chengji Gong, Yufei Li, Xuechao Yang

{"title":"Autonomous Robot-Assisted Endodontic Microsurgery on First Molar in Complex Anatomical Scenarios: A Case Series.","authors":"Lishan Huang, Minting Wan, Xiaoxing Li, Siyu Li, Qingsong Wu, Chengji Gong, Yufei Li, Xuechao Yang","doi":"10.1016/j.joen.2025.04.017","DOIUrl":"10.1016/j.joen.2025.04.017","url":null,"abstract":"Endodontic microsurgery (EMS) is an important approach for preserving teeth with failed root canal treatment. However, implementing minimally invasive osteotomies and accurate apicoectomies can be challenging in anatomically complex areas, especially posterior teeth close to critical structures. The introduction of autonomous robotic system into EMS represents a pioneering advancement aimed at enhancing digital endodontic surgery. Robot-assisted EMS (RA-EMS) integrates cone-beam computed tomography and intraoral optical scanning data to plan three-dimensional surgical paths, adopting infrared optical motion-tracking technology and robot autonomous drive, enabling precise apicoectomy. This report presents the successful application of RA-EMS in 4 complex molar cases, during which adjacent vital anatomical structures were preserved. Immediate radiographic examination revealed accurate root-end resections. All patients demonstrated satisfactory healing during the follow-up visits at 1-6 months, with periapical radiolucent area decreased in radiographic examination. RA-EMS is a safe and feasible clinical procedure that minimizes the risk of human error and mitigates technique sensitivity. Meanwhile, it provides a valuable alternative for assisting anatomically challenging EMS.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Type 2 Diabetes Mellitus on Apical Periodontitis Size, Endotoxin Levels, and Bacterial Load in Root Canals with Necrotic Pulp. 2型糖尿病对坏死牙髓根管内牙周炎大小、内毒素水平及细菌负荷的影响。

IF 3.5 2区医学

Journal of endodontics Pub Date : 2025-05-09 DOI: 10.1016/j.joen.2025.05.003

Mirela Cesar Barros, Evelyn Giuliana Velasquez-Espedilla, Luciane Dias de Oliveira, Brenda Paula F A Gomes, Marco Antônio Hungaro Duarte, Carlos Antônio Negrato, Flaviana Bombarda Andrade

{"title":"Impact of Type 2 Diabetes Mellitus on Apical Periodontitis Size, Endotoxin Levels, and Bacterial Load in Root Canals with Necrotic Pulp.","authors":"Mirela Cesar Barros, Evelyn Giuliana Velasquez-Espedilla, Luciane Dias de Oliveira, Brenda Paula F A Gomes, Marco Antônio Hungaro Duarte, Carlos Antônio Negrato, Flaviana Bombarda Andrade","doi":"10.1016/j.joen.2025.05.003","DOIUrl":"10.1016/j.joen.2025.05.003","url":null,"abstract":"Introduction: This clinical study was conducted to describe the endodontic microbiological profile of teeth with apical periodontitis in patients with type 2 diabetes mellitus (T2DM), focusing on bacterial count and endotoxin levels found in primary infection, as well as the size of periapical lesions, determined by cone-beam computed tomography (CBCT) analysis.Methods: Thirty-four patients were selected and divided into 2 groups: 17 with T2DM and 17 nondiabetic controls. Anamnesis, clinical examinations, and radiographic evaluations were performed. Root canal samples were collected using sterile/pyrogen-free paper tips. Endotoxins were quantified using limulus amoebocyte lysate assay, and bacterial counts (colony forming units/mL) were determined using anaerobic culture techniques. The periapical status of the teeth was assessed using the CBCT periapical index. Data were analyzed using Pearson correlation, simple linear regression, t-tests, and Chi-square tests (P < .05).Results: A larger size of periapical lesions (CBCT periapical index ≥4) was observed in patients with T2DM (64.8%) compared to controls (17.7%) (P < .05). There was a significant increase in the number of bacteria by culture and endotoxin levels in diabetic patients. A positive correlation was found between elevated endotoxin levels and the diameter of periapical lesions (P < .05).Conclusions: This study supports the hypothesis that T2DM is associated with a greater microbial load and higher endotoxin levels, contributing to more severe periapical bone destruction, which may negatively affect endodontic treatment outcomes in these patients.","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0