Journal of endodontics最新文献

{"title":"Effectiveness of Post-Endodontic Access-Cavity Cleaning Techniques: A Randomized Clinical Study.","authors":"Ayse Karadayi, Elif Irem Altintas, Ezgi Tuter Bayraktar, Bora Korkut","doi":"10.1016/j.joen.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.joen.2025.10.005","url":null,"abstract":"<p><strong>Introduction: </strong>This randomized clinical study aimed to evaluate the efficacy of different post-endodontic access cavity cleaning techniques in removing residual epoxy resin-based sealer from the pulp chamber floor following root canal obturation.</p><p><strong>Materials and methods: </strong>Seventy patients requiring root canal treatment in maxillary first molars were randomly assigned into seven groups (n=10) according to the cleaning protocol: dry cotton pellet, ethanol-saturated cotton pellet (5 sec), ethanol-saturated cotton pellet (clinically acceptable cleanliness), ethanol-saturated cotton pellet + air polishing, ethanol-saturated microbrush (5 sec), ethanol-saturated microbrush (clinically acceptable cleanliness) and air abrasion. After obturation with gutta-percha and AH Plus sealer, standardized macro photographs were taken before and after cleaning procedures. The sealer-covered area (SCA) was calculated using Adobe Photoshop based on pixel analysis. Statistical analyses included the Shapiro-Wilk, Paired samples t, Kruskal-Wallis and Mann-Whitney U tests. A p-value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>All cleaning protocols significantly reduced SCA values compared to baseline (p < 0.05). The highest SCA reductions were observed in the air abrasion (96.1%), ethanol-saturated microbrush (clinically acceptable cleanliness) (93.9%), ethanol-saturated cotton pellet + air polishing (92.8%) groups, with no significant differences among them (p > 0.05). These groups showed significantly higher cleaning efficacy compared to the ethanol-saturated microbrush (5 sec) (36.1%), dry cotton pellet (26.4%) and the ethanol-saturated cotton pellet (5 sec) (17.7%) groups (p < 0.05).</p><p><strong>Conclusions: </strong>Among the evaluated methods, air abrasion, ethanol-saturated microbrush (clinically acceptable cleanliness), ethanol-saturated cotton pellet + air polishing and ethanol-saturated cotton pellet (clinically acceptable cleanliness) demonstrated superior effectiveness in removing residual sealer from the access cavity. Although no statistically significant differences were observed, aplication of microbrush and mechanically assisted cleaning techniques, including air polishing and air abrasion, emerged as the most reliable and effective cleaning strategies for clinical practice.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145368109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular Bacteria in Stem Cells of the Apical Papilla: A \"Trojan Horse\" for Regenerative Endodontic Failure.","authors":"Shanthini Kalimuthu, Prasanna Neelakantan","doi":"10.1016/j.joen.2025.10.007","DOIUrl":"https://doi.org/10.1016/j.joen.2025.10.007","url":null,"abstract":"<p><strong>Introduction: </strong>Regenerative endodontic procedures (REPs) show unpredictable outcomes in infected teeth due to persistent infection. While current disinfection protocols reduce but do not eliminate root canal bacteria, the fate of residual microorganisms during stem cell recruitment remains unclear. This study tested the hypothesis that endodontic pathogens invade and survive within stem cells of the apical papilla (SCAP), diminishing its biomineralization potential.</p><p><strong>Methods: </strong>Internalization of SCAP by Gram-positive (Enterococcus faecalis, Actinomyces naeslundii) and Gram-negative (Porphyromonas gingivalis, Fusobacterium nucleatum) bacteria was characterized using colony-forming unit assays, confocal microscopy and flow cytometry. Intracellular survival of E. faecalis was monitored for 14 days in both planktonic and biofilm phases. The impact of intracellular E. faecalis on SCAP biomineralization and odontogenic differentiation was assessed using alkaline phosphatase activity, alizarin red staining, and quantitative real-time PCR. Statistical analyses were performed using one-way ANOVA with Dunnett's multiple comparison test or two-way ANOVA with Tukey's multiple comparison test. P<.05 was considered statistically significant.</p><p><strong>Results: </strong>All tested bacteria invaded SCAP with differential efficiencies. E. faecalis and F. nucleatum demonstrated robust internalization (∼5-log CFU), while P. gingivalis and A. naeslundii showed reduced invasion (∼2.5 log CFU). E. faecalis persisted intracellularly for up to 14 days, with biofilm-phase bacteria showing enhanced survival in monolayer SCAP cultures. Intracellular E. faecalis abrogated SCAP mineralization while maintaining cell viability, accompanied by significant downregulation of all tested odontogenic genes (P<0.05).</p><p><strong>Conclusions: </strong>Bacteria invade and establish persistent intracellular infections within SCAP, creating protected reservoirs. These intracellular bacteria severely compromise odontogenic differentiation without killing the host cells, representing a potentially unrecognized mechanism of REP failure. This \"Trojan horse\" strategy may explain the unpredictable outcomes of regenerative endodontics in infected teeth.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Artificial Intelligence for the Computer-aided Detection of Periapical Lesions in Cone-beam Computed Tomographic Images' [Journal of Endodontics Volume 46 (2020) 987-993].","authors":"","doi":"10.1016/j.joen.2025.09.022","DOIUrl":"https://doi.org/10.1016/j.joen.2025.09.022","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical and biological properties of the 'all-in-one' endodontic irrigant Triton.","authors":"Jesus Aranda, Elda Olivia Nobre de Souza, Arturo Javier Aranda Garcia, Renato De Toledo Leonardo, Ana Paula Ramos, Giampiero Rossi-Fedele, Gisele Faria","doi":"10.1016/j.joen.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.joen.2025.10.006","url":null,"abstract":"<p><strong>Aim: </strong>Triton is a newly developed root canal irrigant that acts on both organic and inorganic tissues. This study evaluated the physicochemical properties (pH, surface tension, contact angle, available free chlorine), dentin penetration, and cytotoxicity of Triton, compared with 4% sodium hypochlorite (NaOCl) + etidronic acid (HEDP), 4% NaOCl/17% ethylenediaminetetraacetic acid (EDTA), and 4% NaOCl.</p><p><strong>Methodology: </strong>pH was measured using a pH meter; surface tension and contact angle were assessed by the pendant drop and sessile drop methods, respectively. Available free chlorine was determined by titration with iodine/sodium thiosulfate. For dentin penetration, 39 extracted human premolars were instrumented, stained with crystal violet, irrigated, and analyzed under a stereomicroscope. Cytotoxicity was evaluated on L929 fibroblasts using MTT and neutral red assays.</p><p><strong>Results: </strong>Triton showed a pH of 12.49, available free chlorine of 4.18%, and significantly lower surface tension and contact angle than the other irrigants (p<0.05). In the cervical third, Triton showed greater dentin penetration than 4% NaOCl and 4% NaOCl+HEDP (p<0.05); in the middle third, greater penetration than 4% NaOCl (p<0.05). No significant differences were observed in the apical third (p>0.05). Triton and 4% NaOCl+HEDP groups had significantly lower cell viability compared to other groups (p<0.05).</p><p><strong>Conclusions: </strong>Triton demonstrated an alkaline pH, lower surface tension and contact angle, and greater dentin penetration in the cervical and middle thirds compared to 4% NaOCl. However, its cytotoxicity, similar to that of 4% NaOCl+HEDP, emphasizes the need for safe irrigation dynamics to prevent periradicular tissue damage.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cemental Tear: Systematic Review and Thematic Analysis of Clinical and Imaging Features with a Proposed Diagnostic Framework.","authors":"José Evando da Silva-Filho, Aryanna Celly Rodrigues-Lima, Kayo Lúcio Silveira-Fernandes, Camille de Sousa Veloso, João Paulo Viana Braga, Sandra Régia Albuquerque Ximenes, Elilton Cavalcante Pinheiro-Júnior, Danielle Frota de Albuquerque, Eduardo Diogo Gurgel-Filho","doi":"10.1016/j.joen.2025.10.004","DOIUrl":"10.1016/j.joen.2025.10.004","url":null,"abstract":"<p><strong>Introduction: </strong>Cemental tear (CT) is a rare condition with poorly understood prevalence, etiology, and clinical presentation, often mimicking vertical root fractures or endodontic-periodontal lesions. This review aimed to synthesize current evidence on CT and propose a diagnostic framework.</p><p><strong>Methods: </strong>A comprehensive search was conducted in Cochrane Library, Latin American and Caribbean Health Sciences Literature, PubMed, ScienceDirect, Scopus, Web of Science, and grey literature (Google Scholar, ProQuest) for case reports (2000-2024). Inclusion required full clinical and radiographic documentation. Risk of bias was assessed using the Joanna Briggs Institute checklist. Data on epidemiological, clinical, and imaging features were extracted.</p><p><strong>Results: </strong>Twenty studies reported 24 patients and 39 teeth. Methodological quality was heterogeneous, mostly with moderate risk of bias. CT mainly affected single-rooted teeth, especially incisors (46.1%), in older patients (mean 56.2 years). Frequent clinical findings included deep periodontal pockets (75%), mobility (60%), and fistulas (40%). Radiographically, bone loss (33.3%), radiopaque fragments (28.2%), and lateral radiolucencies (23.1%) were noted. Cone-beam computed tomography proved crucial for detecting buccal/lingual fragments. Histopathology confirmed cementum detachment, often infection-related. Treatments ranged from fragment removal to extraction, with prognosis linked to early diagnosis.</p><p><strong>Conclusions: </strong>CT is rare and challenging, best identified with high-resolution cone-beam computed tomography and integrated clinical evaluation. Early, precise diagnosis guides prognosis, with conservative fragment removal recommended when feasible.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migration of a Separated Endodontic File Into the Mandibular Canal: An 8-Year Follow-up Case Report.","authors":"Chiaki Akiba Katz, Misaki Fujimoto, Hidetaka Kuroda, Koichiro Muromachi","doi":"10.1016/j.joen.2025.10.002","DOIUrl":"10.1016/j.joen.2025.10.002","url":null,"abstract":"<p><p>Separated endodontic instruments in mandibular molars may migrate into the mandibular canal, potentially causing neurological complications. The management of asymptomatic cases remains controversial. This case report presents the long-term conservative management of a separated stainless steel file that migrated into the mandibular canal. A 47-year-old male patient with chronic myeloid leukemia presented with a separated endodontic file that had migrated from the distal root of his mandibular right second molar into the mandibular canal over a 7-year period. Clinical examination, panoramic radiography, and cone-beam computed tomography were performed. Quantitative sensory testing using Semmes-Weinstein monofilament testing and psychological assessment were conducted. Conservative management with periodic observation was selected due to the patient's asymptomatic status. Cone-beam computed tomography revealed the separated file extending 1.43 mm into a mandibular canal with a diameter of 2.54 mm. Despite radiographic evidence of neural canal involvement, the patient remained asymptomatic throughout the 7-year observation period. Semmes-Weinstein monofilament testing detected minimal tactile sensitivity differences (0.1 g vs 0.55 g on the contralateral side), but no clinically significant neurological symptoms developed. Follow-up radiography at 8 years showed continued migration toward the inferior mandibular border without symptom development. Long-term migration of separated stainless steel endodontic files into the mandibular canal may remain asymptomatic. Adequate anatomical space within the mandibular canal, biocompatible properties of stainless steel, and patient-specific factors affecting sensory perception may contribute to the benign clinical course. Conservative management based on clinical symptomatology rather than radiographic findings alone appears appropriate in select asymptomatic cases, with regular monitoring recommended to detect potential delayed complications.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Restoration Strategy and Cavity Location on the Fracture Resistance of Teeth with External Cervical Resorption.","authors":"Saadet Elpe, Öznur Sarıyılmaz","doi":"10.1016/j.joen.2025.10.001","DOIUrl":"10.1016/j.joen.2025.10.001","url":null,"abstract":"<p><strong>Introduction: </strong>The restoration of external cervical resorption (ECR) defects requires materials capable of withstanding functional stresses. This study aimed to compare the fracture resistance of different restorative approaches applied to buccal versus palatal ECR defects under simulated clinical conditions.</p><p><strong>Methods: </strong>Eighty-one extracted human maxillary central incisors were used. Nine intact teeth served as the positive control group (n = 9). The remaining 72 teeth were randomly assigned to standardized buccal or palatal ECR defect groups (n = 36 each). Each subgroup (n = 9) received one of the following treatments: negative control (no restoration), Biodentine alone, Ribbond + Biodentine, or EverX Flow + Biodentine (n = 9 per subgroup). Standardized ECR cavities were created 4 mm apical to the cementoenamel junction, with dimensions of 3 mm in width and 3 mm in depth and connected to the pulp chamber. All specimens underwent chewing simulation (240,000 cycles, 50 N load) and thermocycling (5°C-55°C) prior to fracture testing. The fracture test was performed using a universal testing machine by applying force at a 45° angle, and the maximum load was recorded in Newtons (N). Statistical analysis was performed using parametric or nonparametric tests based on data distribution, with significance set at P < .05.</p><p><strong>Results: </strong>The restorative material significantly influenced fracture resistance (P < .05). In buccal defects, the Ribbond + Biodentine group demonstrated significantly higher fracture resistance compared to negative controls. For palatal defects, Biodentine alone showed significantly greater resistance than negative controls. No significant differences were observed between buccal and palatal locations (P > .05).</p><p><strong>Conclusions: </strong>While the choice of restorative material had a significant effect on the performance of restorations in ECR defects, the location of the cavity (buccal or palatal) did not significantly influence the outcomes.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclic Fatigue and Physical Properties Testing of Different Small Taper Heat-Treated Reciprocating Files.","authors":"Ahmed Altuwalah, Taher Al Omari, Riyadh Alroomy, Mohammed Mashyakhy, Hamza Elfarraj, Rubén A Domínguez-Pérez, Rashid El Abed","doi":"10.1016/j.joen.2025.09.020","DOIUrl":"10.1016/j.joen.2025.09.020","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the cyclic fatigue resistance of small-size reciprocating files at simulated intracanal temperature and analyze their chemical and physical properties.</p><p><strong>Methods: </strong>Sixty new endodontic files were subjected to cyclic fatigue resistance testing, which was performed in a CNC-milled stainless-steel artificial canal (60° curvature, 5 mm radius, 19 mm length; 1.4 mm inner diameter) submerged in a 32.0 °C water bath. Two samples were analyzed using differential scanning calorimetry and Energy Dispersive X-ray Fluorescence, while two fractured samples underwent scanning electron microscopy.</p><p><strong>Results: </strong>R Motion (RM) (2542 s) and Tia Premium Blue (TPB) (2419 s) exhibited significantly higher resistance to cyclic fatigue compared to Tia Viera Gold (283 s), W Plus Gold (318 s), and Wave One Gold (292 s). RM, Tia Viera Gold, and W Plus Gold had significantly longer fractured segments than TPB and Wave One Gold.</p><p><strong>Conclusions: </strong>Blue heat-treated files showed significantly higher cyclic fatigue resistance compared to gold-treated counterparts, with RM and TPB lasting over 2400 seconds, while others failed within 300 seconds.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predoctoral Endodontic Education and Training in the United States and Canadian Dental Schools: A Web-Based Survey.","authors":"Carla Y Falcon, Craig A Dunlap, Summer Youssef","doi":"10.1016/j.joen.2025.09.021","DOIUrl":"10.1016/j.joen.2025.09.021","url":null,"abstract":"<p><strong>Objective(s): </strong>This study aimed to evaluate endodontic education and training across United States (U.S.) and Canadian dental schools. It investigated clinical practices, curriculum structure, competency assessment methods, and program challenges in order to provide insights into improving endodontic competency among dental school graduates.</p><p><strong>Methods: </strong>A comprehensive survey was electronically distributed to predoctoral program directors from accredited dental schools in the U.S. and Canada. The survey captured data on program characteristics, competency certification, and integration of advanced technologies. Data were evaluated and the significance level was set at P < .05.</p><p><strong>Results: </strong>Of the 87 program directors contacted, 48 responded (response rate: 58.54%). The survey revealed variability in clinical endodontic requirements, with a mean of 4.59 root canal treatments or 4.5 canals completed per student. Nearly one-third of schools reported insufficient patient pools, with 71.43% substituting simulation exercises for clinical experience. Most programs (86.05%) used extracted teeth for training, and 42.86% permitted students to treat routine second molars. Certification methods varied, with 29.27% emphasizing live patient experiences. Notably, 54.76% of directors were uncertain about their graduates' competence to perform molar endodontics in private practice.</p><p><strong>Conclusion: </strong>Endodontic education in the U.S. and Canada exhibits significant variability, with patient access being a key factor influencing training quality. Simulation exercises help mitigate some challenges, but their use raises concerns about the adequacy of clinical preparedness. Standardizing clinical requirements, improving patient access, and increasing integration of advanced resources could enhance educational outcomes.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricalcium silicate endodontic cements: a bibliometric analysis of the 100 most cited articles.","authors":"Betânia de Lourdes Canal Vasconcellos, Luna Chagas Clementino, Thiago César da Silva Lima, Caroline Andrade Maia, Gabriele Andrade-Maia, Paulo Antônio Martins-Júnior, Francine Benetti, Warley Luciano Fonseca Tavares","doi":"10.1016/j.joen.2025.09.017","DOIUrl":"https://doi.org/10.1016/j.joen.2025.09.017","url":null,"abstract":"<p><strong>Introduction: </strong>Bibliometric analysis is an indicator of high-quality evidence for the decision-making process regarding the use of biomaterials. The aim of this study was to analyze the characteristics of the 100 most cited articles on tricalcium silicate endodontic cements.</p><p><strong>Methodology: </strong>A broad search strategy using key terms related to hydraulic endodontic cement was conducted in the Web of Science - Core Collection (WoS-CC) on May 30, 2025. Data were retrieved and organized in descending order of the number of citations in the WoS-CC, and each article was compared with the number of citations in the Scopus and Google Scholar databases. VOSviewer software was used to construct co-authorship networks. Spearman's correlations were performed using the Statistical Package for Social Sciences (SPSS 22.0).</p><p><strong>Results: </strong>The most cited article was \"Physical and chemical properties of a new root-end filling material,\" by Torabinejad et al. (1995), with 821 citations in WoS-CC. Of the 100 articles, the corresponding authors were predominantly from the United States (n = 37). The institution of origin of most articles was Loma Linda University (USA) (n = 15). Experimental laboratory studies were the most common study design among the included articles (58%), followed by literature reviews (14%) and observational studies (11%). The Mineral Trioxide Aggregate (MTA), whether ProRoot MTA or MTA Angelus, was the predominant studied material (21,84%) and most studies focused on the evaluation of material properties (48%).</p><p><strong>Conclusions: </strong>This list of the most cited articles can provide a reference point to guide research and biomaterial selection.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}