Journal of endodontics最新文献

{"title":"Patient-Centered Outcome Assessment of Static and Dynamic Navigation-Aided Endodontic Microsurgery: A Randomized Controlled Trial.","authors":"Chen Chen, Rui Zhang, Li Qin, Yeyu Lin, Xining Zhang, Fangzhe Li, Liuyan Meng","doi":"10.1016/j.joen.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.joen.2025.03.005","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the quality of life (QoL) and analgesic use one week after surgery, as well as the surgical duration, associated with static navigation (SN) and dynamic navigation (DN)-aided endodontic microsurgery (EMS).</p><p><strong>Methods: </strong>Sixty patients were randomly assigned to the SN group (n=30) or the DN group (n=30). Both groups underwent EMS based on a pre-surgical plan. The primary outcomes were patient-reported QoL and analgesic use during the first week, while the secondary outcome was the duration of guided procedures, including osteotomy and root-end resection. QoL was assessed using a visual analog scale-based questionnaire. The questionnaire evaluated symptoms (pain, swelling, bleeding) and functional impact (mouth opening, chewing, talking, sleeping, daily routine), with average scores for each component calculated daily. The Mann-Whitney U test was used to compare QoL scores and surgery duration between groups, with statistical significance set at P < 0.05.</p><p><strong>Results: </strong>Participants in the SN group had significantly shorter surgery duration compared to DN group. Postoperative adverse reactions within the first week after SN- and DN-aided EMS were short-lived, peaking early in the postoperative period and gradually subsiding. No significant differences were observed in QoL or analgesic use between the SN and DN groups.</p><p><strong>Conclusion: </strong>Both SN and DN enable minimally invasive EMS with equivalent patient-centered outcomes, though SN demonstrates a significant advantage in reducing the duration of guided osteotomy and root-end resection. These findings provide a valuable patient-centered reference metrics for the selection between the two guided approaches in clinical practice.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OPTIMIZATION OF CONE BEAM COMPUTED TOMOGRAPHY PROTOCOLS TO DETECT THE SECOND MESIOBUCCAL CANAL IN THE PRESENCE OF ARTIFACTS.","authors":"Janaína Zechin, Érica Pozo Mautone, Claudio Antônio Perottoni, Thago Oliveira Gamba, Janete Eunice Zorzi","doi":"10.1016/j.joen.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.joen.2025.03.002","url":null,"abstract":"<p><p>There is difficulty in identifying the mesiobuccal canal in clinical routine. The use of cone beam computed tomography (CBCT) helps overcome this difficulty by providing volumetric details of the teeth and surroundings. Thus, the objective of this study was to determine the effectiveness of different CBCT protocols, with different image resolutions, in visualizing the second mesiobuccal canal in maxxilary molars in the presence of artifacts. To perform the study, the visualization of the second mesiobuccal canal of 28 maxxilary molars with root canal preparation and obturation was used, with the exception of the second mesiobuccal canal. The teeth were placed in a dry maxilla and then scanned with the OP300 MAXIO CBCT unit (4 protocols) and 3D Veraview X800 F150P (3 protocols). Five experienced and blinded evaluators analyzed the images to assess accuracy, sensitivity and specificity. The presence of the second mesiobuccal canal was confirmed by light microscopy (50x magnification) of cross-sections of the roots. Our data showed that the Veraview X800 CT scanner provided better results for accuracy (96%), sensitivity (100%) and specificity (86%). The 50x50/0.085 protocol showed the highest sensitivity (78%), specificity (100%) and accuracy (82%). It was possible to visualize the second mesiovestibular canals in both CT scanners tested; however, the 3D Veraview X800 F150P offered better results for the evaluated patterns. The best protocol in the presence of artifacts was 80x40 FOV and 0.125 voxel size of 3D Veraview X800 F150P.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT-Assessed Outcomes and Prognostic Factors of Primary Endodontic Treatment and Retreatment: A Systematic Review and Meta-Analysis.","authors":"Jf Brochado Martins, Ac Georgiou, P Diogo, R de Vries, V Freixo, Pj Palma, H Shemesh","doi":"10.1016/j.joen.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.joen.2025.03.004","url":null,"abstract":"<p><strong>Introduction: </strong>Periapical radiographs (PR) have limitations in assessing endodontic treatment outcomes, which can be addressed by cone beam computed tomography (CBCT). This systematic review evaluates primary root canal treatment and retreatment outcomes using CBCT, focusing on periapical healing, success, and prognostic factors.</p><p><strong>Methods: </strong>A literature search (in PubMed, Embase and Web of Science) was performed up to March 8, 2024, in collaboration with a medical information specialist. Three reviewers independently performed article selection and data extraction. Risk of bias was assessed, and evidence quality using the Grading of Recommendations, Assessment, Development, and Evaluation approach. Meta-analysis and meta-regression established pooled periapical healing and outcome rates, 95% confidence intervals (CIs), and identify outcome predictors (P < .05).</p><p><strong>Results: </strong>Nineteen studies were included in the meta-analysis. The pooled periapical healing rate using 'loose criteria' was 87% (95% CI: 81-91%) for teeth and 84% (95% CI: 78-88%) for roots; using 'strict criteria' was 36% (95% CI: 22-53%) for teeth, and 44% (95% CI: 16-76%) for roots. The weighted pooled success rates for teeth were 85% (95% CI: 80-89%) under 'loose criteria' and 45% (95% CI: 31-59%) under 'strict' criteria. Meta-regression identified outcome predictors include number of visits, irrigant type, tooth type, operator experience, apical preparation size and taper, and obturation technique.</p><p><strong>Conclusion: </strong>CBCT reveals lower success rates under strict criteria compared to loose criteria (36% vs. 88%). While CBCT offers greater diagnostic accuracy, its routine use for outcome evaluation may not be necessary, as it yields results similar to PR under loose criteria.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentional replantation of C-shaped mandibular second premolar with radicular groove.","authors":"Siwen Wu, Jeen Nee Lui","doi":"10.1016/j.joen.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.joen.2025.03.003","url":null,"abstract":"<p><p>C-shaped roots with radicular grooves are uncommon in mandibular premolars. Bacteria residing in the radicular groove and associated accessory canals can contribute to persistent periradicular infections. Eradicating bacteria in these less accessible areas remains a significant challenge in endodontic procedures. This report describes the successful management of a left mandibular second premolar (#20) with a persistent lesion related to a lingual radicular groove through an intentional replantation (IR) procedure. A 31-year-old Chinese male complained of a gum swelling related to tooth #20 which was endodontically treated and crowned 6 years ago. Clinical examination revealed a lingually located sinus tract and a clinically intact crown restoration. The tooth was not tender to percussion or palpation, with probing depths not exceeding 4mm, and showed physiological mobility. A periapical radiograph showed the lingual sinus tract traced to the mid third of the root, which had an adequate root canal filling and an intact periodontal ligament around the apical region. A cone-beam computed tomography (CBCT) image revealed a radiolucency at the mid third region and on the lingual aspect related to the radicular groove of this C-shaped premolar. IR was performed due to the location of the mid-root lesion related to the lingual radicular groove. Tooth #20 was extracted atraumatically, a stained radicular groove was identified, cleansed and sealed with Biodentine and the tooth replanted. At 2.5-year follow-up, the patient was clinically asymptomatic. Tooth #20 presented with normal probing depths and mobility and healing was observed on the CBCT images.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Morphological and Chemical Composition of Dental Pulp Stones: A Combined Microanalytical Approach.","authors":"Vincenzo Tosco, Riccardo Monterubbianesi, Jose Aranguren, Michele Furlani, Nicole Riberti, Angelo Putignano, Giovanna Orsini","doi":"10.1016/j.joen.2025.02.014","DOIUrl":"10.1016/j.joen.2025.02.014","url":null,"abstract":"<p><strong>Introduction: </strong>Pulp stones (PSs) are mineralized ectopic structures within the dental pulp that vary in morphology, composition, and location. Their etiology remains uncertain and poses clinical challenges in endodontics. This study hypothesized that combined analytical techniques would enhance understanding of PS morphology and composition, facilitating clinical management of complex cases.</p><p><strong>Methods: </strong>Fifteen permanent molars with radiographic evidence of PSs were analyzed using microcomputed tomography (μ-CT), light microscopy, and scanning electron microscopy associated with energy-dispersive spectroscopy (SEM-EDS). The samples underwent qualitative and quantitative assessments to explore their morphology, distribution, and chemical composition. Statistical analysis was conducted using one-way analysis of variance to evaluate differences in Ca/P ratios between PS and dentin, with significance set at P < .05.</p><p><strong>Results: </strong>μ-CT and histological evaluations revealed distinct morphological differences between coronal and radicular PS. Coronal PS exhibited regular nodular or mold shapes, whereas radicular PS showed irregular and diffuse patterns. Histological findings highlighted the nature of PS as mineralized ectopic connective tissue in coronal regions. On the other hand, radicular PSs displayed linear arrangement of collagen fibers intertwined with vascular bundles. SEM-EDS demonstrated no significant differences in mineralization between PS and dentin, with comparable Ca/P ratios.</p><p><strong>Conclusions: </strong>PSs exhibit distinct morphological and structural characteristics depending on their location. Despite these differences, PSs and dentin share similar chemical compositions, as demonstrated by similar Ca/P ratios. The combined microanalytical approach employed provides novel insights into PS morphology and composition, offering a foundation for translational advancements in diagnostic and therapeutic strategies.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Number of Missing Tooth Surfaces and the Molecular Findings on the Outcomes of Vital Pulp Therapy Using 2 Calcium Silicate Materials: A Randomized Clinical Study.","authors":"Mostafa Sami Abdelaziz, Nelly Abdelsalam, Dalia Mukhtar Fayyad","doi":"10.1016/j.joen.2025.03.001","DOIUrl":"10.1016/j.joen.2025.03.001","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the clinical and radiographic outcomes of full pulpotomy in mandibular molar teeth with symptomatic irreversible pulpitis. It compared class I and class II cavity defects and correlated these outcomes with the quantification of 2 biomolecules (tumor necrosis factor-alpha [TNF-α] and matrix metalloproteinase-9 [MMP-9]) using 2 types of pulpotomy dressing materials (MTA+ and Well-Root PT).</p><p><strong>Methods: </strong>Sixty patients were selected and categorized based on cavity class. Full pulpotomy was conducted under aseptic conditions and rubber dam isolation. Pulpal blood samples were taken for TNF-α and MMP-9 quantification. Sodium hypochlorite was used as a hemostatic agent. The teeth were randomly divided based on the pulpotomy dressing material, MTA+, or Well-Root PT. Clinical and radiographic assessments were conducted after 1 week, 3, 6, and 12 months.</p><p><strong>Results: </strong>The overall clinical and radiographic success rate of pulpotomy procedures after a 1-year follow-up was 88.3%. There were nonsignificant differences in the success rates between the groups and subgroups (93.3% in MTA class I, 86.7% in Well-Root PT class I, 80.0% in MTA class II, and 93.3% in Well-Root PT class II). TNF-α and MMP-9 showed a significant correlation with the outcomes.</p><p><strong>Conclusion: </strong>Class I and II cavity defects do not significantly impact the pulpotomy success rate. TNF-α and MMP-9 levels are potential indicators of pulpotomy outcomes. Well-Root PT offers easier handling and lacks the discoloration effect associated with MTA+.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A vitro study of the effect of different methods of removing calcium hydroxide from root canals.","authors":"Yanzhi Wang, Changjie Xiao, Panpan Zhang, Ying Liu, Jie Li","doi":"10.1016/j.joen.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.joen.2025.02.015","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficiency of four methods for removing calcium hydroxide in root canals.</p><p><strong>Methods: </strong>80 mandibular single-tube permanent premolars were instrumented to ProTaper Universal F4. The teeth were split in two lengthwise, standardized grooves, and depressions were prepared on the wall of the root canal and filled with calcium hydroxide. The samples were randomly divided into 4 groups according to different rinsing methods, namely, syringe rinsing group (SYIG), sonic vibration group (SOIG), ultrasonic lancing Group (ULIG), and Er: YAG laser rinsing group (LAIG). The calcium hydroxide was removed from the root canal. The residual calcium hydroxide area percentage was calculated microscopically and photographed before and after rinsing. The removal effect of irregular areas (grooves and depressions) was evaluated by scoring.</p><p><strong>Results: </strong>In the root canal crown, the clearance rate of SOIG, ULIG, and LAIG was better than that of SYIG. ULIG and LAIG had the best clearance rate (P < 0.05). In the middle root canal and root canal tip, the clearance rate of SOIG, ULIG, and LAIG was better than that of SYIG. Among them, LAIG had the best clearance rate (P < 0.05). There was no obvious difference in the clearance rate between SOIG and ULIG (P > 0.05). For the calcium hydroxide removal scores of different flushing techniques in grooves and depressions, LAIG was the best (P > 0.05).</p><p><strong>Conclusions: </strong>None of the four methods can completely remove calcium hydroxide. However, LAIG has greater advantages than other washing methods, with higher cleaning efficiency.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Endodontic Treatment: Which Measures Are Important?","authors":"Ashraf F Fouad","doi":"10.1016/j.joen.2025.02.016","DOIUrl":"10.1016/j.joen.2025.02.016","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of an Ultrasonic Device into Dynamic Navigation System for a Fully Guided Dynamic Endodontic Microsurgery Workflow: An In Vitro Study.","authors":"Frederico C Martinho, Nicholas Stroeters, Bruno G Bisi, Giulio Gavini, Ina L Griffin, Patricia A Tordik","doi":"10.1016/j.joen.2025.02.013","DOIUrl":"https://doi.org/10.1016/j.joen.2025.02.013","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the feasibility of integrating an ultrasonic device (US) into a dynamic navigation system (DNS) for a fully guided dynamic endodontic microsurgery (EMS) workflow. It compares the accuracy and efficiency of fully guided dynamic US + DNS to US + freehand (FH) workflow.</p><p><strong>Methods: </strong>Thirty-eight mandibular molars were divided into two groups: US + DNS (n=19) and US + FH (n=19). CBCT scans were taken pre- and postoperatively. Bone-window cut (BWC), root-end resection (RER), root-end cavity preparation (RECP), and root-end filling (REF) were planned in the X-guide. BWC, RER, RECP, and REF were all conducted under dynamic navigation. 3D deviations were measured for BWC. Resected root length and resection angle were calculated for the RER. Frequency long-axis deviation was recorded for RECP, and REF depth was measured. Total operating time was recorded.</p><p><strong>Results: </strong>The Fully guided US + DNS was more accurate than US + FH, showing lesser 3D deviations for BWC (p<.0001). The resected root length was ∼ 3 mm (p>.05). The RER angle was lower in US + DNS (p<.0001). RECP long-axis deviations were lesser in US + DNS (p<.05). The REF depth average was 3 mm for US + DNS and 2.78 mm for US + FH (p<.05). Both EMS workflows were time efficient for EMS, with US + FH taking less time (p<.05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, it is feasible to integrate US into a DNS for a fully guided dynamic EMS workflow. Fully guided dynamic EMS workflow improved overall EMS accuracy.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Calcium Dynamics in Regular-Set versus Fast-Set Bioceramics: Impact on Cytotoxicity and Apatite Formation","authors":"Wafaa A. Khalil PhD, MSc, BDS,&nbsp;Hanan Alharbi BDS, MMSc, MEndo RCSEd","doi":"10.1016/j.joen.2024.12.002","DOIUrl":"10.1016/j.joen.2024.12.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The objective of this study was to assess the calcium ions (Ca²⁺) release, pH shift, bioactivity, and cytotoxicity of both forms of EndoSequence Root Repair Material: regular set (ES) and fast set (ESF).</div></div><div><h3>Methods</h3><div>ES (<em>n</em> = 10) and ESF (<em>n</em> = 10) forms were tested for their bioactivity. Elemental analysis was done on the fresh material and material immersed in phosphate-buffered saline (PBS) for 30 days. The surface crystal formation was studied. Cytotoxicity was evaluated at different material concentrations using a human hepatocellular cancer cell line (Huh-7).</div></div><div><h3>Results</h3><div>Both materials contain Ca, P, Ta, Zr, and Si as major elements. Both ES and ESF have a limited percentage of ytterbium and neodymium. In the fresh material, compared with the ESF, the ES had a higher Ca²⁺ concentration with a homogeneous surface distribution. However, the ESF released significantly more Ca²⁺ (<em>P</em> &lt; .05) and had a higher pH over the 7-day course. When the material was immersed in PBS, the ESF exhibited a significantly higher Ca/P ratio of 2.95, while ES had 2.16 Ca/P ratio (<em>P</em> &lt; .05). The ESF had a greater capacity to precipitate and grow hydroxyapatite (HA) than ES, resulting in more mature crystals forming on the surface. Both SE and ESF demonstrated low cytotoxicity against Huh-7 cells.</div></div><div><h3>Conclusions</h3><div>When ES and ESF were submerged in simulated bodily fluid, both forms produced apatite crystals at the dentin material interface, releasing high Ca²⁺ and displaying a prolonged high pH with high bioactivity potential. Both forms had comparable low cytotoxicity. A higher Ca²⁺ release in ESF indicates dynamic bioactivity, which should be aligned with the clinical requirements.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 325-331"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}