Journal of endodontics最新文献

{"title":"Postoperative pain following the use of the TruNatomy and XP-endo Shaper systems: A randomized clinical study.","authors":"Christianne Velozo, Silmara Silva, Wesley Viana, Marina Isaltino, Carolina Viana, Pedro Freitas, Diana Santana de Albuquerque","doi":"10.1016/j.joen.2025.01.022","DOIUrl":"https://doi.org/10.1016/j.joen.2025.01.022","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aimed to clinically compare the incidence of postoperative pain after endodontic treatment of posterior teeth using XP-endo Shaper (XPES; FKG Dentaire, La Chaux-de-Fons, Switzerland) and TruNatomy (TNY; Dentsply Sirona, Ballaigues, Switzerland) systems.</p><p><strong>Methods: </strong>In a single-blind randomized clinical trial, 104 vital teeth with an indication for conventional endodontic treatment for prosthetic purposes were treated by a single specialist following a pre-established protocol. All participants were unaware of the treatment they received. The teeth were randomly divided into 2 groups (n = 52) according to the instrumentation system used (TNY group and XPES group). The treatments were performed in a single visit. The participants were asked to rate the intensity of postoperative pain on a numeric rating scale and a visual analogue scale (no pain, mild pain, moderate pain, and severe pain) after 24, 48, 72 hours and after 7 days.</p><p><strong>Results: </strong>The incidence of postoperative pain was zero in both groups at 48 h, 72 h, and 7 days. At 24 h, most patients in the XPES and TNY groups had no pain, while the remaining participants in either group experienced mild pain (1 to 3), with no significant difference between groups (p > .05, Mann-Whitney test).</p><p><strong>Conclusions: </strong>The instruments used in this study are associated with minimal postoperative pain, which only occurred in the first 24 h. Based on the parameters analyzed, we conclude that the systems tested cause mild postoperative pain over a short period of time.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of antimicrobial peptide-loaded hydrogels as potential scaffolds for pulp-dentine complex regeneration: A comparative study.","authors":"Parisa Noohi, Mohammad J Abdekhodaie, Mohammad H Nekoofar, Miguel Gama, Maryam Saadatmand, Paul M H Dummer","doi":"10.1016/j.joen.2025.01.018","DOIUrl":"https://doi.org/10.1016/j.joen.2025.01.018","url":null,"abstract":"<p><strong>Introduction: </strong>As a recently developed treatment modality, regeneration of the pulp-dentin-like complex via tissue engineering (TE) approaches is the focus of considerable attention. The persistence of bacteria within the root canal spaces is well known as the major challenge of dental pulp regeneration. Antimicrobial peptides (AMPs) are short peptides with inhibitory activities against a broad spectrum of microorganisms.</p><p><strong>Methods: </strong>In the present study, antimicrobial hydrogels based on two photo-reactive biopolymers, i.e. collagen methacrylate (ColMA) and chitosan methacrylate (ChitMA), and containing two different AMPs, i.e. LLKKK18 and Tet213, were used to develop a potential scaffold with antimicrobial and regenerative features.</p><p><strong>Results: </strong>The incorporation of AMPs had no significant effect on the physical, mechanical, rheological, and morphological properties of the new systems. The optimized concentration of LLKKK18 and Tet213 had appropriate antimicrobial activity against Gram-positive Enterococcus fæcalis (E. fæcalis) and did not exhibit any cytotoxicity to stem cells from the apical papilla (SCAP) encapsulated within the hydrogels compared to the control group without AMPs. The presence of AMPs also significantly promoted migration and differentiation of SCAP. In the AMP-loaded groups, greater levels of calcified nodules deposition, ALP, COL I, DSPP, DMP1, and VEGF mRNA gene expression, and COL I and DSPP protein expression were observed.</p><p><strong>Conclusions: </strong>The results indicated the potential of engineered antimicrobial ColMA/ChitMA hydrogels for application in TE-based strategies to regenerate the pulp-dentin complex.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN APICAL PERIODONTITIS AND AUTOIMMUNE DISEASES: A SYSTEMATIC REVIEW WITH META-ANALYSIS.","authors":"Tatiana A M do Nascimento, Francielle S Verner, Cleidiel Aparecido Araújo Lemos, Rafael B Junqueira","doi":"10.1016/j.joen.2025.01.021","DOIUrl":"https://doi.org/10.1016/j.joen.2025.01.021","url":null,"abstract":"<p><strong>Objectives: </strong>the aim of this study was to perform a qualitative and quantitative synthesis of the available studies evaluating the possible relationship between apical periodontitis and autoimmune diseases.</p><p><strong>Methods: </strong>The literature search was conducted across six electronic databases (PubMed/MEDLINE, Embase, SciELO, Web of Science, Cochrane Library, and Scopus). The search covered articles published up to September 2023. There was no disagreement between the 2 reviewers. The RevMan software (V5.3) was used for the meta-analysis. A dichotomized analysis was performed using the Mantel-Haenszel statistical method with a fixed-effect model and the risk ratio as the effect measure. A 95% confidence interval was adopted, and the significance level was set at p < 0.05. The presence of apical periodontitis was pre-defined as the event, with the experimental group consisting of patients with autoimmune disease and the control group consisting of patients without autoimmune disease (healthy individuals). The data used included the number of individuals presenting the event versus the total number of study participants.</p><p><strong>Results: </strong>9 studies were included and considered eligible. The methodological quality of the studies was classified as moderate in 5 of the 9 included studies, while 2 were rated as low, and 2 were rated as high-quality. The relative risk was 1.24 with a 95% confidence interval (1.08 to 1.62), in which the prevalence of apical periodontitis in comparing patients with autoimmune diseases and healthy patients yielded statistically significant results (p < 0.0001). Thus, patients with autoimmune diseases had a 24% higher relative risk of developing apical periodontitis compared to the healthy/control group.</p><p><strong>Conclusions: </strong>The analysis of the studies included in this review suggests a potential association between apical periodontitis and autoimmune diseases. However, it is important to consider that the selected studies have limitations, primarily because they are observational studies.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Novel Cryotherapy Technique on Postoperative Pain for Pulpotomy in Permanent Molars with Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial.","authors":"Kübra Gürler, Koray Yilmaz","doi":"10.1016/j.joen.2025.01.020","DOIUrl":"https://doi.org/10.1016/j.joen.2025.01.020","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to evaluate the effect of cryotherapy application on postoperative pain in permanent molars with symptomatic irreversible pulpitis after full pulpotomy procedures.</p><p><strong>Methods: </strong>Sixty-two patients with permanent maxillary and mandibular molars diagnosed with symptomatic irreversible pulpitis were included in the study. The teeth were randomly divided into two groups: the control group (n = 32) and the cryotherapy group (n = 30). In both groups, cotton pellets moistened with 2.5% NaOCl were used to achieve hemostasis. In the cryotherapy group, after hemostasis was achieved, the pulpotomy area was irrigated with saline solution at 2.5°C for 5 minutes. Then, in both groups, the pulp chamber was covered with Bio MTA+ (Cerkamed Company, Poland) and the composite restoration of the teeth (Clearfil Majesty Posterior, Kuraray Medical Inc., Tokyo, Japan) was completed. The participants were asked to rate the intensity of their postoperative pain via a Visual Analog Scale (VAS) at 6h, 12h, 24h, 48h, and 72 hours. The data were analyzed using the Shapiro-Wilk, Levene's, Student t, Repeated Measures ANOVA and the Chi-square test.</p><p><strong>Results: </strong>The basic demographic data and analgesic intake of the two study groups were similar. Compared with those in the control group, the postoperative pain scores at 6h and 12 hours were significantly lower in the cryotherapy group (p < .05). The postoperative pain scores at 24h, 48h, and 72 hours were similar in both study groups.</p><p><strong>Conclusions: </strong>During vital pulp treatment, the cryotherapy application after hemostasis reduced postoperative pain in permanent molars with symptomatic irreversible pulpitis in the early period.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracanal Antibacterial Effects of a Bioceramic Medication Compared With Calcium Hydroxide Pastes in Different Vehicles","authors":"Andrea F. Campello PhD ,&nbsp;Renata C.V. Rodrigues PhD ,&nbsp;Sabrina C. Brasil PhD ,&nbsp;Thais M. Souza Msc ,&nbsp;Flávio R.F. Alves PhD ,&nbsp;Ibrahimu Mdala MSc, PhD ,&nbsp;José F. Siqueira Jr. PhD ,&nbsp;Isabela N. Rôças PhD","doi":"10.1016/j.joen.2024.11.016","DOIUrl":"10.1016/j.joen.2024.11.016","url":null,"abstract":"<div><h3>Introduction</h3><div>The intracanal antibacterial effectiveness of a bioceramic medication was compared with calcium hydroxide pastes in different vehicles.</div></div><div><h3>Methods</h3><div>Extracted mandibular incisors with a single long oval canal were selected and distributed into 5 groups based on anatomically paired microcomputed tomographic analyses. The root canals were prepared up to an instrument size 35/04 and contaminated for 30 days with a mixed bacterial culture from subgingival biofilm added with <em>Enterococcus faecalis</em>. The canals were medicated with Bio-C Temp (Angelus Indústria de Produtos Odontológicos, Londrina, PR, Brazil) or a calcium hydroxide paste in glycerin, camphorated paramonochlorophenol and glycerin (CHPG), or 2% chlorhexidine (CHCX). Control specimens were filled with sterile saline. After 7 days, the medication was removed by using rotary instruments and saline irrigation. A supplementary approach was conducted, which consisted of 2.5% sodium hypochlorite irrigation and agitation with XP-endo Finisher. Bacteriological samples were taken before application (S1) and after removal (S2) of the intracanal medication, and after the supplementary approach (S3). Bacterial DNA extracted from the samples was quantified using real-time polymerase chain reaction.</div></div><div><h3>Results</h3><div>Bacterial counts were significantly reduced from S1 to S2 in all groups, except for the control group. As for S1-to-S3 changes, all groups (control included) showed significant bacterial reduction. S2-to-S3 changes were only significant in the CHPG and CHCX groups (<em>P</em> &lt; .05). Intergroup comparisons showed no significant differences in S2 (<em>P</em> &gt; .05), with all medications significantly better than the control (<em>P</em> &lt; .05). In S3, only the CHPG and CHCX groups showed further significant bacterial reductions. Categorical data analysis showed no intergroup differences (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>All tested medications significantly reduced the intracanal bacterial counts, with no significant differences between them. Final sodium hypochlorite irrigation and agitation using XP-endo Finisher further enhanced disinfection in the CHCX and CHPG groups.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 207-212"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukemia and Lymphoma Mimicking Periapical Conditions Resulting in Endodontic Treatment: A Systematic Review","authors":"Isis Samara de Melo Queiroga DDS ,&nbsp;Victor Zanetti Drumond DDS ,&nbsp;Lucas Guimarães Abreu DDS, MSc, PhD ,&nbsp;Lauren Frenzel Schuch DDS, MSc, PhD ,&nbsp;Ricardo Alves Mesquita DDS, MSc, PhD ,&nbsp;Erick Miranda Souza DDS, MSc, PhD ,&nbsp;Bruno Augusto Benevenuto de Andrade DDS, MSc, PhD ,&nbsp;José Alcides Almeida de Arruda DDS, MSc, PhD ,&nbsp;Gerhilde Callou Sampaio DDS, MSc, PhD","doi":"10.1016/j.joen.2024.11.005","DOIUrl":"10.1016/j.joen.2024.11.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Leukemia and lymphoma mimicking periapical conditions can lead to significant diagnostic pitfalls. Guidance for endodontists in managing such cases is barely explored. This systematic review aimed to summarize the clinicopathologic, imaging, and management aspects of leukemia/lymphoma that mimicked periapical conditions and resulted in endodontic treatment.</div></div><div><h3>Methods</h3><div>Searches were conducted in PubMed, Embase, Scopus, Web of Science, and LILACS, supplemented by manual scrutiny and gray literature. Case reports and/or case series were included. Critical appraisal of the studies was performed using the Joanna Briggs Institute tool.</div></div><div><h3>Results</h3><div>Among 3,617 identified records, 32 studies involving 37 individuals (mean age 43.6 years; male-to-female ratio 1.2:1) were included. Diffuse large B-cell lymphoma was diagnosed in 21 (56.8%) individuals. The anterior maxilla and posterior mandible were the most frequently affected sites (29.7% each). Radiographically, 97.3% of the lesions exhibited radiolucency in the periapical region. Endodontic treatment preceded the diagnosis of leukemia/lymphoma in 94.6% of cases, while retreatment occurred in 5.4%. The mean time to final diagnosis was 4.9 months.</div></div><div><h3>Conclusion</h3><div>Leukemia and lymphoma can be misdiagnosed as periapical conditions, leading to inappropriate endodontic treatments and delayed diagnoses. Endodontists should become familiar with the broad clinicoradiographic spectrum of these rare, but potentially life-threatening hematolymphoid malignancies.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 106-117"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenomedullin-loaded Gelatin Methacryloyl Hydrogel Promotes Endogenous Dental Pulp Regeneration: An In Vitro and In Vivo Study","authors":"Yangpeng Zhao MD ,&nbsp;Qian Zhang MD ,&nbsp;Song Zhang MD ,&nbsp;Jianan Chen MD ,&nbsp;Lingtong Kong MD ,&nbsp;Jianyong Gao MD ,&nbsp;Qiang Zhu MD","doi":"10.1016/j.joen.2024.11.011","DOIUrl":"10.1016/j.joen.2024.11.011","url":null,"abstract":"<div><h3>Introduction</h3><div>To prepare a gelatin methacryloyl (GelMA) hydrogel scaffold embedded with adrenomedullin (ADM) and investigate its impact and underlying mechanisms in endogenous pulp regeneration.</div></div><div><h3>Methods</h3><div>ADM was evenly distributed within the GelMA hydrogel through a simple and conventional physical mixing technique. The scaffold underwent characterization via scanning electron microscopy, alongside assessments of swelling, degradation, and release properties. Biocompatibility was evaluated using cytoskeletal and live-dead staining techniques. The hydrogel's influence on dental pulp stem cells' proliferation, migration, and differentiation was assessed with CCK-8 assays, Transwell assays, and alizarin red and alkaline phosphatase staining. Transcriptomics provided insights into potential mechanisms. The angiogenic effects on umbilical vein endothelial cells were examined using scratch and tube formation assays. <em>In vivo</em>, the composite hydrogel's regenerative capacity was tested in a rat model of pulp regeneration. Statistical analysis involved Student's <em>t</em>-test and one-way analysis of variance, with significance set at <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>The ADM-loaded GelMA (GelMA@ADM) hydrogel displayed a porous architecture under electron microscopy conducive to cell adhesion and demonstrated excellent biocompatibility. <em>In vitro</em> experiments showed that GelMA@ADM significantly boosted dental pulp stem cells' migration, proliferation, and differentiation, and enhanced the angiogenic activity of umbilical vein endothelial cells after one week of treatment. Corresponding <em>in vivo</em> experiments revealed that GelMA@ADM facilitated the formation of new vascularized pulp tissue after 2 weeks of treatment.</div></div><div><h3>Conclusions</h3><div>The GelMA@ADM hydrogel effectively promotes dental pulp stem cells' proliferation and differentiation, augments vascularization by umbilical vein endothelial cells, and fosters the creation of new vascularized pulp tissue. These findings underscore the potential of GelMA@ADM hydrogel for endogenous pulp regeneration.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 172-184"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Debris Apical Extrusion, Unprepared Surface Areas, and Dentinal Crack Formation after Root Canal Preparation Using ProTaper Next, ProTaper Ultimate, and R-Motion File Systems","authors":"Haider A. Ibrahim BDS ,&nbsp;Ahmed H. Ali BDS, MSc, PhD (UK) ,&nbsp;Francesco Mannocci MD, DDS, PhD, FHEA","doi":"10.1016/j.joen.2024.11.014","DOIUrl":"10.1016/j.joen.2024.11.014","url":null,"abstract":"<div><h3>Introduction</h3><div>This study evaluated and compared the amount of apically extruded debris, unprepared wall surface areas, and dentinal crack formation resulting from root canal preparation using ProTaper Next (PTN), ProTaper Ultimate (PTU), and R-Motion (RM) file systems.</div></div><div><h3>Methods</h3><div>Forty-five palatal roots of maxillary first molars were shortened to a uniform length of 12 mm. The samples were divided randomly into 3 groups (<em>n</em> = 15/group) to be prepared using either PTN, PTU, and RM file systems. The investigator adopted modified Myers and Montgomery's approach to replicate the temperature of the human body. Debris was collected in vials and weighed before and after instrumentation with a sensitive balance. Every specimen was irrigated using distilled water during preparation, utilizing a side-vented needle. Weight before instrumentation was subtracted from weight after instrumentation to identify the weight of the collected debris. Cone-beam computed tomography (CBCT) scans were taken before and after canal preparation using a Planmeca ProMax CBCT machine. The unprepared canal surface area was calculated by superimposing preoperative and postoperative CBCT images using the Mimics Medical program. After preparation, a low-speed diamond disc horizontally sectioned the roots at 3, 6, and 9 millimeters from the apex. The specimens were examined under a digital microscope to detect crack formation. Statistical analysis was carried out using one-way (ANOVA) and Tukey (HSD) tests, with a significance level of <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>There was no statistically significant difference in the quantity of debris extruded apically and dentinal crack numbers among the 3 shaping files (<em>P</em> &gt; .05). Only the apical third of root canals prepared by PTU displayed a significantly lower unprepared surface area compared to PTN and RM.</div></div><div><h3>Conclusions</h3><div>Instrumentation with PTN, PTU, and RM yielded similar amounts of apically extruded debris and dentinal cracks. The PTU files demonstrated higher effectiveness in preparing the apical third by reducing the unprepared surface area in the prepared root canal.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 200-206"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Apical Periodontitis with Glycated Hemoglobin Levels and Systemic Inflammatory Markers in Patients with Type 2 Diabetes: A Cross-Sectional Study","authors":"Ritika Dhamija MDS ,&nbsp;Sanjay Tewari MDS ,&nbsp;Paramjeet Singh Gill MD ,&nbsp;Nitika Monga MDS ,&nbsp;Shweta Mittal MDS ,&nbsp;Jigyasa Duhan MDS","doi":"10.1016/j.joen.2024.11.008","DOIUrl":"10.1016/j.joen.2024.11.008","url":null,"abstract":"<div><h3>Introduction</h3><div>This cross-sectional study, as a preliminary part of an ongoing project, aimed to investigate the effect of apical peridontitis (AP) on glycated hemoglobin (HbA1c) and systemic inflammatory markers in diabetic individuals.</div></div><div><h3>Methods</h3><div>A total of 280 individuals (140 with type 2 diabetes mellitus [T2DM] and 140 healthy) with and without AP were enrolled. Sixty-four age-, gender-, and body mass index–matched participants each in T2DM with AP group (DAP), T2DM without apical periodontitis (D), systemically healthy controls with apical periodontitis (CAP), and without apical periodontitis (C) groups were evaluated. Radiologic and clinical oral examination was performed for confirming the diagnosis of AP and periapical index scoring (PAI). Blood analyses were carried out for interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, high-sensitivity C-reactive protein (hsCRP), and HbA1c assessment.</div></div><div><h3>Results</h3><div>Significantly higher levels of IL-1β, TNF-α, and hsCRP were observed in patients with AP in both diabetes and control groups (<em>P</em> &lt; .05). In the diabetes group, AP contributed to significantly raised levels of HbA1c compared with T2DM group patients without AP. After controlling for possible confounders, partial corelation coefficients revealed positive corelation of presence of AP as well as size of the periapical lesion with HbA1c and serum levels of inflammatory markers in both diabetic and healthy individuals. Multivariate linear regression analysis revealed both presence of AP (<em>P</em> &lt; .05) as well as the size of lesion (<em>P</em> &lt; .001) were found to significantly predict the HbA1c levels as well as the levels of IL-1β, IL-6, TNF-α, and hsCRP in both diabetic and non-diabetic individuals.</div></div><div><h3>Conclusions</h3><div>These findings suggest that both presence of AP and size of periapical lesion was associated with glycemic control and systemic inflammatory burden in patients with T2DM.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 124-131"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the February 2025 Issue of the JOE","authors":"Anita Aminoshariae DDS, MS,&nbsp;Amir Azarpazhooh DDS, MSc, PhD, FRCD(C),&nbsp;Gerald N. Glickman DDS, MS, MBA, JD,&nbsp;Jianing He DMD, PhD,&nbsp;Sahng G. Kim DDS, MS,&nbsp;Anil Kishen BDS, MDS, PhD,&nbsp;Ariadne M. Letra DDS, MS, PhD,&nbsp;Linda Levin DDS, PhD,&nbsp;Ronald Ordinola-Zapata,&nbsp;Frank C. Setzer DMD, PhD, MS,&nbsp;Franklin R. Tay BDSc(Hons), PhD,&nbsp;Kenneth M. Hargreaves DDS, PhD","doi":"10.1016/j.joen.2025.01.017","DOIUrl":"10.1016/j.joen.2025.01.017","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 103-105"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}