Journal of endodontics最新文献

{"title":"Dentinal Defects, Cracks, and Fracture Generation during Ultrasonic Root-End Preparation: A Systematic Review and Meta-Analysis of In Vivo Studies.","authors":"Aruna K Veronica, Anand V Susila, Venkatachalam Prakash","doi":"10.1016/j.joen.2025.05.015","DOIUrl":"10.1016/j.joen.2025.05.015","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate whether ultrasonic root-end preparation in surgical endodontics contributes to the formation of cracks, fractures, or dentinal defects.</p><p><strong>Methods: </strong>This systematic review was registered with prospective register of systematic reviews (CRD42021251665) and conducted in accordance with the preferred reporting items for systematic reviews and meta analyses 2020 guidelines. Only clinical studies involving surgical endodontics, human participants, and ultrasonic tips for root-end preparation were included; in vitro and animal studies were excluded. A comprehensive search was performed across PubMed, Clinical Trial Registry, and Cochrane databases. Prevalence data on cracks, dentinal defects, and fractures were extracted from the included studies and analyzed using MedCalc (v22.023). The strength of evidence was assessed using Agency for Healthcare Research and Quality standards. Bias in randomized controlled trials was assessed using the Cochrane Risk of Bias-2 tool, while the Joanna Briggs Institute Critical Appraisal tools were used to evaluate bias in cohort studies.</p><p><strong>Results: </strong>Seventeen studies met the inclusion criteria: five investigated cracks, one assessed both cracks and fractures, three evaluated dentinal defects and fractures, and eight focused solely on fractures. A meta-analysis was conducted for thirteen of these studies. Five studies reported a 4.5% prevalence of crack with up to 3 years follow-up, while five other studies reported a 2.6% prevalence of fracture with the same timeframe. Prevalence increased to 5.3% in another three studies with 10 years follow-up. A 40% prevalence of dentinal defects was observed in three studies with up to 3 years of follow-up. Cracks did not significantly impact healing based on the risk ratio but did increase the hazard ratio (HR) for development at 3 years. Dentinal defects significantly affected the healing as per risk ratio but did not increase the HR for development at 3 years; while fractures significantly impacted the risk and HR. Significantly greater fractures were seen in retreatment cases and posterior teeth. A key limitation of this review is that most included studies were cohort design, with only two randomized controlled trials. Moreover, there is a lack of studies directly comparing ultrasonic root-end preparation with other methods, limiting the strength of the conclusions.</p><p><strong>Conclusions: </strong>Ultrasonic root-end preparation results in a significantly greater number of dentinal defects than cracks and fractures. Fractures and dentinal defects impacted healing significantly, while cracks did not. Besides, cracks and fractures also increased the HR for any surviving tooth at 3 year analysis.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Multispecies Biofilm on the Chemical and Mechanical Characteristics of Radicular Dentin from Diabetic and Non-Diabetic Patients: An in-vitro Study.","authors":"Kirtana Gopalasamy, Sridevi Krishnamoorthy, Jayalakshmi Somasundaram, Tiju Thomas, PradeepKumar Angambakkam Rajasekaran, Anil Kishen","doi":"10.1016/j.joen.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.joen.2025.05.028","url":null,"abstract":"<p><strong>Introduction: </strong>This in-vitro study examined the effect of a multispecies biofilm on the chemical characteristics and mechanical properties of root dentin from patients with or without type 2 diabetes mellitus (DM).</p><p><strong>Methods: </strong>Intact mandibular molars were obtained from diabetic and non-diabetic donors. Rectangular root dentin beams were prepared and categorized based on age (40-60 and 61-80 years), presence/absence of DM, and the site of dentin beam extraction (mesiodistal/buccolingual). Pentosidine, collagen cross-linking ratio, and mineral-to-collagen ratio were determined by Fourier-transform infrared spectroscopy (FTIR) and fatigue resistance was evaluated by the four-point flexure test to failure with or without exposure to a multispecies biofilm for 21 days.</p><p><strong>Results: </strong>DM and biofilm exposure significantly increased pentosidine, mineral-to-collagen ratio, and collagen cross-linking ratio in root dentin from both age groups (P<.05). Control root dentin from the 61-80 years group had significantly lower fatigue strength than root dentin from the 40-60 years group (P<.05). DM reduced the fatigue resistance of root dentin but not significantly (P>.05). After biofilm exposure, root dentin with DM had significantly lower fatigue resistance than root dentin without DM (P<.05). Biofilm exposure significantly reduced the fatigue resistance of root dentin with or without DM when compared with the controls only in the 40-60 years group (P<.05).</p><p><strong>Conclusions: </strong>Aging decreased the fatigue resistance of root dentin. DM and biofilm exposure increased pentosidine, mineral-to-collagen ratio, and collagen cross-linking in root dentin across both age groups. Biofilm exposure further reduced the fatigue resistance of root dentin with DM compared to root dentin without DM.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthognathic surgery and its relationship on pulpal blood flow and pulp sensibility: A systematic review and meta-analysis.","authors":"Oscar Lozano González, Marco Felipe Salas Orozco, Nuria Patiño Marín, Noé Gustavo Martínez Cuellar, Jaime Trigueros Mancera","doi":"10.1016/j.joen.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.joen.2025.06.001","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review and meta-analysis aimed to evaluate the impact of orthognathic surgery (OS) on pulp sensibility (PS) and pulpal blood flow (PBF).</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Cochrane, Web of Science, Scopus, and ScienceDirect. A comprehensive search was conducted in multiple databases covering studies published up to August 2024 to include both peer-reviewed studies and gray literature. to include both peer-reviewed studies and gray literature. The included studies reported on pulp blood flow and sensitivity following orthognathic surgery, with preoperative values used as control measurements. The quality of the included studies was assessed using the ROBINS-I tool for non-randomized studies, and the GRADE tool was applied to evaluate the certainty of the evidence. A random-effects model meta-analysis was conducted to account for variability across studies.</p><p><strong>Results: </strong>Fourteen studies were included, with an overall \"Moderate\" quality assessed by ROBINS-I. The GRADE assessment indicated that the certainty of evidence was low overall due to serious concerns regarding the risk of bias and inconsistency. A significant reduction in PBF was observed in the orthognathic surgery group at all time points. The primary analysis at 3 months reported a standard mean difference (SMD) of -2.20 (95% CI: -3.98 to -0.41), with substantial heterogeneity (I² = 91%). Subgroup analysis, excluding studies contributing to heterogeneity, yielded a SMD of -0.59 (95% CI: -1.09 to -0.10), reducing I² to 0%. At 6 months, the SMD was -1.75 (95% CI: -2.96 to -0.54; p < 0.05), with high heterogeneity (I² = 89%). Subgroup analysis reduced heterogeneity to 0%, but the effect size decreased (SMD: -0.50, 95% CI: -0.90 to -0.10; p < 0.05). At 12 months, the pooled SMD was -1.99 (95% CI: -3.30 to -0.67), with moderate heterogeneity (I² = 76%) CONCLUSION: This meta-analysis provides evidence of the impact of OS on PBF and PS. It demonstrates an initial reduction in both parameters, followed by a progressive trend toward recovery. However, BF values remain lower in OS patients compared to controls, and substantial heterogeneity was observed across studies.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations among Antibacterial Efficacy in Dentinal Tubules, pH, and Calcium Ion Release of 5 Premixed Calcium Silicate-based Sealers in a Novel ex vivo Model.","authors":"He Liu, Chanchan Chen, Zhejun Wang, Ya Shen","doi":"10.1016/j.joen.2025.05.026","DOIUrl":"10.1016/j.joen.2025.05.026","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the antibacterial efficacy of 5 premixed calcium silicate-based sealers in infected dentinal tubules using a novel ex vivo model, and to investigate correlations among antibacterial efficacy, pH, and calcium ion release.</p><p><strong>Methods: </strong>Forty human premolars with a single canal were selected and stored in 0.01% sodium hypochlorite solution at 4 °C. The teeth were sectioned to obtain 64 dentin blocks, which were sterilized and inoculated with Enterococcus faecalis for 3 weeks. Four infected blocks were analyzed using scanning electron microscopy. Sixty infected blocks were fitted into 3D-printed teeth and assigned to 6 groups based on the sealer used: Control, BIO-C SEALER ION⁺ (BIOC⁺), EndoSequence BC Sealer HiFlow, EndoSequence BC Sealer, NeoSEALER Flo, and BioRoot Flow. Specimens were subsequently obturated using the single-cone technique. Antibacterial efficacy was evaluated at 1 and 4 weeks using viability staining and confocal laser scanning microscopy. Leachates from sealer discs were collected to analyze pH and calcium ion at day 1, 1 week, and 4 weeks. Statistical analysis was performed using one-way ANOVA, unpaired t-test, and Spearman's correlation (α = 0.05).</p><p><strong>Results: </strong>At 1 and 4 weeks after obturation, no significant differences in antibacterial efficacy were observed among the sealer groups; all groups exhibited significantly higher antibacterial efficacy at 4 weeks compared to 1 week (P < .05). At day 1, 1 week, and 4 weeks, all sealers exhibited pH values above 11, with significant differences observed among them at each time point (P < .05). Calcium ion concentrations differed significantly among sealers at all-time points (P < .05). HiFlow, BC Sealer, and BioRoot Flow showed higher pH values and calcium ion concentrations than BIOC⁺ and NeoSEALER Flo at all-time points (P < .05). A strong positive correlation was found between pH values and calcium ion concentrations at all-time points (P < .05).</p><p><strong>Conclusions: </strong>The tested premixed calcium silicate-based sealers demonstrated similar antibacterial efficacy in dentinal tubules, despite variations in pH and calcium ion release.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Different Methods of Heating Sodium Hypochlorite Irrigating Solution on the External Root Surface Temperature.","authors":"Amr M Elhenawy, Sybel M Moussa, Mohamed A Alnakeeb, Salma Genena","doi":"10.1016/j.joen.2025.05.025","DOIUrl":"10.1016/j.joen.2025.05.025","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to examine the temperature changes on the external root surface across coronal, middle, and apical root thirds upon intracanal and extracanal heating of 5.25% NaOCl.</p><p><strong>Methods: </strong>Seventeen mandibular premolar teeth were trimmed to a length of 20 mm and prepared up to the X3 file of the Protaper Next rotary system. To measure temperatures on different thirds of the external root surface, 3 thermocouples were positioned outside the root. Irrigation was performed by heating the irrigation solution with different methods (room temperature, preheated to 50 °C, intracanal heating at 180 °C for 8 seconds). Temperature changes occurring on different root thirds were recorded and subjected to statistical analysis.</p><p><strong>Results: </strong>Using the irrigation solution, either extracanal or intracanal heated, resulted in a significant increase in root surface temperatures compared to using at room temperature (P < .05). In intracanal heating group, coronal and middle thirds showed significant increase in root surface temperatures compared to apical third (P < .05). However, in extracanal heating and room temperature groups, coronal third showed significant increase in root surface temperatures compared to middle and apical thirds (P < .05). None of the applications caused a temperature change on the root surface exceeding 10 °C.</p><p><strong>Conclusions: </strong>Heating of irrigation solution, either extracanal or intracanal, can significantly increase the temperature of the external root surface across its different thirds. Temperatures transmitted outside the root were considered safe for periodontal tissues.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium Hypochlorite Accidents: A Retrospective case-series analysis of CBCT Imaging and Clinician Surveys.","authors":"Dan Cho-Kee, Bettina R Basrani, Jorge Vera, Ronald Ordinola-Zapata, Rubén Rosas Aguilar","doi":"10.1016/j.joen.2025.05.024","DOIUrl":"https://doi.org/10.1016/j.joen.2025.05.024","url":null,"abstract":"<p><strong>Aim: </strong>This case series study aims to investigate retrospectively the causes underlying sodium hypochlorite (NaOCl) accidents in endodontic practices through analysis of cone beam computed tomography (CBCT) imaging and comprehensive clinician surveys.</p><p><strong>Methodology: </strong>Twenty-four dental practitioners who encountered a NaOCl accident during the treatment of a permanent tooth in adult patients provided deidentified patient data, facial photographs, and a limited field of view CBCT of the involved tooth. Providers also had to report patient's immediate presence of pain and swelling after root canal irrigation to include the dataset into the study. Modified surveys were administered to collect information on other demographic factors including age, sex, tooth involved, apical diagnosis, presence of ecchymosis, pain severity among others. The CBCT volume was used to identify the presence of fenestration, root perforation, and apical pathosis. CBCT data was evaluated by four examiners.</p><p><strong>Results: </strong>Among the 26 NaOCl accidents investigated, a higher incidence was observed in females (65%) and maxillary teeth (92%). All cases presented immediate swelling and edema; intracanal bleeding and hematoma were present in 80.7 and 84.6% of the cases respectively. CBCT interpretation revealed that bone fenestrations were evident in all cases studied (100%), iatrogenic perforations were present in 19% of the cases, and apical pathosis was present in 30.7% of the cases.</p><p><strong>Conclusion: </strong>This case series study highlights that a direct communication between the root apex and surrounding soft tissues is highly prevalent in NaOCl accidents. Early identification of bone fenestrations or perforations present in maxillary teeth of female patients can play a pivotal role in preventing NaOCl extrusion accidents during endodontic treatment.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jasminum-Based Nano-Reinforced Calcium Hydroxide Reduces Postoperative Pain in Symptomatic Apical Periodontitis: A Randomized Controlled Trial.","authors":"Nehal Amir, Emaan Mansoor, Nabiha Eeman, Muhammad Nouman Ahmed, Ezza Mansoor, Efrah Mansoor, Khadim Hussain, Vera Afreixo, Afsheen Mansoor, João F Brochado Martins, Paulo J Palma","doi":"10.1016/j.joen.2025.05.016","DOIUrl":"https://doi.org/10.1016/j.joen.2025.05.016","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the efficacy of a novel Jasminum-based titanium dioxide (TiO₂) nano-reinforced calcium hydroxide (Ca(OH)₂) intracanal medicament in reducing postoperative pain (PP) compared to conventional Ca(OH)₂ in patients with symptomatic apical periodontitis (AP).</p><p><strong>Methods: </strong>A triple-blind randomized clinical trial, registered at ClinicalTrials.gov (NCT06653608, 10/19/2024) included patients with single-rooted teeth diagnosed with pulp necrosis and symptomatic AP. Patients referred for endodontic treatment fulfilling the inclusion criteria were included. The patients were grouped into nano-reinforced Ca(OH)₂ group (n=30) and conventional-Ca(OH)₂ (n=30). Preoperative pain and PP at 4, 24, 48, 72, and 96 hours were recorded using a Visual Analogue Scale (VAS). Data were analyzed using linear mixed-effects models (R software), with significance set at P < .05.</p><p><strong>Results: </strong>Sixty patients with comparable demographic and clinical characteristics, including preoperative pain scores, were recruited. Both groups exhibited significant pain reduction over 96 hours (P < .001). However, a significant group-time interaction was observed (P < .001), with the nano-reinforced Ca(OH)₂group reporting consistently lower PP scores and greater reductions in PP compared to the conventional Ca(OH)₂ group at all time points.</p><p><strong>Conclusion: </strong>The incorporation of Jasminum-based TiO₂ nanoparticles to Ca(OH)₂ significantly improved the reduction in PP intensity and duration compared to conventional Ca(OH)₂, making it a superior option for PP management.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Retreatability of BC Sealer, BC Sealer Hiflow, and AH Plus: A Micro-Computed Tomography Study","authors":"Priscilla Gouveia DDS, MSc ,&nbsp;Ana Grasiela Limoeiro DDS, MSc, PhD ,&nbsp;Caroline Beatriz Farias Silva DDS, MSc ,&nbsp;Marília Fagury Videira Marceliano-Alves DDS, MSc, PhD ,&nbsp;Carlos Eduardo Fontana DDS, MSc, PhD ,&nbsp;Daniel Guimarães Pedro Rocha DDS, MSc, PhD ,&nbsp;Carlos Eduardo da Silveira Bueno DDS, MSc, PhD ,&nbsp;Alexandre Sigrist De Martin DDS, MSc, PhD","doi":"10.1016/j.joen.2025.02.009","DOIUrl":"10.1016/j.joen.2025.02.009","url":null,"abstract":"<div><h3>Introduction</h3><div>In this study, the ability to remove obturation material in canals filled with Bio C Sealer, BC Sealer Hiflow, and AH Plus was compared using micro-computed tomography.</div></div><div><h3>Materials and methods</h3><div>In phase 1, 45 premolars were prepared with Reciproc Blue 25 files and divided into 3 experimental groups according to sealer and obturation techniques (<em>n</em> = 15): Group HI - BC Sealer Hiflow and continuous wave technique; Group AH - AH Plus and continuous wave technique; Group BC - Bio C Sealer and single cone technique. The teeth were stored for 30 days and scanned by micro-computed tomography to evaluate the volume of the obturation material. In phase 2, the teeth were unblocked with the Reciproc R40 file and the Flatsonic ultrasonic insert and scanned again. In phase 3, all samples were subjected to passive ultrasonic irrigation and a final scan was performed. The volume of obturation material was compared across all phases and groups. The volume of obturation material was calculated for the entire canal using an ANOVA analysis with a significance level of 5%.</div></div><div><h3>Results</h3><div>The BC group showed a significant difference compared to the AH group (<em>P</em> = .005) and HI group (<em>P</em> &lt; .001). There was no significant difference between the AH and HI groups. Within the groups, only the comparison of phase 2–3 in the HI group showed no significant difference (<em>P</em> = .005). No group achieved complete removal of the obturation material.</div></div><div><h3>Conclusion</h3><div>Bio C Sealer had the least residual obturation material and passive ultrasonic irrigation improved material removal in AH Plus and Bio C Sealer sealers, but not in the BC Sealer Hiflow sealer.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 6","pages":"Pages 748-754"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT-Assessed Outcomes and Prognostic Factors of Primary Endodontic Treatment and Retreatment: A Systematic Review and Meta-Analysis","authors":"Joāo Filipe Brochado Martins DDS, MSc ,&nbsp;Athina Christina Georgiou DDS, MSc, PhD ,&nbsp;Patrícia Diogo Nunes MSc, PhD ,&nbsp;Ralph de Vries MSc ,&nbsp;Vera Mónica Almeida Afreixo MSc, PhD ,&nbsp;Paulo Jorge Rocha da Palma DMD, MSc, PhD ,&nbsp;Hagay Shemesh DDS, PhD","doi":"10.1016/j.joen.2025.03.004","DOIUrl":"10.1016/j.joen.2025.03.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Periapical radiographs have limitations in assessing endodontic treatment outcomes, which can be addressed by cone-beam computed tomography (CBCT). This systematic review evaluates primary root canal treatment and retreatment outcomes using CBCT, focusing on periapical healing, success, and prognostic factors.</div></div><div><h3>Methods</h3><div>A literature search (in PubMed, Embase, and Web of Science) was performed up to March 8, 2024, in collaboration with a medical information specialist. Three reviewers (J.F.B.M., A.C.G, P.D.N.) independently performed article selection and data extraction. Risk of bias was assessed, and evidence quality using the Grading of Recommendations, Assessment, Development, and Evaluation approach. Meta-analysis and meta-regression established pooled periapical healing and outcome rates, 95% confidence intervals (CIs), and identify outcome predictors (<em>P</em> &lt; .05).</div></div><div><h3>Results</h3><div>Nineteen studies were included in the meta-analysis. The pooled periapical healing rate using “loose criteria” was 87% (95% CI: 81%–91%) for teeth and 84% (95% CI: 78%–88%) for roots; using “strict criteria” was 36% (95% CI: 22%–53%) for teeth, and 44% (95% CI: 16%–76%) for roots. The weighted pooled success rates for teeth were 85% (95% CI: 80%–89%) under “loose criteria” and 45% (95% CI: 31%–59%) under “strict” criteria. Meta-regression identified outcome predictors include number of visits, irrigant type, tooth type, operator experience, apical preparation size and taper, and obturation technique.</div></div><div><h3>Conclusions</h3><div>CBCT reveals lower success rates under strict criteria compared to loose criteria (36% vs 88%). While CBCT offers greater diagnostic accuracy, its routine use for outcome evaluation may not be necessary, as it yields results similar to periapical radiograph under loose criteria.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 6","pages":"Pages 687-706"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associate Registry","authors":"","doi":"10.1016/S0099-2399(25)00307-3","DOIUrl":"10.1016/S0099-2399(25)00307-3","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 6","pages":"Pages 793-824"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}