Nehal Amir, Emaan Mansoor, Nabiha Eeman, Muhammad Nouman Ahmed, Ezza Mansoor, Efrah Mansoor, Khadim Hussain, Vera Afreixo, Afsheen Mansoor, João Filipe Brochado Martins, Paulo J Palma
{"title":"茉莉基纳米增强氢氧化钙减轻症状性根尖牙周炎术后疼痛：一项随机对照试验。","authors":"Nehal Amir, Emaan Mansoor, Nabiha Eeman, Muhammad Nouman Ahmed, Ezza Mansoor, Efrah Mansoor, Khadim Hussain, Vera Afreixo, Afsheen Mansoor, João Filipe Brochado Martins, Paulo J Palma","doi":"10.1016/j.joen.2025.05.016","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the efficacy of a novel Jasminum-based titanium dioxide nano-reinforced calcium hydroxide (Ca(OH)<sub>2</sub>) intracanal medicament in reducing postoperative pain (PP) compared to conventional Ca(OH)<sub>2</sub> in patients with symptomatic apical periodontitis.</p><p><strong>Methods: </strong>A triple-blind randomized clinical trial, registered at ClinicalTrials.gov (NCT06653608, 10/19/2024) included patients with single-rooted teeth diagnosed with pulp necrosis and symptomatic AP. Patients referred for endodontic treatment fulfilling the inclusion criteria were included. The patients were grouped into nano-reinforced Ca(OH)<sub>2</sub> group (n = 30) and conventional-Ca(OH)<sub>2</sub> (n = 30). Preoperative pain and PP at 4, 24, 48, 72, and 96 hours were recorded using a visual analog scale. Data were analyzed using linear mixed-effects models (R software, version 4.3.2., R Core Team, Vienna, Austria), with significance set at P < .05.</p><p><strong>Results: </strong>Sixty patients with comparable demographic and clinical characteristics, including preoperative pain scores, were recruited. Both groups exhibited significant pain reduction over 96 hours (P < .001). However, a significant group-time interaction was observed (P < .001), with the nano-reinforced Ca(OH)<sub>2</sub> group reporting consistently lower PP scores and greater reductions in PP compared to the conventional Ca(OH)<sub>2</sub> group at all-time points.</p><p><strong>Conclusion: </strong>The incorporation of Jasminum-based TiO<sub>2</sub> nanoparticles to Ca(OH)<sub>2</sub> significantly improved the reduction in PP intensity and duration compared to conventional Ca(OH)<sub>2</sub>, making it a superior option for PP management.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":"996-1005"},"PeriodicalIF":3.6000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Jasminum-based Nano-reinforced Calcium Hydroxide Reduces Postoperative Pain in Symptomatic Apical Periodontitis: A Randomized Controlled Trial.\",\"authors\":\"Nehal Amir, Emaan Mansoor, Nabiha Eeman, Muhammad Nouman Ahmed, Ezza Mansoor, Efrah Mansoor, Khadim Hussain, Vera Afreixo, Afsheen Mansoor, João Filipe Brochado Martins, Paulo J Palma\",\"doi\":\"10.1016/j.joen.2025.05.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study evaluated the efficacy of a novel Jasminum-based titanium dioxide nano-reinforced calcium hydroxide (Ca(OH)<sub>2</sub>) intracanal medicament in reducing postoperative pain (PP) compared to conventional Ca(OH)<sub>2</sub> in patients with symptomatic apical periodontitis.</p><p><strong>Methods: </strong>A triple-blind randomized clinical trial, registered at ClinicalTrials.gov (NCT06653608, 10/19/2024) included patients with single-rooted teeth diagnosed with pulp necrosis and symptomatic AP. Patients referred for endodontic treatment fulfilling the inclusion criteria were included. The patients were grouped into nano-reinforced Ca(OH)<sub>2</sub> group (n = 30) and conventional-Ca(OH)<sub>2</sub> (n = 30). Preoperative pain and PP at 4, 24, 48, 72, and 96 hours were recorded using a visual analog scale. Data were analyzed using linear mixed-effects models (R software, version 4.3.2., R Core Team, Vienna, Austria), with significance set at P < .05.</p><p><strong>Results: </strong>Sixty patients with comparable demographic and clinical characteristics, including preoperative pain scores, were recruited. Both groups exhibited significant pain reduction over 96 hours (P < .001). However, a significant group-time interaction was observed (P < .001), with the nano-reinforced Ca(OH)<sub>2</sub> group reporting consistently lower PP scores and greater reductions in PP compared to the conventional Ca(OH)<sub>2</sub> group at all-time points.</p><p><strong>Conclusion: </strong>The incorporation of Jasminum-based TiO<sub>2</sub> nanoparticles to Ca(OH)<sub>2</sub> significantly improved the reduction in PP intensity and duration compared to conventional Ca(OH)<sub>2</sub>, making it a superior option for PP management.</p>\",\"PeriodicalId\":15703,\"journal\":{\"name\":\"Journal of endodontics\",\"volume\":\" \",\"pages\":\"996-1005\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of endodontics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.joen.2025.05.016\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of endodontics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.joen.2025.05.016","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/2 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Jasminum-based Nano-reinforced Calcium Hydroxide Reduces Postoperative Pain in Symptomatic Apical Periodontitis: A Randomized Controlled Trial.
Introduction: This study evaluated the efficacy of a novel Jasminum-based titanium dioxide nano-reinforced calcium hydroxide (Ca(OH)2) intracanal medicament in reducing postoperative pain (PP) compared to conventional Ca(OH)2 in patients with symptomatic apical periodontitis.
Methods: A triple-blind randomized clinical trial, registered at ClinicalTrials.gov (NCT06653608, 10/19/2024) included patients with single-rooted teeth diagnosed with pulp necrosis and symptomatic AP. Patients referred for endodontic treatment fulfilling the inclusion criteria were included. The patients were grouped into nano-reinforced Ca(OH)2 group (n = 30) and conventional-Ca(OH)2 (n = 30). Preoperative pain and PP at 4, 24, 48, 72, and 96 hours were recorded using a visual analog scale. Data were analyzed using linear mixed-effects models (R software, version 4.3.2., R Core Team, Vienna, Austria), with significance set at P < .05.
Results: Sixty patients with comparable demographic and clinical characteristics, including preoperative pain scores, were recruited. Both groups exhibited significant pain reduction over 96 hours (P < .001). However, a significant group-time interaction was observed (P < .001), with the nano-reinforced Ca(OH)2 group reporting consistently lower PP scores and greater reductions in PP compared to the conventional Ca(OH)2 group at all-time points.
Conclusion: The incorporation of Jasminum-based TiO2 nanoparticles to Ca(OH)2 significantly improved the reduction in PP intensity and duration compared to conventional Ca(OH)2, making it a superior option for PP management.
期刊介绍：
The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.
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