Journal of endodontics最新文献

{"title":"CBCT-Assessed Outcomes and Prognostic Factors of Primary Endodontic Treatment and Retreatment: A Systematic Review and Meta-Analysis.","authors":"Jf Brochado Martins, Ac Georgiou, P Diogo, R de Vries, V Freixo, Pj Palma, H Shemesh","doi":"10.1016/j.joen.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.joen.2025.03.004","url":null,"abstract":"<p><strong>Introduction: </strong>Periapical radiographs (PR) have limitations in assessing endodontic treatment outcomes, which can be addressed by cone beam computed tomography (CBCT). This systematic review evaluates primary root canal treatment and retreatment outcomes using CBCT, focusing on periapical healing, success, and prognostic factors.</p><p><strong>Methods: </strong>A literature search (in PubMed, Embase and Web of Science) was performed up to March 8, 2024, in collaboration with a medical information specialist. Three reviewers independently performed article selection and data extraction. Risk of bias was assessed, and evidence quality using the Grading of Recommendations, Assessment, Development, and Evaluation approach. Meta-analysis and meta-regression established pooled periapical healing and outcome rates, 95% confidence intervals (CIs), and identify outcome predictors (P < .05).</p><p><strong>Results: </strong>Nineteen studies were included in the meta-analysis. The pooled periapical healing rate using 'loose criteria' was 87% (95% CI: 81-91%) for teeth and 84% (95% CI: 78-88%) for roots; using 'strict criteria' was 36% (95% CI: 22-53%) for teeth, and 44% (95% CI: 16-76%) for roots. The weighted pooled success rates for teeth were 85% (95% CI: 80-89%) under 'loose criteria' and 45% (95% CI: 31-59%) under 'strict' criteria. Meta-regression identified outcome predictors include number of visits, irrigant type, tooth type, operator experience, apical preparation size and taper, and obturation technique.</p><p><strong>Conclusion: </strong>CBCT reveals lower success rates under strict criteria compared to loose criteria (36% vs. 88%). While CBCT offers greater diagnostic accuracy, its routine use for outcome evaluation may not be necessary, as it yields results similar to PR under loose criteria.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentional Replantation of C-shaped Mandibular Second Premolar with Radicular Groove.","authors":"Siwen Wu, Jeen Nee Lui","doi":"10.1016/j.joen.2025.03.003","DOIUrl":"10.1016/j.joen.2025.03.003","url":null,"abstract":"<p><p>C-shaped roots with radicular grooves are uncommon in mandibular premolars. Bacteria residing in the radicular groove and associated accessory canals can contribute to persistent periradicular infections. Eradicating bacteria in these less accessible areas remains a significant challenge in endodontic procedures. This report describes the successful management of a left mandibular second premolar (#20) with a persistent lesion related to a lingual radicular groove through an intentional replantation procedure. A 31-year-old Chinese male complained of a gum swelling related to tooth #20 which was endodontically treated and crowned 6 years ago. Clinical examination revealed a lingually located sinus tract and a clinically intact crown restoration. The tooth was not tender to percussion or palpation, with probing depths not exceeding 4 mm, and showed physiological mobility. A periapical radiograph showed the lingual sinus tract traced to the mid third of the root, which had an adequate root canal filling and an intact periodontal ligament around the apical region. A cone-beam computed tomography image revealed radiolucency at the mid third region and on the lingual aspect related to the radicular groove of this C-shaped premolar. Intentional replantation was performed due to the location of the mid-root lesion related to the lingual radicular groove. Tooth #20 was extracted atraumatically, a stained radicular groove was identified, cleansed and sealed with Biodentine, and the tooth replanted. At 2.5-year follow-up, the patient was clinically asymptomatic. Tooth #20 presented with normal probing depths and mobility and healing was observed on the cone-beam computed tomography images.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Morphological and Chemical Composition of Dental Pulp Stones: A Combined Microanalytical Approach.","authors":"Vincenzo Tosco, Riccardo Monterubbianesi, Jose Aranguren, Michele Furlani, Nicole Riberti, Angelo Putignano, Giovanna Orsini","doi":"10.1016/j.joen.2025.02.014","DOIUrl":"10.1016/j.joen.2025.02.014","url":null,"abstract":"<p><strong>Introduction: </strong>Pulp stones (PSs) are mineralized ectopic structures within the dental pulp that vary in morphology, composition, and location. Their etiology remains uncertain and poses clinical challenges in endodontics. This study hypothesized that combined analytical techniques would enhance understanding of PS morphology and composition, facilitating clinical management of complex cases.</p><p><strong>Methods: </strong>Fifteen permanent molars with radiographic evidence of PSs were analyzed using microcomputed tomography (μ-CT), light microscopy, and scanning electron microscopy associated with energy-dispersive spectroscopy (SEM-EDS). The samples underwent qualitative and quantitative assessments to explore their morphology, distribution, and chemical composition. Statistical analysis was conducted using one-way analysis of variance to evaluate differences in Ca/P ratios between PS and dentin, with significance set at P < .05.</p><p><strong>Results: </strong>μ-CT and histological evaluations revealed distinct morphological differences between coronal and radicular PS. Coronal PS exhibited regular nodular or mold shapes, whereas radicular PS showed irregular and diffuse patterns. Histological findings highlighted the nature of PS as mineralized ectopic connective tissue in coronal regions. On the other hand, radicular PSs displayed linear arrangement of collagen fibers intertwined with vascular bundles. SEM-EDS demonstrated no significant differences in mineralization between PS and dentin, with comparable Ca/P ratios.</p><p><strong>Conclusions: </strong>PSs exhibit distinct morphological and structural characteristics depending on their location. Despite these differences, PSs and dentin share similar chemical compositions, as demonstrated by similar Ca/P ratios. The combined microanalytical approach employed provides novel insights into PS morphology and composition, offering a foundation for translational advancements in diagnostic and therapeutic strategies.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Number of Missing Tooth Surfaces and the Molecular Findings on the Outcomes of Vital Pulp Therapy Using 2 Calcium Silicate Materials: A Randomized Clinical Study.","authors":"Mostafa Sami Abdelaziz, Nelly Abdelsalam, Dalia Mukhtar Fayyad","doi":"10.1016/j.joen.2025.03.001","DOIUrl":"10.1016/j.joen.2025.03.001","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the clinical and radiographic outcomes of full pulpotomy in mandibular molar teeth with symptomatic irreversible pulpitis. It compared class I and class II cavity defects and correlated these outcomes with the quantification of 2 biomolecules (tumor necrosis factor-alpha [TNF-α] and matrix metalloproteinase-9 [MMP-9]) using 2 types of pulpotomy dressing materials (MTA+ and Well-Root PT).</p><p><strong>Methods: </strong>Sixty patients were selected and categorized based on cavity class. Full pulpotomy was conducted under aseptic conditions and rubber dam isolation. Pulpal blood samples were taken for TNF-α and MMP-9 quantification. Sodium hypochlorite was used as a hemostatic agent. The teeth were randomly divided based on the pulpotomy dressing material, MTA+, or Well-Root PT. Clinical and radiographic assessments were conducted after 1 week, 3, 6, and 12 months.</p><p><strong>Results: </strong>The overall clinical and radiographic success rate of pulpotomy procedures after a 1-year follow-up was 88.3%. There were nonsignificant differences in the success rates between the groups and subgroups (93.3% in MTA class I, 86.7% in Well-Root PT class I, 80.0% in MTA class II, and 93.3% in Well-Root PT class II). TNF-α and MMP-9 showed a significant correlation with the outcomes.</p><p><strong>Conclusion: </strong>Class I and II cavity defects do not significantly impact the pulpotomy success rate. TNF-α and MMP-9 levels are potential indicators of pulpotomy outcomes. Well-Root PT offers easier handling and lacks the discoloration effect associated with MTA+.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A vitro study of the effect of different methods of removing calcium hydroxide from root canals.","authors":"Yanzhi Wang, Changjie Xiao, Panpan Zhang, Ying Liu, Jie Li","doi":"10.1016/j.joen.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.joen.2025.02.015","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficiency of four methods for removing calcium hydroxide in root canals.</p><p><strong>Methods: </strong>80 mandibular single-tube permanent premolars were instrumented to ProTaper Universal F4. The teeth were split in two lengthwise, standardized grooves, and depressions were prepared on the wall of the root canal and filled with calcium hydroxide. The samples were randomly divided into 4 groups according to different rinsing methods, namely, syringe rinsing group (SYIG), sonic vibration group (SOIG), ultrasonic lancing Group (ULIG), and Er: YAG laser rinsing group (LAIG). The calcium hydroxide was removed from the root canal. The residual calcium hydroxide area percentage was calculated microscopically and photographed before and after rinsing. The removal effect of irregular areas (grooves and depressions) was evaluated by scoring.</p><p><strong>Results: </strong>In the root canal crown, the clearance rate of SOIG, ULIG, and LAIG was better than that of SYIG. ULIG and LAIG had the best clearance rate (P < 0.05). In the middle root canal and root canal tip, the clearance rate of SOIG, ULIG, and LAIG was better than that of SYIG. Among them, LAIG had the best clearance rate (P < 0.05). There was no obvious difference in the clearance rate between SOIG and ULIG (P > 0.05). For the calcium hydroxide removal scores of different flushing techniques in grooves and depressions, LAIG was the best (P > 0.05).</p><p><strong>Conclusions: </strong>None of the four methods can completely remove calcium hydroxide. However, LAIG has greater advantages than other washing methods, with higher cleaning efficiency.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of an Ultrasonic Device into Dynamic Navigation System for a Fully Guided Dynamic Endodontic Microsurgery Workflow: An In Vitro Study.","authors":"Frederico C Martinho, Nicholas H Stroeters, Bruno G Bisi, Giulio Gavini, Ina L Griffin, Patricia A Tordik","doi":"10.1016/j.joen.2025.02.013","DOIUrl":"10.1016/j.joen.2025.02.013","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the feasibility of integrating an ultrasonic (US) device into a dynamic navigation system (DNS) for a fully guided dynamic endodontic microsurgery (EMS) workflow. It compares the accuracy and efficiency of fully guided dynamic US + DNS to US + freehand (FH) workflow.</p><p><strong>Methods: </strong>Thirty-eight mandibular molars were divided into 2 groups: US + DNS (n = 19) and US + FH (n = 19). Cone-beam computed tomography scans were taken pre- and postoperatively. Bone window cut (BWC), root-end resection (RER), root-end cavity preparation (RECP), and root-end filling (REF) were planned in the X-guide. BWC, RER, RECP, and REF were all conducted under dynamic navigation. Three-dimensional deviations were measured for BWC. Resected root length and resection angle were calculated for the RER. Frequency long-axis deviation was recorded for RECP, and REF depth was measured. Total operating time was recorded.</p><p><strong>Results: </strong>The fully guided US + DNS was more accurate than US + FH, showing lesser 3-dimensional deviations for BWC (P < .0001). The resected root length was ∼3 mm (P > .05). The RER angle was lower in US + DNS (P < .0001). RECP long-axis deviations were lesser in US + DNS (P < .05). The REF depth average was 3 mm for US + DNS and 2.78 mm for US + FH (P < .05). Both EMS workflows were time efficient for EMS, with US + FH taking less time (P < .05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, it is feasible to integrate US into a DNS for a fully guided dynamic EMS workflow. Fully guided dynamic EMS workflow improved overall EMS accuracy.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Calcium Dynamics in Regular-Set versus Fast-Set Bioceramics: Impact on Cytotoxicity and Apatite Formation","authors":"Wafaa A. Khalil PhD, MSc, BDS,&nbsp;Hanan Alharbi BDS, MMSc, MEndo RCSEd","doi":"10.1016/j.joen.2024.12.002","DOIUrl":"10.1016/j.joen.2024.12.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The objective of this study was to assess the calcium ions (Ca²⁺) release, pH shift, bioactivity, and cytotoxicity of both forms of EndoSequence Root Repair Material: regular set (ES) and fast set (ESF).</div></div><div><h3>Methods</h3><div>ES (<em>n</em> = 10) and ESF (<em>n</em> = 10) forms were tested for their bioactivity. Elemental analysis was done on the fresh material and material immersed in phosphate-buffered saline (PBS) for 30 days. The surface crystal formation was studied. Cytotoxicity was evaluated at different material concentrations using a human hepatocellular cancer cell line (Huh-7).</div></div><div><h3>Results</h3><div>Both materials contain Ca, P, Ta, Zr, and Si as major elements. Both ES and ESF have a limited percentage of ytterbium and neodymium. In the fresh material, compared with the ESF, the ES had a higher Ca²⁺ concentration with a homogeneous surface distribution. However, the ESF released significantly more Ca²⁺ (<em>P</em> &lt; .05) and had a higher pH over the 7-day course. When the material was immersed in PBS, the ESF exhibited a significantly higher Ca/P ratio of 2.95, while ES had 2.16 Ca/P ratio (<em>P</em> &lt; .05). The ESF had a greater capacity to precipitate and grow hydroxyapatite (HA) than ES, resulting in more mature crystals forming on the surface. Both SE and ESF demonstrated low cytotoxicity against Huh-7 cells.</div></div><div><h3>Conclusions</h3><div>When ES and ESF were submerged in simulated bodily fluid, both forms produced apatite crystals at the dentin material interface, releasing high Ca²⁺ and displaying a prolonged high pH with high bioactivity potential. Both forms had comparable low cytotoxicity. A higher Ca²⁺ release in ESF indicates dynamic bioactivity, which should be aligned with the clinical requirements.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 325-331"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential of Nitrofurantoin for Infection Control in Regenerative Endodontics: In Vitro Study","authors":"Fabiano Palmeira Gonçalves DDS, MSD, PhD ,&nbsp;Olney Vieira-da-Motta PhD ,&nbsp;Pantaleo Scelza Neto DDS, MSD, PhD ,&nbsp;Solange Silva Samarão PhD ,&nbsp;Sandro Junio de Oliveira Tavares DDS, MSD, PhD ,&nbsp;Sérgio Henrique Seabra PhD ,&nbsp;Gabriel Bonan Taveira PhD ,&nbsp;Miriam Fatima Zaccaro Scelza DDS, MSD, PhD","doi":"10.1016/j.joen.2024.12.009","DOIUrl":"10.1016/j.joen.2024.12.009","url":null,"abstract":"<div><h3>Introduction</h3><div>This study assessed a new antimicrobial paste formulation containing nitrofurantoin for regenerative endodontics against multispecies biofilms.</div></div><div><h3>Methods</h3><div>Four groups of 11 single-root teeth each were tested: Negative control group (brain-heart infusion broth + micro-organisms); Hoshino 1 conventional tri-antibiotic paste group (1:1:1 ratio); Hoshino 5 group (5:5:5 ratio); Experimental group with nitrofurantoin, ciprofloxacin, and metronidazole. Minimum inhibitory concentrations of each antimicrobial were determined. A polymicrobial biofilm (<em>Enterococcus faecalis</em>, <em>Staphylococcus aureus</em>, <em>Pseudomonas aeruginosa</em>, <em>Candida albicans</em>) was created in root canals, and pastes were inserted for 3 minutes with lentulo. After 7 days, samples were sonicated and spectrophotometrically analyzed. Microbiological assays, plasma membrane permeabilization, confocal laser scanning microscopy, and scanning electron microscopy evaluated biofilm eradication. Statistical significance was set at <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>Spectrophotometry indicated Experimental group outperformed Hoshino 1 group and Negative control group (<em>P</em> &lt; .05), with results similar to Hoshino 5 group (<em>P</em> &gt; .05). Experimental group showed increased membrane damage compared to Hoshino 1 group and Hoshino 5 group. Confocal laser scanning microscopy and scanning electron microscopy revealed fewer microorganisms and no residual biofilm in Experimental group.</div></div><div><h3>Conclusions</h3><div>Substituting minocycline with nitrofurantoin in the paste effectively reduced microorganism counts in root canals system.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 303-315"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mirogabalin as a Therapeutic Option for Neuropathic Pain Emerging Postendodontic Treatment: An Observational Study","authors":"Kohei Shimizu DDS, PhD ,&nbsp;Takuya Yasukawa DDS, PhD ,&nbsp;Takuro Izumida DDS ,&nbsp;Kana Ozasa DDS, PhD ,&nbsp;Keita Takizawa DDS ,&nbsp;Noboru Noma DDS, PhD ,&nbsp;Makoto Hayashi DDS, PhD ,&nbsp;Osamu Takeichi DDS, PhD","doi":"10.1016/j.joen.2024.12.015","DOIUrl":"10.1016/j.joen.2024.12.015","url":null,"abstract":"<div><h3>Introduction</h3><div>We have recently reported the clinical efficacy of mirogabalin for occlusal pain due to post-traumatic trigeminal neuropathic pain (PTTN-occlusal pain) after endodontic treatment according to the International Classification of Orofacial Pain criteria. This study aimed to determine the mirogabalin administration period and timing of dose reduction and suspension for treating this condition based on managing a certain number of cases.</div></div><div><h3>Methods</h3><div>Patients diagnosed with PTTN-occlusal pain after or during endodontic treatment were included in the study. An endodontist retreated if necessary. Patients who initially experienced occlusal pain but gradually adapted to bite well without medication were classified into the provisional restoration group (<em>n</em> = 13). Patients who experienced severe pain during mastication and could not chew with a provisional restoration were classified into the mirogabalin medication group (<em>n</em> = 15). Mirogabalin (10 mg/day) was prescribed once a day before bedtime. The patients receiving visual analog scale (VAS) were instructed to record daily changes in pain intensity in a VAS diary. The practitioners also recorded scores during consultations.</div></div><div><h3>Results</h3><div>In the provisional restoration group, VAS scores significantly decreased from week 6 and plateaued from week 11 (<em>P</em> &lt; .05). This adaptation period was applied to reduction or discontinuation of mirogabalin treatment in the mirogabalin medication group. After initiating mirogabalin, VAS scores significantly decreased gradually from week 1 (<em>P</em> &lt; .05). Although the dose was tapered around week 7 and discontinued by week 11, no recurrence of pain was observed following dose reduction or discontinuation.</div></div><div><h3>Conclusions</h3><div>Mirogabalin was effective in treating PTTN-occlusal pain.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 279-286"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to Registration and Selective Outcome Reporting in Randomized Clinical Trials Published in Endodontic Journals Over the Past 5 Years: A Meta-Research Study","authors":"Filipe Colombo Vitali PhD ,&nbsp;Pablo Silveira Santos PhD ,&nbsp;Aurélio de Oliveira Rocha MS ,&nbsp;Lucianne Cople Maia PhD ,&nbsp;Lucas da Fonseca Roberti Garcia PhD ,&nbsp;Cleonice da Silveira Teixeira PhD","doi":"10.1016/j.joen.2024.12.001","DOIUrl":"10.1016/j.joen.2024.12.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Prospective registration of randomized clinical trials (RCTs) is highly recommended to ensure research transparency and prevent selective outcome reporting (SOR). This study aimed to evaluate the adherence to registration and the presence of SOR in RCTs published in endodontic journals over the past 5 years.</div></div><div><h3>Methods</h3><div>Electronic searches were conducted in PubMed and the libraries of the <em>Journal of Endodontics</em>, <em>International Endodontic Journal</em>, <em>European Endodontic Journal</em>, and <em>Australian Endodontic Journal</em>. Two reviewers were involved in the study selection and evaluation. Publications were assessed for key methodological aspects, including the presence and timing of trial registration. RCT registries were examined to identify discrepancies between publication and registered protocols and the presence of SOR. Logistic regression was used to explore the effect of study variables on registration practices and SOR.</div></div><div><h3>Results</h3><div>Of the 144 RCTs included, 104 (72.2%) were registered. Among those registered, only 19 (18.3%) adhered to prospective registration. Registration practice increased by 53% per year (OR 1.53; 95% CI: 1.34–2.08; <em>P</em> &lt; .01). Discrepancies between publication and protocol were identified in 55.8% of studies, primarily related to sample size (33.7%). SOR was identified in 41 trials (39.4%), mainly due to discrepancies in the outcome time frame (18.3%). Studies evaluating multiple outcomes had 4.95 times higher odds of exhibiting SOR (OR 4.95; 95% CI: 1.63–12.95; <em>P</em> &lt; .01). Furthermore, studies that were registered retrospectively or exhibited discrepancies between publication and protocol accounted for 6.10 times (OR 6.10; 95% CI: 1.81–18.96; <em>P</em> = .03) and 5.61 times (OR 5.61; 95% CI: 2.93–16.58; <em>P</em> &lt; .01) higher odds of exhibiting SOR, respectively.</div></div><div><h3>Conclusions</h3><div>RCTs published in endodontic journals over the past 5 years presented low adherence to prospective trial registration and a high prevalence of SOR.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 258-267.e7"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}