Journal of endodontics最新文献

{"title":"Current Perspectives on the Adjunctive Use of Botulinum Toxin A in Endodontic Practice for Nonodontogenic Pain Management: A Web-Based Survey","authors":"Connie Y. Winegar DDS, MS ,&nbsp;Andre K. Mickel DDS, MSD, MDiv ,&nbsp;Nivine Y. El-Refai BDS, DDS, MSD ,&nbsp;Kristin A. Williams DDS, MPH","doi":"10.1016/j.joen.2024.10.012","DOIUrl":"10.1016/j.joen.2024.10.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the increasing use of botulinum toxin A (BoNT-A) in dentistry, there is limited research on its use in endodontics, a specialty that often receives referrals for dental pain that can coexist with nonodontogenic pain. The purpose of this study was to assess whether endodontists believe BoNT-A can be useful in an endodontic practice as an adjunctive treatment for nonodontogenic conditions overlapping with dental pain.</div></div><div><h3>Methods</h3><div>A 23-question survey was emailed to 3,979 members of the American Association of Endodontists. Descriptive statistics, bivariate analysis, and logistic regression were performed with significance at α = 0.05.</div></div><div><h3>Results</h3><div>Among the 211 respondents confirmed to be endodontists in the United States, 1 in 11 (9.14%) currently administer BoNT-A treatment. The top nonodontogenic conditions indicated for BoNT-A were myofascial orofacial pain (49.22%) and temporomandibular joint disorders (41.97%). Half of the endodontists (50.26%) believe that BoNT-A could be useful for nonodontogenic conditions overlapping with dental pain. Regression analysis identified variables significantly associated with this belief: BoNT-A can improve patient satisfaction (<em>P</em> &lt; .05), BoNT-A training should be offered in residency (<em>P</em> &lt; .05), BoNT-A would increase profitability (<em>P</em> &lt; .05), and BoNT-A will be incorporated more in the future (<em>P</em> &lt; .05).</div></div><div><h3>Conclusion</h3><div>Endodontists have split opinions on administering BoNT-A for nonodontogenic conditions overlapping with dental pain. Including BoNT-A training in residency may be key to encouraging multidisciplinary pain management in endodontics.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 1","pages":"Pages 21-27"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided Intentional Replantation of a Mandibular Premolar with Type IIIb Dens Invaginatus Associated with Peri-invagination Periodontitis without Root Canal Treatment: A Case Report.","authors":"Francesc Abella Sans, Marc Garcia-Font, Nandini Suresh, Paul M H Dummer, Venkateshbabu Nagendrababu","doi":"10.1016/j.joen.2024.12.017","DOIUrl":"10.1016/j.joen.2024.12.017","url":null,"abstract":"<p><p>This report highlights successful management of a rare case of a mandibular premolar with Oehler's Type IIIb Dens Invaginatus (DI) and peri-invagination periodontitis with guided intentional replantation without root canal treatment. A 22-year-old female patient reported with discomfort and a sinus tract associated with tooth number 21. Clinical examination and cone beam computed tomography revealed tooth number 21 had an Oehler's Type IIIb DI with peri-invagination periodontitis. The patient had partially healed sockets in the number 19 and number 30 regions. Thus, guided intentional replantation for tooth number 21 and guided double autotransplantation in the position of teeth number 19 and number 30 in a single visit was planned. Three-dimensional replicas of the donor teeth (numbers 16 and 32) as well as number 21 with type IIIb DI were printed based on intraoral scanning and cone beam computed tomography images. Tooth number 21 was extracted with its buccal cortical plate and root-end resection followed by root-end filling with mineral trioxide aggregate was performed. The tooth was replanted into the modified socket, and stabilized using a flexible wire-composite splint for 4 weeks. Unfortunately, the patient was lost to follow-up, but reported 2 years later when all teeth were retained without signs of disease. Two years following intentional replantation without root canal treatment, tooth number 21 with an Oehler's Type IIIb DI with peri-invagination periodontitis had no symptoms and radiographic examination revealed a reduction in the dimensions of the peri-invagination periodontitis.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel Assessment to Explore the Cutting Performance of Rotary Instruments Using Dynamic Finite Element Analysis With Failure Mode.","authors":"Chih-Wen Chi, Weng-Pin Chen, Wei-Ting Liu, Ting-Ju Lai, Chun-Pin Lin","doi":"10.1016/j.joen.2024.12.018","DOIUrl":"10.1016/j.joen.2024.12.018","url":null,"abstract":"<p><strong>Introduction: </strong>The separation of Nickel-Titanium (NiTi) endodontic instruments due to excessive torque adversely affects treatment outcomes. Previous studies have analyzed torque values under static conditions and failed to accurately simulate the dynamic conditions of instruments within root canals. This study aimed to apply a novel finite element analysis (FEA) to assess the real-time dynamic performance of NiTi endodontic instruments during operation in root canals.</p><p><strong>Methods: </strong>In this study, three-dimensional geometric models of commercial NiTi endodontic instruments (ProTaper Universal) and simulated root canals were developed. In the first part, dynamic analyses of the instruments operating within root canals were simulated using finite element fracture theory and validated through experimental methods. To assess the consistency between the experimental results generated by different instruments (ProTaper Universal SX, S1, S2, and F1) and the FEA results, we utilized Bland-Altman plots for visualization and the Intraclass Correlation Coefficient for comparing continuous data. In the second part, the FEA was employed to establish a safe and efficient sequence for root canal shaping.</p><p><strong>Results: </strong>The findings indicated a similar trend between the analyzed and experimental groups. The Bland-Altman plot demonstrated a high level of consistency, with Intraclass Correlation Coefficient values ranging from 0.6407 to 0.9351. To evaluate the dynamic performance of commercial endodontic instruments in canals, the instruments experienced excessive torque values and significant loading. Based on torque control, new sequences for safe and effective root canal preparation were proposed.</p><p><strong>Conclusion: </strong>FEA with failure mode was demonstrated to simulate the real-time dynamic performance of instruments working in the simulated canals. This assessment offers guidance for clinical protocols and the development of innovative instruments with improving safety and efficacy in endodontic treatments through computer-aided techniques.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Cavity Designs on Instrumentation, Obturation, and Fracture Resistance of Mandibular First Premolars With Vertucci V Canal.","authors":"Yuxuan Liu, Yi Luo, Yaxu Feng, Xianhua Gao, Wei Fan, Bing Fan","doi":"10.1016/j.joen.2024.12.014","DOIUrl":"10.1016/j.joen.2024.12.014","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess the effect of cavity designs on instrumentation, obturation and fracture resistance for mandibular first premolars with Vertucci V canal.</p><p><strong>Methods: </strong>Mandibular first premolars with Vertucci V canal were scanned with microcomputed tomography. A total of 20 teeth with moderately curved canal were prepared with conservative endodontic cavity (CEC/M) or traditional endodontic cavity (TEC/M), and 30 with severely curved canal were prepared with CEC (CEC/S), modified CEC (MCEC/S) or TEC (TEC/S). CECs and MCEC were prepared using dynamic navigation systems. TECs were prepared freehand. Canals were prepared with WaveOne Gold, irrigated and then obturated with single-cone technique using iRoot SP sealer and WaveOne Gold gutta-percha cones. After restoration, all teeth were submitted to fracture resistance test. Removal of pericervical dentin, volume of dentin removal, area of untouched canal wall, accumulated hard tissue debris, centering ability, voids in canal filling, and load at fracture were evaluated.</p><p><strong>Results: </strong>MCEC and CEC groups preserved more pericervical dentin above the alveolar bone level and more fracture resistance than TEC groups. At 3 mm from apical foramen, lower centering ability in mesiodistal direction was found in buccal canal of CEC/S group. More voids were found in the lingual canal for CEC/S compared with TEC/S (P < .05).</p><p><strong>Conclusions: </strong>CEC and MCEC prepared with dynamic navigation system could preserve more dentin above the alveolar bone and fracture resistance than TEC prepared freehand. For teeth with severely curved V canal, MCEC showed similar ability in instrumentation and obturation as TEC.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Pulpal Mineralization in Mandibular Anteriors: A Micro-computed Tomography Analysis","authors":"Georgina Marshall BDS, BScD(Hons) ,&nbsp;Konstantinos Verdelis DDS, PhD ,&nbsp;Ove A. Peters DMD, MS, PhD","doi":"10.1016/j.joen.2024.09.010","DOIUrl":"10.1016/j.joen.2024.09.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Current understanding of the morphology of pulpal mineralizations is limited. Understanding the specific location and type of such mineralizations will aid clinicians in diagnosis, case complexity assessment, and treatment planning. Therefore, this study correlated the appearance of a reduced canal volume (CV) in conventional radiographs with the presence of pulp mineralizations (PMs) utilizing micro-computed tomography (CT) analysis. The morphology of PMs utilizing micro-CT technology was also analyzed.</div></div><div><h3>Methods</h3><div>One hundred and twenty-one extracted permanent mandibular incisors were collected. Periapical radiographs were taken of the teeth to determine if a reduced canal space was present, in which case the sample was included for micro-CT assessment. Various descriptors for PM were then determined and these labels were then applied to the entire sample to demonstrate PM. Numerical analysis was undertaken for all teeth scanned; the following data was extracted: the presence or absence of PMs, types of PM, and their morphological structures; CVs were determined. Cohen's kappa test was used to assess intraexaminer agreement.</div></div><div><h3>Results</h3><div>Based on radiographic appearance, forty-two teeth were included for micro-CT analysis. PMs were demonstrable in 57% and absent 43% of teeth. When PMs were absent, the CV was significantly smaller compared to when they were present (<em>P</em> &lt; .05). Discrete mineralizations were more frequently located in the coronal and middle thirds compared to diffuse mineralization (<em>P</em> &lt; .01). No differences in the prevalence of the individual features of discrete or diffuse mineralizations were detected (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>Two detectable forms of PMs were found in micro-CT analysis at all levels of the canal: discrete and diffuse mineralizations. A reduced CV on a PA was reflective of mineralized changes within the pulp but the type of PM could not be determined. PMs occurred at any level of the root canal; clinicians need to be aware of this when performing root canal treatment.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1734-1742"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of Variable Taper Files and Corresponding Gutta-Percha Cones Amongst Manufacturers","authors":"Aaron M. Keith DDS, MS ,&nbsp;Susan E. Hinman DDS, MS ,&nbsp;Noel E. Dickens DMD, PhD, MPhil, MPH ,&nbsp;Jeffrey J. Kim DDS, PhD ,&nbsp;Rodney V. Scott DDS, MS ,&nbsp;Nancy H. Osborne DDS, MS","doi":"10.1016/j.joen.2024.10.002","DOIUrl":"10.1016/j.joen.2024.10.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Currently there is no standardization of variable taper endodontic files and corresponding gutta-percha (GP) cones. The aim of this study was to evaluate intramanufacturer and intermanufacturer variability of diameter and taper in the apical third of GP master cones and finishing files from 3 commercially available variable taper endodontic systems.</div></div><div><h3>Methods</h3><div>Diameter measurements were recorded using digital microscopy at 1-mm increments (D1-D4) for F2 files and corresponding GP cones (<em>n</em> = 20 per system) from ProTaper Gold (Dentsply Tulsa Dental Specialties, Johnson City, TN), EdgeTaper Platinum (EdgeEndo, Albuquerque, NM), and ExactTaper H (SS White, Lakewood, NJ). Taper was defined as the rate of change in diameter per 1-mm increment. Mean differences in diameter were assessed using repeated measures of analysis of variance for D1 to D4 and the Wilks test for differences in taper.</div></div><div><h3>Results</h3><div>In the apical third, ProTaper and EdgeEndo mean file diameters were significantly smaller than corresponding GP cone diameters (<em>P</em> &lt; .01, <em>P</em> &lt; .01, respectively). Contrastingly, SS White file diameters were significantly larger than their corresponding GP cones (<em>P</em> = .02). Files from all manufacturers had significantly smaller diameters than advertised (nominal) values (<em>P</em> &lt; .01). ProTaper GP cones had similar diameters to nominal values (<em>P</em> = .30), while EdgeEndo and SS White GP cones were significantly smaller (<em>P</em> &lt; .01). Amongst files and corresponding GP cones from all systems, taper was nonstandardized.</div></div><div><h3>Conclusions</h3><div>Size discrepancies between finishing files and corresponding GP cones can be expected amongst variable taper endodontic systems. Therefore, clinicians should be prepared to make intraoperative adjustments when obturating.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1766-1771"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Implants on the Periapical Health of Natural Adjacent Teeth: A Systematic Review and Meta-Analysis","authors":"Mohammad A. Sabeti DDS, MA,&nbsp;Heather Kim DDS","doi":"10.1016/j.joen.2024.06.015","DOIUrl":"10.1016/j.joen.2024.06.015","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this systematic review was to evaluate the pooled estimate and relative risk of periapical lesions in natural teeth adjacent to implants.</div></div><div><h3>Methods</h3><div>MEDLINE (PubMed), Embase, Cochrane Library, and gray literature were searched (inception-November 2023) to identify studies. Eligible studies were selected and data extracted. Studies were critically assessed for risk of bias and quality of evidence. Quantitative analysis was performed to determine the pooled estimate of periapical radiolucent lesions (PARLs) in teeth adjacent to implants and to assess the relative risk of developing such lesions in these teeth compared to teeth adjacent to nonimplants.</div></div><div><h3>Results</h3><div>A total of 6 studies were included. The pooled estimate of PARL in implant adjacent teeth was 2.55%. The risk ratio for PARL in a tooth adjacent to an implant in comparison to a tooth adjacent to a nonimplant was 2.12. Analyses presented low certainty of evidence.</div></div><div><h3>Conclusions</h3><div>A natural tooth adjacent to an implant has 2.12 times higher probability of developing a PARL compared to a tooth adjacent to a nonimplant. The overall quality of evidence was low.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1705-1713"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PAINe: An Artificial Intelligence–based Virtual Assistant to Aid in the Differentiation of Pain of Odontogenic versus Temporomandibular Origin","authors":"Bianca Marques de Mattos de Araujo MDS, PhD ,&nbsp;Pedro Felipe de Jesus Freitas DDS ,&nbsp;Angela Graciela Deliga Schroder MDS, PhD ,&nbsp;Erika Calvano Küchler MDS, PhD ,&nbsp;Flares Baratto-Filho MDS, PhD ,&nbsp;Vania Portela Ditzel Westphalen MDS, PhD ,&nbsp;Everdan Carneiro MDS, PhD ,&nbsp;Ulisses Xavier da Silva-Neto MDS, PhD ,&nbsp;Cristiano Miranda de Araujo MDS, PhD","doi":"10.1016/j.joen.2024.09.008","DOIUrl":"10.1016/j.joen.2024.09.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Pain associated with temporomandibular dysfunction (TMD) is often confused with odontogenic pain, which is a challenge in endodontic diagnosis. Validated screening questionnaires can aid in the identification and differentiation of the source of pain. Therefore, this study aimed to develop a virtual assistant based on artificial intelligence using natural language processing techniques to automate the initial screening of patients with tooth pain.</div></div><div><h3>Methods</h3><div>The PAINe chatbot was developed in Python (Python Software Foundation, Beaverton, OR) language using the PyCharm (JetBrains, Prague, Czech Republic) environment and the openai library to integrate the ChatGPT 4 API (OpenAI, San Francisco, CA) and the Streamlit library (Snowflake Inc, San Francisco, CA) for interface construction. The validated TMD Pain Screener questionnaire and 1 question regarding the current pain intensity were integrated into the chatbot to perform the differential diagnosis of TMD in patients with tooth pain. The accuracy of the responses was evaluated in 50 random scenarios to compare the chatbot with the validated questionnaire. The kappa coefficient was calculated to assess the agreement level between the chatbot responses and the validated questionnaire.</div></div><div><h3>Results</h3><div>The chatbot achieved an accuracy rate of 86% and a substantial level of agreement (κ = 0.70). Most responses were clear and provided adequate information about the diagnosis.</div></div><div><h3>Conclusions</h3><div>The implementation of a virtual assistant using natural language processing based on large language models for initial differential diagnosis screening of patients with tooth pain demonstrated substantial agreement between validated questionnaires and the chatbot. This approach emerges as a practical and efficient option for screening these patients.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1761-1765.e2"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Silk Fibroin Methacrylated Scaffolds for Regenerative Endodontics","authors":"Ramyasaketha Narayanam BDS ,&nbsp;Lais M. Cardoso DDS, MS, PhD ,&nbsp;Alexandre H. dos Reis-Prado DDS, MS ,&nbsp;Ana Beatriz G. de Carvalho DDS, MS, PhD ,&nbsp;Caroline Anselmi DDS, MS ,&nbsp;Abdel H. Mahmoud BDS, MS ,&nbsp;J. Christopher Fenno PhD ,&nbsp;Renan Dal-Fabbro DDS, MS, PhD ,&nbsp;Marco C. Bottino DDS, MSc, PhD","doi":"10.1016/j.joen.2024.08.004","DOIUrl":"10.1016/j.joen.2024.08.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Recognizing the necessity of novel disinfection strategies for improved bacterial control to ultimately favor tissue regeneration, this study developed and characterized antibiotics-laden silk fibroin methacrylated (SilkMA) scaffolds for regenerative endodontics.</div></div><div><h3>Methods</h3><div>SilkMA-based solutions (10% w/v) containing Clindamycin (CLI) or Tinidazole (TIN) (0 – control; 5, 10, or 15% w/w) or the combination of both drugs (BiMix CLI/TIN 10%) were electrospun and photocrosslinked. Morphology and composition were assessed using scanning electron microscopy and Fourier-transform infrared spectroscopy. Additionally, swelling and degradation profiles were also determined. Cytotoxicity was evaluated in stem cells from apical papilla. Antibacterial efficacy was tested using direct and indirect contact assays against <em>Aggregatibacter actinomycetemcomitans</em>/<em>Aa</em>, <em>Actinomyces naeslundii</em>/<em>An</em>, <em>Enterococcus faecalis</em>/<em>Ef,</em> and <em>Fusobacterium nucleatum</em>/<em>Fn</em>. <em>E. faecalis</em> biofilm inhibition on dentin discs was specifically evaluated for BiMix-laden scaffolds. Data were statistically analyzed with a significance level of 5%.</div></div><div><h3>Results</h3><div>Scanning electron microscopy revealed that all scaffolds had similar characteristics, including fiber morphology and bead absence. Fourier-transform infrared spectroscopy showed the incorporation of CLI and TIN into the fibers and in BiMix scaffolds. Antibiotic-laden scaffolds exhibited lower swelling capacity than the control and were degraded entirely after 45 days. Scaffolds laden with CLI, TIN, or BiMix throughout all time points did not reduce stem cells from apical papilla's viability. CLI-laden scaffolds inhibited the growth of <em>Aa</em>, <em>An</em>, and <em>Ef</em>, while TIN-laden scaffolds inhibited <em>Fn</em> growth. BiMix-laden scaffolds significantly inhibited <em>Aa</em>, <em>An</em>, <em>Ef</em>, and <em>Fn</em> in direct contact, and their aliquots inhibited <em>An</em> and <em>Fn</em> through indirect contact, with additional biofilm inhibition against <em>Ef</em>.</div></div><div><h3>Conclusions</h3><div>BiMix-laden SilkMA scaffolds are cytocompatible and exhibit antimicrobial effects against endodontic pathogens, indicating their therapeutic potential as a drug delivery system for regenerative endodontics.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1752-1760.e2"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associate Registry","authors":"","doi":"10.1016/S0099-2399(24)00644-7","DOIUrl":"10.1016/S0099-2399(24)00644-7","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"50 12","pages":"Pages 1784-1793"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}