Journal of endodontics最新文献

{"title":"Evaluation of the Retreatability of BC Sealer, BC Sealer Hiflow, and AH Plus: A Micro-Computed Tomography Study.","authors":"Priscilla Gouveia, Ana Grasiela Limoeiro, Caroline Beatriz Farias Silva, Marília Fagury Videira Marceliano-Alves, Carlos Eduardo Fontana, Daniel Guimarães Pedro Rocha, Carlos Eduardo da Silveira Bueno, Alexandre Sigrist De Martin","doi":"10.1016/j.joen.2025.02.009","DOIUrl":"10.1016/j.joen.2025.02.009","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, the ability to remove obturation material in canals filled with Bio C Sealer, BC Sealer Hiflow, and AH Plus was compared using micro-computed tomography.</p><p><strong>Materials and methods: </strong>In phase 1, 45 premolars were prepared with Reciproc Blue 25 files and divided into 3 experimental groups according to sealer and obturation techniques (n = 15): Group HI - BC Sealer Hiflow and continuous wave technique; Group AH - AH Plus and continuous wave technique; Group BC - Bio C Sealer and single cone technique. The teeth were stored for 30 days and scanned by micro-computed tomography to evaluate the volume of the obturation material. In phase 2, the teeth were unblocked with the Reciproc R40 file and the Flatsonic ultrasonic insert and scanned again. In phase 3, all samples were subjected to passive ultrasonic irrigation and a final scan was performed. The volume of obturation material was compared across all phases and groups. The volume of obturation material was calculated for the entire canal using an ANOVA analysis with a significance level of 5%.</p><p><strong>Results: </strong>The BC group showed a significant difference compared to the AH group (P = .005) and HI group (P < .001). There was no significant difference between the AH and HI groups. Within the groups, only the comparison of phase 2-3 in the HI group showed no significant difference (P = .005). No group achieved complete removal of the obturation material.</p><p><strong>Conclusion: </strong>Bio C Sealer had the least residual obturation material and passive ultrasonic irrigation improved material removal in AH Plus and Bio C Sealer sealers, but not in the BC Sealer Hiflow sealer.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the Filling Technique on Endodontic Retreatment in Curved Mesial Canals of Mandibular Molars: An In Vitro Study.","authors":"Felipe Andretta Copelli, Lisa Yurie Oda, Renata Maira de Souza Leal, Clarissa Teles Rodrigues, Marco Antonio Hungaro Duarte, Bruno Cavalini Cavenago","doi":"10.1016/j.joen.2025.02.010","DOIUrl":"10.1016/j.joen.2025.02.010","url":null,"abstract":"<p><strong>Introduction: </strong>The root curvature represents a challenge during the endodontic retreatment. Considering the different techniques to fill the root canals and the growing use of bioceramic sealers, this study aimed to evaluate the influence of the filling technique associated with a bioceramic sealer on the remaining filling material and the impact on the remaining dentin after the filling removal in the retreatment of curved mesial canals of mandibular molars.</p><p><strong>Methods: </strong>Eighteen curved mesial roots of mandibular molars with Vertucci type IV canals were prepared up to instrument 35/.05. Two groups were established according to the filling technique: single-cone (n = 18) and continuous wave of condensation (n = 18). Bio-C Sealer was used for both techniques. The filling was removed using the Reciproc Blue R25 instrument, and the repreparation was carried out using the Reciproc Blue R40 instrument. The samples were scanned by micro-computed tomography before and after the filling removal and analyzed regarding the volume of the remaining filling material and dentin thickness for calculating transportation and centering ability. For statistical analysis, the data normality was checked, and parametric tests were used for normal distribution and nonparametric tests for nonnormal distribution.</p><p><strong>Results: </strong>The remaining filling material was observed in both groups during retreatment, with no differences. Analyses of transportation and centering ability also indicated similarities between the two groups.</p><p><strong>Conclusions: </strong>Endodontic retreatment in curved mesial canals of mandibular molars filled with single-cone or continuous wave of condensation technique and bioceramic sealer was similar. The use of reciprocating instruments for filling removal and repreparation was efficient in curved mesial canals of mandibular molars, with no complications.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Iterative Reconstruction of Cone-beam Computed Tomography for Detecting Vertical Root Fractures in the Presence of Metal Artifacts.","authors":"Matheus Barros-Costa, Gustavo Santaella, Christiano Oliveira-Santos, Deborah Queiroz Freitas, William C Scarfe, Francisco Carlos Groppo","doi":"10.1016/j.joen.2025.02.008","DOIUrl":"10.1016/j.joen.2025.02.008","url":null,"abstract":"<p><strong>Introduction: </strong>Vertical root fractures (VRFs) are challenging to detect, especially in endodontically treated teeth. Cone-beam computed tomography (CBCT) has improved VRF detection over periapical radiography but is limited by metal artifacts. Iterative Reconstruction (IR) algorithms are an alternative to the traditional Filtered-Back Projection (FBP) and have been shown to reduce image noise due to metal artifacts. This study aimed to evaluate the impact of IR on VRF detection in the presence of metal artifacts from intracanal materials and/or adjacent implants.</p><p><strong>Methods: </strong>This ex-vivo study included 22 single-rooted teeth (10 fractured, 12 nonfractured) placed in a human mandible phantom. CBCT scans were performed using Midmark EIOS CBCT with both reconstruction methods (FBP and IR), with and without metal artifact reduction (MAR) tool activation. Clinical conditions included the presence or absence of gutta-percha and adjacent titanium dental implants. Five oral radiologists evaluated the anonymized images for VRF presence using a 5-point scale. Diagnostic accuracy, sensitivity, specificity, and intra- and interobserver agreement were assessed using receiver operating characteristic curves and multiway ANOVA.</p><p><strong>Results: </strong>The area under the curve values ranged from 0.60 to 0.85, with no significant differences between reconstruction methods (P > .05). Sensitivity and specificity were generally unaffected by reconstruction method or MAR activation (P > .05), except when MAR reduced sensitivity in FBP with gutta-percha (P < .05). Metal artifacts from gutta-percha and implants negatively impacted VRF detection.</p><p><strong>Conclusions: </strong>The reconstruction method did not significantly influence VRF detection, suggesting that either method can be used in clinical practice without compromising diagnostic accuracy, even in the presence of metal artifacts.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Endodontically Treated Teeth in Patients Undergoing Treatment for Painful Temporomandibular Disorders: An Observational Study.","authors":"Nara Sarmento Macedo Signorelli, Camilla Christian Gomes Moura, Roger Ferreira Borges, Paulo Cézar Simamoto Júnior, Jennifer L Gibbs","doi":"10.1016/j.joen.2025.02.006","DOIUrl":"10.1016/j.joen.2025.02.006","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular disorders (TMDs) and endodontic pain often present overlapping symptoms, complicating the diagnosis and treatment of patients experiencing orofacial pain.</p><p><strong>Methods: </strong>This observational retrospective cohort study aims to determine the prevalence of endodontically treated teeth on the side of pain complaint in patients with TMD, and to explore the association between TMD diagnoses and the presence of endodontically treated teeth. Dental records of patients treated at the TMD and Pain clinic at the Federal University of Uberlândia was reviewed. The study included 85 patients, and demographic data, TMD diagnosis, and the side of referred pain were extracted from the records. Diagnostic imaging exams, including panoramic and periapical radiographs, and cone-beam computed tomography, were analyzed to count the number of endodontically treated teeth on each side of the mouth.</p><p><strong>Results: </strong>The study population consisted of 88% (n = 70) women, with a mean age of 40.5 ± 16.3 years. A significant association was found between the side of TMD pain and the number of endodontically treated teeth, with more treated teeth on the side of pain complaint (median = 1) compared to the pain-free side (median = 0), with P < .001. When analyzing specific TMD diagnoses, the association was significant in muscle-related and mixed TMD diagnoses but not in joint-related TMD pain. Additionally, a binary analysis confirmed this association, showing that patients were significantly more likely to have at least 1 endodontically treated tooth on the side of TMD pain compared to the nonpain side (χ² = 13.06, P = .0003).</p><p><strong>Conclusion: </strong>This study underscores the importance of comprehensive diagnostic evaluations in patients with orofacial pain to avoid unnecessary endodontic treatments and ensure appropriate care. Further research is needed to explore the underlying mechanisms linking endodontic and TMD pain and to validate these findings in diverse populations.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Regenerative Endodontic Procedure: Periapical Healing, Root Development, and Intracanal Calcification.","authors":"Minju Song, Hoi In Jung, Sahng Gyoon Kim","doi":"10.1016/j.joen.2025.02.007","DOIUrl":"10.1016/j.joen.2025.02.007","url":null,"abstract":"<p><strong>Introduction: </strong>This retrospective study aimed to investigate the clinical outcomes and prognostic factors of regenerative endodontic procedure in terms of the resolution of apical periodontitis (AP), root development (RtDev), and intracanal calcification (IC).</p><p><strong>Methods: </strong>The clinical outcomes of a total of 111 cases from 94 patients who underwent regenerative endodontic procedures between 2015 and 2020 were assessed based on clinical and radiographic evaluations.</p><p><strong>Results: </strong>The cumulative survival rate was 85.15%, and RtDev was identified in 67.33% of cases. The incidence of IC has increased over time, reaching 43.45%. The median follow-up time was 1267 days (95% confidence interval, 991-∞) for AP healing and RtDev and 776 days (95% confidence interval, 563-1754) for IC. The 4th stage of RtDev and intracanal medication for less than 14 days or more than 60 days were associated with significantly lower AP healing (P < .05). Patients younger than 8 years of age, absence of a periapical lesion, 2nd and 3rd stage of RtDev, and 14-30 days of intracanal medication were associated with a higher incidence of RtDev (P < .05). Dens evaginatus was associated with a significantly higher incidence of IC (P < .05).</p><p><strong>Conclusions: </strong>The stage of RtDev and duration of intracanal medication significantly affected AP healing and RtDev. Additionally, age and the presence of a periapical lesion were found to influence RtDev, whereas etiology was identified as the only predictor of IC.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nine-year Follow-up of Autotransplantation in the Maxillary Anterior Region: Replacing a Fused Incisor with a Supernumerary Tooth.","authors":"Berkant Sezer, Betül Şen Yavuz, Bora Korkut, Ali Menteş","doi":"10.1016/j.joen.2025.02.003","DOIUrl":"10.1016/j.joen.2025.02.003","url":null,"abstract":"<p><p>The goal of tooth autotransplantation is to restore a missing tooth by using a functional tooth from the same patient. Although this procedure is gaining more recognition as a viable treatment option in dentistry, it is important to monitor and report long-term results. This case report presents the long-term follow-up of a fused maxillary central incisor that was extracted and replaced with a supernumerary tooth. Although the donor tooth displayed favorable characteristics, including an intact periodontal ligament and minimal extraoral time, which contributed to the success of the transplantation, it also presented certain disadvantages, such as having a fully developed root apex. Over a 9-year follow-up period, no clinical symptoms indicative of functional failure were observed. However, external cervical root resorption, first detected at the 6-year follow-up, progressed by the ninth year. Despite the lack of clinical symptoms, radiographic findings suggested that the root resorption was a significant concern. This case underscores the potential for long-term success of autotransplanted teeth, even in complex scenarios involving fused teeth. However, it also highlights the importance of thorough, long-term monitoring to detect complications such as root resorption. The findings suggest that, while autotransplantation can offer favorable outcomes, careful management and periodic evaluations are essential to ensure the longevity of the transplanted tooth.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracanal Antibacterial Effects of a Bioceramic Medication Compared With Calcium Hydroxide Pastes in Different Vehicles","authors":"Andrea F. Campello PhD ,&nbsp;Renata C.V. Rodrigues PhD ,&nbsp;Sabrina C. Brasil PhD ,&nbsp;Thais M. Souza Msc ,&nbsp;Flávio R.F. Alves PhD ,&nbsp;Ibrahimu Mdala MSc, PhD ,&nbsp;José F. Siqueira Jr. PhD ,&nbsp;Isabela N. Rôças PhD","doi":"10.1016/j.joen.2024.11.016","DOIUrl":"10.1016/j.joen.2024.11.016","url":null,"abstract":"<div><h3>Introduction</h3><div>The intracanal antibacterial effectiveness of a bioceramic medication was compared with calcium hydroxide pastes in different vehicles.</div></div><div><h3>Methods</h3><div>Extracted mandibular incisors with a single long oval canal were selected and distributed into 5 groups based on anatomically paired microcomputed tomographic analyses. The root canals were prepared up to an instrument size 35/04 and contaminated for 30 days with a mixed bacterial culture from subgingival biofilm added with <em>Enterococcus faecalis</em>. The canals were medicated with Bio-C Temp (Angelus Indústria de Produtos Odontológicos, Londrina, PR, Brazil) or a calcium hydroxide paste in glycerin, camphorated paramonochlorophenol and glycerin (CHPG), or 2% chlorhexidine (CHCX). Control specimens were filled with sterile saline. After 7 days, the medication was removed by using rotary instruments and saline irrigation. A supplementary approach was conducted, which consisted of 2.5% sodium hypochlorite irrigation and agitation with XP-endo Finisher. Bacteriological samples were taken before application (S1) and after removal (S2) of the intracanal medication, and after the supplementary approach (S3). Bacterial DNA extracted from the samples was quantified using real-time polymerase chain reaction.</div></div><div><h3>Results</h3><div>Bacterial counts were significantly reduced from S1 to S2 in all groups, except for the control group. As for S1-to-S3 changes, all groups (control included) showed significant bacterial reduction. S2-to-S3 changes were only significant in the CHPG and CHCX groups (<em>P</em> &lt; .05). Intergroup comparisons showed no significant differences in S2 (<em>P</em> &gt; .05), with all medications significantly better than the control (<em>P</em> &lt; .05). In S3, only the CHPG and CHCX groups showed further significant bacterial reductions. Categorical data analysis showed no intergroup differences (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>All tested medications significantly reduced the intracanal bacterial counts, with no significant differences between them. Final sodium hypochlorite irrigation and agitation using XP-endo Finisher further enhanced disinfection in the CHCX and CHPG groups.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 207-212"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukemia and Lymphoma Mimicking Periapical Conditions Resulting in Endodontic Treatment: A Systematic Review","authors":"Isis Samara de Melo Queiroga DDS ,&nbsp;Victor Zanetti Drumond DDS ,&nbsp;Lucas Guimarães Abreu DDS, MSc, PhD ,&nbsp;Lauren Frenzel Schuch DDS, MSc, PhD ,&nbsp;Ricardo Alves Mesquita DDS, MSc, PhD ,&nbsp;Erick Miranda Souza DDS, MSc, PhD ,&nbsp;Bruno Augusto Benevenuto de Andrade DDS, MSc, PhD ,&nbsp;José Alcides Almeida de Arruda DDS, MSc, PhD ,&nbsp;Gerhilde Callou Sampaio DDS, MSc, PhD","doi":"10.1016/j.joen.2024.11.005","DOIUrl":"10.1016/j.joen.2024.11.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Leukemia and lymphoma mimicking periapical conditions can lead to significant diagnostic pitfalls. Guidance for endodontists in managing such cases is barely explored. This systematic review aimed to summarize the clinicopathologic, imaging, and management aspects of leukemia/lymphoma that mimicked periapical conditions and resulted in endodontic treatment.</div></div><div><h3>Methods</h3><div>Searches were conducted in PubMed, Embase, Scopus, Web of Science, and LILACS, supplemented by manual scrutiny and gray literature. Case reports and/or case series were included. Critical appraisal of the studies was performed using the Joanna Briggs Institute tool.</div></div><div><h3>Results</h3><div>Among 3,617 identified records, 32 studies involving 37 individuals (mean age 43.6 years; male-to-female ratio 1.2:1) were included. Diffuse large B-cell lymphoma was diagnosed in 21 (56.8%) individuals. The anterior maxilla and posterior mandible were the most frequently affected sites (29.7% each). Radiographically, 97.3% of the lesions exhibited radiolucency in the periapical region. Endodontic treatment preceded the diagnosis of leukemia/lymphoma in 94.6% of cases, while retreatment occurred in 5.4%. The mean time to final diagnosis was 4.9 months.</div></div><div><h3>Conclusion</h3><div>Leukemia and lymphoma can be misdiagnosed as periapical conditions, leading to inappropriate endodontic treatments and delayed diagnoses. Endodontists should become familiar with the broad clinicoradiographic spectrum of these rare, but potentially life-threatening hematolymphoid malignancies.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 106-117"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenomedullin-loaded Gelatin Methacryloyl Hydrogel Promotes Endogenous Dental Pulp Regeneration: An In Vitro and In Vivo Study","authors":"Yangpeng Zhao MD ,&nbsp;Qian Zhang MD ,&nbsp;Song Zhang MD ,&nbsp;Jianan Chen MD ,&nbsp;Lingtong Kong MD ,&nbsp;Jianyong Gao MD ,&nbsp;Qiang Zhu MD","doi":"10.1016/j.joen.2024.11.011","DOIUrl":"10.1016/j.joen.2024.11.011","url":null,"abstract":"<div><h3>Introduction</h3><div>To prepare a gelatin methacryloyl (GelMA) hydrogel scaffold embedded with adrenomedullin (ADM) and investigate its impact and underlying mechanisms in endogenous pulp regeneration.</div></div><div><h3>Methods</h3><div>ADM was evenly distributed within the GelMA hydrogel through a simple and conventional physical mixing technique. The scaffold underwent characterization via scanning electron microscopy, alongside assessments of swelling, degradation, and release properties. Biocompatibility was evaluated using cytoskeletal and live-dead staining techniques. The hydrogel's influence on dental pulp stem cells' proliferation, migration, and differentiation was assessed with CCK-8 assays, Transwell assays, and alizarin red and alkaline phosphatase staining. Transcriptomics provided insights into potential mechanisms. The angiogenic effects on umbilical vein endothelial cells were examined using scratch and tube formation assays. <em>In vivo</em>, the composite hydrogel's regenerative capacity was tested in a rat model of pulp regeneration. Statistical analysis involved Student's <em>t</em>-test and one-way analysis of variance, with significance set at <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>The ADM-loaded GelMA (GelMA@ADM) hydrogel displayed a porous architecture under electron microscopy conducive to cell adhesion and demonstrated excellent biocompatibility. <em>In vitro</em> experiments showed that GelMA@ADM significantly boosted dental pulp stem cells' migration, proliferation, and differentiation, and enhanced the angiogenic activity of umbilical vein endothelial cells after one week of treatment. Corresponding <em>in vivo</em> experiments revealed that GelMA@ADM facilitated the formation of new vascularized pulp tissue after 2 weeks of treatment.</div></div><div><h3>Conclusions</h3><div>The GelMA@ADM hydrogel effectively promotes dental pulp stem cells' proliferation and differentiation, augments vascularization by umbilical vein endothelial cells, and fosters the creation of new vascularized pulp tissue. These findings underscore the potential of GelMA@ADM hydrogel for endogenous pulp regeneration.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 172-184"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Debris Apical Extrusion, Unprepared Surface Areas, and Dentinal Crack Formation after Root Canal Preparation Using ProTaper Next, ProTaper Ultimate, and R-Motion File Systems","authors":"Haider A. Ibrahim BDS ,&nbsp;Ahmed H. Ali BDS, MSc, PhD (UK) ,&nbsp;Francesco Mannocci MD, DDS, PhD, FHEA","doi":"10.1016/j.joen.2024.11.014","DOIUrl":"10.1016/j.joen.2024.11.014","url":null,"abstract":"<div><h3>Introduction</h3><div>This study evaluated and compared the amount of apically extruded debris, unprepared wall surface areas, and dentinal crack formation resulting from root canal preparation using ProTaper Next (PTN), ProTaper Ultimate (PTU), and R-Motion (RM) file systems.</div></div><div><h3>Methods</h3><div>Forty-five palatal roots of maxillary first molars were shortened to a uniform length of 12 mm. The samples were divided randomly into 3 groups (<em>n</em> = 15/group) to be prepared using either PTN, PTU, and RM file systems. The investigator adopted modified Myers and Montgomery's approach to replicate the temperature of the human body. Debris was collected in vials and weighed before and after instrumentation with a sensitive balance. Every specimen was irrigated using distilled water during preparation, utilizing a side-vented needle. Weight before instrumentation was subtracted from weight after instrumentation to identify the weight of the collected debris. Cone-beam computed tomography (CBCT) scans were taken before and after canal preparation using a Planmeca ProMax CBCT machine. The unprepared canal surface area was calculated by superimposing preoperative and postoperative CBCT images using the Mimics Medical program. After preparation, a low-speed diamond disc horizontally sectioned the roots at 3, 6, and 9 millimeters from the apex. The specimens were examined under a digital microscope to detect crack formation. Statistical analysis was carried out using one-way (ANOVA) and Tukey (HSD) tests, with a significance level of <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>There was no statistically significant difference in the quantity of debris extruded apically and dentinal crack numbers among the 3 shaping files (<em>P</em> &gt; .05). Only the apical third of root canals prepared by PTU displayed a significantly lower unprepared surface area compared to PTN and RM.</div></div><div><h3>Conclusions</h3><div>Instrumentation with PTN, PTU, and RM yielded similar amounts of apically extruded debris and dentinal cracks. The PTU files demonstrated higher effectiveness in preparing the apical third by reducing the unprepared surface area in the prepared root canal.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 2","pages":"Pages 200-206"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}