Mario Alovisi DDS, PhD , Andrea Baldi DDS, PhD , Edoardo Moccia DDS, PhD , Ivan Gaviglio PhD , Allegra Comba DDS, PhD , Lia Giordano DDS , Nicola Scotti DDS, PhD , Damiano Pasqualini DDS
{"title":"Micro-CT and Finite Element Analysis of Dentin Preservation and Stress Distribution in Mesial Roots of Mandibular Molars after Shaping with Different Tapers","authors":"Mario Alovisi DDS, PhD , Andrea Baldi DDS, PhD , Edoardo Moccia DDS, PhD , Ivan Gaviglio PhD , Allegra Comba DDS, PhD , Lia Giordano DDS , Nicola Scotti DDS, PhD , Damiano Pasqualini DDS","doi":"10.1016/j.joen.2025.06.017","DOIUrl":"10.1016/j.joen.2025.06.017","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to evaluate the dentin preservation and fracture resistance of mandibular molar mesial roots after shaping with different tapers using micro–computed tomography (micro-CT) and finite element analysis (FEA).</div></div><div><h3>Methods</h3><div>Forty-eight mandibular first molars with independent mesial canals were selected. The mesio-lingual and mesio-buccal canals were randomly assigned (<em>n</em> = 12) to ProTaper Gold (PG), ProTaper Next (PTN), ProTaper Ultimate (PTU), and B4U instrumentation systems. Pre- and post-shaping micro-CT scans were performed to compare root canal volume and cervical dentin volume. The centroid shift and the percentage and distribution of the dentin removal in correspondence of the mesial canals were analyzed in coronal, middle, and apical points of analysis and below the furcation at the “danger zone.” The residual dentin thickness in the distal and mesial aspects of the mesial canals was measured. A linear elastic model of a mesial root of a mandibular molar was created through the finite element method (FEM) and a 200N perpendicular load was applied on the root canal coronal third. One-way factorial analysis of variance with Bonferroni correction and post hoc Tukey-Kramer tests were used (<em>P</em> < .05).</div></div><div><h3>Results</h3><div>The mean cervical dentin volume removal was statistically lower for the B4U compared with the PG system (<em>P</em> < .05). The canal centering ability was statistically more accentuated for the B4U group in the coronal and middle third and higher centroid shift variations occurred for PG system (<em>P</em> < .05). The residual dentin thickness appeared statistically higher after shaping with B4U through the mesial and distal root aspect at the coronal point of analysis and at the danger zone (<em>P</em> < .05). PG removed more dentin in the coronal root canal third (<em>P</em> < .05). The FEM analysis showed no statistically significant differences between groups (<em>P</em> > .05).</div></div><div><h3>Conclusions</h3><div>The reduction of the root canal taper may improve the instruments’ centering ability and the preservation of the residual dentin tissue, especially in the coronal and middle third. The root canal taper seems not to influence the stress distribution pattern through the mesial root of the lower molars.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 10","pages":"Pages 1477-1484"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aysha M. Saad BDS , Mohamed M. Elashiry BDS, MDS, PhD , Alia H. Mansour MD, PhD , Ahmed Elbokl MD, PhD , Mohamed M. Nagy BDS, MDS, PhD , Ahmed A. Hashem BDS, MDS, PhD
{"title":"Electroencephalogram as an Objective Method for Recording Pain after Endodontic Noxious Stimuli","authors":"Aysha M. Saad BDS , Mohamed M. Elashiry BDS, MDS, PhD , Alia H. Mansour MD, PhD , Ahmed Elbokl MD, PhD , Mohamed M. Nagy BDS, MDS, PhD , Ahmed A. Hashem BDS, MDS, PhD","doi":"10.1016/j.joen.2025.05.019","DOIUrl":"10.1016/j.joen.2025.05.019","url":null,"abstract":"<div><h3>Introduction</h3><div><span>This study evaluated the significance of brain wave activity, particularly theta waves, in detecting noxious </span>endodontic stimuli and to determine their validity as an objective method for monitoring pain severity.</div></div><div><h3>Methods</h3><div><span>The study included 300 patients with symptomatic irreversible pulpitis<span> on 1 side of their jaws. Each participant wore a consumer-grade electroencephalogram (EEG) device, the EMOTIV EPOC X, for 10 minutes while seated in a dental chair. The control and inflamed teeth were evaluated to assess the patient's response to applied stimuli. Patients were asked to rate their pain intensity using a visual analog scale (VAS), while their theta wave brain activity was recorded using the EEG. Pain scores and EEG data were then collected and analyzed. Various comparisons were conducted using the signed-rank test, and correlations were assessed using Spearman's rank-order correlation coefficient. </span></span><em>P</em> values were adjusted for multiple comparisons using Bonferroni's correction, with the significance level set at <em>P</em> < .05 for all tests.</div></div><div><h3>Results</h3><div><span>The results showed that in the inflamed side, theta wave activity (10.57 [6.76]) and VAS pain scores (7 [4]) were significantly higher (</span><em>P</em> < .001) than the control side (6.99 [4.87] and 1 [1.62], respectively). There was a moderate positive correlation between theta wave activity and VAS pain scores across all readings (0.3 < rs < 0.5, <em>P</em> < .001). Females had significantly higher theta band power readings than males on both sides (<em>P</em> < .05). However, females reported significantly higher pain scores than males only on the inflamed side (<em>P</em> < .001).</div></div><div><h3>Conclusions</h3><div>This study illustrates the promising potential of monitoring theta brain wave activity as an objective method for assessing pain levels.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 10","pages":"Pages 1405-1412"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poorya Jalali DDS , Hossein Mohammad-Rahimi DDS , Feng-Ming Wang DDS, PhD , Fatemeh Sohrabniya DDS , Seyed AmirHossein Ourang DDS , Yuke Tian BS, MS , Frederico C. Martinho DDS, MSc, PhD , Ali Nosrat DDS, MS, MDS
{"title":"Performance of 7 Artificial Intelligence Chatbots on Board-style Endodontic Questions","authors":"Poorya Jalali DDS , Hossein Mohammad-Rahimi DDS , Feng-Ming Wang DDS, PhD , Fatemeh Sohrabniya DDS , Seyed AmirHossein Ourang DDS , Yuke Tian BS, MS , Frederico C. Martinho DDS, MSc, PhD , Ali Nosrat DDS, MS, MDS","doi":"10.1016/j.joen.2025.06.014","DOIUrl":"10.1016/j.joen.2025.06.014","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to assess the overall performance of artificial intelligence chatbots in answering board-style endodontic questions.</div></div><div><h3>Methods</h3><div>One hundred multiple choice endodontic questions, following the style of American Board of Endodontics Written Exam, were generated by two board-certified endodontists. The questions were submitted to the following chatbots, three times in a row: Gemini Advanced, Gemini, Microsoft Copilot, GPT-3.5, GPT-4o, GPT-4.0, and Claude 3.5 Sonnet. The chatbot was asked to choose the correct response and to explain the justification. The response to the question was considered “correct” only if the chatbot picked the right choice in ALL 3 attempts. The quality of reasoning as to why the chatbot selected the answer choice was scored using a three-ordinal scale (0, 1, 2). Two calibrated reviewers scored all 2100 responses independently. Categorical data were analyzed using Chi-square test; ordinal data were analyzed using Kruskal–Wallis and Mann–Whitney tests.</div></div><div><h3>Results</h3><div>The accuracy scores ranged from 48% (Microsoft Copilot) to 71% (Gemini Advanced, GPT-3.5, and Claude 3.5 Sonnet) (<em>P</em> < .05). Gemini Advanced, Gemini, and Microsoft Copilot showed similar performance regardless of the question source (textbook or literature) (<em>P</em> > .05). GPT-3.5, GPT-4o, GPT-4.0 and Claude 3.5 Sonnet performed significantly better with textbook-based questions (<em>P</em> < .05). Reasoning scores showed different distribution among chatbots (<em>P</em> < .05). Gemini Advanced had the highest rate of score 2 (81%) and the lowest rate of score 0 (18.5%).</div></div><div><h3>Conclusions</h3><div>Comprehensive assessment of seven AI chatbots’ performance on board-style endodontic questions revealed their capacities and limitations as educational resources in the field of endodontics.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 10","pages":"Pages 1413-1419"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Nosrat DDS, MS, MDS , Alireza Kolahdouzan DDS, MS , Rajeshwari Hadagalu Revana Siddappa BDS, MDS, PhD , Changjun Cheng MS, PhD , Fang-Chi Li DDS, MSc, PhD , Meisam Moradi DDS, MS , Amir Hossein Khatibi DDS, MS , Davoud Jamshidi DDS, MS , Azin Parsa DDS, MSc, PhD , Jeffery B. Price DDS, MS , Anibal Diogenes DDS, MS, PhD , Yu Zou BEng, MEngDrSc , Anil Kishen BDS, MDS, PhD
{"title":"Biomechanical Characterization of Immature Roots Following Regenerative Endodontic Treatment and MTA Apexification: A Clinical Study","authors":"Ali Nosrat DDS, MS, MDS , Alireza Kolahdouzan DDS, MS , Rajeshwari Hadagalu Revana Siddappa BDS, MDS, PhD , Changjun Cheng MS, PhD , Fang-Chi Li DDS, MSc, PhD , Meisam Moradi DDS, MS , Amir Hossein Khatibi DDS, MS , Davoud Jamshidi DDS, MS , Azin Parsa DDS, MSc, PhD , Jeffery B. Price DDS, MS , Anibal Diogenes DDS, MS, PhD , Yu Zou BEng, MEngDrSc , Anil Kishen BDS, MDS, PhD","doi":"10.1016/j.joen.2025.06.018","DOIUrl":"10.1016/j.joen.2025.06.018","url":null,"abstract":"<div><h3>Introduction</h3><div>This clinical investigation aims to determine and compare the volume, hardness, and elastic modulus of immature roots following regenerative endodontic treatment (RET) and mineral trioxide aggregate (MTA) apexification.</div></div><div><h3>Methods</h3><div>A total of six volunteers aged between 9 and 14 years participated in the study, each providing a pair of mandibular or maxillary premolars with normal pulp and periapex planned for extraction due to orthodontic reasons. After full pulpectomy, each pair received either an MTA obturation or RET using blood clot as scaffold, followed by permanent restoration. Teeth were extracted ∼6.5 months later. Micro–computed tomographic images of teeth were taken for volumetric analyses and roots were subjected to nanoindentation physical testing.</div></div><div><h3>Results</h3><div>Root volumes ranged from 168 mm<sup>3</sup>–236 mm<sup>3</sup> (202.5 ± 31.07) in the MTA group and 178 mm<sup>3</sup>–251 mm<sup>3</sup> (223 ± 28.09) in the RET group (<em>P</em> < .05). The median values of hardness in all regions (apical and middle) and all sites (periphery to canal lumen) ranged from 0.56–1.04 giga pascal (GPa) in the MTA group and 0.32–0.65 GPa in the RET group (<em>P</em> < .05). The median values of elastic modulus in all regions (apical and middle) and all sites (periphery to canal lumen) ranged from 10.4–22.9 GPa in the MTA group and 4.8–12.1 GPa in the RET groups (<em>P</em> < .05). Except the hardness in apical third in the MTA group, the values of hardness and elastic modulus increased from periphery towards lumen in all other regions in both groups (<em>P</em> < .05).</div></div><div><h3>Conclusions</h3><div>After a period of 6.5 months RET resulted in increased root volumes, with the root structure indicative of newly formed hard tissue, which exhibited lower hardness and elastic modulus compared to those treated with MTA apexification.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 10","pages":"Pages 1429-1437"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dan Cho-Kee DDS , Bettina R. Basrani DDS, MSc, PhD , Jorge Vera DDS, MS , Ronald Ordinola-Zapata DDS MS, PhD , Rubén Rosas Aguilar DDS, MS
{"title":"Sodium Hypochlorite Accidents: A Retrospective Case-series Analysis of CBCT Imaging and Clinician Surveys","authors":"Dan Cho-Kee DDS , Bettina R. Basrani DDS, MSc, PhD , Jorge Vera DDS, MS , Ronald Ordinola-Zapata DDS MS, PhD , Rubén Rosas Aguilar DDS, MS","doi":"10.1016/j.joen.2025.05.024","DOIUrl":"10.1016/j.joen.2025.05.024","url":null,"abstract":"<div><div>This case series study aims to investigate retrospectively the causes underlying sodium hypochlorite (NaOCl) accidents in endodontic<span><span><span> practices through analysis of cone beam computed tomography (CBCT) imaging and comprehensive clinician surveys. Twenty-four dental practitioners who encountered a NaOCl accident during the treatment of a permanent tooth in adult patients provided deidentified patient data, facial photographs, and a limited field of view </span>CBCT of the involved tooth. Providers also had to report patient's immediate presence of pain and swelling after root canal irrigation to include the dataset into the study. Modified surveys were administered to collect information on other demographic factors including age, sex, tooth involved, apical diagnosis, presence of ecchymosis, pain severity, among others. The CBCT volume was used to identify the presence of </span>fenestration, root perforation, and apical pathosis. CBCT data were evaluated by 4 examiners. Among the 26 NaOCl accidents investigated, a higher incidence was observed in females (65.30%) and maxillary teeth (92.30%). All cases presented immediate swelling and edema; intracanal bleeding and hematoma were observed in 80.70 and 84.60% of the cases respectively. CBCT interpretation revealed that bone fenestrations were evident in all cases studied (100%), iatrogenic perforations were detected in 19.23% of the cases, and apical pathosis was noted in 30.70% of the cases. This case series study highlights that a direct communication between the root apex and surrounding soft tissues is highly prevalent in NaOCl accidents. Early identification of bone fenestrations or perforations identified in maxillary teeth of female patients can play a pivotal role in preventing NaOCl extrusion accidents during endodontic treatment.</span></div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 10","pages":"Pages 1485-1489"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Systemic Statin Intake on Healing of Apical Periodontitis after Nonsurgical Root Canal Treatment: A Retrospective Cohort Study","authors":"Esha Goel BDS, MClinDent (Endodontology), MEndo RCSEd , Shahrah Mkhreb BDS, MSc , Elisabetta Cotti DDS, MS , Francesca Ideo DDS, PhD , Sadia Niazi BDS, MSc, PhD, MEndo RCSEd, F(Endo) RCSEd, MEndo RCS Eng, FHEA , Garrit Koller BDS, MSc, PhD , Samira Farzadi BDS, BSc , Francesco Mannocci MD, DDS, PhD, FHEA","doi":"10.1016/j.joen.2025.06.010","DOIUrl":"10.1016/j.joen.2025.06.010","url":null,"abstract":"<div><h3>Introduction</h3><div>This retrospective cohort study compared the radiographic healing of apical periodontitis following root canal treatments and retreatments in patients regularly taking statins versus those who had never taken statins.</div></div><div><h3>Methods</h3><div>Patients who underwent root canal treatment or retreatment performed by undergraduate and postgraduate students were included. The patients were divided into 2 age-matched groups: those who reported regularly taking statins and those who had never taken statins. The outcome was assessed using periapical radiographs taken at least at 1-year post-treatment. Teeth with short root canal fillings were excluded. Single and multiple binary logistic regression tested the association between statin use and radiographic treatment outcome while adjusting for root-canal and restoration quality, diabetes mellitus, cardiovascular diseases, patient age, tooth type, and follow-up period.</div></div><div><h3>Results</h3><div>A total of 122 teeth were analyzed: 62 from patients taking statins and 60 from patients not taking statins. Using lenient criteria, logistic regression showed no significant difference in healing rates between the statin and control groups (90.3% vs. 90%; OR = 1.04; <em>P</em> = .952). However, under strict criteria, patients taking statins had a significantly lower probability of success compared to controls (62.9% vs 85%; OR = 0.30; <em>P</em> = .008).</div></div><div><h3>Conclusions</h3><div>Patients taking statins had a lower number of radiographic complete healings than those not taking statins. The results of this study challenge the presumed benefits of systemic statins intake on AP healing.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 10","pages":"Pages 1384-1392"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyoko Inamoto, Bruna Motta Minusculi Sander, Fernando Gustavo Exposto, Alberto Herrero Babiloni, Peter Svensson, Yuri Martins Costa
{"title":"Intraoral Sensory Alterations in Myofascial Orofacial Pain Patients: Implications for Clinical Management.","authors":"Kyoko Inamoto, Bruna Motta Minusculi Sander, Fernando Gustavo Exposto, Alberto Herrero Babiloni, Peter Svensson, Yuri Martins Costa","doi":"10.1016/j.joen.2025.09.013","DOIUrl":"10.1016/j.joen.2025.09.013","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated differences in intraoral sensitivity to thermal and mechanical stimuli, and pulp sensibility between patients with myofascial orofacial pain (MOP) and healthy controls. We hypothesized that patients would exhibit increased sensitivity to these stimuli.</p><p><strong>Methods: </strong>A controlled study was performed, including 50 MOP patients and 104 controls aged 18-65. Intraoral and extraoral sensitivities were assessed at various sites using simple quantitative sensory testing (numerical ratings of thermal/mechanical stimuli) and qualitative somatosensory testing (side-to-side differences in sensitivity to touch, cold and pinprick as hyper-, hypo- or normal). Pulp sensibility was evaluated using cold stimuli. Statistical analyses included repeated-measures analysis of variance and Fisher's exact test (α = 0.05).</p><p><strong>Results: </strong>Patients exhibited significantly higher intraoral hypersensitivity at the buccal gingiva to touch (14%), cold (34%), and pinprick stimuli (36%) compared to controls (0%, 14%, 15%). Similar trends were observed at extraoral sites including the masseter, temporalis, and thenar region. Pulp testing revealed significantly longer pain durations in patients (mean: 5.9 seconds) compared to controls (mean: 3.7 seconds), although pain intensity did not differ significantly. While simple quantitative sensory testing showed no significant group differences, qualitative somatosensory testing effectively identified intraoral and extraoral somatosensory abnormalities.</p><p><strong>Conclusions: </strong>Patients with MOP exhibited heightened intraoral sensitivity and prolonged pain responses. These findings underscore the diagnostic challenge of distinguishing sensitivity associated with MOP from odontogenic pain, such as pulpitis, which may lead to unnecessary dental procedures. Thorough assessments may help clinicians avoid misdiagnosis and improve outcomes, while longitudinal studies are needed to assess the possibility of clinical consequences.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tai-Wei Feng, Ming-Fa Hsieh, Shiuh-Tzung Liu, Chun-Pin Lin
{"title":"Inorganic Ion Permeation through Human Dentinal Tubules: Implications for Bioactive Endodontic and Desensitizing Therapies.","authors":"Tai-Wei Feng, Ming-Fa Hsieh, Shiuh-Tzung Liu, Chun-Pin Lin","doi":"10.1016/j.joen.2025.09.011","DOIUrl":"10.1016/j.joen.2025.09.011","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the effects of pH, molecular weight, and ion charge on the permeation efficiency of selected inorganic ions through dentinal tubules.</p><p><strong>Methods: </strong>Standardized 0.5 mm-thick human dentin slices were prepared and exposed to various inorganic salt solutions under pH = 4, 7, and 10 conditions. Ion permeation was quantified over a 60-minute period. Morphologic changes were examined via scanning electron microscopy. ANOVA and Spearman's correlation were used to analyze the influence of multiple variables on the diffusion of ions.</p><p><strong>Results: </strong>pH values were found to be the most influential factor: ion permeation is significantly enhanced under acidic environments and is hindered under alkaline conditions. Molecular weight and ion charge also affected diffusion, with lower molecular weight and +1 charge ions showing superior permeation. No significant difference was observed between cations and anions. Scanning electron microscopy analysis revealed no crystal deposition or tubule occlusion under the conditions investigated in this work.</p><p><strong>Conclusions: </strong>Ion permeation through dentinal tubules is primarily governed by environmental pH, followed by ion charge and molecular weight. These findings inform the rational design of ion-releasing dental materials tailored for acidic environments. Further research should explore long-term effects and multiion interactions to enhance clinical relevance.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Top 100 Most-cited Articles in Root Canal Anatomy: A Scopus-based Bibliometric Study.","authors":"Yu-Chiao Wu, Ho-Sheng Chiang, Zi-Jun Dai, Yi-Jie Chen, Yen-Ching Chao, Hsiao-Wen Yeh, Ren-Yeong Huang, Yi-Shing Shieh","doi":"10.1016/j.joen.2025.09.010","DOIUrl":"10.1016/j.joen.2025.09.010","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding root canal anatomy is fundamental for successful endodontic treatment. This bibliometric study aimed to identify and analyze the 100 most-cited articles related to root canal morphology to discover research trends, influential publications, and methodological progress in the field.</p><p><strong>Methods: </strong>Data were extracted from the Scopus database using the search terms \"root canal anatomy\" OR \"root canal morphology\" AND NOT \"Preparation,\" with selection finalized on July 28, 2025. Articles were manually screened, and only English-language original research related to human teeth was included. Citation counts, publication years, journal names, countries of origin, study designs, and methodologies were analyzed.</p><p><strong>Results: </strong>Most of the top-cited studies were published in the Journal of Endodontics and International Endodontic Journal, which together contributed 80% of the articles. Cone-beam computed tomography was the most used method, followed by dye-injected decalcified teeth and micro-computed tomography. The most frequently studied teeth were mandibular and maxillary first molars. Geographically, the United States, Brazil, and China led in publication output. Notably, there were no articles from Africa, highlighting a potential area for collaborative development. Over time, research has shifted from invasive in vitro techniques to advanced non-invasive imaging. The most-cited article was Vertucci's 1984 classification study, which remains widely used today.</p><p><strong>Conclusions: </strong>This bibliometric analysis delivers a comprehensive overview of influential studies in root canal anatomy, offering insights into global research patterns and technological advancement.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}