Journal of endodontics最新文献

{"title":"Microtomographic Analysis of the Biomechanical Performance of Thermally Treated Instruments in Flattened and Curved Root Canals","authors":"Julia Godoi Lopes DDS ,&nbsp;Jeneffer Vieira Rodrigues DDS, MSc ,&nbsp;Iago Ramirez DDS, MSc ,&nbsp;Rafael Verardino de Camargo DDS, MSc ,&nbsp;Graziela Bianchi Leoni DDS, MSc, PhD ,&nbsp;Manoel Damião Sousa-Neto DDS, MSc, PhD ,&nbsp;Fabiane Carneiro Lopes-Olhê DDS, MSc, PhD ,&nbsp;Jardel Francisco Mazzi-Chaves DDS, MSc, PhD","doi":"10.1016/j.joen.2024.12.012","DOIUrl":"10.1016/j.joen.2024.12.012","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to evaluate, using microcomputed tomography, the impact of various mechanized systems on the geometry of the root canal system and dentin thickness in mandibular first molars. The hypothesis proposed that different systems would produce significant variations in root canal system preparation.</div></div><div><h3>Methods</h3><div>Mesial and distal canals of mandibular molars were selected and divided into 5 groups (n = 10) based on the system used: 2Shape (25.06), Reciproc Blue (25.08), ProTaper Ultimate (25.08), ProTaper Next (25.06), and Univy New (25.06). Biomechanical preparation was performed following each manufacturer's instructions. Microcomputed tomography scans were conducted before and after preparation to assess 3-dimensional parameters (volume, surface area, Structural Model Index, and prepared root canal walls) and 2-dimensional parameters (area, perimeter, diameters, roundness, and transportation).</div></div><div><h3>Results</h3><div>ProTaper Ultimate exhibited the greatest volume increase in mesial canals (1.73 ± 0.19), while ProTaper Next demonstrated the highest increase in distal canals (1.95 ± 0.25). Furthermore, ProTaper Ultimate resulted in the greatest dentin removal and the largest postpreparation area. Reciproc Blue achieved the best results for roundness and had the lower unprepared walls (15.3 ± 6.97).</div></div><div><h3>Conclusions</h3><div>All systems produced comparable outcomes, with ProTaper Ultimate yielding the greatest volume increase and dentin removal, indicating a less conservative preparation. Reciproc Blue provided optimal roundness and minimized unprepared root canal wall surfaces.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 348-358"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Pulp Regeneration in Dogs Using a Chemokine Receptor 3 Antagonist Without Transplantation of Dental Pulp Stem Cells","authors":"Koichiro Iohara DDS, PhD ,&nbsp;Akiho Nagumo ,&nbsp;Michiyo Tominaga ,&nbsp;S.M. Ziauddin DDS, PhD ,&nbsp;Haruki Shibata PhD","doi":"10.1016/j.joen.2024.12.010","DOIUrl":"10.1016/j.joen.2024.12.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Our previous study showed that transplantation of dental pulp stem cells in combination with a chemokine receptor 3 (CCR3) antagonist into the root canals of aged dogs promoted dental pulp regeneration. In this study, we attempted to regenerate dental pulp in young dogs using a CCR3 antagonist without dental pulp stem cell transplantation.</div></div><div><h3>Methods</h3><div>The teeth of dogs were histologically evaluated 4 weeks after extraction of the pulp and administration of scaffold materials and CCR3 antagonist (KDH-136) into the root canal. The effects of KDH-136 on the inflammatory response of RAW264.7 cells were investigated <em>in vitro</em>. In addition, we also examined whether KDH-136 affected neurite outgrowth of PC12 cells.</div></div><div><h3>Results</h3><div>Application of KDH-136 resulted in the formation of dental pulp-like tissue. Furthermore, nerve and blood vessel regeneration were observed. KDH-136 suppressed chemokine production from RAW264.7 cells and promoted nerve growth factor-stimulated neurite outgrowth of PC12 cells.</div></div><div><h3>Conclusions</h3><div>CCR3 antagonists may be useful for developing novel methods of dental pulp regeneration that do not require transplantation of dental pulp stem cells.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 316-324"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reciprocating Torsional Fatigue and Mechanical Tests of Thermal-Treated Nickel Titanium Instruments","authors":"Victor Talarico Leal Vieira DDS, MSc, PhD ,&nbsp;Alejandro Jaime DDS ,&nbsp;Carlos Garcia Puente DDS ,&nbsp;Giuliana Soimu DDS, MSc ,&nbsp;Emmanuel João Nogueira Leal Silva DDS, MSc, PhD ,&nbsp;Carlos Nelson Elias PhD ,&nbsp;Gustavo de Deus DDS, MSc, PhD","doi":"10.1016/j.joen.2024.12.013","DOIUrl":"10.1016/j.joen.2024.12.013","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to evaluate the mechanical properties of Reciproc, Reciproc Blue, One RECI, and R-Motion, specifically focusing on their flexibility and buckling resistance and to assess their torsional fatigue behavior under 2 different reciprocation angles (150°/30° or 70°/30°).</div></div><div><h3>Methods</h3><div>A total of 160 instruments (40 per brand) were tested. Flexion and buckling tests were conducted using a Universal testing machine (DL 200 MF). For the flexion test, instruments were positioned at a 45° angle and flexed toward the ground plane. In the buckling test, the load was applied along the instrument's axis. A 20 N load cell and a test speed of 15 mm/s were used for both tests. Torsion test was performed using a torsiometer. The test speed was 100 rpm and the instruments were driven by an endodontic motor in 150°/30° and 70°/30° reciprocating angles. One-way analysis of variance <em>post hoc</em> Tukey tests and Student's <em>t</em> test were used for statistical comparisons (<em>α</em> = 5%).</div></div><div><h3>Results</h3><div>The instruments exhibited significant differences in flexibility (<em>P</em> &lt; .05), with One RECI demonstrating the highest flexibility and Reciproc the lowest. In terms of buckling resistance, Reciproc showed the highest values, while One RECI had the lowest (<em>P</em> &lt; .05). Reciproc and Reciproc Blue displayed greater torque to fracture compared to One RECI and R-Motion (<em>P</em> &lt; .05). Reducing the reciprocation angle did not affect the torque to fracture (<em>P</em> &gt; .05). However, the reduced angle of 70°/30° significantly increased the time to fracture for all instruments when compared to angle of 150°/30° (<em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>The tested instruments demonstrated notable differences in their mechanical performance, highlighting variability in flexibility, buckling resistance, and torsional behavior. Reducing the reciprocation angle prolonged the time to fracture without affecting maximum torque, underscoring the influence of reciprocation kinematics on instrument performance.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"51 3","pages":"Pages 359-366"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Etiology and Pathogenesis of Multiple Cervical Root Resorption - A Scoping Review.","authors":"Yuhong Lin, Vivek Thumbigere-Math, Anil Kishen, Jianing He","doi":"10.1016/j.joen.2025.02.012","DOIUrl":"10.1016/j.joen.2025.02.012","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple Cervical Root Resorption (MCRR) is a rare condition characterized by the progressive destruction of the cervical region of multiple tooth roots, leading to significant tooth loss. The etiology and pathogenesis of MCRR remain poorly understood. Existing knowledge is largely derived from case reports/series. A comprehensive review of literature is crucial to identify potential systemic and dental factors that contribute to the development and progression of MCRR.</p><p><strong>Methods: </strong>A scoping review was conducted following PRISMA guidelines. Five major health science databases were systematically searched to capture all reported cases of MCRR published to date. Potential etiologic factors were identified and categorized based on their association with MCRRs.</p><p><strong>Results: </strong>A total of 65 reports documenting 101 patients and involving 921 teeth were included in the analysis. The review identified several potential etiologic factors, including skeletal disorders, autoimmune diseases, viral infections, genetic diseases, specific genetic mutations, liver dysfunctions, the use of antiresorptive medications, and endocrine disturbances. Each of these factors may influence osteoclast/odontoclast functioning, implicating them in the pathogenesis of MCRR.</p><p><strong>Conclusions: </strong>Systemic diseases and medications that alter bone remodeling process or osteoclast/odontoclast function play a significant role in the development of a large proportion of MCRR cases. Given the complex and multifactorial nature of this condition, an interdisciplinary approach involving general dentists, specialists, and physicians is essential. Early detection, prevention, and personalized management of MCRR are critical in minimizing the risk of extensive tooth loss and improving patient outcomes.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Capacity of Intraoral Scanner and Expert Scoring in Detecting Potential Deviations in Guided Endodontics: An In Vitro Study.","authors":"Pauline Binvignat, Marine Hénaut, Lieven Robberecht, Davide Mancino, Naji Kharouf, Jean-Christophe Maurin, Cyril Villat, Maxime Ducret, Raphael Richert","doi":"10.1016/j.joen.2025.02.011","DOIUrl":"10.1016/j.joen.2025.02.011","url":null,"abstract":"<p><strong>Introduction: </strong>Guided endodontics recently offers a conservative solution for conducting root canal treatment in cases of obliterated canals, but guide mispositioning remains a challenge. Recently, intraoral scanners (IOS) were proposed to detect deviations, but their effectiveness compared to expert visual assessments during guide insertion is uncertain. The objective of the present study was to primarily compare the risk of deviation predicted by an IOS vs expert assessment and secondarily identify factors influencing this risk.</p><p><strong>Methods: </strong>Using a design of experiments approach, 16 endodontic guides were 3D-printed to assess the influence of guide thickness, internal offset, number of supporting teeth, and presence of windows. Guide positioning was evaluated digitally with the Trios 4 IOS to calculate angular deviation and visually by 10 experts using a Likert scale. The overall agreement between the value of angular deviation (less than or greater than 2°) and the expert score (positive or negative) was calculated.</p><p><strong>Results: </strong>The mean angular deviation was 4.32° (SD = 2.40°) and the mean expert score was -0.29 (SD = 1.39). Angular deviation was most influenced by greater guide thickness (41.4%) and internal offset (27.0%), which both increased it. The most influential factor for expert scores was internal offset (90.5%), which decreased ratings. Agreement between IOS and expert scores averaged 60.6% (SD = 39.1%), with the highest agreement for guides with a high internal offset.</p><p><strong>Conclusions: </strong>Experts effectively detected positioning errors with high internal offset but struggled with other factors where IOS was more accurate. IOS shows promising potential for improving guide fitting in clinical practice.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Retreatability of BC Sealer, BC Sealer Hiflow, and AH Plus: A Micro-Computed Tomography Study.","authors":"Priscilla Gouveia, Ana Grasiela Limoeiro, Caroline Beatriz Farias Silva, Marília Fagury Videira Marceliano-Alves, Carlos Eduardo Fontana, Daniel Guimarães Pedro Rocha, Carlos Eduardo da Silveira Bueno, Alexandre Sigrist De Martin","doi":"10.1016/j.joen.2025.02.009","DOIUrl":"10.1016/j.joen.2025.02.009","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, the ability to remove obturation material in canals filled with Bio C Sealer, BC Sealer Hiflow, and AH Plus was compared using micro-computed tomography.</p><p><strong>Materials and methods: </strong>In phase 1, 45 premolars were prepared with Reciproc Blue 25 files and divided into 3 experimental groups according to sealer and obturation techniques (n = 15): Group HI - BC Sealer Hiflow and continuous wave technique; Group AH - AH Plus and continuous wave technique; Group BC - Bio C Sealer and single cone technique. The teeth were stored for 30 days and scanned by micro-computed tomography to evaluate the volume of the obturation material. In phase 2, the teeth were unblocked with the Reciproc R40 file and the Flatsonic ultrasonic insert and scanned again. In phase 3, all samples were subjected to passive ultrasonic irrigation and a final scan was performed. The volume of obturation material was compared across all phases and groups. The volume of obturation material was calculated for the entire canal using an ANOVA analysis with a significance level of 5%.</p><p><strong>Results: </strong>The BC group showed a significant difference compared to the AH group (P = .005) and HI group (P < .001). There was no significant difference between the AH and HI groups. Within the groups, only the comparison of phase 2-3 in the HI group showed no significant difference (P = .005). No group achieved complete removal of the obturation material.</p><p><strong>Conclusion: </strong>Bio C Sealer had the least residual obturation material and passive ultrasonic irrigation improved material removal in AH Plus and Bio C Sealer sealers, but not in the BC Sealer Hiflow sealer.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the Filling Technique on Endodontic Retreatment in Curved Mesial Canals of Mandibular Molars: An In Vitro Study.","authors":"Felipe Andretta Copelli, Lisa Yurie Oda, Renata Maira de Souza Leal, Clarissa Teles Rodrigues, Marco Antonio Hungaro Duarte, Bruno Cavalini Cavenago","doi":"10.1016/j.joen.2025.02.010","DOIUrl":"10.1016/j.joen.2025.02.010","url":null,"abstract":"<p><strong>Introduction: </strong>The root curvature represents a challenge during the endodontic retreatment. Considering the different techniques to fill the root canals and the growing use of bioceramic sealers, this study aimed to evaluate the influence of the filling technique associated with a bioceramic sealer on the remaining filling material and the impact on the remaining dentin after the filling removal in the retreatment of curved mesial canals of mandibular molars.</p><p><strong>Methods: </strong>Eighteen curved mesial roots of mandibular molars with Vertucci type IV canals were prepared up to instrument 35/.05. Two groups were established according to the filling technique: single-cone (n = 18) and continuous wave of condensation (n = 18). Bio-C Sealer was used for both techniques. The filling was removed using the Reciproc Blue R25 instrument, and the repreparation was carried out using the Reciproc Blue R40 instrument. The samples were scanned by micro-computed tomography before and after the filling removal and analyzed regarding the volume of the remaining filling material and dentin thickness for calculating transportation and centering ability. For statistical analysis, the data normality was checked, and parametric tests were used for normal distribution and nonparametric tests for nonnormal distribution.</p><p><strong>Results: </strong>The remaining filling material was observed in both groups during retreatment, with no differences. Analyses of transportation and centering ability also indicated similarities between the two groups.</p><p><strong>Conclusions: </strong>Endodontic retreatment in curved mesial canals of mandibular molars filled with single-cone or continuous wave of condensation technique and bioceramic sealer was similar. The use of reciprocating instruments for filling removal and repreparation was efficient in curved mesial canals of mandibular molars, with no complications.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Iterative Reconstruction of Cone-beam Computed Tomography for Detecting Vertical Root Fractures in the Presence of Metal Artifacts.","authors":"Matheus Barros-Costa, Gustavo Santaella, Christiano Oliveira-Santos, Deborah Queiroz Freitas, William C Scarfe, Francisco Carlos Groppo","doi":"10.1016/j.joen.2025.02.008","DOIUrl":"10.1016/j.joen.2025.02.008","url":null,"abstract":"<p><strong>Introduction: </strong>Vertical root fractures (VRFs) are challenging to detect, especially in endodontically treated teeth. Cone-beam computed tomography (CBCT) has improved VRF detection over periapical radiography but is limited by metal artifacts. Iterative Reconstruction (IR) algorithms are an alternative to the traditional Filtered-Back Projection (FBP) and have been shown to reduce image noise due to metal artifacts. This study aimed to evaluate the impact of IR on VRF detection in the presence of metal artifacts from intracanal materials and/or adjacent implants.</p><p><strong>Methods: </strong>This ex-vivo study included 22 single-rooted teeth (10 fractured, 12 nonfractured) placed in a human mandible phantom. CBCT scans were performed using Midmark EIOS CBCT with both reconstruction methods (FBP and IR), with and without metal artifact reduction (MAR) tool activation. Clinical conditions included the presence or absence of gutta-percha and adjacent titanium dental implants. Five oral radiologists evaluated the anonymized images for VRF presence using a 5-point scale. Diagnostic accuracy, sensitivity, specificity, and intra- and interobserver agreement were assessed using receiver operating characteristic curves and multiway ANOVA.</p><p><strong>Results: </strong>The area under the curve values ranged from 0.60 to 0.85, with no significant differences between reconstruction methods (P > .05). Sensitivity and specificity were generally unaffected by reconstruction method or MAR activation (P > .05), except when MAR reduced sensitivity in FBP with gutta-percha (P < .05). Metal artifacts from gutta-percha and implants negatively impacted VRF detection.</p><p><strong>Conclusions: </strong>The reconstruction method did not significantly influence VRF detection, suggesting that either method can be used in clinical practice without compromising diagnostic accuracy, even in the presence of metal artifacts.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Endodontically Treated Teeth in Patients Undergoing Treatment for Painful Temporomandibular Disorders: An Observational Study.","authors":"Nara Sarmento Macedo Signorelli, Camilla Christian Gomes Moura, Roger Ferreira Borges, Paulo Cézar Simamoto Júnior, Jennifer L Gibbs","doi":"10.1016/j.joen.2025.02.006","DOIUrl":"10.1016/j.joen.2025.02.006","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular disorders (TMDs) and endodontic pain often present overlapping symptoms, complicating the diagnosis and treatment of patients experiencing orofacial pain.</p><p><strong>Methods: </strong>This observational retrospective cohort study aims to determine the prevalence of endodontically treated teeth on the side of pain complaint in patients with TMD, and to explore the association between TMD diagnoses and the presence of endodontically treated teeth. Dental records of patients treated at the TMD and Pain clinic at the Federal University of Uberlândia was reviewed. The study included 85 patients, and demographic data, TMD diagnosis, and the side of referred pain were extracted from the records. Diagnostic imaging exams, including panoramic and periapical radiographs, and cone-beam computed tomography, were analyzed to count the number of endodontically treated teeth on each side of the mouth.</p><p><strong>Results: </strong>The study population consisted of 88% (n = 70) women, with a mean age of 40.5 ± 16.3 years. A significant association was found between the side of TMD pain and the number of endodontically treated teeth, with more treated teeth on the side of pain complaint (median = 1) compared to the pain-free side (median = 0), with P < .001. When analyzing specific TMD diagnoses, the association was significant in muscle-related and mixed TMD diagnoses but not in joint-related TMD pain. Additionally, a binary analysis confirmed this association, showing that patients were significantly more likely to have at least 1 endodontically treated tooth on the side of TMD pain compared to the nonpain side (χ² = 13.06, P = .0003).</p><p><strong>Conclusion: </strong>This study underscores the importance of comprehensive diagnostic evaluations in patients with orofacial pain to avoid unnecessary endodontic treatments and ensure appropriate care. Further research is needed to explore the underlying mechanisms linking endodontic and TMD pain and to validate these findings in diverse populations.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Regenerative Endodontic Procedure: Periapical Healing, Root Development, and Intracanal Calcification.","authors":"Minju Song, Hoi In Jung, Sahng Gyoon Kim","doi":"10.1016/j.joen.2025.02.007","DOIUrl":"10.1016/j.joen.2025.02.007","url":null,"abstract":"<p><strong>Introduction: </strong>This retrospective study aimed to investigate the clinical outcomes and prognostic factors of regenerative endodontic procedure in terms of the resolution of apical periodontitis (AP), root development (RtDev), and intracanal calcification (IC).</p><p><strong>Methods: </strong>The clinical outcomes of a total of 111 cases from 94 patients who underwent regenerative endodontic procedures between 2015 and 2020 were assessed based on clinical and radiographic evaluations.</p><p><strong>Results: </strong>The cumulative survival rate was 85.15%, and RtDev was identified in 67.33% of cases. The incidence of IC has increased over time, reaching 43.45%. The median follow-up time was 1267 days (95% confidence interval, 991-∞) for AP healing and RtDev and 776 days (95% confidence interval, 563-1754) for IC. The 4th stage of RtDev and intracanal medication for less than 14 days or more than 60 days were associated with significantly lower AP healing (P < .05). Patients younger than 8 years of age, absence of a periapical lesion, 2nd and 3rd stage of RtDev, and 14-30 days of intracanal medication were associated with a higher incidence of RtDev (P < .05). Dens evaginatus was associated with a significantly higher incidence of IC (P < .05).</p><p><strong>Conclusions: </strong>The stage of RtDev and duration of intracanal medication significantly affected AP healing and RtDev. Additionally, age and the presence of a periapical lesion were found to influence RtDev, whereas etiology was identified as the only predictor of IC.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}